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Predicting Hepatocellular Carcinoma Using Brightness Change Curves Derived From Contrast-enhanced Ultrasound Images
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作者 CHEN Ying-Ying JIANG Shang-Lin +3 位作者 HUANG Liang-Hui ZENG Ya-Guang WANG Xue-Hua ZHENG Wei 《生物化学与生物物理进展》 北大核心 2025年第8期2163-2172,共10页
Objective Primary liver cancer,predominantly hepatocellular carcinoma(HCC),is a significant global health issue,ranking as the sixth most diagnosed cancer and the third leading cause of cancer-related mortality.Accura... Objective Primary liver cancer,predominantly hepatocellular carcinoma(HCC),is a significant global health issue,ranking as the sixth most diagnosed cancer and the third leading cause of cancer-related mortality.Accurate and early diagnosis of HCC is crucial for effective treatment,as HCC and non-HCC malignancies like intrahepatic cholangiocarcinoma(ICC)exhibit different prognoses and treatment responses.Traditional diagnostic methods,including liver biopsy and contrast-enhanced ultrasound(CEUS),face limitations in applicability and objectivity.The primary objective of this study was to develop an advanced,lightweighted classification network capable of distinguishing HCC from other non-HCC malignancies by leveraging the automatic analysis of brightness changes in CEUS images.The ultimate goal was to create a user-friendly and cost-efficient computer-aided diagnostic tool that could assist radiologists in making more accurate and efficient clinical decisions.Methods This retrospective study encompassed a total of 161 patients,comprising 131 diagnosed with HCC and 30 with non-HCC malignancies.To achieve accurate tumor detection,the YOLOX network was employed to identify the region of interest(ROI)on both B-mode ultrasound and CEUS images.A custom-developed algorithm was then utilized to extract brightness change curves from the tumor and adjacent liver parenchyma regions within the CEUS images.These curves provided critical data for the subsequent analysis and classification process.To analyze the extracted brightness change curves and classify the malignancies,we developed and compared several models.These included one-dimensional convolutional neural networks(1D-ResNet,1D-ConvNeXt,and 1D-CNN),as well as traditional machine-learning methods such as support vector machine(SVM),ensemble learning(EL),k-nearest neighbor(KNN),and decision tree(DT).The diagnostic performance of each method in distinguishing HCC from non-HCC malignancies was rigorously evaluated using four key metrics:area under the receiver operating characteristic(AUC),accuracy(ACC),sensitivity(SE),and specificity(SP).Results The evaluation of the machine-learning methods revealed AUC values of 0.70 for SVM,0.56 for ensemble learning,0.63 for KNN,and 0.72 for the decision tree.These results indicated moderate to fair performance in classifying the malignancies based on the brightness change curves.In contrast,the deep learning models demonstrated significantly higher AUCs,with 1D-ResNet achieving an AUC of 0.72,1D-ConvNeXt reaching 0.82,and 1D-CNN obtaining the highest AUC of 0.84.Moreover,under the five-fold cross-validation scheme,the 1D-CNN model outperformed other models in both accuracy and specificity.Specifically,it achieved accuracy improvements of 3.8%to 10.0%and specificity enhancements of 6.6%to 43.3%over competing approaches.The superior performance of the 1D-CNN model highlighted its potential as a powerful tool for accurate classification.Conclusion The 1D-CNN model proved to be the most effective in differentiating HCC from non-HCC malignancies,surpassing both traditional machine-learning methods and other deep learning models.This study successfully developed a user-friendly and cost-efficient computer-aided diagnostic solution that would significantly enhances radiologists’diagnostic capabilities.By improving the accuracy and efficiency of clinical decision-making,this tool has the potential to positively impact patient care and outcomes.Future work may focus on further refining the model and exploring its integration with multimodal ultrasound data to maximize its accuracy and applicability. 展开更多
