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腹腔镜超声在腹腔镜肝脏外科中的应用进展 被引量:5
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作者 汪磊 李宏 《中国介入影像与治疗学》 CSCD 2014年第11期756-759,共4页
腹腔镜超声(LUS)可弥补腹腔镜手术的缺陷,有助于提高手术的精准性。利用LUS可对肝脏恶性肿瘤进行准确地临床分期,有助于降低术后复发率和避免不必要的剖腹探查术,LUS引导的射频消融为肝癌晚期患者提供了更有价值的治疗手段。带有彩色多... 腹腔镜超声(LUS)可弥补腹腔镜手术的缺陷,有助于提高手术的精准性。利用LUS可对肝脏恶性肿瘤进行准确地临床分期,有助于降低术后复发率和避免不必要的剖腹探查术,LUS引导的射频消融为肝癌晚期患者提供了更有价值的治疗手段。带有彩色多普勒功能的探头可精准显示肝中静脉位置及走行,以此为标准的半肝切除术更加精准,提高了手术的安全性。随着3DLUS的出现及发展,术中3D超声"实时导航"给术者提供了更多的手术相关信息。本文就LUS在肝脏外科中的临床应用和最新进展进行综述。 展开更多
关键词 腹腔镜 超声检查 肝脏外科
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High Expression of INF2 Predicts Poor Prognosis and Promotes Hepatocellular Carcinoma Progression
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作者 WANG Hai-Biao LIN Man +4 位作者 YE Fu-Sang SHI Jia-Xin LI Hong YE Meng WANG Jie 《生物化学与生物物理进展》 北大核心 2025年第1期194-208,共15页
Objective INF2 is a member of the formins family.Abnormal expression and regulation of INF2 have been associated with the progression of various tumors,but the expression and role of INF2 in hepatocellular carcinoma(H... Objective INF2 is a member of the formins family.Abnormal expression and regulation of INF2 have been associated with the progression of various tumors,but the expression and role of INF2 in hepatocellular carcinoma(HCC)remain unclear.HCC is a highly lethal malignant tumor.Given the limitations of traditional treatments,this study explored the expression level,clinical value and potential mechanism of INF2 in HCC in order to seek new therapeutic targets.Methods In this study,we used public databases to analyze the expression of INF2 in pan-cancer and HCC,as well as the impact of INF2 expression levels on HCC prognosis.Quantitative real time polymerase chain reaction(RT-qPCR),Western blot,and immunohistochemistry were used to detect the expression level of INF2 in liver cancer cells and human HCC tissues.The correlation between INF2 expression and clinical pathological features was analyzed using public databases and clinical data of human HCC samples.Subsequently,the effects of INF2 expression on the biological function and Drp1 phosphorylation of liver cancer cells were elucidated through in vitro and in vivo experiments.Finally,the predictive value and potential mechanism of INF2 in HCC were further analyzed through database and immunohistochemical experiments.Results INF2 is aberrantly high expression in HCC samples and the high expression of INF2 is correlated with overall survival,liver cirrhosis and pathological differentiation of HCC patients.The expression level of INF2 has certain diagnostic value in predicting the prognosis and pathological differentiation of HCC.In vivo and in vitro HCC models,upregulated expression of INF2 triggers the proliferation and migration of the HCC cell,while knockdown of INF2 could counteract this effect.INF2 in liver cancer cells may affect mitochondrial division by inducing Drp1 phosphorylation and mediate immune escape by up-regulating PD-L1 expression,thus promoting tumor progression.Conclusion INF2 is highly expressed in HCC and is associated with poor prognosis.High expression of INF2 may promote HCC progression by inducing Drp1 phosphorylation and up-regulation of PD-L1 expression,and targeting INF2 may be beneficial for HCC patients with high expression of INF2. 展开更多
关键词 HCC INF2 EXPRESSION PROGNOSIS Drp1
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雷替曲塞联合腹腔镜肝切除术对原发性肝癌患者肝功能及CIART、AFP-L3、GP73的影响 被引量:5
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作者 王高卿 江伟 华永飞 《中国临床药理学与治疗学》 CAS CSCD 2020年第7期752-756,共5页
目的:探讨雷替曲塞联合腹腔镜肝切除术对原发性肝癌患者肝功能及昼夜相关转录抑制因子(CIART)、胎蛋白异质体(AFP-L3)、高尔基体膜蛋白-73(GP73)的影响。方法:选择2012年7月到2019年7月于宁波市医疗中心李惠利医院肝胆外科进行治疗的原... 目的:探讨雷替曲塞联合腹腔镜肝切除术对原发性肝癌患者肝功能及昼夜相关转录抑制因子(CIART)、胎蛋白异质体(AFP-L3)、高尔基体膜蛋白-73(GP73)的影响。方法:选择2012年7月到2019年7月于宁波市医疗中心李惠利医院肝胆外科进行治疗的原发性肝癌患者100例作为研究对象,采用简单随机分组法根据入院顺序分为观察组(n=52)和对照组(n=48),对照组使用腹腔镜肝切除术治疗,观察组在对照组的基础上加用雷替曲塞进行治疗。比较两组的治疗前及治疗后血清CIART、AFP-L3、GP73、谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)水平、1年、3年和5年肿瘤复发率及不良反应发生情况。结果:治疗前,两组患者CIART、AFP-L3、GP73、ALT、AST及TBIL水平水平无显著性差异;治疗后,两组患者血清CIART、AFP-L3、GP73水平均较治疗前显著下降,且观察组患者血清CIART、AFP-L3、GP73水平显著低于对照组(P<0.05);两组患者血清ALT、AST及TBIL水平无明显差异(P>0.05)。观察组患者5年复发率明显低于对照组,差异有统计学意义(P<0.05);两组患者1年和3年复发率差异无统计学意义(P>0.05)。两组患者不良反应总发生率分别为53.84%、52.08%,差异无统计学意义(P>0.05)。结论:腹腔镜切除联合雷替曲塞治疗原发性肝癌,可有效降低CIART、AFP-L3、GP73水平,且具有安全性。 展开更多
关键词 雷替曲塞 腹腔镜肝切除术 原发性肝癌 肝功能 昼夜相关转录抑制因子 胎蛋白异质体 高尔基体膜蛋白-73
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