Currently,research on N^(6)-methyladenine(m^(6)A)is extensive in the field of oncology,while studies involving m^(6)A and skin diseases remain relatively limited.Based on existing reports,we searched PubMed and Web of...Currently,research on N^(6)-methyladenine(m^(6)A)is extensive in the field of oncology,while studies involving m^(6)A and skin diseases remain relatively limited.Based on existing reports,we searched PubMed and Web of Science for literature related to m^(6)A and dermatological conditions.Analysis of citation counts and journal impact factors revealed a significant upward trend in the volume of m^(6)A-related research.Term frequency analysis of titles and abstracts indicated that studies mainly focus on skin tumors and inflammatory or immune-related skin diseases,particularly melanoma,psoriasis,and skin development.Transcriptomic data from the Gene Expression Omnibus(GEO)were analyzed,revealing differential expression of m^(6)A-related genes in 4 types of skin tumors(including squamous cell carcinoma and basal cell carcinoma)as well as in inflammatory skin diseases such as psoriasis and atopic dermatitis,and potential mechanisms of action were also explored.Findings suggest that m^(6)A modifications exhibit heterogeneity between neoplastic and nonneoplastic skin diseases.However,the regulatory mechanisms of m^(6)A dynamic modifications on key genes involved in dermatological disorders remain unclear and warrant further investigation.展开更多
目的:对性病门诊就诊的男男同性恋的性行为方式、安全套使用情况、艾滋病相关知识掌握情况等进行问卷调查,以了解该人群的行为特征,为制定相应的健康教育及行为干预提供科学的依据。方法:2009年1月至12月在多家综合医院性病门诊采用自...目的:对性病门诊就诊的男男同性恋的性行为方式、安全套使用情况、艾滋病相关知识掌握情况等进行问卷调查,以了解该人群的行为特征,为制定相应的健康教育及行为干预提供科学的依据。方法:2009年1月至12月在多家综合医院性病门诊采用自行设计调查问卷对200名就诊MSM(men who have sex with men,男男同性恋)的人口学特征、性行为方式、安全套使用情况、HIV相关知识的掌握程度等进行匿名式问卷调查。结果:被调查者年龄(26.7±8.9)岁,近1年来有121人(62.6%)被确诊过性病。近6个月来,同性性伴侣数为(9.2±4.8)人,102人有异性性伴侣(52.8%)。与同性性交时,123人有肛交行为(63.7%),117人有口交行为(60.6%)。与异性性交时,92人有阴道交(90.2%),37人有肛交行为(36.2%),59人有口交行为(57.8%)。经卡方检验,同性性行为和异性性行为的行构成有统计学差异(P<0.01)。不同性行为方式安全套使用频率有统计学差异(χ2=188.396,P<0.001)。而人免疫缺陷病毒(human immunodeficiency virus,HIV)相关知识与安全套使用情况分析发现除异性肛交安全套使用与HIV知识得分有线性关系外,其他性行为方式的安全套使用与HIV知识得分间无线性相关关系。结论:被调查对象艾滋病知识知晓率较高,能够主动通过多种途径获得艾滋病知识,但其HIV相关知识掌握程度与安全套使用频率无明显相关性。MSM在与异性性交时无保护性行为比例高。如何对性病门诊的MSM采取更为有效的方式进行干预以减少其高危性行为值得思考。展开更多
基金supported by the National Natural Science Foundation,China(82103704).
文摘Currently,research on N^(6)-methyladenine(m^(6)A)is extensive in the field of oncology,while studies involving m^(6)A and skin diseases remain relatively limited.Based on existing reports,we searched PubMed and Web of Science for literature related to m^(6)A and dermatological conditions.Analysis of citation counts and journal impact factors revealed a significant upward trend in the volume of m^(6)A-related research.Term frequency analysis of titles and abstracts indicated that studies mainly focus on skin tumors and inflammatory or immune-related skin diseases,particularly melanoma,psoriasis,and skin development.Transcriptomic data from the Gene Expression Omnibus(GEO)were analyzed,revealing differential expression of m^(6)A-related genes in 4 types of skin tumors(including squamous cell carcinoma and basal cell carcinoma)as well as in inflammatory skin diseases such as psoriasis and atopic dermatitis,and potential mechanisms of action were also explored.Findings suggest that m^(6)A modifications exhibit heterogeneity between neoplastic and nonneoplastic skin diseases.However,the regulatory mechanisms of m^(6)A dynamic modifications on key genes involved in dermatological disorders remain unclear and warrant further investigation.
文摘目的:对性病门诊就诊的男男同性恋的性行为方式、安全套使用情况、艾滋病相关知识掌握情况等进行问卷调查,以了解该人群的行为特征,为制定相应的健康教育及行为干预提供科学的依据。方法:2009年1月至12月在多家综合医院性病门诊采用自行设计调查问卷对200名就诊MSM(men who have sex with men,男男同性恋)的人口学特征、性行为方式、安全套使用情况、HIV相关知识的掌握程度等进行匿名式问卷调查。结果:被调查者年龄(26.7±8.9)岁,近1年来有121人(62.6%)被确诊过性病。近6个月来,同性性伴侣数为(9.2±4.8)人,102人有异性性伴侣(52.8%)。与同性性交时,123人有肛交行为(63.7%),117人有口交行为(60.6%)。与异性性交时,92人有阴道交(90.2%),37人有肛交行为(36.2%),59人有口交行为(57.8%)。经卡方检验,同性性行为和异性性行为的行构成有统计学差异(P<0.01)。不同性行为方式安全套使用频率有统计学差异(χ2=188.396,P<0.001)。而人免疫缺陷病毒(human immunodeficiency virus,HIV)相关知识与安全套使用情况分析发现除异性肛交安全套使用与HIV知识得分有线性关系外,其他性行为方式的安全套使用与HIV知识得分间无线性相关关系。结论:被调查对象艾滋病知识知晓率较高,能够主动通过多种途径获得艾滋病知识,但其HIV相关知识掌握程度与安全套使用频率无明显相关性。MSM在与异性性交时无保护性行为比例高。如何对性病门诊的MSM采取更为有效的方式进行干预以减少其高危性行为值得思考。
基金supported by the Natural Science Foundation of Hunan Province(2015JJ6120)the Health and Family Planning Research Foundation of Hunan Province(B2015-34)Development and Reform Commission Project of Hunan Province([2014]658),China