关键词 computer-aided diagnostic deep learning hepatocellular carcinoma contrast-enhanced ultrasound brightness change curve
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Annealing temperature influence on forming limit curve and fracture toughness of aluminium/silver bilayer sheets 被引量:1
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作者 Mohammad Delshad GHOLAMI Mojtaba KHODAKARAMI +1 位作者 Mohammad ABADIAN Ramin HASHEMI 《Journal of Central South University》 2025年第1期34-48,共15页
This article examines the influence of annealing temperature on fracture toughness and forming limit curves of dissimilar aluminum/silver sheets.In the cold roll bonding process,after brushing and acid washing,the pre... This article examines the influence of annealing temperature on fracture toughness and forming limit curves of dissimilar aluminum/silver sheets.In the cold roll bonding process,after brushing and acid washing,the prepared surfaces are placed on top of each other and by rolling with reduction more than 50%,the bonding between layers is established.In this research,the roll bonding process was done at room temperature,without the use of lubricants and with a 70%thickness reduction.Then,the final thickness of the Ag/Al bilayer sheet reached 350μm by several stages of cold rolling.Before cold rolling,it should be noted that to decrease the hardness created due to plastic deformation,the roll-bonded samples were subjected to annealing heat treatment at 400℃for 90 min.Thus,the final samples were annealed at 200,300 and 400℃for 90 min and cooled in a furnace to examine the annealing temperature effects.The uniaxial tensile and microhardness tests measured mechanical properties.Also,to investigate the fracture mechanism,the fractography of the cross-section was examined by scanning electron microscope(SEM).To evaluate the formability of Ag/Al bilayer sheets,forming limit curves were obtained experimentally through the Nakazima test.The resistance of composites to failure due to cracking was also investigated by fracture toughness.The results showed that annealing increases the elongation and formability of the Ag/Al bilayer sheet while reduces the ultimate tensile strength and fracture toughness.However,the changing trend is not the same at different temperatures,and according to the results,the most significant effect is obtained at 300℃and aluminum layers.It was also determined that by increasing annealing temperature,the fracture mechanism from shear ductile with small and shallow dimples becomes ductile with deep cavities. 展开更多
关键词 cold roll bonding Ag/Al bilayer sheet mechanical properties forming limit curve fracture toughness
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Optimal Receiver Operating Characteristic Curve of Classical Conditional Power under Normal Models
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作者 ZHANG Ying-Ying 《应用概率统计》 北大核心 2025年第2期277-304,共28页
A Receiver Operating Characteristic(ROC)analysis of a power is important and useful in clinical trials.A Classical Conditional Power(CCP)is a probability of a classical rejection region given values of true treatment ... A Receiver Operating Characteristic(ROC)analysis of a power is important and useful in clinical trials.A Classical Conditional Power(CCP)is a probability of a classical rejection region given values of true treatment effect and interim result.For hypotheses and reversed hypotheses under normal models,we obtain analytical expressions of the ROC curves of the CCP,find optimal ROC curves of the CCP,investigate the superiority of the ROC curves of the CCP,calculate critical values of the False Positive Rate(FPR),True Positive Rate(TPR),and cutoff of the optimal CCP,and give go/no go decisions at the interim of the optimal CCP.In addition,extensive numerical experiments are carried out to exemplify our theoretical results.Finally,a real data example is performed to illustrate the go/no go decisions of the optimal CCP. 展开更多
