摘要
目的 探讨骨化三醇应用于透析性贫血患者对其甲状旁腺激素(PTH)及贫血三项的影响。方法 将我院2019年1月-2021年12月收治的60例透析性贫血患者分为观察组和对照组,每组各30例。对照组采用常规重组人促红细胞生长素注射治疗,观察组在此基础上还需实施骨化三醇。比较两组铁蛋白、叶酸、维生素B12、PTH水平,另外统计两组不良反应。结果 与治疗前及对照组治疗后比较,观察组治疗后铁蛋白水平显著降低,叶酸、维生素B12水平显著增高(P<0.05)。两组PTH水平比较,治疗前>治疗1周后>治疗3周后(P<0.05);与对照组比较,观察组治疗1、3周后PTH水平显著降低(P<0.05)。两组不良反应总发生率分别为23.33%、16.67%,无明显差异(P>0.05)。结论 骨化三醇应用于透析性贫血患者对PTH及贫血三项表达有着纠正作用。
Objective: To explore the effect of calcitriol on the parathyroid hormone(PTH) and anemia in patients with dialysis anemia. Methods: 60 patients with dialysis anemia treated in our hospital from January 2019 to December 2021 were divided into observation group and control group, with 30 cases in each group. The control group was treated with routine recombinant human erythropoietin injection, while the observation group needed calcitriol on the basis of the above. The levels of ferritin, folic acid, vitamin B12 and PTH were compared between the two groups,and the adverse reactions of the two groups were also counted. Results: Compared with before and after treatment in the control group, the level of ferritin in the observation group decreased significantly, while the levels of folic acid and vitamin B12 increased significantly(P<0.05). Compared with the two groups, the PTH level before treatment > 1 week after treatment > 3 weeks after treatment(P<0.05);Compared with the control group, the PTH level in the observation group decreased significantly after 1 and 3 weeks of treatment(P<0.05). The total incidence of adverse reactions in the two groups was 23.33% and 16.67%, respectively, with no significant difference(P>0.05). Conclusion: The application of calcitriol in dialysis anemia patients can correct the expression of PTH and anemia.
作者
洪丽娟
陶俐
HONG Li-juan;TAO Li(Second People's Hospital of Jingdezhen,Jingdezhen Jiangxi 333000,China)
出处
《透析与人工器官》
2022年第4期26-28,共3页
Chinese Journal of Dialysis and Artificial Organs
作者简介
通讯作者:洪丽娟,E-mail:siyaqq@163.com
