Cardiac arrest(CA)is a critical condition in the field of cardiovascular medicine.Despite successful resuscitation,patients continue to have a high mortality rate,largely due to post CA syndrome(PCAS).However,the inju...Cardiac arrest(CA)is a critical condition in the field of cardiovascular medicine.Despite successful resuscitation,patients continue to have a high mortality rate,largely due to post CA syndrome(PCAS).However,the injury and pathophysiological mechanisms underlying PCAS remain unclear.Experimental animal models are valuable tools for exploring the etiology,pathogenesis,and potential interventions for CA and PCAS.Current CA animal models include electrical induction of ventricular fibrillation(VF),myocardial infarction,high potassium,asphyxia,and hemorrhagic shock.Although these models do not fully replicate the complexity of clinical CA,the mechanistic insights they provide remain highly relevant,including post-CA brain injury(PCABI),post-CA myocardial dysfunction(PAMD),systemic ischaemia/reperfusion injury(IRI),and the persistent precipitating pathology.Summarizing the methods of establishing CA models,the challenges encountered in the modeling process,and the mechanisms of PCAS can provide a foundation for developing standardized CA modeling protocols.展开更多
Higher Himalayan Crystalline (HHC) rocks often show metamorphic zonations from lower greenschist facies to migmatites associated with leucogranite intrusions that are classically described as examples of Tertiary inve...Higher Himalayan Crystalline (HHC) rocks often show metamorphic zonations from lower greenschist facies to migmatites associated with leucogranite intrusions that are classically described as examples of Tertiary inverted metamorphism. The present study, based on structural, petrological and geochronological investigations in the Kinnar Kailas Granite (KKG) and surrounding HHC sequence, evidences a discordant intrusive contact of the Ordovician KKG with respect to Pre\|Alpine high grade deformed HHC sequence in the Sutlej valley.Four main phases of deformation are recorded in this HHC sequence and pre\|Ordovician sediments. The first three phases of deformation occurred under high\|grade metamorphic conditions, before the intrusion of the KKG. The geometry of the main progressive ductile deformation (D2—D3) results from SW vergent doming and migmatisation. The latest deformation is expressed by local shearing under greenschist facies conditions. This late D4 deformation corresponds to N—S oriented ductile normal faults lowering the eastern blocks. The KKG is a shallow depth intrusion, showing discordant contacts with the surrounding basement rocks and large scale magmatic stoping. The KKG crosscuts the high\|grade deformation structures (D2—D3) but is locally affected by the local late D4 extensional deformation. The granite textures reflect only slight orientation related to magmatic deformation and even at few centimetres from the intrusion contact, the granite appears undeformed in contrast to the surrounding highly foliated rocks. Furthermore, xenoliths of Kyanite\|Sillimanite bearing basement rocks are present within the KKG.展开更多
基金supported by the National Key Research and Development Program(2021YFC3002205)the Postgraduate Research and Innovation Program of Tianjin Municipal Education Commission(2022BKY113),China.
文摘Cardiac arrest(CA)is a critical condition in the field of cardiovascular medicine.Despite successful resuscitation,patients continue to have a high mortality rate,largely due to post CA syndrome(PCAS).However,the injury and pathophysiological mechanisms underlying PCAS remain unclear.Experimental animal models are valuable tools for exploring the etiology,pathogenesis,and potential interventions for CA and PCAS.Current CA animal models include electrical induction of ventricular fibrillation(VF),myocardial infarction,high potassium,asphyxia,and hemorrhagic shock.Although these models do not fully replicate the complexity of clinical CA,the mechanistic insights they provide remain highly relevant,including post-CA brain injury(PCABI),post-CA myocardial dysfunction(PAMD),systemic ischaemia/reperfusion injury(IRI),and the persistent precipitating pathology.Summarizing the methods of establishing CA models,the challenges encountered in the modeling process,and the mechanisms of PCAS can provide a foundation for developing standardized CA modeling protocols.
基金the National Natural Science Foundation of China under Grant No.60503054( 国家自然科学基金)the National Grand Fundamental Research 973 Program of China under Grant No.2002CB312103(国家重点基础研究发展规划(973)).
文摘Higher Himalayan Crystalline (HHC) rocks often show metamorphic zonations from lower greenschist facies to migmatites associated with leucogranite intrusions that are classically described as examples of Tertiary inverted metamorphism. The present study, based on structural, petrological and geochronological investigations in the Kinnar Kailas Granite (KKG) and surrounding HHC sequence, evidences a discordant intrusive contact of the Ordovician KKG with respect to Pre\|Alpine high grade deformed HHC sequence in the Sutlej valley.Four main phases of deformation are recorded in this HHC sequence and pre\|Ordovician sediments. The first three phases of deformation occurred under high\|grade metamorphic conditions, before the intrusion of the KKG. The geometry of the main progressive ductile deformation (D2—D3) results from SW vergent doming and migmatisation. The latest deformation is expressed by local shearing under greenschist facies conditions. This late D4 deformation corresponds to N—S oriented ductile normal faults lowering the eastern blocks. The KKG is a shallow depth intrusion, showing discordant contacts with the surrounding basement rocks and large scale magmatic stoping. The KKG crosscuts the high\|grade deformation structures (D2—D3) but is locally affected by the local late D4 extensional deformation. The granite textures reflect only slight orientation related to magmatic deformation and even at few centimetres from the intrusion contact, the granite appears undeformed in contrast to the surrounding highly foliated rocks. Furthermore, xenoliths of Kyanite\|Sillimanite bearing basement rocks are present within the KKG.