关键词 area under the curve(AUC) classical conditional power(CCP) go/no go decisions historical and interim data receiver operating characteristic(ROC)curve
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Grain morphology and plasticizing mechanism of AZ31 magnesium alloy curved profiles by staggered extrusion
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作者 CHEN Zi-yu LI Feng +2 位作者 LI Yuan-qi LI Chao SUN Lu 《Journal of Central South University》 2025年第2期319-331,共13页
Traditional manufacturing processes for lightweight curved profiles are often associated with lengthy procedures,high costs,low efficiency,and high energy consumption.In order to solve this problem,a new staggered ext... Traditional manufacturing processes for lightweight curved profiles are often associated with lengthy procedures,high costs,low efficiency,and high energy consumption.In order to solve this problem,a new staggered extrusion(SE)process was used to form the curved profile of AZ31 magnesium alloy in this paper.The study investigates the mapping relationship between the curvature,microstructure,and mechanical properties of the formed profiles by using different eccentricities of the die.Scanning electron microscopy(SEM)and electron backscatter diffraction techniques are employed to examine the effects of different eccentricity values(e)on grain morphology,recrystallization mechanisms,texture,and Schmid factors of the products.The results demonstrate that the staggered extrusion method promotes the deep refinement of grain size in the extruded products,with an average grain size of only 15%of the original billet,reaching 12.28μm.The tensile strength and elongation of the curved profiles after extrusion under the eccentricity value of 10 mm,20 mm and 30 mm are significantly higher than those of the billet,with the tensile strength is increased to 250,270,235 MPa,and the engineering strain elongation increased to 10.5%,12.1%,15.9%.This indicates that staggered extrusion enables curvature control of the profiles while improving their strength. 展开更多
关键词 staggered extrusion ECCENTRICITY curved profiles MICROSTRUCTURE mechanical properties
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A novel five-axis on-machine measurement optimization method for complex curved surfaces
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作者 GUO Yan-heng WAN Neng ZHUANG Qi-xin 《Journal of Central South University》 2025年第2期523-537,共15页
On-machine measurement(OMM)stands out as a pivotal technology in complex curved surface adaptive machining.However,the complex structure inherent in workpieces poses a significant challenge as the stylus orientation f... On-machine measurement(OMM)stands out as a pivotal technology in complex curved surface adaptive machining.However,the complex structure inherent in workpieces poses a significant challenge as the stylus orientation frequently shifts during the measurement process.Consequently,a substantial amount of time is allocated to calibrating pre-travel error and probe movement.Furthermore,the frequent movement of machine tools also increases the influence of machine errors.To enhance both accuracy and efficiency,an optimization strategy for the OMM process is proposed.Based on the kinematic chain of the machine tools,the relationship between the angle combination of rotary axes,the stylus orientation,and the calibration position of pre-travel error is disclosed.Additionally,an OMM efficiency optimization model for complex curved surfaces is developed.This model is solved to produce the optimal efficiency angle combinations for each to-be-measured point.Within each angle combination,the effects of positioning errors on measurement results are addressed by coordinate system offset and measurement result compensation method.Finally,the experiments on an impeller are used to demonstrate the practical utility of the proposed method. 展开更多
