Objective To explore the sequential effects of hypoxic exercising on miR-27/PPARγand lipid metabolism targetgene and protein expression levels in the obesity rats’liver.Methods 13-week-old male diet-induced obesity ...Objective To explore the sequential effects of hypoxic exercising on miR-27/PPARγand lipid metabolism targetgene and protein expression levels in the obesity rats’liver.Methods 13-week-old male diet-induced obesity rats were randomlydivided into three groups(n=10):normal oxygen concentration quiet group(N),hypoxia quiet group(H),hypoxic exercise group(HE).Exercise training on the horizontal animal treadmill for 1 h/d,5 d/week for a total of 4 week,and the intensity of horizontaltreadmill training was 20 m/min(hypoxic concentration was 13.6%).Comparison of the weights of perirenal fat and epididymal fat in rats across different groups and calculation of Lee’s index based on body weight and body length of rats in each group were done.And the serum concentrations of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high-densitylipoprotein cholesterol(HDL-C)levels were detected.RT-PCR and Western Blot were used to detect the levels of miR-27,PPARγ,CYP7A1 and CD36.Results Hypoxic exercise decreased the expression levels of miR-27 in the obese rats’liver,however,theexpression level of PPARγwas gradually increased.The expression levels of miR-27 in HE group were significantly lower than Ngroup(P<0.05).The expression levels of PPARγmRNA in N group were significantly lower than H group(P<0.05),especially lowerthan HE group(P<0.01).The protein expression of PPARγprotein in N group was significantly lower than that other groups(P<0.01).The expression of lipid metabolism-related genes and proteins increased in the obese rats’liver.The expression of CYP7A1mRNA in N group was significantly lower than H group(P<0.05),especially lower than HE group(P<0.01).The expression ofCYP7A1 protein in the obese rats’liver in N group was extremely lower than H group and HE group(P<0.01).The proteinexpression of CD36 in N group was significantly lower than that in HE group(P<0.05).Hypoxia exercise improved the relatedphysiological and biochemical indexes of lipid metabolism disorder.The perirenal fat weight of obese rats in HE group wasextremely lower than N group and H group(P<0.01),and the perirenal fat weight in N group was significantly higher than H group(P<0.05).The epididymal fat weight in N group was significantly higher than H group(P<0.05),and extremely higher than HEgroup(P<0.01).The Lee’s index in HE group was extremely lower than N group and H group(P<0.01).The serum concentration ofTC in obese rats in HE group was extremely lower than N group and H group(P<0.01).The serum concentration of TG in HE groupwas extremely lower than N group and H group(P<0.01).The serum concentration of LDL-C in N group was extremely higher thanHE group(P<0.01).The serum concentration of HDL-C in N group was extremely lower than H group(P<0.01).Conclusion Hypoxiaand hypoxia exercise may negatively regulate the levels of PPARγby inhibiting miR-27 in the obese rats’liver,thereby affecting theexpression of downstream target genes CYP7A1 and CD36,and promoting cholesterol,fatty acid oxidation and HDL-C transport inthe liver,and ultimately the lipid levels in obese rats were improved.The effect of hypoxia exercise on improving blood lipid isbetter than simple hypoxia intervention.展开更多
采用文献资料等方法对"Exercise is Medicine"领域现状进行了研究及探讨其对我国健康事业发展的启示。研究结果显示,EIM项目已在美国逐步兴起、发展并得到社会大众的认可,形成了比较完整的知识应用体系。目前,EIM项目主要应...采用文献资料等方法对"Exercise is Medicine"领域现状进行了研究及探讨其对我国健康事业发展的启示。研究结果显示,EIM项目已在美国逐步兴起、发展并得到社会大众的认可,形成了比较完整的知识应用体系。目前,EIM项目主要应用于心肺耐力、心血管疾病、骨质疏松、内分泌功能紊乱、消化系统等与静坐不运动密切关联身体疾病。对我国主要的启示:引进EIM项目并推广;构建符合我国国情的EIM体系;构建我国EIM从业资格和职业认证体系;引进社会资源,推动EIM快速发展;政府给予绿色通道,政策给予保障。展开更多
