目的:分析中心性浆液性脉络膜视网膜病变(centralserous cho rio retinopathy,CSC)的不典型眼底荧光血管造影(fundus fluorescein angiography,FFA)表现特点。方法:采用海德堡共焦激光扫描系统对64例(90眼)CSC患者行FFA检查,分析其结果...目的:分析中心性浆液性脉络膜视网膜病变(centralserous cho rio retinopathy,CSC)的不典型眼底荧光血管造影(fundus fluorescein angiography,FFA)表现特点。方法:采用海德堡共焦激光扫描系统对64例(90眼)CSC患者行FFA检查,分析其结果。结果:CSC的FFA表现归纳5种类型:(1)典型渗漏点型;(2)不典型渗漏点型;(3)色素上皮脱离型;(4)严重型(泡状视网膜脱离型);(5)正常荧光造影所见型。第1种类型为CSC的典型荧光造影表现,后4种类型为CSC的特殊型荧光造影表现。结论:CSC的FFA表现形式各异,需与Vogt_小柳原田病、特发性脉络膜新生血管膜及色素上皮炎鉴别。展开更多
目的评估内窥镜下经筛径路眶内壁减压(endoscopic transethmoidal orbital wall decompres⁃sion,ETMOWD)联合脂肪减压(fat orbital decompression,FROD)术对甲状腺相关眼病(thyroid-associated ophthalmopathy,TAO)限制性斜视的影响效...目的评估内窥镜下经筛径路眶内壁减压(endoscopic transethmoidal orbital wall decompres⁃sion,ETMOWD)联合脂肪减压(fat orbital decompression,FROD)术对甲状腺相关眼病(thyroid-associated ophthalmopathy,TAO)限制性斜视的影响效果。方法回顾性系列病例研究,选取2021年12月至2024年8月确诊为TAO的病例,按照是否行眶减压术,分成眶减压组(OD组)和非眶减压组(NOD组),比较两组之间围手术期的一般资料,斜视类型、眼球运动限制程度、眼肌后徙量及手术效果,并对OD组评估ET⁃MOWD联合脂肪减压术式对斜视的影响。手术成功的定义为复视消失,术后斜视度≤5 PD。结果共计65例纳入分析,其中OD组40例、NOD组25例,所有患者的甲状腺指标均在正常范围内,活动性评分均≤3分,处于静止期内,两组间的一般资料及术前斜视类型,包括水平和垂直斜视度差异无统计学意义(P>0.05),而OD组眼球运动限制分级、手术次数、手术总肌肉数、水平肌肉数量以及水平肌肉后徙效应量明显高于NOD组,术后所有患者的眼球运动限制程度及复视情况均有明显缓解,ODG组治愈率为70%,NOD组治愈率为72%。并且,OD组经眶减压手术影响,眼压由术前的(19.43±3.9)mmHg降至术后的(15.05±2.2)mmHg(P<0.001),而水平斜视度与垂直斜视度在术后均有所增加。结论与NOD相比,OD组斜视手术的复杂性增加,包括斜视程度、手术次数、总肌肉条数、水平肌条数及水平肌后徙效应量,ETMOWD联合脂肪减压术对水平肌的影响更为显著,但两种治疗方案的长期手术效果相似。展开更多
Objective INF2 is a member of the formins family.Abnormal expression and regulation of INF2 have been associated with the progression of various tumors,but the expression and role of INF2 in hepatocellular carcinoma(H...Objective INF2 is a member of the formins family.Abnormal expression and regulation of INF2 have been associated with the progression of various tumors,but the expression and role of INF2 in hepatocellular carcinoma(HCC)remain unclear.HCC is a highly lethal malignant tumor.Given the limitations of traditional treatments,this study explored the expression level,clinical value and potential mechanism of INF2 in HCC in order to seek new therapeutic targets.Methods In this study,we used public databases to analyze the expression of INF2 in pan-cancer and HCC,as well as the impact of INF2 expression levels on HCC prognosis.Quantitative real time polymerase chain reaction(RT-qPCR),Western blot,and immunohistochemistry were used to detect the expression level of INF2 in liver cancer cells and human HCC tissues.The correlation between INF2 expression and clinical pathological features was analyzed using public databases and clinical data of human HCC samples.Subsequently,the effects of INF2 expression on the biological function and Drp1 phosphorylation of liver cancer cells were elucidated through in vitro and in vivo experiments.Finally,the predictive value and potential mechanism of INF2 in HCC were further analyzed through database and immunohistochemical experiments.Results INF2 is aberrantly high expression in HCC samples and the high expression of INF2 is correlated with overall survival,liver cirrhosis and pathological differentiation of HCC patients.The expression level of INF2 has certain diagnostic value in predicting the prognosis and pathological differentiation of HCC.In vivo and in vitro HCC models,upregulated expression of INF2 triggers the proliferation and migration of the HCC cell,while knockdown of INF2 could counteract this effect.INF2 in liver cancer cells may affect mitochondrial division by inducing Drp1 phosphorylation and mediate immune escape by up-regulating PD-L1 expression,thus promoting tumor progression.Conclusion INF2 is highly expressed in HCC and is associated with poor prognosis.High expression of INF2 may promote HCC progression by inducing Drp1 phosphorylation and up-regulation of PD-L1 expression,and targeting INF2 may be beneficial for HCC patients with high expression of INF2.展开更多