关键词 on-machine measurement complex curved surfaces efficiency optimization error compensation
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Blasingame production decline type curves for analysing a multi-fractured horizontal well in tight gas reservoirs 被引量:5
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作者 魏明强 段永刚 +3 位作者 陈伟 方全堂 李政澜 郭希冉 《Journal of Central South University》 SCIE EI CAS CSCD 2017年第2期394-401,共8页
Production decline analysis has been considered as an important method to obtain the flow parameters, reservoir properties and original gas in place. Although advanced Blasingame production decline analysis methods fo... Production decline analysis has been considered as an important method to obtain the flow parameters, reservoir properties and original gas in place. Although advanced Blasingame production decline analysis methods for vertical wells, fractured wells and horizontal wells are widely used, limited study has conducted on Blasingame production decline type curves for multi-fractured horizontal well(MFHW). Based on the perpendicular bisection(PEBI) grids, a numerical model was developed and the solution was obtained using control volume finite element method and the fully implicit method. Blasingame production decline-type curves of the infinitely conductive MFHW were plotted through computer programming. A field case was presented to analyse and verify the model developed. Five flow regimes, including early formation linear flow, early radial flow, compound linear flow, transient flow and pseudo-radial flow, are recognized. Fracture spacing is the main factor that affects early radial flow, compound linear flow and transient flow, the distance from the well to the circular boundary affects the pseudo-radial flow, and the type curves are also significantly affected by the formation permeability, fracture number and fracture half-length. The validation of field case suggests that the Blasingame production decline type curves proposed in this work can be applied to the production decline analysis for MFHW in tight gas reservoirs. 展开更多
关键词 tight gas reservoir fractured horizontal well unstructured grid production decline type curves
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Estimating probability curves of rock variables using orthogonal polynomials and sample moments 被引量:3
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作者 邓建 边利 《Journal of Central South University of Technology》 2005年第3期349-353,共5页
A new algorithm using orthogonal polynomials and sample moments was presented for estimating probability curves directly from experimental or field data of rock variables. The moments estimated directly from a sample ... A new algorithm using orthogonal polynomials and sample moments was presented for estimating probability curves directly from experimental or field data of rock variables. The moments estimated directly from a sample of observed values of a random variable could be conventional moments (moments about the origin or central moments) and probability-weighted moments (PWMs). Probability curves derived from orthogonal polynomials and conventional moments are probability density functions (PDF), and probability curves derived from orthogonal polynomials and PWMs are inverse cumulative density functions (CDF) of random variables. The proposed approach is verified by two most commonly-used theoretical standard distributions: normal and exponential distribution. Examples from observed data of uniaxial compressive strength of a rock and concrete strength data are presented for illustrative purposes. The results show that probability curves of rock variable can be accurately derived from orthogonal polynomials and sample moments. Orthogonal polynomials and PWMs enable more secure inferences to be made from relatively small samples about an underlying probability curve. 展开更多
