摘要
目的:观察大黄附子汤对脓毒症致急性胃肠损伤(AGI)患者胃肠功能及炎症因子、氧化应激损伤的影响。方法:将70例脓毒症致AGI患者随机分为治疗组和对照组,每组35例。两组患者均予常规治疗,治疗组加用大黄附子汤,疗程为14 d。疗程结束后评价两组中医临床疗效,并观察两组中医证候积分、胃肠功能指标、氧化应激指标、炎症指标的变化情况。结果:①治疗后,治疗组总有效率为91.4%,对照组总有效率为77.1%;两组临床疗效比较差异有统计学意义(P<0.05)。②治疗后,两组中医证候积分较治疗前均有改善(P<0.05),且治疗组积分低于对照组(P<0.05)。③治疗后,两组腹内压、排便次数较治疗前均有改善(P<0.05),且治疗组优于对照组(P<0.05)。④治疗后,两组AGI分级、APACHEⅡ评分较治疗前均有改善(P<0.05),且治疗组优于对照组(P<0.05)。⑤治疗后两组ROS、MDA水平均较治疗前下降(P<0.05),且治疗组比对照组降低更明显(P<0.05);治疗后两组SOD水平均较治疗前升高(P<0.05),且治疗组比对照组升高更明显(P<0.05);治疗后两组TNF-α、IL-6水平均较治疗前降低(P<0.05),且治疗组比对照组降低更明显(P<0.05)。结论:大黄附子汤可恢复脓毒症致AGI患者的胃肠功能,减轻炎症反应及氧化应激损伤,缓解临床症状,提高中医临床疗效。
Objective:To observe the effect of Dahuang Fuzi Decoction on gastrointestinal function,inflammatory factors and oxidative stress injury in the patients with acute gastrointestinal injury(AGI)caused by sepsis.Methods:Seventy AGI patients caused by sepsis were randomly divided into treatment group and control group,35 cases in each group.Both groups were treated with routine treatment,and the treatment group was additionally treated with Dahuang Fuzi Decoction,the treatment course was 14 days.After the treatment,the clinical efficacy of both groups was evaluated,and the changes in TCM syndrome score,gastrointestinal function indexe,inflammatory indexe,oxidative stress indexe were observed.Results:①After treatment,the total effective rate was 91.4%in the treatment group and 77.1%in the control group,the difference in clinical efficacy between the two groups was statistically significant(P<0.05).②After treatment,the TCM symptom scores in two groups were both improved compared with those before treatment(P<0.05),and the scores in the treatment group are lower than those in the control group(P<0.05).③After treatment,intra-abdominal pressure and defecation frequency in the two groups were improved compared with those before treatment(P<0.05),and the treatment group was superior than the control group(P<0.05).④After treatment,the AGI grade and APACHEⅡscore of the two groups were improved(P<0.05),and the treatment group was superior than the control group.(P<0.05).⑤After treatment,the levels of ROS and MDA in the two groups were decreased compared with those before treatment(P<0.05),and the treatment group decreased more significantly than the control group(P<0.05).After treatment,the level of SOD in the two groups was increased compared with that before treatment,and the treatment group increased more significantly than the control group(P<0.05).After treatment,the levels of TNF-α and IL-6 in the two groups were decreased compared with those before treatment(P<0.05),and the treatment group decreased more significantly than the control group(P<0.05).Conclusion:Dahuang Fuzi Decoction can restore the gastrointestinal function of AGI patients caused by sepsis,reduce inflammatory reaction and oxidative stress injury,alleviate clinical symptoms and improve the clinical curative effect of traditional Chinese medicine.
作者
韩丹
吴芳
黎林
王倩
HAN dan;WU Fang;LI Lin;WANG Qian(Emergency Department,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Intensive Care Unit,Sixth People’s Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200233,China)
出处
《上海中医药大学学报》
CAS
2022年第S01期16-19,共4页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
上海市卫健委科研项目(20204Y0473)
关键词
脓毒症
急性胃肠损伤
大黄附子汤
氧化应激损伤
炎症因子
临床研究
sepsis
acute gastrointestinal injury
Dahuang Fuzi Decoction
oxidative stress injury
inflammatory factors
clinical study
作者简介
韩丹,女,在读博士生,主治医师,主要从事中医急诊临床研究;通信作者:王倩,主任医师,E-mail:13564635813@163.com
