OBJECTIVE To observe the regulating effect of Weiliuan on digestive enzyme and relevant gastrointestinal hormone in spleen-deficiency rats.METHODS The rats were given the decoction of Radix et Rhizoma combine with die...OBJECTIVE To observe the regulating effect of Weiliuan on digestive enzyme and relevant gastrointestinal hormone in spleen-deficiency rats.METHODS The rats were given the decoction of Radix et Rhizoma combine with dietary disorder to induce spleen-deficiency syndrome.Spleen-deficiency rats were divided into 8groups:normal control group,spleen deficiency model group,Mengtuoshi San group(0.15g·kg-1),Weiliuan 31.5and 15.75g·kg-1 groups,Weiliuan splited prescriptionⅠ 31.5 and 15.75g·kg-1groups,Weiliuan splited prescriptionⅡ 31.5and 15.75g·kg-1 groups.At the end of experiment,the level of amylase(AMS),lactic dehydrogenase(LDH),succinate dehydrogenase(SDH),motilin(MTL),somatostatin(SS),gastrin(GAS)and organ coefficient were detected.RESULTS Weiliuan group,Weiliuan splited prescriptionⅠ group and Weiliuan splited prescriptionⅡ group can significantly reduce the spleen index,the level of SDH and LDH,it can also improve the level of the AMS(P<0.05,P<0.01)In the regulation of hormone levels,Weiliuan group,Weiliuan splited prescriptionⅠ group and Weiliuan splited prescriptionⅡ group can significantly improve the levels MTL and GAS(P<0.05),but had no obvious effect on SS.CONCLUSION Weiliuan group,Weiliuan splited prescriptionⅠ group and Weiliuan splited prescriptionⅡ group can improve the symptoms of spleen deficiency syndrome significantly.Its mechanism may be to regulate the levels of AMS,SDH,LDH,MTL and GAS.展开更多
目的考察麻黄附子细辛汤联合非免疫抑制治疗对脾肾阳虚型局灶节段性肾小球硬化患者的临床疗效。方法60例患者随机分为对照组和观察组,每组30例,对照组给予非免疫抑制治疗,观察组在对照组基础上加用麻黄附子细辛汤,疗程24周。检测临床疗...目的考察麻黄附子细辛汤联合非免疫抑制治疗对脾肾阳虚型局灶节段性肾小球硬化患者的临床疗效。方法60例患者随机分为对照组和观察组,每组30例,对照组给予非免疫抑制治疗,观察组在对照组基础上加用麻黄附子细辛汤,疗程24周。检测临床疗效、中医证候疗效、中医证候评分、24 h UTP、ALB、eGFR、Nephrin、Podocin、安全性指标变化。结果观察组总有效率、中医证候有效率高于对照组(P<0.05)。治疗后,2组中医证候评分、24 h UTP、Nephrin、Podocin降低(P<0.05),ALB升高(P<0.05),以观察组更明显(P<0.05)。2组未发生明显不良反应。结论麻黄附子细辛汤联合非免疫抑制治疗可安全有效地改善脾肾阳虚型局灶节段性肾小球硬化患者中医证候,其作用机制可能与缓解足细胞损伤有关。展开更多
基金The project supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘OBJECTIVE To observe the regulating effect of Weiliuan on digestive enzyme and relevant gastrointestinal hormone in spleen-deficiency rats.METHODS The rats were given the decoction of Radix et Rhizoma combine with dietary disorder to induce spleen-deficiency syndrome.Spleen-deficiency rats were divided into 8groups:normal control group,spleen deficiency model group,Mengtuoshi San group(0.15g·kg-1),Weiliuan 31.5and 15.75g·kg-1 groups,Weiliuan splited prescriptionⅠ 31.5 and 15.75g·kg-1groups,Weiliuan splited prescriptionⅡ 31.5and 15.75g·kg-1 groups.At the end of experiment,the level of amylase(AMS),lactic dehydrogenase(LDH),succinate dehydrogenase(SDH),motilin(MTL),somatostatin(SS),gastrin(GAS)and organ coefficient were detected.RESULTS Weiliuan group,Weiliuan splited prescriptionⅠ group and Weiliuan splited prescriptionⅡ group can significantly reduce the spleen index,the level of SDH and LDH,it can also improve the level of the AMS(P<0.05,P<0.01)In the regulation of hormone levels,Weiliuan group,Weiliuan splited prescriptionⅠ group and Weiliuan splited prescriptionⅡ group can significantly improve the levels MTL and GAS(P<0.05),but had no obvious effect on SS.CONCLUSION Weiliuan group,Weiliuan splited prescriptionⅠ group and Weiliuan splited prescriptionⅡ group can improve the symptoms of spleen deficiency syndrome significantly.Its mechanism may be to regulate the levels of AMS,SDH,LDH,MTL and GAS.
文摘目的考察麻黄附子细辛汤联合非免疫抑制治疗对脾肾阳虚型局灶节段性肾小球硬化患者的临床疗效。方法60例患者随机分为对照组和观察组,每组30例,对照组给予非免疫抑制治疗,观察组在对照组基础上加用麻黄附子细辛汤,疗程24周。检测临床疗效、中医证候疗效、中医证候评分、24 h UTP、ALB、eGFR、Nephrin、Podocin、安全性指标变化。结果观察组总有效率、中医证候有效率高于对照组(P<0.05)。治疗后,2组中医证候评分、24 h UTP、Nephrin、Podocin降低(P<0.05),ALB升高(P<0.05),以观察组更明显(P<0.05)。2组未发生明显不良反应。结论麻黄附子细辛汤联合非免疫抑制治疗可安全有效地改善脾肾阳虚型局灶节段性肾小球硬化患者中医证候,其作用机制可能与缓解足细胞损伤有关。