关键词 rock variables probability curve orthogonal polynomials conventional moments probability-weighted moments
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Stochastic simulation of growth curves of Acidithiobacillus ferrooxidans 被引量:1
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作者 杨宇 彭宏 +2 位作者 邱冠周 柳建设 胡岳华 《Journal of Central South University of Technology》 EI 2006年第5期473-476,共4页
To reveal the low growth rate of Acidithiobacillus ferrooxidans, a stochastic growth model was proposed to analyze growth curves of these bacteria in a batch culture. An algorithm was applied to simulate the bacteria ... To reveal the low growth rate of Acidithiobacillus ferrooxidans, a stochastic growth model was proposed to analyze growth curves of these bacteria in a batch culture. An algorithm was applied to simulate the bacteria population during lag and exponential phase. The results show that the model moderately fits the experimental data. Further, the mean growth constant (K) of growth curves is obtained by fitting the logarithm of the simulating population data versus the generation numbers with the different initial population number (N0) and initial mean activity of population (A0). When No is 300 and 700 respectively, the discrepancy of K value is only 0.91%, however, A0 is 0.34 and 0.38 respectively, the discrepancy of K value is 19.53%. It suggests that the effect of A0 on the lag phase exceeds No, though both parameters could shorten the lag phase by increasing their values. 展开更多
关键词 Acidithiobacillus ferrooxidans stochastic simulation growth curves lag phase
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Growth Curves Analysis of Five Meat Rabbit Breeds
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作者 LIHua LONGJi-rong 《Journal of Northeast Agricultural University(English Edition)》 CAS 2001年第2期111-114,共4页
The growth curves of five meat rabbit breeds are fitted in form of Gompertz model.The results are shown as follows:the goodness of fit is higher than 99 50%;considering the body weight at one hundred day?the maximum ... The growth curves of five meat rabbit breeds are fitted in form of Gompertz model.The results are shown as follows:the goodness of fit is higher than 99 50%;considering the body weight at one hundred day?the maximum weight(A)?the instantaneous relative growth rate(K)?the turning weight(W )?the turning age (t )?the early average daily gain (KW ) selection,the Checkered Giant(GG) and the New Zealand White (NN) are better than other meat breeds,the slauthter age should be at the age of 90 day. 展开更多
关键词 meat rabbit growth curves ANALYSIS
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Relations of complete creep processes and triaxial stress-strain curves of rock
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作者 李云鹏 王芝银 +1 位作者 唐明明 王怡 《Journal of Central South University》 SCIE EI CAS 2008年第S1期311-315,共5页
Based on the results of triaxial compressive creep tests for five kinds of rock under the different stress loading,unloading and cycle-loading-unloading conditions,the creep deformation is not only a function of stres... Based on the results of triaxial compressive creep tests for five kinds of rock under the different stress loading,unloading and cycle-loading-unloading conditions,the creep deformation is not only a function of stress and time,but also it has the corresponding relations to the triaxial stress-strain curves of rock.The deformation properties of soften-strain,harden-strain and ideal plasticity presented by conventional triaxial compressive test curves under the different stress states were utilized,and the creep characteristics,the creep starting stress and the different entire creep process curves of rock were studied systematically according to creep experiment results,and the relations of the triaxial stress-strain curves to the creeping starting stress,the terminating curve,the different creep processes,and the different creep fracture properties were established.The relations presented in this paper were verified partially by the creep experiment results of five types of rock. 展开更多
