A Review] Endothelial cells produce both superoxide and nitric oxide. Nitric oxide and superox- ide are known to react rapidly to form the stable peroxynitrite anion. Peroxynitrite mediates the oxidation of protein, l...A Review] Endothelial cells produce both superoxide and nitric oxide. Nitric oxide and superox- ide are known to react rapidly to form the stable peroxynitrite anion. Peroxynitrite mediates the oxidation of protein, lipid, deoxyribose and inhibits mitochondrial electron transport. Peroxynitrite may break DNA strands and activate poly(ADP - ribose) syntheatase. If the reaction is excessive, it results in a depletion of intracelular NAD+ and ATP. There is ultimately cell death.展开更多
NF-κB is a member of Rel family. It can transduct the extracellular signal into nucleus and activate the expression of target gene on special point in eukaryon. This review briefly discussed about Rel family and IκB...NF-κB is a member of Rel family. It can transduct the extracellular signal into nucleus and activate the expression of target gene on special point in eukaryon. This review briefly discussed about Rel family and IκB family, the activation of NF-κB, and the relationship between NF-κB and apoptosis.展开更多
文摘A Review] Endothelial cells produce both superoxide and nitric oxide. Nitric oxide and superox- ide are known to react rapidly to form the stable peroxynitrite anion. Peroxynitrite mediates the oxidation of protein, lipid, deoxyribose and inhibits mitochondrial electron transport. Peroxynitrite may break DNA strands and activate poly(ADP - ribose) syntheatase. If the reaction is excessive, it results in a depletion of intracelular NAD+ and ATP. There is ultimately cell death.
文摘NF-κB is a member of Rel family. It can transduct the extracellular signal into nucleus and activate the expression of target gene on special point in eukaryon. This review briefly discussed about Rel family and IκB family, the activation of NF-κB, and the relationship between NF-κB and apoptosis.
