IC 50 values of 13 flavonoids to lipid peroxidation induced by OH · in liver microsomer from rat were evaluated and the relationship between structure and activity was studied. The flavonoids with catechol group,...IC 50 values of 13 flavonoids to lipid peroxidation induced by OH · in liver microsomer from rat were evaluated and the relationship between structure and activity was studied. The flavonoids with catechol group, which usually have a higher energy in the highest occupied molecular orbital and lower ΔHOF values, have higher inhibitory activities than those without catechol group. The flavonoids without catechol group in B ring not being suitable structure to chelate with Fe 2+ have little inhibitory activities. The results suggest the anti-lipid peroxidation activity of flavonoids is related with the structure of flavonoids.展开更多
A new binuclear copper ?complex with 1,10-phen and fluoroquinolone ligands, [Cu2(cfc)2(phen)2(pip)](NO3)2(CO)2,was synthesized and its crystal structure was solved.The formula of the complex is C28H24ClCuFN5O7, <IM...A new binuclear copper ?complex with 1,10-phen and fluoroquinolone ligands, [Cu2(cfc)2(phen)2(pip)](NO3)2(CO)2,was synthesized and its crystal structure was solved.The formula of the complex is C28H24ClCuFN5O7, <IMG SRC="IMAGE/09150030. JPG" HEIGHT=11 WIDTH=12>and the crystallography data are as follows, triclinic, space group , a=0.80372(6)nm, b=0.94712 (7)nm, c=1.67826(13)nm, α=88.5650(10)° , β=80.9920(10)°, γ=70.2780(10)°, V=1.18722(6)nm3, Z=2, D=1.848g·cm-3, F(0 00)=676. R1=0.0627 and wR2=0.1684 (I >2σ(I)). The copper atom is five-coordina te with square-based pyramidal geometry and involves two nitrogen atoms from ph en, two oxygen atoms from cfc and one nitrogen atom from pip anion. The stacking effect between cfc and phen ligands from two neighboring molecules was observed . FT-IR spectrum of the complex was also discussed. Both ligand and complex wer e assayed against gram-positive and gram-negative bacteria by doubling dilutio ns method; the complex shows the same minimal inhibitory concentration (MIC) as the corresponding ligand against S. Aureus, E. Coli and M. Lutens bacteria. The inhibitory effect of the ligand and complex on leukemia HL-60 cell line and liv er cancer BEL-7402 cell line have been measured by using MTT (Methyl-Thiazol- Tetrozolium) and SRB (Sulphurhodamin B) assay methods, respectively. The results indicated that the complex has strong inhibitory effect on HL-60 and BEL-7402 cell line. CCDC: 203964.展开更多
A new Cadmium!-Ciprofloxacin ionic compound, (HCPFX)2CdCl4·3H2O, is synthesized and its crys- tal structure is determined. The crystallography data are as follows, monoclinic, space group P21/c, a=1.01039(6) nm, ...A new Cadmium!-Ciprofloxacin ionic compound, (HCPFX)2CdCl4·3H2O, is synthesized and its crys- tal structure is determined. The crystallography data are as follows, monoclinic, space group P21/c, a=1.01039(6) nm, b=1.39989(9) nm, c=2.82245(18) nm, β=95.765 0(10)°, V=3.972 0(4) nm3, Z=4, Dc=1.627 g·cm-3, F(000)= 1984. R1=0.0540, wR2=0.1503 (I>2σ(I)). In the title compound, four chloride ions are coordinated to the cadmi- um ion forming a slightly distorted tetrahedron. Both Ciprofloxacin and the compound were assayed against gram- positive and gram-negative bacteria by doubling dilutions method, the compound shows the same minimal in- hibitory concentration (MIC) as the Ciprofloxacin against S. Aureus, M. Lutens, E. Coli and P. Aeruginosa bacte- ria. The inhibitory effect of the two compounds on leukemia HL-60 cell line has been measured by using MTT (Methyl-Thiazol-Tetrozolium) assay method. The results indicate that the complex has very strong inhibitory effect on HL-60 cell line. CCDC: 259367.展开更多
文摘IC 50 values of 13 flavonoids to lipid peroxidation induced by OH · in liver microsomer from rat were evaluated and the relationship between structure and activity was studied. The flavonoids with catechol group, which usually have a higher energy in the highest occupied molecular orbital and lower ΔHOF values, have higher inhibitory activities than those without catechol group. The flavonoids without catechol group in B ring not being suitable structure to chelate with Fe 2+ have little inhibitory activities. The results suggest the anti-lipid peroxidation activity of flavonoids is related with the structure of flavonoids.
