摘要
目的探讨调强放射治疗(IMRT)与三维适型放疗(3D-CRT)联合同步化疗治疗子宫颈癌的临床疗效。方法选取2012年5月至2014年5月间深圳市人民医院收治的105例Ⅱb~Ⅲb期子宫颈癌患者,根据放疗方式不同分为观察组53例和对照组52例。观察组患者采用IMRT联合含顺铂同步化疗的治疗方式,对照组患者采用3D-CRT联合含顺铂同步化疗,比较两组患者治疗后缓解率、不良反应及5年复发率。结果治疗后,观察组患者缓解率为96.2%,对照组为94.2%,两组比较,差异无统计学意义(P>0.05)。治疗后,两组患者均出现不同程度的白细胞下降、贫血、血小板下降、恶心、呕吐、放射性膀胱炎和放射性直肠炎等不良反应,观察组患者白细胞下降、放射性膀胱炎及放射性直肠炎发生率均低于对照组,差异均有统计学意义(均P<0.05)。治疗后,观察组患者5年内总复发率为17.0%,对照组为38.5%,观察组低于对照组,差异有统计学意义(P<0.05)。结论IMRT联合同步化疗治疗子宫颈癌患者,可降低白细胞下降、放射性膀胱炎及放射性直肠炎等不良反应发生率,降低5年局部复发率,提高患者5年内生存质量。
Objective To investigate the efficacy of intensity-modulated radiation therapy(IMRT) and three dimensional conformal radiation therapy(3 D-CRT)combined with concomitant chemotherapy in the treatment of cervical cancer.Methods A total of 105 patients with stage IIb to IIIb cervical cancer admitted to Shenzhen People’s Hospital from May 2012 to May 2014 were selected and randomly divided into an observation group(53 patients)and a control group(52 patients)according to different radiotherapy methods they received.The observation group was treated with IMRT combined with chemotherapy containing cisplatin.The control group was treated with 3 D-CRT combined with cisplatin chemotherapy.The remission rate,adverse reactions and 5-year recurrence were compared.Results After the treatment,the remission rate was 96.2%in the observation group and 94.2%in the control group(P>0.05).Adverse reactions such as serious neutropenia,anemia,platelet,nausea and vomiting,radiation cystitis and radiation proctitis occurred in both groups and the incidence of neutropenia,radiation cystitis and radiation proctitis was significantly lower in the observation group than in the control group(all P<0.05).After the treatment,the overall 5-year recurrence rate was 17.0%in the observation group which was significantly lower than 38.5%of the control group(P<0.05).Conclusion IMRT combined with concomitant chemotherapy for cervical cancer can reduce the incidence of adverse reactions such as neutropenia,radiation cystitis and radiation proctitis and the recurrence rate within 5 years,and improve the quality of life within 5 years.
作者
张皓昇
李先明
周亚燕
徐钢
ZHANG Hao-sheng;LI Xian-ming;ZHOU Ya-yan;XU Gang(Second Clinical Medical College of Jinan University,Guangzhou 510632,China;Department of Radiotherapy,Shenzhen People's Hospital/Second Affiliated Hospital of Jinan University,Shenzhen 518020,China)
出处
《中国肿瘤临床与康复》
2020年第2期164-167,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
调强放疗
三维适形放疗
顺铂
药物疗法
子宫颈肿瘤
Intensity-modulated radiation therapy
Three dimensional conformal radiation therapy
Cisplatin
Drug therapy
Cervical neoplasms
作者简介
张皓昇,男,在读研究生,主要从事肿瘤放射治疗学专业;通信作者:李先明,Email:lxm1828@hotmail.com