关键词 ROCK TRIAXIAL STRESS-STRAIN curve complete CREEP process CREEP fracture properties CREEP STARTING and ENDING
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Precision Analysis of Three Dimension Free Curves Nanofabrication
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作者 ZHENG Wei 1, WANG Er-qi 2, SONG De-hui 2, W B LEE 3, S andy TO 3 (1. Department of Mechatronics, Xiamen University, 2. College of Computer and Information Engineering, Xiamen University, Xiamen 361005, China 3. Ultra-Precision Machining Centre, Department of Industrial and Systems Engin eering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China) 《厦门大学学报(自然科学版)》 CAS CSCD 北大核心 2002年第S1期279-,共1页
Three dimension free curves find wide applications in engineering. There is no problem to express them exactly mathematically, but th e reportage has not been done on the investigation of precision analysis of thre e-... Three dimension free curves find wide applications in engineering. There is no problem to express them exactly mathematically, but th e reportage has not been done on the investigation of precision analysis of thre e-dimension free curves nanofabrication. Nanofabrication Precision includes the geometrical precision and the precision of driving system (below simply cal led the system precision). This paper submits the precision analysis method of c urve normal vector to analyze geometrical precision. Take an aspherical surf ace for example, it can be fitted and constructed by tensor product parameter cu rves, such as linear drawing curves, straight veins curves, rotating curves, swe eping curves, DUCT curves and Geomap curves. Then the curves of the aspherical s urface is iterated and modified to select the best fitted curves of the aspheric al surface. Finally, the geometrical precision of perfect approximate aspherical surface fitting has been sought. This kind of geometrical fitting construction is very important. Another is the system precision, which contains axial position precision, line p recision, and twisting and swinging precision, etc. The paper adopts the theory of precision optimum match (Prof. Wang Er-qi first put forward in 19 83) to allocate precision optimumly. The minimum cost is used as an objective fu nction, and weight method matches the precision. To obtain the optimum match combination of the minimum cost design parameters and every composing element t olerance, the precision is iterated and sought optimumly to design the system op timumly. The theoretical analysis shows that it’s feasible to control three dim ension free curves nanofabrication within nanometer scale precision. 展开更多
关键词 three dimension curves PRECISION optimum match advanced manufacturing technology micro-/nano-technology
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Curve25519点乘算法的高效FPGA实现
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作者 胡越 肖昊 +1 位作者 赵延睿 刘笑帆 《合肥工业大学学报(自然科学版)》 CAS 北大核心 2024年第11期1493-1497,1504,共6页
为了提高X25519密钥交换算法的运算效率,文章基于现场可编程门阵列(field programmable gate array,FPGA)提出一种高效的曲线Curve25519的点乘设计方案。首先在底层的有限域计算上,针对模约减计算次数多的问题,提出一种基于冗余数的模... 为了提高X25519密钥交换算法的运算效率,文章基于现场可编程门阵列(field programmable gate array,FPGA)提出一种高效的曲线Curve25519的点乘设计方案。首先在底层的有限域计算上,针对模约减计算次数多的问题,提出一种基于冗余数的模运算单元,减少了约减次数;同时,所提出的结构可以减少点乘中常系数乘法的运算周期,从而优化了点乘运算通路,提高了并行度,最终减少了运算时间。该文在Xilinx XC7Z020 FPGA上实现了该点乘设计方案,完成一次点乘需要125μs。研究结果表明,与现有的设计相比,所提出的方案具有较低的面积时间积,达到了面积和性能的平衡。 展开更多
关键词 现场可编程门阵列(FPGA) 椭圆曲线 曲线curve25519 点乘 模乘
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Bending results of graphene origami reinforced doubly curved shell
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作者 Nan Yang Yunhe Zou Mohammad Arefi 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第5期198-210,共13页