The wind effects on steady-state scan characteristics and hit probability of terminal-sensitive projectile were discussed in this paper. Considering wind as the constitutions of the average wind and the impulsive wind...The wind effects on steady-state scan characteristics and hit probability of terminal-sensitive projectile were discussed in this paper. Considering wind as the constitutions of the average wind and the impulsive wind, a simplified wind field model was established for the ballistic calculation of the steady-state scan phase; under the windy condition, the effects of the range wind and the beam wind on the steady-state scan characteristics of the terminal-sensitive projectile were analyzed in detail and its hit probabilities for a certain armored target were calculated. The calculated results show that, when the wind speed exceeds a certain value, the hit probabilities of terminal-sensitive projectile drop rapidly; the wind effects must be considered in the application of the terminal-sensitive projectiles. This paper provides some theoretical references for the fire wind speed correction and the global structure optimization of the terminal-sensitive projectile.展开更多
To make rat do active exercise to counteract bone loss in the rat tail-suspension model, a pulse electrical stimulator based on single-electrode with a low-current and a high-voltage was designed. The stimulator was c...To make rat do active exercise to counteract bone loss in the rat tail-suspension model, a pulse electrical stimulator based on single-electrode with a low-current and a high-voltage was designed. The stimulator was controlled by SCM (single chip micyoco) that could accurately control the stimulation duration and the interval between stimulations, and cease the operation after the recorded number of stimulation had reached the value set by the program. With the help of posture estimation part, the device would operate intelligently by determining whether to stimulate or not, depending on the posture of rat's limb. Software was developed to make operator control the stimulator using computer, save the experiment data and print the report. In practical experiment, the voltaic arc is generated by the stimulator, and impacted on the rat's thenar. This induced pain to the rat and the rat would actively contract its hindlimb to evade the pain, so active exercise was carried out. The tail-suspension rats were trained twice every day for 14 d. At the 0 and 14th day, bone mineral density of rat femurs was determined by dual energy X-ray absorptiometry (DXA). The results show that the active exercise stimulated by the pulse electrical arc stimulator can attenuate weightlessness-induced bone loss, and this device is a convenient steady performance electrical stimulator that can surely induce rat's hindlimb to do active exercise.展开更多
In this study,a novel energy-efficient single-phase induction motor with three stator windings is proposed as shown in Fig 1.The winding A constitutes the first branch.The series connection of the capacitor C and the ...In this study,a novel energy-efficient single-phase induction motor with three stator windings is proposed as shown in Fig 1.The winding A constitutes the first branch.The series connection of the capacitor C and the winding B constitute the second branch,and the series connection of the capacitor C2 and the winding C constitute the third one.The above three branches are connected in parallel as shown in Fig.2.展开更多
Objective Cardiopulmonary exercise testing(CPET)is helpful to identify right ventriclar(RV)dysfunction in patients with rapair of Tetralogy of Fallot(rTOF),but its predictive value on early outcomes of pulmonary valve...Objective Cardiopulmonary exercise testing(CPET)is helpful to identify right ventriclar(RV)dysfunction in patients with rapair of Tetralogy of Fallot(rTOF),but its predictive value on early outcomes of pulmonary valve replacement(PVR)of these patients is unclear when similar preoperative ventricular size and function in cardiovascular magnetic resonance(CMR)exist.The aim of this study is to evaluate whether CPET is useful to predict the early outcomes of rTOF patients after PVR.展开更多
Objective:To compare the effects of different conservative managements on patients with adolescent idiopathic scoliosis (AIS). Method:One hundred and four AIS patients were recruited for this study. The patients were ...Objective:To compare the effects of different conservative managements on patients with adolescent idiopathic scoliosis (AIS). Method:One hundred and four AIS patients were recruited for this study. The patients were divided into 3 groups:exercise (E group), brace (B group) and combined rehabilitation treatment (brace treatment combined with exercise, CR group). Radiological parameter were used to assess AIS patients before and after treatment. The Chinese version of scoliosis research society-22(SRS-22) patient