Objective Repetitive transcranial magnetic stimulation(rTMS)has demonstrated efficacy in enhancing neurocognitive performance in Alzheimer’s disease(AD),but the neurobiological mechanisms linking synaptic pathology,n...Objective Repetitive transcranial magnetic stimulation(rTMS)has demonstrated efficacy in enhancing neurocognitive performance in Alzheimer’s disease(AD),but the neurobiological mechanisms linking synaptic pathology,neural oscillatory dynamics,and brain network reorganization remain unclear.This investigation seeks to systematically evaluate the therapeutic potential of rTMS as a non-invasive neuromodulatory intervention through a multimodal framework integrating clinical assessments,molecular profiling,and neurophysiological monitoring.Methods In this prospective double-blind trial,12 AD patients underwent a 14-day protocol of 20 Hz rTMS,with comprehensive multimodal assessments performed pre-and postintervention.Cognitive functioning was quantified using the mini-mental state examination(MMSE)and Montreal cognitive assessment(MOCA),while daily living capacities and neuropsychiatric profiles were respectively evaluated through the activities of daily living(ADL)scale and combined neuropsychiatric inventory(NPI)-Hamilton depression rating scale(HAMD).Peripheral blood biomarkers,specifically Aβ1-40 and phosphorylated tau(p-tau181),were analyzed to investigate the effects of rTMS on molecular metabolism.Spectral power analysis was employed to investigate rTMS-induced modulations of neural rhythms in AD patients,while brain network analyses incorporating topological properties were conducted to examine stimulus-driven network reorganization.Furthermore,systematic assessment of correlations between cognitive scale scores,blood biomarkers,and network characteristics was performed to elucidate cross-modal therapeutic associations.Results Clinically,MMSE and MOCA scores improved significantly(P<0.05).Biomarker showed that Aβ1-40 level increased(P<0.05),contrasting with p-tau181 reduction.Moreover,the levels of Aβ1-40 were positively correlated with MMSE and MOCA scores.Post-intervention analyses revealed significant modulations in oscillatory power,characterized by pronounced reductions in delta(P<0.05)and theta bands(P<0.05),while concurrent enhancements were observed in alpha,beta,and gamma band activities(all P<0.05).Network analysis revealed frequency-specific reorganization:clustering coefficients were significantly decreased in delta,theta,and alpha bands(P<0.05),while global efficiency improvement was exclusively detected in the delta band(P<0.05).The alpha band demonstrated concurrent increases in average nodal degree(P<0.05)and characteristic path length reduction(P<0.05).Further research findings indicate that the changes in the clinical scale HAMD scores before and after rTMS stimulation are negatively correlated with the changes in the blood biomarkers Aβ1-40 and p-tau181.Additionally,the changes in the clinical scales MMSE and MoCA scores were negatively correlated with the changes in the node degree of the alpha frequency band and negatively correlated with the clustering coefficient of the delta frequency band.However,the changes in MMSE scores are positively correlated with the changes in global efficiency of both the delta and alpha frequency bands.Conclusion 20 Hz rTMS targeting dorsolateral prefrontal cortex(DLPFC)significantly improves cognitive function and enhances the metabolic clearance ofβ-amyloid and tau proteins in AD patients.This neurotherapeutic effect is mechanistically associated with rTMS-mediated frequency-selective neuromodulation,which enhances the connectivity of oscillatory networks through improved neuronal synchronization and optimized topological organization of functional brain networks.These findings not only support the efficacy of rTMS as an adjunctive therapy for AD but also underscore the importance of employing multiple assessment methods—including clinical scales,blood biomarkers,and EEG——in understanding and monitoring the progression of AD.This research provides a significant theoretical foundation and empirical evidence for further exploration of rTMS applications in AD treatment.展开更多
