2013年10月"首届国际学习型城市大会"在北京隆重召开。102个国家的500多名代表一致通过了《建设学习型城市北京宣言》。其中有十二项承诺,而第一承诺便是"Empowering Individuals and Promoting Social Cohesion"(...2013年10月"首届国际学习型城市大会"在北京隆重召开。102个国家的500多名代表一致通过了《建设学习型城市北京宣言》。其中有十二项承诺,而第一承诺便是"Empowering Individuals and Promoting Social Cohesion"(促进个体赋权增能和增强社会凝聚)。何谓"赋权增能"和"社会凝聚"不能从简单的汉译来理解,需从词源来准确辨析,更需要从政治学、社会学、法学、心理学等角度领略其深刻的内涵。"赋权增能"与"社会凝聚"有密切的内在联系,其指向目标、目的、效能等核心价值构成完整体系。学习型城市建设与"赋权增能"和"社会凝聚"有着高度的重要关联。在改革开放的今天,践履"第一承诺"已经成为我国唯一选择。怎样践履这一庄严承诺,《北京宣言》指出了基本路向,在表达教育机会、基本能力、社会参与、性别平等、贫富差距、社区建设等兑现承诺的特定语境中,充分揭示了《北京宣言》将"赋权增能"、"社会凝聚"作为第一承诺的理由和重要意义。这应是对《北京宣言》第一承诺的完整理解。展开更多
OBJECTIVE To explain the high inter-individual variability and the frequency of exceeding the therapeutic reference range and the laboratory alert level of amisulpride,a popula⁃tion pharmacokinetic model in Chinese pa...OBJECTIVE To explain the high inter-individual variability and the frequency of exceeding the therapeutic reference range and the laboratory alert level of amisulpride,a popula⁃tion pharmacokinetic model in Chinese patients with schizophrenia was built based on therapeu⁃tic drug monitoring data to guide individualized therapy.METHODS Plasma concentration data(330 measurements from 121 patients)were ana⁃lyzed using a nonlinear mixed-effects model⁃ing approach with first-order conditional estima⁃tion with interaction(FOCE I).The concentra⁃tions of amisulpride were detected by HPLC-MS/MS.Age,weight,sex,combination medication history and renal function status were evaluated as main covariates.The model was internally val⁃idated using goodness-of-fit,bootstrap and nor⁃malized prediction distribution error.Recom⁃mended dosage regimens for patients with key covariates were estimated on the basis of Monte Carlo simulations and the established model.RESULTS A one-compartment model with first-order absorption and elimination was found to adequately characterize amisulpride concentra⁃tion in Chinese patients with schizophrenia.The population estimates of the apparent volume of distribution(V/F)and apparent clearance(CL/F)were 12.7 L and 1.12 L·h-1,respectively.Age sig⁃nificantly affected the clearance of amisulpride and the final model was as follow:CL/F=1.04×(AGE/32)-0.624(L·h-1).To avoid exceeding the lab⁃oratory alert level(640μg·L-1),the model-based simulation results showed that the recommended dose of amisulpride was no more than 600 mg per day for patients aged 60 years,800 mg per day for those aged 40 years and 1200 mg per day for those aged 20 years,respectively.CON⁃CLUSION Dosage optimization of amisulpride can be carried out according to age to reduce the risk of adverse reactions.The model can be used as a suitable tool for designing individual⁃ized therapy for Chinese patients with schizo⁃phrenia.展开更多
With the development of ordnance technology,the survival and safety of individual combatants in hightech warfare are under serious threat,and the Personal Protective Equipment(PPE),as an important guarantee to reduce ...With the development of ordnance technology,the survival and safety of individual combatants in hightech warfare are under serious threat,and the Personal Protective Equipment(PPE),as an important guarantee to reduce casualties and maintain military combat effectiveness,is widely developed.This paper systematically reviewed various PPE based on individual combat through literature research and comprehensive discussion,and introduced in detail the latest application progress of PPE in terms of material and technology from three aspects:individual integrated protection system,traditional protection equipment,and intelligent protection equipment,respectively,and discussed in depth the functional improvement and optimization status brought by advanced technology for PPE,focusing on the achievements of individual equipment technology application.Finally,the problems and technical bottlenecks in the development of PPE were analyzed and summarized,and the development trend of PPE were pointed out.The results of the review will provide a forward-looking reference for the current development of individual PPE,and are important guidance for the design and technological innovation of advanced equipment based on the future technological battlefield.展开更多
Gossypium, as the one of the biggest genera, the most diversity, and the highest economic value in field crops, is assuming an increasingly important role in studies on plant taxonomy, polyploidization, phylogeny, cyt...Gossypium, as the one of the biggest genera, the most diversity, and the highest economic value in field crops, is assuming an increasingly important role in studies on plant taxonomy, polyploidization, phylogeny, cytogenetics, and genomics. Here we update and provide a brief summary of the emerging picture of species relationships and diversification, and a set of the designations for individual genomes and chromosomes in Gossypium. This cytogenetic and genomic nomenclature will facilitate comparative studies worldwide, which range from basic taxonomic exploration to breeding and germplasm introgression.展开更多
Individual identification of dairy cows is the prerequisite for automatic analysis and intelligent perception of dairy cows'behavior.At present,individual identification of dairy cows based on deep convolutional n...Individual identification of dairy cows is the prerequisite for automatic analysis and intelligent perception of dairy cows'behavior.At present,individual identification of dairy cows based on deep convolutional neural network had the disadvantages in prolonged training at the additions of new cows samples.Therefore,a cow individual identification framework was proposed based on deep feature extraction and matching,and the individual identification of dairy cows based on this framework could avoid repeated training.Firstly,the trained convolutional neural network model was used as the feature extractor;secondly,the feature extraction was used to extract features and stored the features into the template feature library to complete the enrollment;finally,the identifies of dairy cows were identified.Based on this framework,when new cows joined the herd,enrollment could be completed quickly.In order to evaluate the application performance of this method in closed-set and open-set individual identification of dairy cows,back images of 524 cows were collected,among which the back images of 150 cows were selected as the training data to train feature extractor.The data of the remaining 374 cows were used to generate the template data set and the data to be identified.The experiment results showed that in the closed-set individual identification of dairy cows,the highest identification accuracy of top-1 was 99.73%,the highest identification accuracy from top-2 to top-5 was 100%,and the identification time of a single cow was 0.601 s,this method was verified to be effective.In the open-set individual identification of dairy cows,the recall was 90.38%,and the accuracy was 89.46%.When false accept rate(FAR)=0.05,true accept rate(TAR)=84.07%,this method was verified that the application had certain research value in open-set individual identification of dairy cows,which provided a certain idea for the application of individual identification in the field of intelligent animal husbandry.展开更多
Multiple BAC-FISH is a powerful tool for modern cytogenetic researching in both animals and plants.But in cotton,this technique is unavailable due to the high percentage of repetitive sequences.
