Fluid shear stress play an important role in many physiological and pathophysiological processes of cardiovascular system. Shear stress-induced signal transduction throughout the vascular endothelial cell includes ion...Fluid shear stress play an important role in many physiological and pathophysiological processes of cardiovascular system. Shear stress-induced signal transduction throughout the vascular endothelial cell includes ion channels, G-protein linked receptors, tyrosine kinase receptors and integrins. The one impossible pathway of shear stress-induced signal transduction was biochemical reaction through second messenger, activating protein kinases and cytosolic transcription factors, and then regulating gene transcription . The other pathway was cytoskeletal system. This article reviewed the cellular and molecular mechanism of potassium channel signal transduction resulting from shear stress.展开更多
文摘Fluid shear stress play an important role in many physiological and pathophysiological processes of cardiovascular system. Shear stress-induced signal transduction throughout the vascular endothelial cell includes ion channels, G-protein linked receptors, tyrosine kinase receptors and integrins. The one impossible pathway of shear stress-induced signal transduction was biochemical reaction through second messenger, activating protein kinases and cytosolic transcription factors, and then regulating gene transcription . The other pathway was cytoskeletal system. This article reviewed the cellular and molecular mechanism of potassium channel signal transduction resulting from shear stress.