为提升地震预测方法评价的标准化和应用的规范化,依托国家重点研发计划尝试把CSEP(Collaboratory for the Study of Earthquake Predictability)移植到中国,建立中国CSEP检验中心。自主研发了加卸载响应比(LURR)、地壳振动、态矢量和地...为提升地震预测方法评价的标准化和应用的规范化,依托国家重点研发计划尝试把CSEP(Collaboratory for the Study of Earthquake Predictability)移植到中国,建立中国CSEP检验中心。自主研发了加卸载响应比(LURR)、地壳振动、态矢量和地震综合概率预测模块;引进了国外的图像信息(PI)、相对强度(RI)、传染型余震序列(ETAS)预测模型并完成模块研发;遴选出Molchan检验、R值评分、N值检验和ROC检验等国际认可的地震预报效能评价方法,以集成方式搭建运行平台。作为开放性检验中心,通过不断纳入新的算法,着力提升地震预测能力、推进地震预测实践,将地震预报业务中常用的地震发生率指数、小震调制比、b值等预测方法纳入到中心运行。中心的软件系统既能够完成回顾性预测检验,又能够实现前瞻性预测分析,可为现有预测方法提供运行环境和技术支持。展开更多
This paper investigates interception missiles’trajectory tracking guidance problem under wind field and external disturbances in the boost phase.Indeed,the velocity control in such trajectory tracking guidance system...This paper investigates interception missiles’trajectory tracking guidance problem under wind field and external disturbances in the boost phase.Indeed,the velocity control in such trajectory tracking guidance systems of missiles is challenging.As our contribution,the velocity control channel is designed to deal with the intractable velocity problem and improve tracking accuracy.The global prescribed performance function,which guarantees the tracking error within the set range and the global convergence of the tracking guidance system,is first proposed based on the traditional PPF.Then,a tracking guidance strategy is derived using the integral sliding mode control techniques to make the sliding manifold and tracking errors converge to zero and avoid singularities.Meanwhile,an improved switching control law is introduced into the designed tracking guidance algorithm to deal with the chattering problem.A back propagation neural network(BPNN)extended state observer(BPNNESO)is employed in the inner loop to identify disturbances.The obtained results indicate that the proposed tracking guidance approach achieves the trajectory tracking guidance objective without and with disturbances and outperforms the existing tracking guidance schemes with the lowest tracking errors,convergence times,and overshoots.展开更多
An adaptive integral dynamic surface control approach based on fully tuned radial basis function neural network （FTRBFNN） is presented for a general class of strict-feedback nonlinear systems,which may possess a wid...An adaptive integral dynamic surface control approach based on fully tuned radial basis function neural network （FTRBFNN） is presented for a general class of strict-feedback nonlinear systems,which may possess a wide class of uncertainties that are not linearly parameterized and do not have any prior knowledge of the bounding functions.FTRBFNN is employed to approximate the uncertainty online,and a systematic framework for adaptive controller design is given by dynamic surface control. The control algorithm has two outstanding features,namely,the neural network regulates the weights,width and center of Gaussian function simultaneously,which ensures the control system has perfect ability of restraining different unknown uncertainties and the integral term of tracking error introduced in the control law can eliminate the static error of the closed loop system effectively. As a result,high control precision can be achieved.All signals in the closed loop system can be guaranteed bounded by Lyapunov approach.Finally,simulation results demonstrate the validity of the control approach.展开更多
In this paper,an integrated estimation guidance and control(IEGC)system is designed based on the command filtered backstepping approach for circular field-of-view(FOV)strapdown missiles.The threedimensional integrated...In this paper,an integrated estimation guidance and control(IEGC)system is designed based on the command filtered backstepping approach for circular field-of-view(FOV)strapdown missiles.The threedimensional integrated estimation guidance and control nonlinear model with limited actuator deflection angle is established considering the seeker's FOV constraint.The boundary time-varying integral barrier Lyapunov function(IBLF)is employed in backstepping design to constrain the body line-of-sight(BLOS)in IEGC system to fit a circular FOV.Then,the nonlinear adaptive controller is designed to estimate the changing aerodynamic parameters.The generalized extended state observer(GESO)is designed to estimate the acceleration of the maneuvering targets and the unmatched time-varying disturbances for improving tracking accuracy.Furthermore,the command filters are used to solve the"differential expansion"problem during the backstepping design.The Lyapunov theory is used to prove the stability of the overall closed-loop IEGC system.Finally,the simulation results validate the integrated system's effectiveness,achieving high accuracy strikes against maneuvering targets.展开更多