The present work investigates higher order stress,strain and deformation analyses of a shear deformable doubly curved shell manufactures by a Copper(Cu)core reinforced with graphene origami auxetic metamaterial subjec... The present work investigates higher order stress,strain and deformation analyses of a shear deformable doubly curved shell manufactures by a Copper(Cu)core reinforced with graphene origami auxetic metamaterial subjected to mechanical and thermal loads.The effective material properties of the graphene origami auxetic reinforced Cu matrix are developed using micromechanical models cooperate both material properties of graphene and Cu in terms of temperature,volume fraction and folding degree.The principle of virtual work is used to derive governing equations with accounting thermal loading.The numerical results are analytically obtained using Navier's technique to investigate impact of significant parameters such as thermal loading,graphene amount,folding degree and directional coordinate on the stress,strain and deformation responses of the structure.The graphene origami materials may be used in aerospace vehicles and structures and defence technology because of their low weight and high stiffness.A verification study is presented for approving the formulation,solution methodology and numerical results. 展开更多
关键词 Graphene origami Copper matrix Doubly curved Shear deformable Auxetic metamaterial
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Method for assessing the similarity and distance between curves/trials and its applications in gait analysis
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作者 Wang Weijie Ming Dong Wan Baikun 《仪器仪表学报》 EI CAS CSCD 北大核心 2008年第10期2017-2023,共7页
In clinical assessment or sports exercise,it is common that a subject is required to repeat a specific per- formance so that a stable movement pattern is obtained and analysed.In practice,however,the trials done by a ... In clinical assessment or sports exercise,it is common that a subject is required to repeat a specific per- formance so that a stable movement pattern is obtained and analysed.In practice,however,the trials done by a sub- ject vary more or less,depending on the psychological or physical conditions.Some of the trials can be used as rep- resentatives of the stable movement pattern,and some not.Therefore,there is a demand for a new method to identify which trials/curves are similar.The traditional methods used to assess curve similarity are not perfectly suitable for the case where there are only a few of trials available.This study proposes a similarity-distance coefficient to assess the similarity of curves/trials.A group of designed curves are used to validate the coefficient.The results show that given joint kinematic data during gait as examples,the proposed coefficient can be used to quantitatively evaluate the similarity of trials,and thus find which trials would be representative (s) for the gait investigated.The proposed method could be applied in various situations where repeat movements have to be measured and analysed. 展开更多
关键词 曲线 相似性 模拟技术 测量方法
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Explicit G2-constrained Merging of a Pair of Bezier Curves by Control Point Optimization
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作者 LU Li-Zheng QIU Yu-Yang 《自动化学报》 EI CSCD 北大核心 2014年第7期1505-1508,共4页
关键词 贝塞尔曲线 控制点 合并 G2 优化 二次函数 距离 最小化
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缝洞型碳酸盐岩气藏斜井Blasingame产量递减模型 被引量:1
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作者 鲜波 朱松柏 +2 位作者 周杰 聂延波 范秋海 《大庆石油地质与开发》 北大核心 2025年第1期93-100,共8页
为了更准确地认识缝洞型碳酸盐岩气藏产量递减规律,假设气藏顶底边界和外边界封闭,储集层水平等厚,建立了斜井三孔单渗和三孔双渗的Blasingame产量递减模型。采用拉普拉斯变化等数学方法求解模型,得到井底压力解并将其代入转换方程后获... 为了更准确地认识缝洞型碳酸盐岩气藏产量递减规律,假设气藏顶底边界和外边界封闭,储集层水平等厚,建立了斜井三孔单渗和三孔双渗的Blasingame产量递减模型。采用拉普拉斯变化等数学方法求解模型,得到井底压力解并将其代入转换方程后获得递减产量解,再通过数值反演得到真实空间下的产量解。绘制且对比了斜井三孔单渗和三孔双渗Blasingame产量递减曲线,并对斜井三孔双渗的产量递减曲线进行了参数敏感性分析。结果表明:斜井三孔双渗产量递减曲线位置在初期比单渗的产量递减曲线位置更低,且窜流凹子更浅;裂缝渗透率比值越大,窜流凹子越深、曲线位置越低;窜流系数越大,窜流发生越早、曲线位置左移;基质弹性储容比越大,基质向裂缝窜流的窜流凹子越宽越深、溶洞向裂缝窜流的窜流凹子越窄越浅;斜井长度越长、井斜角越大,产量递减曲线位置越高且曲线向左移动;结合现场实例井解释,斜井三孔双渗模型比斜井三孔单渗模型拟合效果更好、解释结果更可靠。建立的单双渗模型和绘制的Blasingame产量递减曲线可预测碳酸盐岩气藏斜井的产量递减规律。 展开更多