questionnaires were filled out by patients after treatment. The SRS-22 scores were compared among management groups. Result:The maximal Cobb angles were smaller in E group than in B group or CR group both before and af- ter treatment. The maximal Cobb angles were significantly smaller after treatment than before treatment in B group and CR group. Function/activity was better in E group than in B group or CR group. Self-image/appear- ance and satisfaction with management were better in E group and CR group than in B group. There was no significant difference among treatment groups in pain and mental health. Conclusion:Both brace and combined rehabilitation treatment can reduce the spinal curve of AIS patients. Both exercise and combined rehabilitation treatment have positive influence on self-image/appearance and satis- faction with management. We support preference of combined rehabilitation treatment above brace treatment.展开更多
The article presents the most important results of metabolic (hormonal) study of dosed vibration training (DVT).The author presents vibrating training as an alternative to anabolic steroids on the basis of a compariso...The article presents the most important results of metabolic (hormonal) study of dosed vibration training (DVT).The author presents vibrating training as an alternative to anabolic steroids on the basis of a comparison of the effectiveness of two types of stimulants - forbidden (doping) and non-medicinal non-invasive, relating to permitted physical means.The study shows that the level of androgens (testosterone),corticosteroids (cortisol), thyroid hormones (thyroxine,triiodothyronine),hormones of adenohypophysis (prolactin) increased under the effect of dosed vibration training.At the same time the level of hormones have no changes under traditional strength training with the use of a synthetic anabolic steroid (retabolil).For the duration of a limited period of time (1 microcycles) dosed vibrotraining causes a more powerful secretion of testosterone than the traditional strength training with the use of anabolic steroids. In this case,the overall time spent on the performance of the DVT training program comprises not more than 15% of the time spent on the traditional training exercises.展开更多
通过检索PubMed、Web of Science、中国知网和万方等数据库,对近年来发表的有关扁平足在生物力学上的成因和治疗方法的相关内容进行综述。其中,扁平足的形成原因包括先天性因素和后天性因素,而治疗方法主要有矫形鞋垫、物理疗法、手术...通过检索PubMed、Web of Science、中国知网和万方等数据库,对近年来发表的有关扁平足在生物力学上的成因和治疗方法的相关内容进行综述。其中,扁平足的形成原因包括先天性因素和后天性因素,而治疗方法主要有矫形鞋垫、物理疗法、手术治疗和运动疗法。这些方法在一定程度上能够纠正足部结构异常,优化生物力学性能,提高足部的稳定性和活动范围。对于未来的研究,将利用先进的影像和仿真技术进行精确的病情评估,新型材料和非手术疗法的应用将能够长期缓解症状,而基因研究将推动早期诊断和个性化治疗的发展,智能矫形器的使用将实现实时监测和动态调整,从而为扁平足的评估、干预和治疗提供更多更有效的方法和手段。展开更多
文摘Objective To explore the sequential effects of hypoxic exercising on miR-27/PPARγand lipid metabolism targetgene and protein expression levels in the obesity rats’liver.Methods 13-week-old male diet-induced obesity rats were randomlydivided into three groups(n=10):normal oxygen concentration quiet group(N),hypoxia quiet group(H),hypoxic exercise group(HE).Exercise training on the horizontal animal treadmill for 1 h/d,5 d/week for a total of 4 week,and the intensity of horizontaltreadmill training was 20 m/min(hypoxic concentration was 13.6%).Comparison of the weights of perirenal fat and epididymal fat in rats across different groups and calculation of Lee’s index based on body weight and body length of rats in each group were done.And the serum concentrations of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high-densitylipoprotein cholesterol(HDL-C)levels were detected.RT-PCR and Western Blot were used to detect the levels of miR-27,PPARγ,CYP7A1 and CD36.Results Hypoxic exercise decreased the expression levels of miR-27 in the obese rats’liver,however,theexpression level of PPARγwas gradually increased.The expression levels of miR-27 in HE group were significantly lower than Ngroup(P<0.05).The expression levels of PPARγmRNA in N group were significantly lower than H group(P<0.05),especially lowerthan HE group(P<0.01).The protein expression of PPARγprotein in N group was significantly lower than that other groups(P<0.01).The expression of lipid metabolism-related genes and proteins increased in the obese rats’liver.The expression of CYP7A1mRNA in N group was significantly lower than H group(P<0.05),especially lower than HE group(P<0.01).The