摘要
目的研究蝙蝠蛾拟青霉菌丝体中环二肽类化合物的化学成分。方法采用硅胶柱色谱、制备型HPLC等色谱方法,对蝙蝠蛾拟青霉菌丝体的甲醇浸提物的正丁醇萃取物进行分离纯化,并根据理化性质及波谱数据鉴定分离得到化合物的结构。结果分离得到8个环二肽类化合物,经鉴定分别为环(脯-缬)二肽[cyclo(Pro-Val)](1)、环(脯-苯丙)二肽[cyclo(Pro-Phe)](2)、环(脯-异亮)二肽[cyclo(Pro-Ile)](3)、环(脯-亮)二肽[cyclo(Pro-Leu)](4)、环(亮-缬)二肽[cyclo(Leu-Val)](5)、环(苯丙-缬)二肽[cyclo(Val-Phe)](6)、环(丙-缬)二肽[cyclo(Val-Ala)](7)、环(丙-苯丙)二肽[cyclo(Ala-Phe)](8)。结论化合物1-8为首次从瓶梗青霉属植物中分离得到。
Objective To study the chemical constituents of cyclo-dipeptide compounds from Paecilomyces hepiali mycelium.Methods The compounds were isolated and purified from the n-butanol extract of methanol extract of Paecilomyces hepiali by chromatographic methods such as silica gel column chromatography and preparative liquid chromatography.The structures were identified on the basis of physico-chemical properties and spectral data.Results Eight cyclo-dipeptide compounds were isolated and identified as cyclo(Pro-Val)(1),cyclo(Pro-Phe)(2),cyclo(Pro-Ile)(3),cyclo(Pro-Leu)(4),cyclo(Leu-Val)(5),cyclo(Val-Phe)(6),cyclo(Val-Ala)(7)and cyclo(Ala-Phe)(8),respectively.Conclusion Compounds 1-8 are obtained from Paecilomyces Bain for the first time.
作者
吴双凤
赵益铭
董冰
崔轶达
邓博文
张国刚
WU Shuangfeng;ZHAO Yiming;DONG Bing;CUI Yida;DENG Bowen;ZHANG Guogang(School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China)
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2020年第3期236-239,共4页
Journal of Shenyang Pharmaceutical University
基金
沈阳药科大学创新创业训练计划项目(201810163090).
关键词
蝙蝠蛾拟青霉
环二肽类
结构鉴定
Paecilomyces hepiali
cyclo-dipeptide
structure identification
作者简介
吴双凤(1997-),女(汉族),贵州桐梓人,本科生,E-mail:1834313730@qq.com;通信作者:张国刚(1965-),男(汉族),辽宁沈阳人,教授,博士,主要从事中药天然药物活性成分及中药新药的研究工作,Tel.02423986511,E-mail:zggth@163.com。
