2-hydroxy N methyl N phenyl acetamide was synthesized by using N methylaniline, chloracetyl chloride, anhydrous sodium acetate and methanol through the acetylation, esterfication and ester interchange steps. The acety...2-hydroxy N methyl N phenyl acetamide was synthesized by using N methylaniline, chloracetyl chloride, anhydrous sodium acetate and methanol through the acetylation, esterfication and ester interchange steps. The acetylation of N methylaniline with chloracetyl chloride, catalyzed by triethylamide with mole ratio n (C 6H 5NHCH 3)∶ n (ClCH 2C(O)Cl)∶ n (N(C 2H 5) 3)=1∶1.05∶1, the yield of 2 chloro N methyl N phenyl acetamide(Ⅰ) was 93.8%; Then the esterification of Ⅰ with anhydrous sodium acetate in the presence of phase transfer catalyst tetrabutyl ammonia bromide gave 97.3% yield of 2 acetoxyl N methyl N phenyl acetamide (Ⅱ); The ester interchange of with methanol catalyzed by potassium hydroxide gave 2 hydroxy N methyl N phenyl acetamide (Ⅲ) in 96.4% yield. And the total yield was 88.0%. IR and MS spectroscopy of products were analyzed and their characteristic peaks were assigned. Combining the results of elemental analysis, the molecular structure of Ⅰ, Ⅱ and Ⅲ was identified.展开更多
The enthalpies of solution of glycine in aqueous solutions of urea,formamide,acetamide,DMSOand acetone were measured at298.15 K by a RD496-Ⅲ microcalorimeter.The transfer enthalpies(ΔtrH) ofglycine from water to aqu...The enthalpies of solution of glycine in aqueous solutions of urea,formamide,acetamide,DMSOand acetone were measured at298.15 K by a RD496-Ⅲ microcalorimeter.The transfer enthalpies(ΔtrH) ofglycine from water to aqueous organic mixtures were derived and interpreted qualitatively with structural hydra-tion interaction model.The results suggest that hydrophilic-hydrophilic interaction between glycine and cosol-vent molecule gives a negative contribution to the transfer enthalpies of glycine,while the hydrophilic hydro-phobic interaction makes a positive contribution.The relative position ofΔtrH-composition profiles viz.urea <formamide <0 <acetamide <DMSO<acetone,characterizes the hydrophobicity or hydrophilicity of the cosol-vent molecule and correctly reflectes the solute-solvent interaction in the transfer process.展开更多
文摘2-hydroxy N methyl N phenyl acetamide was synthesized by using N methylaniline, chloracetyl chloride, anhydrous sodium acetate and methanol through the acetylation, esterfication and ester interchange steps. The acetylation of N methylaniline with chloracetyl chloride, catalyzed by triethylamide with mole ratio n (C 6H 5NHCH 3)∶ n (ClCH 2C(O)Cl)∶ n (N(C 2H 5) 3)=1∶1.05∶1, the yield of 2 chloro N methyl N phenyl acetamide(Ⅰ) was 93.8%; Then the esterification of Ⅰ with anhydrous sodium acetate in the presence of phase transfer catalyst tetrabutyl ammonia bromide gave 97.3% yield of 2 acetoxyl N methyl N phenyl acetamide (Ⅱ); The ester interchange of with methanol catalyzed by potassium hydroxide gave 2 hydroxy N methyl N phenyl acetamide (Ⅲ) in 96.4% yield. And the total yield was 88.0%. IR and MS spectroscopy of products were analyzed and their characteristic peaks were assigned. Combining the results of elemental analysis, the molecular structure of Ⅰ, Ⅱ and Ⅲ was identified.
文摘The enthalpies of solution of glycine in aqueous solutions of urea,formamide,acetamide,DMSOand acetone were measured at298.15 K by a RD496-Ⅲ microcalorimeter.The transfer enthalpies(ΔtrH) ofglycine from water to aqueous organic mixtures were derived and interpreted qualitatively with structural hydra-tion interaction model.The results suggest that hydrophilic-hydrophilic interaction between glycine and cosol-vent molecule gives a negative contribution to the transfer enthalpies of glycine,while the hydrophilic hydro-phobic interaction makes a positive contribution.The relative position ofΔtrH-composition profiles viz.urea <formamide <0 <acetamide <DMSO<acetone,characterizes the hydrophobicity or hydrophilicity of the cosol-vent molecule and correctly reflectes the solute-solvent interaction in the transfer process.