expression ofCYP7A1 protein in the obese rats’liver in N group was extremely lower than H group and HE group(P<0.01).The proteinexpression of CD36 in N group was significantly lower than that in HE group(P<0.05).Hypoxia exercise improved the relatedphysiological and biochemical indexes of lipid metabolism disorder.The perirenal fat weight of obese rats in HE group wasextremely lower than N group and H group(P<0.01),and the perirenal fat weight in N group was significantly higher than H group(P<0.05).The epididymal fat weight in N group was significantly higher than H group(P<0.05),and extremely higher than HEgroup(P<0.01).The Lee’s index in HE group was extremely lower than N group and H group(P<0.01).The serum concentration ofTC in obese rats in HE group was extremely lower than N group and H group(P<0.01).The serum concentration of TG in HE groupwas extremely lower than N group and H group(P<0.01).The serum concentration of LDL-C in N group was extremely higher thanHE group(P<0.01).The serum concentration of HDL-C in N group was extremely lower than H group(P<0.01).Conclusion Hypoxiaand hypoxia exercise may negatively regulate the levels of PPARγby inhibiting miR-27 in the obese rats’liver,thereby affecting theexpression of downstream target genes CYP7A1 and CD36,and promoting cholesterol,fatty acid oxidation and HDL-C transport inthe liver,and ultimately the lipid levels in obese rats were improved.The effect of hypoxia exercise on improving blood lipid isbetter than simple hypoxia intervention.
文摘采用文献资料等方法对"Exercise is Medicine"领域现状进行了研究及探讨其对我国健康事业发展的启示。研究结果显示,EIM项目已在美国逐步兴起、发展并得到社会大众的认可,形成了比较完整的知识应用体系。目前,EIM项目主要应用于心肺耐力、心血管疾病、骨质疏松、内分泌功能紊乱、消化系统等与静坐不运动密切关联身体疾病。对我国主要的启示:引进EIM项目并推广;构建符合我国国情的EIM体系;构建我国EIM从业资格和职业认证体系;引进社会资源,推动EIM快速发展;政府给予绿色通道,政策给予保障。
基金Sponsored by Doctoral Foundation of Ministry of Education of China (20093219120006)
文摘The wind effects on steady-state scan characteristics and hit probability of terminal-sensitive projectile were discussed in this paper. Considering wind as the constitutions of the average wind and the impulsive wind, a simplified wind field model was established for the ballistic calculation of the steady-state scan phase; under the windy condition, the effects of the range wind and the beam wind on the steady-state scan characteristics of the terminal-sensitive projectile were analyzed in detail and its hit probabilities for a certain armored target were calculated. The calculated results show that, when the wind speed exceeds a certain value, the hit probabilities of terminal-sensitive projectile drop rapidly; the wind effects must be considered in the application of the terminal-sensitive projectiles. This paper provides some theoretical references for the fire wind speed correction and the global structure optimization of the terminal-sensitive projectile.
基金Project(10872024) supported by the National Natural Science Foundation of China
文摘To make rat do active exercise to counteract bone loss in the rat tail-suspension model, a pulse electrical stimulator based on single-electrode with a low-current and a high-voltage was designed. The stimulator was controlled by SCM (single chip micyoco) that could accurately control the stimulation duration and the interval between stimulations, and cease the operation after the recorded number of stimulation had reached the value set by the program. With the help of posture estimation part, the device would operate intelligently by determining whether to stimulate or not, depending on the posture of rat's limb. Software was developed to make operator control the stimulator using computer, save the experiment data and print the report. In practical experiment, the voltaic arc is generated by the stimulator, and impacted on the rat's thenar. This induced pain to the rat and the rat would actively contract its hindlimb to evade the pain, so active exercise was carried out. The tail-suspension rats were trained twice every day for 14 d. At the 0 and 14th day, bone mineral density of rat femurs was determined by dual energy X-ray absorptiometry (DXA). The results show that the active exercise stimulated by the pulse electrical arc stimulator can attenuate weightlessness-induced bone loss, and this device is a convenient steady performance electrical stimulator that can surely induce rat's hindlimb to do active exercise.