目的探讨针刺联合重复经颅磁刺激疗法(transcranial magnetic stimulation,TMS)对帕金森患者认知功能的改善效果。方法选择2021年5月—2023年4月于丽水市中医院就诊的87例帕金森患者,依照随机数字表法将其分为A组(43例)与B组(44例)。A...目的探讨针刺联合重复经颅磁刺激疗法(transcranial magnetic stimulation,TMS)对帕金森患者认知功能的改善效果。方法选择2021年5月—2023年4月于丽水市中医院就诊的87例帕金森患者,依照随机数字表法将其分为A组(43例)与B组(44例)。A组给予TMS治疗,B组在此基础上联合针刺治疗。两组均治疗8周,比较两组临床疗效、治疗前及治疗8周后P300潜伏期、波幅、血清脑神经递质5-羟色胺(5-hydroxytryptamine,5-HT)、去甲肾上腺(norepinephrine,NE)、神经营养因子-3(neurotrophic factor-3,NT-3)、胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)、过氧化氢酶(catalase,CAT)、丙二醛(malondialdehyde,MDA)、谷胱甘肽(glutathione,GSH-px)、髓过氧化物酶(myeloperoxidase,MPO)、简易智力状态评分量表(mini-mental state rating scale,MMSE)评分、统一帕金森病评定量表(unified Parkinson′s disease rating scale,UPDRS)评分、中医证候积分。结果与A组比较,B组临床总有效率更高;与治疗前比较,治疗8周后两组P300潜伏期均缩短,B组短于A组;与治疗前比较,治疗8周后两组波幅、MMSE、UPDRS评分、5-HT、NE、NT-3、IGF-1、CAT、MDA水平均增高,B组高于A组;与治疗前比较,治疗8周后两组中医证候积分、GSH-px、MPO水平均下降,B组低于A组;差异有统计学意义(P<0.05)。结论针刺联合TMS用于帕金森治疗可有效提升临床疗效,缓解相关症状,修复神经损伤,改善认知功能,且可降低氧化应激反应。展开更多
空天地一体化网络作为6G技术的关键组成,在整合天基、空基和地基网络时,面临节点异构性、业务多样性等挑战,进而引发资源分配、竞争及故障风险等问题。基于此,聚焦基于软件定义网络(software defined network,SDN)与网络功能虚拟化(netw...空天地一体化网络作为6G技术的关键组成,在整合天基、空基和地基网络时,面临节点异构性、业务多样性等挑战,进而引发资源分配、竞争及故障风险等问题。基于此,聚焦基于软件定义网络(software defined network,SDN)与网络功能虚拟化(network functions virtualization,NFV)的空天地一体化网络任务部署与恢复,首先阐述了空天地一体化网络系统架构,介绍了各层网络构成、SDN和NFV原理及其相关应用,然后,针对上述挑战,以服务功能链技术为抓手,提出了面向任务的服务功能链优化部署、利用智能算法实现动态调度、通过匹配博弈算法完成失效恢复等策略,最后,构建了一个用例,设定节点部署、服务功能链建模等,验证了所提策略在提升服务功能链完成效率以及应对资源故障方面的有效性,旨在为空天地一体化网络资源管理提供理论基础。展开更多
s Western Yunnan is located at the boundary of collision or underthrusting zone of Eurasian plate and is influenced by many times tectonic movements. With very complex geological environment and tectonic background, i...s Western Yunnan is located at the boundary of collision or underthrusting zone of Eurasian plate and is influenced by many times tectonic movements. With very complex geological environment and tectonic background, it is one of the seismically active areas. In the paper, the teleseismic records were selected from 16 national, local and mo-bile stations, including 4 very-wide-band mobile stations of PASSCAL. And nearly 2 000 receiver functions were extracted. Two measuring lines are 650 km and 450 km, respectively and across some major tectonic units in Western Yunnan. It is indicated that Nujiang might be a seam characterized by underthrusting. The western and eastern boundaries of Sichuan-Yunnan rhombus block, i.e., Honghe and Xiaojiang faults, might be an erection seam or collision belt. Panxi tectonic zone still has the characteristics of continental rift valley, that is, the surface is hollow and the upper mantle is upwarping. The tectonic situation in Western Yunnan is of certain regulation with the interlacing distribution of orogenic zone and seam. The crustal thickness decreases gradually from the north to the south and the S wave velocity is globally lower here.展开更多
文摘Objective Repetitive transcranial magnetic stimulation(rTMS)has demonstrated efficacy in enhancing neurocognitive performance in Alzheimer’s disease(AD),but the neurobiological mechanisms linking synaptic pathology,neural oscillatory dynamics,and brain network reorganization remain unclear.This investigation seeks to systematically evaluate the therapeutic potential of rTMS as a non-invasive neuromodulatory intervention through a multimodal framework integrating clinical assessments,molecular profiling,and neurophysiological monitoring.Methods In this prospective double-blind trial,12 AD patients underwent a 14-day protocol of 20 Hz rTMS,with comprehensive multimodal assessments performed pre-and postintervention.Cognitive functioning was quantified using the mini-mental state examination(MMSE)and Montreal cognitive assessment(MOCA),while daily living capacities and neuropsychiatric profiles were respectively evaluated through the activities of daily living(ADL)scale and combined neuropsychiatric inventory(NPI)-Hamilton depression rating scale(HAMD).Peripheral blood biomarkers,specifically Aβ1-40 and phosphorylated tau(p-tau181),were analyzed to investigate the effects of rTMS on molecular metabolism.Spectral power analysis was employed to investigate rTMS-induced modulations of neural rhythms in AD patients,while brain network analyses