The synthesis of sodium glycidazole yields three products detected by HPLC. Electrospray ionization mass spectrometry has been successfully applied to identify the three products. ESI mass spectrometry demonstrated th...The synthesis of sodium glycidazole yields three products detected by HPLC. Electrospray ionization mass spectrometry has been successfully applied to identify the three products. ESI mass spectrometry demonstrated that the first component is 2-nitro-5-emthylimidazole as impurity and the third component is the target compound, sodium glycidazole, as main product. The second and the third components were further investigated by the scanning of the daughter ion at m/z 373[M+H]+, m/z 520[M+H]+ using ESI tandem mass spectrometry. The experimental results show that the second component has the structure similar to the desired product but without one imidazolering.展开更多
文摘The synthesis of sodium glycidazole yields three products detected by HPLC. Electrospray ionization mass spectrometry has been successfully applied to identify the three products. ESI mass spectrometry demonstrated that the first component is 2-nitro-5-emthylimidazole as impurity and the third component is the target compound, sodium glycidazole, as main product. The second and the third components were further investigated by the scanning of the daughter ion at m/z 373[M+H]+, m/z 520[M+H]+ using ESI tandem mass spectrometry. The experimental results show that the second component has the structure similar to the desired product but without one imidazolering.