文摘In this study,a novel energy-efficient single-phase induction motor with three stator windings is proposed as shown in Fig 1.The winding A constitutes the first branch.The series connection of the capacitor C and the winding B constitute the second branch,and the series connection of the capacitor C2 and the winding C constitute the third one.The above three branches are connected in parallel as shown in Fig.2.
文摘Objective Cardiopulmonary exercise testing(CPET)is helpful to identify right ventriclar(RV)dysfunction in patients with rapair of Tetralogy of Fallot(rTOF),but its predictive value on early outcomes of pulmonary valve replacement(PVR)of these patients is unclear when similar preoperative ventricular size and function in cardiovascular magnetic resonance(CMR)exist.The aim of this study is to evaluate whether CPET is useful to predict the early outcomes of rTOF patients after PVR.
基金supported by the Science and Technology Committee of Shanghai Gran(t114119a2700)
文摘Objective:To compare the effects of different conservative managements on patients with adolescent idiopathic scoliosis (AIS). Method:One hundred and four AIS patients were recruited for this study. The patients were divided into 3 groups:exercise (E group), brace (B group) and combined rehabilitation treatment (brace treatment combined with exercise, CR group). Radiological parameter were used to assess AIS patients before and after treatment. The Chinese version of scoliosis research society-22(SRS-22) patient questionnaires were filled out by patients after treatment. The SRS-22 scores were compared among management groups. Result:The maximal Cobb angles were smaller in E group than in B group or CR group both before and af- ter treatment. The maximal Cobb angles were significantly smaller after treatment than before treatment in B group and CR group. Function/activity was better in E group than in B group or CR group. Self-image/appear- ance and satisfaction with management were better in E group and CR group than in B group. There was no significant difference among treatment groups in pain and mental health. Conclusion:Both brace and combined rehabilitation treatment can reduce the spinal curve of AIS patients. Both exercise and combined rehabilitation treatment have positive influence on self-image/appearance and satis- faction with management. We support preference of combined rehabilitation treatment above brace treatment.
文摘The article presents the most important results of metabolic (hormonal) study of dosed vibration training (DVT).The author presents vibrating training as an alternative to anabolic steroids on the basis of a comparison of the effectiveness of two types of stimulants - forbidden (doping) and non-medicinal non-invasive, relating to permitted physical means.The study shows that the level of androgens (testosterone),corticosteroids (cortisol), thyroid hormones (thyroxine,triiodothyronine),hormones of adenohypophysis (prolactin) increased under the effect of dosed vibration training.At the same time the level of hormones have no changes under traditional strength training with the use of a synthetic anabolic steroid (retabolil).For the duration of a limited period of time (1 microcycles) dosed vibrotraining causes a more powerful secretion of testosterone than the traditional strength training with the use of anabolic steroids. In this case,the overall time spent on the performance of the DVT training program comprises not more than 15% of the time spent on the traditional training exercises.
文摘通过检索PubMed、Web of Science、中国知网和万方等数据库,对近年来发表的有关扁平足在生物力学上的成因和治疗方法的相关内容进行综述。其中,扁平足的形成原因包括先天性因素和后天性因素,而治疗方法主要有矫形鞋垫、物理疗法、手术治疗和运动疗法。这些方法在一定程度上能够纠正足部结构异常,优化生物力学性能,提高足部的稳定性和活动范围。对于未来的研究,将利用先进的影像和仿真技术进行精确的病情评估,新型材料和非手术疗法的应用将能够长期缓解症状,而基因研究将推动早期诊断和个性化治疗的发展,智能矫形器的使用将实现实时监测和动态调整,从而为扁平足的评估、干预和治疗提供更多更有效的方法和手段。
