目的:探讨双介入治疗对延长肝癌患者总生存期的作用。方法:对36例肝癌患者(治疗组)在经皮导管肝动脉化疗栓塞(TACE)治疗后再经皮穿刺门静脉置管时辰化疗,并与36例对照组患者进行比较。结果:治疗组与对照组甲胎蛋白值及肝癌瘤体大小的变...目的:探讨双介入治疗对延长肝癌患者总生存期的作用。方法:对36例肝癌患者(治疗组)在经皮导管肝动脉化疗栓塞(TACE)治疗后再经皮穿刺门静脉置管时辰化疗,并与36例对照组患者进行比较。结果:治疗组与对照组甲胎蛋白值及肝癌瘤体大小的变化经统计学分析两组之间差异无显著性;两组1、2、3、5年生存率分别为52.78%、38.01%、30.09%和30.09% vs 33.33%、19.12%、11.17%和11.17%;中位生存期为14.00个月 vs 10.33个月,两组的总生存期差异有显著性。结论:门静脉置管时辰化疗联合TACE双介入治疗中晚期肝癌的近期疗效并无明显差异,但可以明显延长肝癌患者的总生存期。展开更多
肥胖已成为严重危害人类健康的社会问题。现有大约十亿的成年人是超重,体重指数（body mass index,BMI）超过25,并且有3亿成年人是肥胖,BMI超过30。肥胖会导致严重的健康问题,降低生活期盼,对生活质量造成重要影响。肥胖和超体重会导致...肥胖已成为严重危害人类健康的社会问题。现有大约十亿的成年人是超重,体重指数（body mass index,BMI）超过25,并且有3亿成年人是肥胖,BMI超过30。肥胖会导致严重的健康问题,降低生活期盼,对生活质量造成重要影响。肥胖和超体重会导致高血压、2型糖尿病、冠状动脉心脏病等严重疾病，展开更多
Telomeres are the unique structure at the end of chromosomes,which pose two special challenges for the cellular DNA replication and repair machinery.Because of the inability of lagging strand synthesis to fully replic...Telomeres are the unique structure at the end of chromosomes,which pose two special challenges for the cellular DNA replication and repair machinery.Because of the inability of lagging strand synthesis to fully replicate a linear template,the chromosome ends is progressively shortening at each replication cycle.The tandem DNA repeats must maintain enough length to allow the cell dividing and mitosing,otherwise the cells would lose the dividing ability and undergo replicative senescence.There are two special pathways to regulate telomere length,which consist of telomerase and alternative lengthening of telomeres(ALT).SUMO is an evolutionarily conserved protein,which is covalently attached to target proteins and alters their conformation,stability,interaction and localization.Currently,a lot of proteins have been proved to be the substrates of SUMOylation.A growing body of evidence implicate that SUMOylation plays a very important role to elongate telomeres in both telomerase and ALT.The Rad5 and Rad52,as well as BLM have been showed either to be modified by SUMO or to interact with SUMO.SUMOylation positively modifies the activity of telomere.展开更多
文摘目的:探讨双介入治疗对延长肝癌患者总生存期的作用。方法:对36例肝癌患者(治疗组)在经皮导管肝动脉化疗栓塞(TACE)治疗后再经皮穿刺门静脉置管时辰化疗,并与36例对照组患者进行比较。结果:治疗组与对照组甲胎蛋白值及肝癌瘤体大小的变化经统计学分析两组之间差异无显著性;两组1、2、3、5年生存率分别为52.78%、38.01%、30.09%和30.09% vs 33.33%、19.12%、11.17%和11.17%;中位生存期为14.00个月 vs 10.33个月,两组的总生存期差异有显著性。结论:门静脉置管时辰化疗联合TACE双介入治疗中晚期肝癌的近期疗效并无明显差异,但可以明显延长肝癌患者的总生存期。
文摘Telomeres are the unique structure at the end of chromosomes,which pose two special challenges for the cellular DNA replication and repair machinery.Because of the inability of lagging strand synthesis to fully replicate a linear template,the chromosome ends is progressively shortening at each replication cycle.The tandem DNA repeats must maintain enough length to allow the cell dividing and mitosing,otherwise the cells would lose the dividing ability and undergo replicative senescence.There are two special pathways to regulate telomere length,which consist of telomerase and alternative lengthening of telomeres(ALT).SUMO is an evolutionarily conserved protein,which is covalently attached to target proteins and alters their conformation,stability,interaction and localization.Currently,a lot of proteins have been proved to be the substrates of SUMOylation.A growing body of evidence implicate that SUMOylation plays a very important role to elongate telomeres in both telomerase and ALT.The Rad5 and Rad52,as well as BLM have been showed either to be modified by SUMO or to interact with SUMO.SUMOylation positively modifies the activity of telomere.
