A tetranuclear Ln(Ⅲ)-based complex:[Dy_(4)(dbm)_(4)(L)_(6)(μ_(3)-OH)_(2)]·CH_(3)CN(1)(HL=5-[(4-methylbenzylidene)amino]quinolin-8-ol,Hdbm=dibenzoylmethane)was manufactured and its structure was characterized in...A tetranuclear Ln(Ⅲ)-based complex:[Dy_(4)(dbm)_(4)(L)_(6)(μ_(3)-OH)_(2)]·CH_(3)CN(1)(HL=5-[(4-methylbenzylidene)amino]quinolin-8-ol,Hdbm=dibenzoylmethane)was manufactured and its structure was characterized in detail.Xray diffraction analysis shows that complex 1 belongs to the monoclinic crystal system and its space group is P2_1/n,which contains a rhombic Dy_(4)core.Magnetic measurements of 1 suggest it possesses extraordinary single-molecule magnet(SMM)behavior.Its energy barrier U_(eff)/k_(B)was 116.7 K,and the pre-exponential coefficient τ_(0)=1.05×10~(-8)s.CCDC:2359322.展开更多
First-principles calculations are performed to investigate the relaxation and electronic properties of sulfide minerals surfaces(MoS2, Sb2S3, Cu2 S, ZnS, PbS and FeS2) in presence of H2 O molecule. The calculated resu...First-principles calculations are performed to investigate the relaxation and electronic properties of sulfide minerals surfaces(MoS2, Sb2S3, Cu2 S, ZnS, PbS and FeS2) in presence of H2 O molecule. The calculated results show that the structure and electronic properties of sulfide minerals surfaces have been influenced in presence of H2 O molecule. The adsorption of the flotation reagent at the interface of mineral-water would be different from that of mineral surface due to the changes of surface structures and electronic properties caused by H2 O molecule. Hence, the influence of H2 O molecule on the reaction of flotation reagent with sulfide mineral surface will attract more attention.展开更多
Now every laboratory is facing a common problem that is seriously lacking in the standard reference molecule in the GMC detecting research center. Constructing the recombinant plasmid is the urgent demand. In order to...Now every laboratory is facing a common problem that is seriously lacking in the standard reference molecule in the GMC detecting research center. Constructing the recombinant plasmid is the urgent demand. In order to overcome this problem, this study respectively cloned CrylA（B）, BAR, CP4-EPSPS, PAT and RBCL genes into PMD 18-T vector. This constructed plasmid could be used as the standard reference molecule in the qualitative detecting of the exogenous CP4-EPSPS gene, CrylA（B） gene, BAR gene and PAT gene. Identification by double restriction endonuclease digestion and identification by PCR proved that the test result was positive. All of these indicated that the established reference molecules in this study were suitable for the qualitative analysis standard of this GMC detection.展开更多
The dynamics of the scattering processes of diatomic molecules from metal surfaces has been studied with different theoretical approaches. Modified LEPS (London-Eyring-Polanyi-Sato) potential surfaces for several diat...The dynamics of the scattering processes of diatomic molecules from metal surfaces has been studied with different theoretical approaches. Modified LEPS (London-Eyring-Polanyi-Sato) potential surfaces for several diatomie molecule-surface systems have been constructed and examined for the dynamic study. The surfaces are treated as rigid but corrugated. The potential parameters are adjusted to produce reliable potential hypersurfaces. Molecular dissociation, diffraction, adsorption and consequent desorption in the scattering processes have been observed through quasiclassieal trajectory calculations. The significance of the effective corrugation of the potential surfaces has been evaluated in calculating the dissociation and adsorption probabilities. Vibration-rotation-translation energy transfer in the inelastic scattering is investigated to understand the mechanism of selective adsorptions mediated through vibrational or rotational degrees of freedom. We have carried out quantum mechanical calculations to obtain the rotational and vibrational transition probabilities. Relative importance of rotational and vibrational transitions for each adsorbed state with respect to incidence energy has been carefully examined to determine the dominant factor which causes the adsorbed state. The results show that vibration mediation is an essential factor to the selective adsorption especially in the ease of higher incidence energies.展开更多