文摘A new binuclear copper ?complex with 1,10-phen and fluoroquinolone ligands, [Cu2(cfc)2(phen)2(pip)](NO3)2(CO)2,was synthesized and its crystal structure was solved.The formula of the complex is C28H24ClCuFN5O7, <IMG SRC="IMAGE/09150030. JPG" HEIGHT=11 WIDTH=12>and the crystallography data are as follows, triclinic, space group , a=0.80372(6)nm, b=0.94712 (7)nm, c=1.67826(13)nm, α=88.5650(10)° , β=80.9920(10)°, γ=70.2780(10)°, V=1.18722(6)nm3, Z=2, D=1.848g·cm-3, F(0 00)=676. R1=0.0627 and wR2=0.1684 (I >2σ(I)). The copper atom is five-coordina te with square-based pyramidal geometry and involves two nitrogen atoms from ph en, two oxygen atoms from cfc and one nitrogen atom from pip anion. The stacking effect between cfc and phen ligands from two neighboring molecules was observed . FT-IR spectrum of the complex was also discussed. Both ligand and complex wer e assayed against gram-positive and gram-negative bacteria by doubling dilutio ns method; the complex shows the same minimal inhibitory concentration (MIC) as the corresponding ligand against S. Aureus, E. Coli and M. Lutens bacteria. The inhibitory effect of the ligand and complex on leukemia HL-60 cell line and liv er cancer BEL-7402 cell line have been measured by using MTT (Methyl-Thiazol- Tetrozolium) and SRB (Sulphurhodamin B) assay methods, respectively. The results indicated that the complex has strong inhibitory effect on HL-60 and BEL-7402 cell line. CCDC: 203964.
文摘A new Cadmium!-Ciprofloxacin ionic compound, (HCPFX)2CdCl4·3H2O, is synthesized and its crys- tal structure is determined. The crystallography data are as follows, monoclinic, space group P21/c, a=1.01039(6) nm, b=1.39989(9) nm, c=2.82245(18) nm, β=95.765 0(10)°, V=3.972 0(4) nm3, Z=4, Dc=1.627 g·cm-3, F(000)= 1984. R1=0.0540, wR2=0.1503 (I>2σ(I)). In the title compound, four chloride ions are coordinated to the cadmi- um ion forming a slightly distorted tetrahedron. Both Ciprofloxacin and the compound were assayed against gram- positive and gram-negative bacteria by doubling dilutions method, the compound shows the same minimal in- hibitory concentration (MIC) as the Ciprofloxacin against S. Aureus, M. Lutens, E. Coli and P. Aeruginosa bacte- ria. The inhibitory effect of the two compounds on leukemia HL-60 cell line has been measured by using MTT (Methyl-Thiazol-Tetrozolium) assay method. The results indicate that the complex has very strong inhibitory effect on HL-60 cell line. CCDC: 259367.
文摘建立小鼠急性高尿酸血症模型,通过灌胃给药考察车前草的降血尿酸作用.采用正交试验设计,以车前草所含大车前苷为指标,考察乙醇浓度、提取时间、提取次数和乙醇用量4种因素对提取结果的影响.大车前苷和血尿酸的含量均用HPLC法测定.结果表明,车前草醇提组的小鼠血清尿酸水平明显低于模型组(P<0.05).乙醇浓度、提取时间、提取次数和乙醇用量4种因素对车前草乙醇提取物中的大车前苷含量均有显著影响.最佳提取工艺为用10倍药材量的60%乙醇提取2次,每次2 h.
