摘要
目的通过对比分析磷酸奥司他韦对甲型流感病毒感染患儿淋巴细胞亚群及临床疗效的影响,为治疗甲型流感病毒感染提供理论依据。方法选取2016年1月~2018年1月丽水市中心医院接诊的91例甲型流感病毒感染患儿为研究对象,均按照预防控制要求处理;按照随机数字表法随机分为对照组和研究组,对照组45例,使用病毒唑注射液治疗,研究组46例,在对照组基础上添加磷酸奥司他韦颗粒治疗;观察记录患儿的淋巴细胞亚群表达水平、血细胞表达水平、免疫学指标表达水平、炎症因子表达水平、临床症状改善情况、患儿治疗效果和不良反应发生情况。结果研究组患儿总有效率高达95.65%,显著高于对照组患儿的68.89%,差异有统计学意义(P<0.05);研究组患儿CD3+T细胞、CD4+T细胞、NK细胞和CD8+T细胞均显著高于对照组患儿,差异有统计学意义(P<0.05);研究组患儿白细胞和血小板水平高于对照组患儿,嗜中性粒细胞低于对照组患儿,差异有统计学意义(P<0.05);研究组患儿IgM和IgG高于对照组患儿,补体C4和补体C3低于对照组患儿,差异有统计学意义(P<0.05);研究组患儿IL-6、IL-8、IL-12、IL-18、TNF-α表达水平均低于对照组患儿,差异有统计学意义(P<0.05);研究组患儿病毒核酸转阴时间、乏力缓解时间和发热消退时间均短于对照组患儿,差异有统计学意义(P<0.05)。结论磷酸奥司他韦可明显提高甲型流感病毒感染患儿淋巴细胞亚群比例,降低患儿炎症反应,提高患儿免疫能力,改善患儿临床症状,治疗效果显著。
Objective By comparing and analyzing the effect of oseltamivir phosphate on lymphocyte subsets and clinical efficacy of children with influenza A virus infection,it provides a theoretical basis for the treatment of influenza A virus infection.Methods A total of 91 children with influenza A virus infection who were admitted to Lishui Central Hospital from January 2016 to January 2018 were enrolled in the study.All patients were treated according to the prevention and control requirements.They were randomly divided into the control group and the study group according to the random number table method.45 patients in the group were treated with ribavirin injection,46 patients in the study group were treated with oseltamivir phosphate on the basis of the control group.The expression of lymphocyte subsets,blood cell expression and immunological indicators were recorded.Level,expression level of inflammatory factors,improvement of clinical symptoms,treatment effect of children and occurrence of adverse reactions.Results The total effective rate of the study group was as high as 95.65%,which was significantly higher than that of the control group(68.89%).The difference was statistically significant(P<0.05);the CD3^+T cells,CD4^+T cells,and NK cells were found in the study group.CD8+T cells were significantly higher than those in the control group(P<0.05).The leukocyte and platelet levels in the study group were higher than those in the control group,and the neutrophils were lower in the study group than in the control group.The difference was statistically significant(P<0.05)..The IgM and IgG in the study group were higher than those in the control group,and the complement C4 and complement C3 were lower.The difference between the control group and the control group was statistically significant(P<0.05);IL-6,IL-8,IL-12,IL in the study group-18.The level of TNF-αexpression was lower in the control group than in the control group(P<0.05).The viral nucleic acid turnover time,fatigue relief time and fever extinction time in the study group were shorter than those in the control group.The difference was statistically significant(P<0.05).Conclusions Oseltamivir phosphate can significantly increase the proportion of lymphocyte subsets in children with influenza A virus infection,reduce the inflammatory response of children,improve the immune ability of children,improve the clinical symptoms of children,and the treatment effect is remarkable.
作者
蒋芬
陈伟楚
潜丽俊
冯鑫
朱莲
茅海燕
JIANG Fen;CHEN Wei-chu;QIAN Li-jun;FENG Xin;ZHU Lian;MAO Hai-yan(Lishui Central Hospital Department of Pediatrics,Ultrasound department Zhejiang Lishui 32300;不详)
出处
《中国预防医学杂志》
CAS
CSCD
2020年第9期974-978,共5页
Chinese Preventive Medicine
基金
浙江省医药卫生省部培育计划基金资助项目(2015KYA050)
关键词
磷酸奥司他韦
甲型流感病毒感染
淋巴细胞亚群
儿童
临床疗效
Oseltamivir phosphate
Influenza A virus infection
Lymphocyte subsets
Children
Clinical efficacy
作者简介
通信作者:蒋芬,本科,副主任医师,主要从事儿科感染性疾病诊治的研究,E-mail:zp521s@163.com