文摘目的:分析中心性浆液性脉络膜视网膜病变(centralserous cho rio retinopathy,CSC)的不典型眼底荧光血管造影(fundus fluorescein angiography,FFA)表现特点。方法:采用海德堡共焦激光扫描系统对64例(90眼)CSC患者行FFA检查,分析其结果。结果:CSC的FFA表现归纳5种类型:(1)典型渗漏点型;(2)不典型渗漏点型;(3)色素上皮脱离型;(4)严重型(泡状视网膜脱离型);(5)正常荧光造影所见型。第1种类型为CSC的典型荧光造影表现,后4种类型为CSC的特殊型荧光造影表现。结论:CSC的FFA表现形式各异,需与Vogt_小柳原田病、特发性脉络膜新生血管膜及色素上皮炎鉴别。
文摘目的评估内窥镜下经筛径路眶内壁减压(endoscopic transethmoidal orbital wall decompres⁃sion,ETMOWD)联合脂肪减压(fat orbital decompression,FROD)术对甲状腺相关眼病(thyroid-associated ophthalmopathy,TAO)限制性斜视的影响效果。方法回顾性系列病例研究,选取2021年12月至2024年8月确诊为TAO的病例,按照是否行眶减压术,分成眶减压组(OD组)和非眶减压组(NOD组),比较两组之间围手术期的一般资料,斜视类型、眼球运动限制程度、眼肌后徙量及手术效果,并对OD组评估ET⁃MOWD联合脂肪减压术式对斜视的影响。手术成功的定义为复视消失,术后斜视度≤5 PD。结果共计65例纳入分析,其中OD组40例、NOD组25例,所有患者的甲状腺指标均在正常范围内,活动性评分均≤3分,处于静止期内,两组间的一般资料及术前斜视类型,包括水平和垂直斜视度差异无统计学意义(P>0.05),而OD组眼球运动限制分级、手术次数、手术总肌肉数、水平肌肉数量以及水平肌肉后徙效应量明显高于NOD组,术后所有患者的眼球运动限制程度及复视情况均有明显缓解,ODG组治愈率为70%,NOD组治愈率为72%。并且,OD组经眶减压手术影响,眼压由术前的(19.43±3.9)mmHg降至术后的(15.05±2.2)mmHg(P<0.001),而水平斜视度与垂直斜视度在术后均有所增加。结论与NOD相比,OD组斜视手术的复杂性增加,包括斜视程度、手术次数、总肌肉条数、水平肌条数及水平肌后徙效应量,ETMOWD联合脂肪减压术对水平肌的影响更为显著,但两种治疗方案的长期手术效果相似。
文摘Objective INF2 is a member of the formins family.Abnormal expression and regulation of INF2 have been associated with the progression of various tumors,but the expression and role of INF2 in hepatocellular carcinoma(HCC)remain unclear.HCC is a highly lethal malignant tumor.Given the limitations of traditional treatments,this study explored the expression level,clinical value and potential mechanism of INF2 in HCC in order to seek new therapeutic targets.Methods In this study,we used public databases to analyze the expression of INF2 in pan-cancer and HCC,as well as the impact of INF2 expression levels on HCC prognosis.Quantitative real time polymerase chain reaction(RT-qPCR),Western blot,and immunohistochemistry were used to detect the expression level of INF2 in liver cancer cells and human HCC tissues.The correlation between INF2 expression and clinical pathological features was analyzed using public databases and clinical data of human HCC samples.Subsequently,the effects of INF2 expression on the biological function and Drp1 phosphorylation of liver cancer cells were elucidated through in vitro and in vivo experiments.Finally,the predictive value and potential mechanism of INF2 in HCC were further analyzed through database and immunohistochemical experiments.Results INF2 is aberrantly high expression in HCC samples and the high expression of INF2 is correlated with overall survival,liver cirrhosis and pathological differentiation of HCC patients.The expression level of INF2 has certain diagnostic value in predicting the prognosis and pathological differentiation of HCC.In vivo and in vitro HCC models,upregulated expression of INF2 triggers the proliferation and migration of the HCC cell,while knockdown of INF2 could counteract this effect.INF2 in liver cancer cells may affect mitochondrial division by inducing Drp1 phosphorylation and mediate immune escape by up-regulating PD-L1 expression,thus promoting tumor progression.Conclusion INF2 is highly expressed in HCC and is associated with poor prognosis.High expression of INF2 may promote HCC progression by inducing Drp1 phosphorylation and up-regulation of PD-L1 expression,and targeting INF2 may be beneficial for HCC patients with high expression of INF2.