incorporating topological properties were conducted to examine stimulus-driven network reorganization.Furthermore,systematic assessment of correlations between cognitive scale scores,blood biomarkers,and network characteristics was performed to elucidate cross-modal therapeutic associations.Results Clinically,MMSE and MOCA scores improved significantly(P<0.05).Biomarker showed that Aβ1-40 level increased(P<0.05),contrasting with p-tau181 reduction.Moreover,the levels of Aβ1-40 were positively correlated with MMSE and MOCA scores.Post-intervention analyses revealed significant modulations in oscillatory power,characterized by pronounced reductions in delta(P<0.05)and theta bands(P<0.05),while concurrent enhancements were observed in alpha,beta,and gamma band activities(all P<0.05).Network analysis revealed frequency-specific reorganization:clustering coefficients were significantly decreased in delta,theta,and alpha bands(P<0.05),while global efficiency improvement was exclusively detected in the delta band(P<0.05).The alpha band demonstrated concurrent increases in average nodal degree(P<0.05)and characteristic path length reduction(P<0.05).Further research findings indicate that the changes in the clinical scale HAMD scores before and after rTMS stimulation are negatively correlated with the changes in the blood biomarkers Aβ1-40 and p-tau181.Additionally,the changes in the clinical scales MMSE and MoCA scores were negatively correlated with the changes in the node degree of the alpha frequency band and negatively correlated with the clustering coefficient of the delta frequency band.However,the changes in MMSE scores are positively correlated with the changes in global efficiency of both the delta and alpha frequency bands.Conclusion 20 Hz rTMS targeting dorsolateral prefrontal cortex(DLPFC)significantly improves cognitive function and enhances the metabolic clearance ofβ-amyloid and tau proteins in AD patients.This neurotherapeutic effect is mechanistically associated with rTMS-mediated frequency-selective neuromodulation,which enhances the connectivity of oscillatory networks through improved neuronal synchronization and optimized topological organization of functional brain networks.These findings not only support the efficacy of rTMS as an adjunctive therapy for AD but also underscore the importance of employing multiple assessment methods—including clinical scales,blood biomarkers,and EEG——in understanding and monitoring the progression of AD.This research provides a significant theoretical foundation and empirical evidence for further exploration of rTMS applications in AD treatment.
文摘为提升地震预测方法评价的标准化和应用的规范化,依托国家重点研发计划尝试把CSEP(Collaboratory for the Study of Earthquake Predictability)移植到中国,建立中国CSEP检验中心。自主研发了加卸载响应比(LURR)、地壳振动、态矢量和地震综合概率预测模块;引进了国外的图像信息(PI)、相对强度(RI)、传染型余震序列(ETAS)预测模型并完成模块研发;遴选出Molchan检验、R值评分、N值检验和ROC检验等国际认可的地震预报效能评价方法,以集成方式搭建运行平台。作为开放性检验中心,通过不断纳入新的算法,着力提升地震预测能力、推进地震预测实践,将地震预报业务中常用的地震发生率指数、小震调制比、b值等预测方法纳入到中心运行。中心的软件系统既能够完成回顾性预测检验,又能够实现前瞻性预测分析,可为现有预测方法提供运行环境和技术支持。
基金the National Natural Science Foundation of China(Grant No.12072090).
文摘This paper investigates interception missiles’trajectory tracking guidance problem under wind field and external disturbances in the boost phase.Indeed,the velocity control in such trajectory tracking guidance systems of missiles is challenging.As our contribution,the velocity control channel is designed to deal with the intractable velocity problem and improve tracking accuracy.The global prescribed performance function,which guarantees the tracking error within the set range and the global convergence of the tracking guidance system,is first proposed based on the traditional PPF.Then,a tracking guidance strategy is derived using the integral sliding mode control techniques to make the sliding manifold and tracking errors converge to zero and avoid singularities.Meanwhile,an improved switching control law is introduced into the designed tracking guidance algorithm to deal with the chattering problem.A back propagation neural network(BPNN)extended state observer(BPNNESO)is employed in the inner loop to identify disturbances.The obtained results indicate that the proposed tracking guidance approach achieves the trajectory tracking guidance objective without and with disturbances and outperforms the existing tracking guidance schemes with the lowest tracking errors,convergence times,and overshoots.
