Protein folding involves the aminoacid sequence to come forth and form an energy minimized structure.Recently molecular crowding leading to increase in viscosity is said to be one of the major concerns affecting prote...Protein folding involves the aminoacid sequence to come forth and form an energy minimized structure.Recently molecular crowding leading to increase in viscosity is said to be one of the major concerns affecting protein folding.Many external fluorescent probes are used to detect such increases in viscosity.Since most of the protein sequences contain L-Phe and L-Trp,in this study we have used these aminoacids as probes to detect changes in viscosity.This study will help to advance the knowledge on molecular crowding effects in protein folding.展开更多
前列腺癌是全球男性最常见的恶性肿瘤之一,严重危害男性身体健康。自前列腺特异性膜抗原(prostate specific membrane antigen,PSMA)被证实是诊断前列腺癌的首选标志物,PSMA靶向放射性药物在前列腺癌诊治中取得显著进展,有效提高了前列...前列腺癌是全球男性最常见的恶性肿瘤之一,严重危害男性身体健康。自前列腺特异性膜抗原(prostate specific membrane antigen,PSMA)被证实是诊断前列腺癌的首选标志物,PSMA靶向放射性药物在前列腺癌诊治中取得显著进展,有效提高了前列腺癌的诊断灵敏度与治疗效果。文章就近年来PSMA靶向放射性分子探针的相关研究进展进行综述,分析探针结构设计理念并总结临床经验,以期对前列腺癌放射性诊疗分子探针的开发有所裨益。展开更多
文摘Protein folding involves the aminoacid sequence to come forth and form an energy minimized structure.Recently molecular crowding leading to increase in viscosity is said to be one of the major concerns affecting protein folding.Many external fluorescent probes are used to detect such increases in viscosity.Since most of the protein sequences contain L-Phe and L-Trp,in this study we have used these aminoacids as probes to detect changes in viscosity.This study will help to advance the knowledge on molecular crowding effects in protein folding.
文摘前列腺癌是全球男性最常见的恶性肿瘤之一,严重危害男性身体健康。自前列腺特异性膜抗原(prostate specific membrane antigen,PSMA)被证实是诊断前列腺癌的首选标志物,PSMA靶向放射性药物在前列腺癌诊治中取得显著进展,有效提高了前列腺癌的诊断灵敏度与治疗效果。文章就近年来PSMA靶向放射性分子探针的相关研究进展进行综述,分析探针结构设计理念并总结临床经验,以期对前列腺癌放射性诊疗分子探针的开发有所裨益。