The immune system as an important defense system of the body,bear the resistance to foreign pathogens invasion,removal of foreign heterogeneity,and protect the body′s safety.Modern research shows that tonic Chinese m...The immune system as an important defense system of the body,bear the resistance to foreign pathogens invasion,removal of foreign heterogeneity,and protect the body′s safety.Modern research shows that tonic Chinese medicine,including single herband compound formula,has the function of improving immune organ index,enhancing immune cellfunction and affecting the immune molecule production and secretion.This article will review the effects of traditional Chinese medicine on immune organs,immune cells and immune molecules,and provide reference for the clinical research of traditional Chinese medicine.展开更多
This study aimed to explore the effect of DT-13 （25（R,S）-ruscogenin- 1-O- [ β-d-glucopyranosyl- （1→2） ] [ β-d-xylopyranosyl-（ 1→3） 1-β -d- fucopyranoside） on tumor necrosis factor （TNF）-α-induced vascu...This study aimed to explore the effect of DT-13 （25（R,S）-ruscogenin- 1-O- [ β-d-glucopyranosyl- （1→2） ] [ β-d-xylopyranosyl-（ 1→3） 1-β -d- fucopyranoside） on tumor necrosis factor （TNF）-α-induced vascular inflamma- tion and the potential molecular mechanisms. In vitro, DT-β suppressed TNF-α-induced adhesion and migration of human umbilical vein endothelial cells （HUVECs） by inhibiting the expression of intercellular adhesion molecule-1 （ ICAM-1 ） and vascular cell adhesion molecule-1 （VCAM-1）. DT-β markedly suppressed NF-KB p65 phosphoryl- ation, and when NF-KB p65 was over-expressed, the inhibitory effect of DT-β on adhesion molecular decreased. DT-β also suppressed TNF-α induced luciferase activities of ICAM-1 and VCAM-1 promoter containing NF-KB binding sites. Furthermore DT-β markedly suppressed p38 phosphorylation and Src degradation induced by TNF-α DT-β at 4 mg·kg- 1 prevented vascular , whereas had no significant effect on ERK and JNK activation. In-vivo, inflammation and the expression of adhesion molecules induced by TNF-α in mice. These findings suggest that DT- β abrogates vascular inflammation by down-regulating adhesion molecules associated with modulating the NF-KB, p38MAPK, Src signaling pathways, and NF-KB binding site is at least one of the targets of DT-β. This study pro- vides novel information regarding the mechanism by which DT-β exerts its effects on vascular inflammation, which is important for the onset and progression of various diseases.展开更多
文摘A tetranuclear Ln(Ⅲ)-based complex:[Dy_(4)(dbm)_(4)(L)_(6)(μ_(3)-OH)_(2)]·CH_(3)CN(1)(HL=5-[(4-methylbenzylidene)amino]quinolin-8-ol,Hdbm=dibenzoylmethane)was manufactured and its structure was characterized in detail.Xray diffraction analysis shows that complex 1 belongs to the monoclinic crystal system and its space group is P2_1/n,which contains a rhombic Dy_(4)core.Magnetic measurements of 1 suggest it possesses extraordinary single-molecule magnet(SMM)behavior.Its energy barrier U_(eff)/k_(B)was 116.7 K,and the pre-exponential coefficient τ_(0)=1.05×10~(-8)s.CCDC:2359322.
基金Project(51164001)supported by the National Natural Science Foundation of China
文摘First-principles calculations are performed to investigate the relaxation and electronic properties of sulfide minerals surfaces(MoS2, Sb2S3, Cu2 S, ZnS, PbS and FeS2) in presence of H2 O molecule. The calculated results show that the structure and electronic properties of sulfide minerals surfaces have been influenced in presence of H2 O molecule. The adsorption of the flotation reagent at the interface of mineral-water would be different from that of mineral surface due to the changes of surface structures and electronic properties caused by H2 O molecule. Hence, the influence of H2 O molecule on the reaction of flotation reagent with sulfide mineral surface will attract more attention.
