Lamellarins isolated from oceanic mollusc are a kind of pyrrole hexacyclic alkaloids.Not only have lamellarins an interesting structural feature,but also exhibit a wide various of significant biological activities.The...Lamellarins isolated from oceanic mollusc are a kind of pyrrole hexacyclic alkaloids.Not only have lamellarins an interesting structural feature,but also exhibit a wide various of significant biological activities.The open-chain lamellarins have the same structure as lamellarin which shown potent cytotoxicity cytotoxic potential.ethyl 1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-2-(2,4,5-trimethoxyphenyl)pyrroloisoquinoline-3-carboxylate as a new compound and an inter mediate for synthesis of lamellarin was prepared via acylation and esterification in one pot after reaction of 1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline and 2-bromo-1-(2,4,5-trimethoxyphenyl)ethanone.The products were identified by means of IR,UV,NMR and MS measurement.展开更多
氧化低密度脂蛋白(oxidized low density lipoprotein,oxLDL)被认为是动脉硬化的关键致病因素。文章综合运用紫外吸收光谱、荧光光谱、同步荧光光谱及圆二色(circular dichroism,CD)光谱研究了Cu2+诱导不同时间的LDL体外氧化过程。随着...氧化低密度脂蛋白(oxidized low density lipoprotein,oxLDL)被认为是动脉硬化的关键致病因素。文章综合运用紫外吸收光谱、荧光光谱、同步荧光光谱及圆二色(circular dichroism,CD)光谱研究了Cu2+诱导不同时间的LDL体外氧化过程。随着氧化时间的增加,生成的丙二醛(malonaldehyde,MDA)的量逐渐增加,其相对应的430nm处的荧光强度也随之加强,氧化过程中生成了新的氧化产物。氧化低密度脂蛋白紫外吸收增强;表征氨基酸残基信息的特征荧光强度和同步荧光强度降低;载脂蛋白B-100(apolipoprotein B-100,apoB-100)α-螺旋含量减少。实验结果表明,LDL氧化过程中Cu2+不仅诱导了氧化产物的生成,而且改变了apoB-100的构象进而导致了生色基团的微环境的变化。展开更多
文摘Lamellarins isolated from oceanic mollusc are a kind of pyrrole hexacyclic alkaloids.Not only have lamellarins an interesting structural feature,but also exhibit a wide various of significant biological activities.The open-chain lamellarins have the same structure as lamellarin which shown potent cytotoxicity cytotoxic potential.ethyl 1-(3,4-dimethoxyphenyl)-8,9-dimethoxy-2-(2,4,5-trimethoxyphenyl)pyrroloisoquinoline-3-carboxylate as a new compound and an inter mediate for synthesis of lamellarin was prepared via acylation and esterification in one pot after reaction of 1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline and 2-bromo-1-(2,4,5-trimethoxyphenyl)ethanone.The products were identified by means of IR,UV,NMR and MS measurement.