关键词 碳酸盐岩气藏 斜井 双渗 Blasingame产量递减曲线 敏感性分析
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大肠腺瘤性息肉危险因素及预测模型的构建与验证 被引量:1
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作者 董魁 吴洁 +3 位作者 燕静 刘海涛 王军 乔冠恩 《实用医学杂志》 北大核心 2025年第6期838-845,共8页
目的运用logistic回归分析法识别大肠腺瘤性息肉的风险因素,并基于这些要素建立预测模型,随后对模型的有效性进行验证及评价。方法纳入2017年1月至2022年1月在邯郸市第一医院接受大肠息肉切除手术的患者1023例,包含腺瘤性息肉患者(腺瘤... 目的运用logistic回归分析法识别大肠腺瘤性息肉的风险因素,并基于这些要素建立预测模型,随后对模型的有效性进行验证及评价。方法纳入2017年1月至2022年1月在邯郸市第一医院接受大肠息肉切除手术的患者1023例,包含腺瘤性息肉患者(腺瘤性息肉组)676例和非腺瘤性息肉患者(非腺瘤性息肉组)347例。收集了患者的基本信息、病史、结肠镜检查结果和息肉病理结果等数据。通过比较两组间的差异,筛选出显著性差异的指标作为模型构建的候选因素,并将患者按8∶2的比例随机分为训练集与验证集。利用训练集数据构建风险预测模型,并利用R studio软件绘制列线图以直观展示模型。最后,采用验证集内部验证模型。通过受试者工作(ROC)曲线来评估模型的区分能力,Calibration校准曲线来评价模型的精确度,决策曲线分析(DCA)评价模型在临床实践中的应用价值。结果两组在年龄、饮酒习惯、大肠癌家族史、高脂血症、胆囊切除史、HP感染和阑尾切除史变量的比较中存在显著性差异(P<0.05),这些因素被纳入模型构建。随机分配了818例进入训练集,205例进入验证集。对训练集进行多元逻辑回归分析确认了年龄(OR=1.021,95%CI:1.006~1.036,P=0.006)、饮酒(OR=3.440,95%CI:2.251~5.257,P<0.001)、大肠癌一级亲属(OR=3.775,95%CI:1.881~7.577,P<0.001)、高脂血症(OR=3.428,95%CI:2.443~4.808,P<0.001)、胆囊切除(OR=3.916,95%CI:1.756~8.735,P<0.001)、幽门螺杆菌(HP)感染(OR=3.292,95%CI:2.309~4.693,P<0.001)、阑尾切除(OR=3.819,95%CI:2.002~7.286,P<0.001)为腺瘤性息肉发病的独立危险因素。据此构建了大肠腺瘤性息肉的预测模型,P=1/(1+e^(-Y)),其中Y=0.020×年龄+1.328×大肠癌一级亲属+1.235×饮酒+1.232×高脂血症+1.365×胆囊切除+1.192×HP感染+1.340×阑尾切除-1.995。该模型的训练集及验证集的AUC分别为0.763(95%CI:0.729~0.797)和0.769(95%CI:0.644~0.787),显示出具有良好的能力。校准曲线显示模型拟合度良好,决策曲线分析表明模型在广泛的获益阈值下均能实现积极的净获益,证实了模型的临床应用价值。结论年龄、饮酒、大肠癌一级亲属、高脂血症、胆囊切除、HP感染、阑尾切除为腺瘤性息肉发病的独立危险因素(P<0.05)。基于上述危险因素构建的预测模型对大肠腺瘤性息肉的预测具有较高的实用价值。 展开更多
关键词 大肠息肉 腺瘤性息肉 非腺瘤性息肉 预测模型 列线图 ROC曲线
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产业集聚对中国林产工业碳排放强度的影响研究 被引量:1
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作者 侯方淼 李申睿 +1 位作者 高帅印 吴成亮 《农林经济管理学报》 北大核心 2025年第2期215-224,共10页
基于2013—2020年中国25个省份的面板数据,采用基准回归模型、门槛模型和工具变量法,实证分析产业集聚对中国林产工业碳排放强度的影响机制。结果表明:产业集聚与林产工业碳排放强度呈现显著的倒“U”型关系,初期产业集聚度的上升会加... 基于2013—2020年中国25个省份的面板数据,采用基准回归模型、门槛模型和工具变量法,实证分析产业集聚对中国林产工业碳排放强度的影响机制。结果表明:产业集聚与林产工业碳排放强度呈现显著的倒“U”型关系,初期产业集聚度的上升会加剧碳排放,但当集聚水平跨越门槛值后逐步降低。异质性分析表明,相较于其他行业,造纸行业因资源依赖度高、能耗大,碳排放强度对产业集聚水平更敏感;由于不同地区的资源禀赋和经济结构存在差异,西部和东北地区的产业集聚与林产工业碳排放强度呈现“U”型关系。此外,产业集聚带来的技术创新和研发投入能够显著降低碳排放强度。据此,建议结合区域林产工业实际情况,推进林产工业产业集群建设,提升区域经济发展质量和优化产业结构;构建低碳技术创新体系,推动技术突破和产学研合作;促进区域联盟合作,提高产业链效率与竞争力。 展开更多
关键词 产业集聚 林产工业 碳排放强度 倒“U”型曲线
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致密气井人工智能压裂参数优化
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作者 刘子雄 钦伟 +3 位作者 贺卫东 徐延涛 李新发 李啸南 《中国海上油气》 北大核心 2025年第4期104-112,共9页
压裂设计时,如何准确为不同储层条件井匹配最优施工程序,以便最大程度释放低渗储层潜力,一直是困扰压裂工艺设计的难题。为了构建压裂施工曲线与无阻流量的关联关系,对鄂尔多斯盆地东缘的某致密气田676个压裂层测井曲线和压裂施工曲线... 压裂设计时,如何准确为不同储层条件井匹配最优施工程序,以便最大程度释放低渗储层潜力,一直是困扰压裂工艺设计的难题。为了构建压裂施工曲线与无阻流量的关联关系,对鄂尔多斯盆地东缘的某致密气田676个压裂层测井曲线和压裂施工曲线提取了232项特征值,并进行特征参数的提取和降维,构建了压裂井的人工智能样本库,并优选了机器学习模型,采用随机森林算法,构建了测井曲线、压裂施工曲线与压裂产能之间的深度学习模型,实现了对给定的测井曲线准确计算出不同压裂方式对应的无阻流量,进而实现了压裂施工参数的优化。研究表明:采用测井和施工曲线的特征值提取方法构建的人工智能样本库,消除了人为解释的干扰,数据质量较高,模型拟合精度达到了93.3%以上;对给定压裂曲线进行定性产能预测的准确率达到86.7%以上。应用该模型能够直接为测井曲线匹配不同的压裂施工方式,并获得对应的无阻流量,减少了压裂井地质建模、油藏数值模拟和压裂施工设计等中间过程,为压裂施工参数优化提供了一种新的方法。 展开更多
关键词 低渗储层 测井曲线 施工曲线 人工智能 无阻流量预测 压裂
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特高压井口法兰设计及复合载荷下密封性能 被引量:1
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作者 韩传军 赵易 +4 位作者 李中华 严金林 尹涛 甯尤军 杜明俊 《中国石油大学学报(自然科学版)》 北大核心 2025年第4期135-143,共9页
针对目前175 MPa特高压井口设备的设计指导空缺问题,参考API 6A标准中的法兰设计参数的确定方法,确定175 MPa额定工作内压下通径分别为78和180 mm的法兰结构尺寸,针对所设计的非标法兰分析其在额定工作内压和1.5倍额定工作内压下的密封... 针对目前175 MPa特高压井口设备的设计指导空缺问题,参考API 6A标准中的法兰设计参数的确定方法,确定175 MPa额定工作内压下通径分别为78和180 mm的法兰结构尺寸,针对所设计的非标法兰分析其在额定工作内压和1.5倍额定工作内压下的密封性能,对比分析78-175型法兰不同凸台直径对法兰性能的影响;参考API TR AF2标准中复合载荷的泄漏曲线,计算得出78-175型和180-175型非标法兰以泄漏为准则的承载能力线组,并对线组上多个工况进行验证分析,补充并完善国内外特高压井口175 MPa法兰密封设计方法。结果表明,所设计的175 MPa特高压法兰具有较好的密封可靠性,通过密封试验和垫环变形测量验证了设计的正确性,得到基于泄漏准则下复合载荷对法兰密封性能的影响规律。 展开更多
关键词 特高压井口 法兰 密封 复合载荷 泄漏曲线 垫环 变形
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