The major role of DNA polymerase β was thought to be limited in its involvement in short patch base excision repair by removing 5’-deoxyribose phosphate and base insertion. However, the recent researches indicate th...The major role of DNA polymerase β was thought to be limited in its involvement in short patch base excision repair by removing 5’-deoxyribose phosphate and base insertion. However, the recent researches indicate that polymerase β might take part in a wide spectrum of DNA metabolism reactions, including long patch base excision repair, DNA replication, recombination, meiosis and transleisional DNA synthesis. Because of its wide and important cellular function, an inappropriate intracellular polymerase β level might be associated with genomic instability. Down-regulation or mutation of polymerase β is mutagenic due to deficient in DNA repair, while overexpression of this error-prone β polymerase might perturb the normal function of other accurate polymerases and cause genomic instability as well.展开更多
Cytochrome P450 (CYP) is a complex gene superfamily of proteins that metabolizes a myriad of endogenous and exogenous substrates. Liver-enriched transcription factors (LETF) play a role in the constitutive and tissue-...Cytochrome P450 (CYP) is a complex gene superfamily of proteins that metabolizes a myriad of endogenous and exogenous substrates. Liver-enriched transcription factors (LETF) play a role in the constitutive and tissue-specific expression of hepatic genes. In this review, six families of LETF that play a role in the tissue-specific, developmental, sexual and temporal regulation of CYP are discussed.展开更多
文摘The major role of DNA polymerase β was thought to be limited in its involvement in short patch base excision repair by removing 5’-deoxyribose phosphate and base insertion. However, the recent researches indicate that polymerase β might take part in a wide spectrum of DNA metabolism reactions, including long patch base excision repair, DNA replication, recombination, meiosis and transleisional DNA synthesis. Because of its wide and important cellular function, an inappropriate intracellular polymerase β level might be associated with genomic instability. Down-regulation or mutation of polymerase β is mutagenic due to deficient in DNA repair, while overexpression of this error-prone β polymerase might perturb the normal function of other accurate polymerases and cause genomic instability as well.
文摘Cytochrome P450 (CYP) is a complex gene superfamily of proteins that metabolizes a myriad of endogenous and exogenous substrates. Liver-enriched transcription factors (LETF) play a role in the constitutive and tissue-specific expression of hepatic genes. In this review, six families of LETF that play a role in the tissue-specific, developmental, sexual and temporal regulation of CYP are discussed.
