摘要
目前我国约有14万血友病患者。未经规范治疗的患者可由轻微外伤导致出血或自发性出血,最终发展为血友病性骨关节病变,逐渐丧失工作、生活能力。近年来,随着凝血因子补充替代治疗的广泛应用,饱受终末期血友病性关节炎、关节挛缩畸形、血友病性假瘤折磨的血友病患者也可以像普通患者一样接受骨科手术,但围手术期处理仍然极具挑战性。本文对血友病骨关节病的病理生理特点、外科治疗、围手术期治疗加以综述。
There are about 140000 hemophiliacs in China.Those hemophiliacs who have not received standard treatment may suffer from hemorrhage from slight trauma or spontaneous hemorrhage which finally develops hemophilic arthropathy,and gradually lose the ability to work and live.In recent years,blood coagulation factor has been widely used as a replacement therapy.As a result,the hemophiliacs who have been suffering from terminal-stage hemophilic arthropathy,flexion contracture and hemophilic pseudotumor can receive orthopedic operation.But perioperative management is still challenging.In this paper,pathophysiological characteristics,surgical treatment and perioperative treatment of hemophilic arthropathy are reviewed.
作者
翁习生
韩畅
WENG Xisheng;HAN Chang(Department of Orthopaedics,Peking Union Medical College Hospital,CAMS&PUMC,Beijing 100730,China)
出处
《中华骨与关节外科杂志》
2021年第5期376-383,共8页
Chinese Journal of Bone and Joint Surgery
关键词
血友病性骨关节病
围手术期
凝血因子
Hemophilic arthropathy
Perioperative periond
Blood coagulation factor
作者简介
通信作者:翁习生,E-mail:xshweng@medmail.com.cn