基金Supported by the Innovative Team Funds of Northeast Agricultural University (CXT004-3-2)Foundation of Heilongjiang Educational Committee (11511030)
文摘Now every laboratory is facing a common problem that is seriously lacking in the standard reference molecule in the GMC detecting research center. Constructing the recombinant plasmid is the urgent demand. In order to overcome this problem, this study respectively cloned CrylA（B）, BAR, CP4-EPSPS, PAT and RBCL genes into PMD 18-T vector. This constructed plasmid could be used as the standard reference molecule in the qualitative detecting of the exogenous CP4-EPSPS gene, CrylA（B） gene, BAR gene and PAT gene. Identification by double restriction endonuclease digestion and identification by PCR proved that the test result was positive. All of these indicated that the established reference molecules in this study were suitable for the qualitative analysis standard of this GMC detection.
基金The projcct supportcd by National Natural Science Foundation of China
文摘The dynamics of the scattering processes of diatomic molecules from metal surfaces has been studied with different theoretical approaches. Modified LEPS (London-Eyring-Polanyi-Sato) potential surfaces for several diatomie molecule-surface systems have been constructed and examined for the dynamic study. The surfaces are treated as rigid but corrugated. The potential parameters are adjusted to produce reliable potential hypersurfaces. Molecular dissociation, diffraction, adsorption and consequent desorption in the scattering processes have been observed through quasiclassieal trajectory calculations. The significance of the effective corrugation of the potential surfaces has been evaluated in calculating the dissociation and adsorption probabilities. Vibration-rotation-translation energy transfer in the inelastic scattering is investigated to understand the mechanism of selective adsorptions mediated through vibrational or rotational degrees of freedom. We have carried out quantum mechanical calculations to obtain the rotational and vibrational transition probabilities. Relative importance of rotational and vibrational transitions for each adsorbed state with respect to incidence energy has been carefully examined to determine the dominant factor which causes the adsorbed state. The results show that vibration mediation is an essential factor to the selective adsorption especially in the ease of higher incidence energies.
基金supported by National Natural Science Foundation of China(81473549)National Natural Science Foundation of China Youth Fund Project(31402237)+1 种基金National "major New Drug Creation" Major Science and Technology Projects(2014ZX09304-306-04)Ministry of Education of the Central University Basic Scientific Research Business Fee(XDJK2015D016)
文摘The immune system as an important defense system of the body,bear the resistance to foreign pathogens invasion,removal of foreign heterogeneity,and protect the body′s safety.Modern research shows that tonic Chinese medicine,including single herband compound formula,has the function of improving immune organ index,enhancing immune cellfunction and affecting the immune molecule production and secretion.This article will review the effects of traditional Chinese medicine on immune organs,immune cells and immune molecules,and provide reference for the clinical research of traditional Chinese medicine.
文摘This study aimed to explore the effect of DT-13 （25（R,S）-ruscogenin- 1-O- [ β-d-glucopyranosyl- （1→2） ] [ β-d-xylopyranosyl-（ 1→3） 1-β -d- fucopyranoside） on tumor necrosis factor （TNF）-α-induced vascular inflamma- tion and the potential molecular mechanisms. In vitro, DT-β suppressed TNF-α-induced adhesion and migration of human umbilical vein endothelial cells （HUVECs） by inhibiting the expression of intercellular adhesion molecule-1 （ ICAM-1 ） and vascular cell adhesion molecule-1 （VCAM-1）. DT-β markedly suppressed NF-KB p65 phosphoryl- ation, and when NF-KB p65 was over-expressed, the inhibitory effect of DT-β on adhesion molecular decreased. DT-β also suppressed TNF-α induced luciferase activities of ICAM-1 and VCAM-1 promoter containing NF-KB binding sites. Furthermore DT-β markedly suppressed p38 phosphorylation and Src degradation induced by TNF-α DT-β at 4 mg·kg- 1 prevented vascular , whereas had no significant effect on ERK and JNK activation. In-vivo, inflammation and the expression of adhesion molecules induced by TNF-α in mice. These findings suggest that DT- β abrogates vascular inflammation by down-regulating adhesion molecules associated with modulating the NF-KB, p38MAPK, Src signaling pathways, and NF-KB binding site is at least one of the targets of DT-β. This study pro- vides novel information regarding the mechanism by which DT-β exerts its effects on vascular inflammation, which is important for the onset and progression of various diseases.
