Kang et al.published a research article on the treatment of ischemic stroke using engineered Treg cells(Kang et al.,Prog Biochem Biophys,2025,52(4):946-956.DOI:10.16476/j.pibb.2025.0019).Their study mainly explores th...Kang et al.published a research article on the treatment of ischemic stroke using engineered Treg cells(Kang et al.,Prog Biochem Biophys,2025,52(4):946-956.DOI:10.16476/j.pibb.2025.0019).Their study mainly explores the immunoregulatory role of regulatory T(Treg)cells in ischemic stroke,providing an innovative therapeutic strategy.Neuroinflammation is a major driver of secondary injury after stroke.Existing treatments focus on vascular recanalization while neglecting immune regulation.Their study proposes to modulate neuroinflammation through in vitro-induced Treg cells,offering a novel approach distinct from traditional thrombolysis and endovascular interventions.展开更多
文摘Kang et al.published a research article on the treatment of ischemic stroke using engineered Treg cells(Kang et al.,Prog Biochem Biophys,2025,52(4):946-956.DOI:10.16476/j.pibb.2025.0019).Their study mainly explores the immunoregulatory role of regulatory T(Treg)cells in ischemic stroke,providing an innovative therapeutic strategy.Neuroinflammation is a major driver of secondary injury after stroke.Existing treatments focus on vascular recanalization while neglecting immune regulation.Their study proposes to modulate neuroinflammation through in vitro-induced Treg cells,offering a novel approach distinct from traditional thrombolysis and endovascular interventions.
文摘目的探讨温阳解郁汤对脑卒中后抑郁(Post stroke depression,PSD)患者血清炎症因子和单胺类递质水平及肠道菌群的影响。方法选择2020年1月—2023年3月收治的PSD患者90例,采用随机数字表法将其分为对照组与观察组各45例。对照组口服盐酸帕罗西汀片,观察组在对照组基础上服用温阳解郁汤。两组治疗周期8周。比较两组治疗疗效;治疗前后日常生活能力、抑郁情绪和神经功能,炎症因子,单胺类神经递质和肠道菌群变化。结果观察组PSD患者总有效率高于对照组(P<0.05)。两组治疗后PSD患者日常生活活动能力(Daily Activity Level,ADL)评分高于治疗前,而汉密尔顿抑郁量表(Hamilton depression scale,HAMD)评分和美国国立卫生研究院卒中量表(National institute of health stroke scale,NIHSS)评分低于治疗前(P<0.05);观察组治疗后PSD患者ADL评分高于对照组,而HAMD评分和NIHSS评分低于对照组(P<0.05)。两组治疗后PSD患者血清肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、超敏C反应蛋白(Hypersensitive C-reactiveprotein,hs-CRP)和白介素-6(Interleukin-6,IL-6)水平低于治疗前(P<0.05);观察组治疗后PSD患者血清TNF-α、hs-CRP和IL-6水平低于对照组(P<0.05)。两组治疗后PSD患者血清NE、5-HT和DA水平高于治疗前(P<0.05);观察组治疗后PSD患者血清去甲肾上腺素(Norepinephrine,NE)、5-羟色胺(5-hydroxytryptamine,5-HT)和多巴胺(Dopamine,DA)水平高于对照组(P<0.05)。两组治疗后PSD患者乳酸杆菌和双歧杆菌高于治疗前,而肠球菌和大肠埃希菌低于治疗前(P<0.05);观察组治疗后PSD患者乳酸杆菌和双歧杆菌高于对照组,而肠球菌和大肠埃希菌低于对照组(P<0.05)。结论温阳解郁汤对PSD患者疗效良好,可显著减轻患者炎症反应,调节单胺类递质水平,及改善肠道菌群变化。
