摘要
目的探讨常用感染性指标在新型冠状病毒肺炎(COVID-19)患者分层中的价值。方法纳入长沙市公共卫生救治中心239例确诊COVID-19病例,对常用感染性指标(WBC、Neu%、Lymph%、CRP及ESR)按流行病学接触史、家族聚集情况、基础疾病、严重程度、住院天数、轻症患者在治疗过程中疾病变化分层,分析各分层因素对感染性指标的影响。结果与无明确流行病学接触史患者比较,有接触史患者Neu%降低,Lymph%升高(P<0.05)。按有无基础疾病分层后,相对于无基础疾病患者,有基础疾病患者Lymph%降低,Neu%和CRP升高(P<0.05)。与轻症患者比较,重症患者Lymph%降低,而Neu%、CRP和ESR升高(P<0.05)。按轻症患者在治疗过程中疾病进展分层发现,相对于病程好转患者,加重患者Lymph%降低,Neu%升高与CRP升高(P<0.05)。结论感染性指标Lymph%,Neu%与CRP在判断COVID-19患者是否伴随基础疾病,病情轻重及疾病诊疗过程中的变化有良好的鉴别意义。Lymph%、Neu%与CRP可作为伴有基础疾病的重症患者的重要指标,为临床诊断和治疗提供的参考价值。
Objective To explore the value of common infectious markers in the stratification of COVID-19 patients.Methods 239 cases of COVID-19 were diagnosed in Changsha Public Health Treatment Center.The common infectious indexes(WBC,Neu%,Lymph%,CRP and ESR)were stratified according to epidemiological exposure history,family aggregation,basic disease,clinical severity,length of stay,and disease change of mild patients in the treatment process,and then we analyzed the influence of various stratification factors on infectivity index.Results Compared with patients with no clear epidemiological exposure history,Neu%decreased and Lymph%increased in patients with epidemiological exposure history(P<0.05).Compared with patients without underlying diseases,Lymph%decreased,Neu%and CRP increased in patients with underlying diseases(P<0.05).In addition,Lymph%decreased and Neu%,CRP and ESR increased(P<0.05)in severe patients which compared with mild patients.Meanwhile,according to the stratification of disease progression in the treatment of mild patients,Lymph%decreased,Neu%and CRP increased in aggravated patients which compared with patients with improved disease course.Conclusions The infectious markers of Lymph%,Neu%and CRP had differential significance in judging whether COVID-19 patients are accompanied by underlying disease,the severity and the changes in the diagnosis and treatment.Lymph%,Neu%and CRP can be used as important indicators for severely ill patients with underlying diseases,providing reference value for clinical diagnosis and treatment.
作者
黄亚熊
肖雯
刘协红
蒋宇
邹联洪
肖薇薇
陈芳
Huang Yaxiong;Xiao Wen;Liu Xiehong;Jiang Yu;Zou Lianhong;Xiao Weiwei;Chen Fang(Department of infectious,The first hospital of Changsha(Changsha Public Health Treatment Center),Changsha,China;Hunan Provincial Institute of Emergency Medicine,Hunan Provincial Key Laboratory of Emergency and Critical Care Metabonomics,Changsha,China;Emergency Department,Hunan Provincial People's Hospital(The first-affiliated hospital of Hunan normal university),Changsha,China)
出处
《实用休克杂志（中英文）》
2020年第3期143-147,159,共6页
Journal of Practical Shock
基金
湖南省科技厅社会发展领域重点研发项目(项目编号:2020SK3011)
作者简介
通信作者:陈芳,E-mail:chenf519@163.com
