摘要
以乙酰丙酮、溴乙酸乙酯和2,6-二氯吡啶为起始原料,经取代、肼基化、环合、水解、酸化及缩合等反应,得到9个未见文献报道的吡啶联吡唑乙酰基类化合物B1~B9。其结构均经核磁共振氢谱和质谱表征。初步生物活性测定表明:在150 g/hm^2的处理剂量下,大部分目标化合物表现出一定的除草活性,其中化合物B2、B3、B6和B8对苘麻Abutilon theophrasti Medicus、反枝苋Amaranthus retroflexus和凹头苋Amaranthus lividus L.生长的抑制率接近100%。
Nine novel 2-（1-（3-chloro pyridin-2-yl）-3,5-dimethyl-1H-pyrazol-4-yl） acetic acid derivatives B1-B9 were synthesized from acetylacetone, ethyl bromoacetate and 2,6-dichloropyridine. The synthesis route included a series of reactions such as substitution, alkylation, cyclization, hydrolysis,and acidification condensation. The chemical structures were characterized by ^1H NMR and MS.Preliminary bioassay showed that most of the above compounds displayed herbicidal activities at the concentration of 150 g/hm^2. The inhibition rates of B2, B3, B6 and B8 against Abutilon theophrasti Medicus, Amaranthus retroflexus and Amaranthus lividus L. were nearly 100%.
作者
胡燕红
何海琴
刘幸海
翁建全
谭成侠
HU Yanhong HE Haiqing LIU Xinghai WENG Jianquan TAN Chengxia(College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China)
出处
《农药学学报》
CAS
CSCD
北大核心
2017年第1期114-118,共5页
Chinese Journal of Pesticide Science
关键词
1
3
4-噻二唑
吡啶联吡唑
乙酰胺类衍生物
合成
除草活性
1
3
4-thiadiazole
pyridyl substituted pyrazole
acetamide derivatives
synthesis
herbicidal activity
作者简介
胡燕红，女，硕士研究生，E-mail：66878391@qq．com
谭成侠，通信作者（Author for correspondence），男，博士，研究员，主要从事新农药研究与开发工作，E-mail：tanchengxia@zjut．edu．cn