基金supported by the China Postdoctoral Science Foundation (200904501035 201003548)+3 种基金the National Natural Science Foundation of China (60835001907160289101600460804017)
文摘An adaptive integral dynamic surface control approach based on fully tuned radial basis function neural network （FTRBFNN） is presented for a general class of strict-feedback nonlinear systems,which may possess a wide class of uncertainties that are not linearly parameterized and do not have any prior knowledge of the bounding functions.FTRBFNN is employed to approximate the uncertainty online,and a systematic framework for adaptive controller design is given by dynamic surface control. The control algorithm has two outstanding features,namely,the neural network regulates the weights,width and center of Gaussian function simultaneously,which ensures the control system has perfect ability of restraining different unknown uncertainties and the integral term of tracking error introduced in the control law can eliminate the static error of the closed loop system effectively. As a result,high control precision can be achieved.All signals in the closed loop system can be guaranteed bounded by Lyapunov approach.Finally,simulation results demonstrate the validity of the control approach.
文摘In this paper,an integrated estimation guidance and control(IEGC)system is designed based on the command filtered backstepping approach for circular field-of-view(FOV)strapdown missiles.The threedimensional integrated estimation guidance and control nonlinear model with limited actuator deflection angle is established considering the seeker's FOV constraint.The boundary time-varying integral barrier Lyapunov function(IBLF)is employed in backstepping design to constrain the body line-of-sight(BLOS)in IEGC system to fit a circular FOV.Then,the nonlinear adaptive controller is designed to estimate the changing aerodynamic parameters.The generalized extended state observer(GESO)is designed to estimate the acceleration of the maneuvering targets and the unmatched time-varying disturbances for improving tracking accuracy.Furthermore,the command filters are used to solve the"differential expansion"problem during the backstepping design.The Lyapunov theory is used to prove the stability of the overall closed-loop IEGC system.Finally,the simulation results validate the integrated system's effectiveness,achieving high accuracy strikes against maneuvering targets.
文摘空天地一体化网络作为6G技术的关键组成,在整合天基、空基和地基网络时,面临节点异构性、业务多样性等挑战,进而引发资源分配、竞争及故障风险等问题。基于此,聚焦基于软件定义网络(software defined network,SDN)与网络功能虚拟化(network functions virtualization,NFV)的空天地一体化网络任务部署与恢复,首先阐述了空天地一体化网络系统架构,介绍了各层网络构成、SDN和NFV原理及其相关应用,然后,针对上述挑战,以服务功能链技术为抓手,提出了面向任务的服务功能链优化部署、利用智能算法实现动态调度、通过匹配博弈算法完成失效恢复等策略,最后,构建了一个用例,设定节点部署、服务功能链建模等,验证了所提策略在提升服务功能链完成效率以及应对资源故障方面的有效性,旨在为空天地一体化网络资源管理提供理论基础。
基金State Key Basic Research Development and Programming Project of China (G1998040700).
文摘s Western Yunnan is located at the boundary of collision or underthrusting zone of Eurasian plate and is influenced by many times tectonic movements. With very complex geological environment and tectonic background, it is one of the seismically active areas. In the paper, the teleseismic records were selected from 16 national, local and mo-bile stations, including 4 very-wide-band mobile stations of PASSCAL. And nearly 2 000 receiver functions were extracted. Two measuring lines are 650 km and 450 km, respectively and across some major tectonic units in Western Yunnan. It is indicated that Nujiang might be a seam characterized by underthrusting. The western and eastern boundaries of Sichuan-Yunnan rhombus block, i.e., Honghe and Xiaojiang faults, might be an erection seam or collision belt. Panxi tectonic zone still has the characteristics of continental rift valley, that is, the surface is hollow and the upper mantle is upwarping. The tectonic situation in Western Yunnan is of certain regulation with the interlacing distribution of orogenic zone and seam. The crustal thickness decreases gradually from the north to the south and the S wave velocity is globally lower here.
