摘要
目的分析阿尔兹海默症相关危险因素的研究热点及发展趋势。方法采用CiteSpace 6.1.R2软件,对从Web of Science^(TM)核心合集检索到的952篇和从CNKI检索到的429篇与阿尔兹海默症危险因素相关的文献进行可视化分析,分析内容包括相关文献增长规律、核心作者、高频关键词、关键词聚类、研究热点的演变等。结果阿尔兹海默症危险因素研究领域国内外发文量差距较大,但总体均呈现上升趋势。国内核心作者为周华东,国外核心作者为Kim S和Kivipelto M。美国在该领域的研究最为突出。国内外关键词共现关系网络中分别识别出了327个节点、629条连线和438个节点、3467条连线。国内研究中关键词“危险因素”“痴呆”“老年人”“认知障碍”的中心性>0.10。国内外关键词共现关系网络分别聚类为14个“簇”和8个“簇”,模块值分别为0.717、0.3032,平均轮廓值分别为0.9229、0.6162。国内突现词主要是:多态性、胆固醇、预防等;国外突现词主要是:冠心病、代谢综合征、创伤性脑损伤等。国外突现词暴发强度显著高于国内,国内外突现词暴发时间均较分散。结论目前国内外对于阿尔兹海默症危险因素的研究处于快速发展阶段,国内的研究热点集中在与身体健康直接相关的指标,而国外在研究直接影响因素的同时还考虑到了老年医保开支、认知储备、态度等外部影响因素。综述、睡眠障碍、认知障碍和一级预防是目前国内该领域的未来研究趋势,国外暂无明显研究趋势。
Objective To analyze the research hotspots of risk factors related to Alzheimer’s disease and their development trends.Methods Literatures related to risk factors for Alzheimer’s disease were retrieved from the Web of Science Core Collection and China National Knowledge Infrastructure.CiteSpace 6.1.R2 software was used to analyze the growth law of relevant literatures,core authors,high-frequency keywords,keyword clustering and the evolution of research hotspots.Results In the field of researches on risk factors for Alzheimer’s disease,the gap between the numbers of literatures published at home and abroad was large,but the overall trend was increasing.Zhou Huadong was the core author in China,while Kim S and Kivipelto M were foreign core authors.The research in this field in the United States was the most prominent.In the network of domestic and foreign keyword co-occurrence relationships,327 nodes,629 connections,438 nodes and 3,467 connections were identified respectively,and the centrality of keywords like risk factors,dementia,the elderly and cognitive impairment in domestic studies was greater than 0.10.The domestic and foreign keyword co-occurrence relationship networks were clustered into 14“clusters”and 8“clusters”respectively,with the module values of 0.717 and 0.3032 respectively,and the average profile values of 0.9229 and 0.6162 respectively.Domestic prominent words were mainly polymorphism,cholesterol and prevention,while foreign prominent words mainly consisted of coronary heart disease,metabolic syndrome and traumatic brain injury.The outbreak intensity of foreign prominent words was significantly higher than that of domestic prominent words,and the outbreak times of domestic and foreign prominent words were relatively scattered.Conclusion At present,the researches on risk factors for Alzheimer’s disease at home and abroad are in a rapid development stage.The domestic research hotspots focus on indicators directly related to physical health,whereas the foreign researches are centered on direct influencing factors as well as external affecting factors such as elderly medical insurance expenditure,cognitive reserve and attitude.Review,sleep disorders,cognitive impairment and primary prevention are the future research trends in this field in China,and there is no obvious trend in the researches abroad.
作者
王凤琳
王爱民
黄一铭
徐雅琪
张文婧
石福艳
王素珍
WANG Fenglin;WANG Aimin;HUANG Yiming;XU Yaqi;ZHANG Wenjing;SHI Fuyan;WANG Suzhen(School of Public Health,Weifang Medical University,Weifang,Shandong 261053,China)
出处
《实用预防医学》
CAS
2024年第1期44-48,共5页
Practical Preventive Medicine
基金
国家自然科学基金(81803337,81872719,82003560)
国家统计局课题(2018LY79)
山东省自然科学基金(ZR2019MH034,ZR2020MH340)
山东省高等学校青创人才引育计划(2019-6-156,Lu-Jiao)
潍坊医学院博士启动基金(2017BSQD51)
作者简介
王凤琳(2000-),女,山东青州人,在读硕士研究生,主要从事流行病与卫生统计方面的研究工作;通信作者:石福艳,E-mailshifuyan@126.com;通信作者:王素珍,E-mail:wangsz@wfmc.edu.cn。