Magnetorheological(MR) cell with multi-coil was designed to enlarge the range of controllable transmission torque by increasing the effective length. Individual input current was proposed to maximize its potential for...Magnetorheological(MR) cell with multi-coil was designed to enlarge the range of controllable transmission torque by increasing the effective length. Individual input current was proposed to maximize its potential for reducing power consumption and generating large yield stress. Finite element analysis was performed to analyze magnetic field distribution, based on which a prototype MR cell was fabricated and tested to investigate the performance of various combinations of individual input currents. A good correlation was identified between experimental results and FEA predications. The results show that the power consumption can be reduced to 42.4%, maintaining large transmission torque, by distributing the total current(2 A) to three individual magnetic coils. In addition, optimal results of four input currents considering a multi-objective function are obtained by changing the weighting factor λ. The advantage of this design, such as lower power consumption and more control flexibility, makes it more competitive in engineering applications that require large energy consumption.展开更多
On the basis of scientific practice,Marx scientifically illustrated the three phases of human development,and put forward that"individual character"is the highest stage of development.He correctly revealed t...On the basis of scientific practice,Marx scientifically illustrated the three phases of human development,and put forward that"individual character"is the highest stage of development.He correctly revealed the man's all-round development thought and implementation approach.As a theoretical source and logical starting point,Lenin combined it with real life.On the one hand,Lenin developed Marx's people theory into a more specific"overall development of individuals"generally,and improved the practical level;on the other hand,he self-consciously implemented the thought in practice so that Marxist theory was pushed to a higher new state.展开更多
文摘2013年10月"首届国际学习型城市大会"在北京隆重召开。102个国家的500多名代表一致通过了《建设学习型城市北京宣言》。其中有十二项承诺,而第一承诺便是"Empowering Individuals and Promoting Social Cohesion"(促进个体赋权增能和增强社会凝聚)。何谓"赋权增能"和"社会凝聚"不能从简单的汉译来理解,需从词源来准确辨析,更需要从政治学、社会学、法学、心理学等角度领略其深刻的内涵。"赋权增能"与"社会凝聚"有密切的内在联系,其指向目标、目的、效能等核心价值构成完整体系。学习型城市建设与"赋权增能"和"社会凝聚"有着高度的重要关联。在改革开放的今天,践履"第一承诺"已经成为我国唯一选择。怎样践履这一庄严承诺,《北京宣言》指出了基本路向,在表达教育机会、基本能力、社会参与、性别平等、贫富差距、社区建设等兑现承诺的特定语境中,充分揭示了《北京宣言》将"赋权增能"、"社会凝聚"作为第一承诺的理由和重要意义。这应是对《北京宣言》第一承诺的完整理解。
文摘OBJECTIVE To explain the high inter-individual variability and the frequency of exceeding the therapeutic reference range and the laboratory alert level of amisulpride,a popula⁃tion pharmacokinetic model in Chinese patients with schizophrenia was built based on therapeu⁃tic drug monitoring data to guide individualized therapy.METHODS Plasma concentration data(330 measurements from 121 patients)were ana⁃lyzed using a nonlinear mixed-effects model⁃ing approach with first-order conditional estima⁃tion with interaction(FOCE I).The concentra⁃tions of amisulpride were detected by HPLC-MS/MS.Age,weight,sex,combination medication history and renal function status were evaluated as main covariates.The model was internally val⁃idated using goodness-of-fit,bootstrap and nor⁃malized prediction distribution error.Recom⁃mended dosage regimens for patients with key covariates were estimated on the basis of Monte Carlo simulations and the established model.RESULTS A one-compartment model with first-order absorption and elimination was found to adequately characterize amisulpride concentra⁃tion in Chinese patients with schizophrenia.The population estimates of the apparent volume of distribution(V/F)and apparent clearance(CL/F)were 12.7 L and 1.12 L·h-1,respectively.Age sig⁃nificantly affected the clearance of amisulpride and the final model was as follow:CL/F=1.04×(AGE/32)-0.624(L·h-1).To avoid exceeding the lab⁃oratory alert level(640μg·L-1),the model-based simulation results showed that the recommended dose of amisulpride was no more than 600 mg per day for patients aged 60 years,800 mg per day for those aged 40 years and 1200 mg per day for those aged 20 years,respectively.CON⁃CLUSION Dosage optimization of amisulpride can be carried out according to age to reduce the risk of adverse reactions.The model can be used as a suitable tool for designing individual⁃ized therapy for Chinese patients with schizo⁃phrenia.
基金supported by the National Outstanding Youth Science Fund Project of National Natural Science Foundation of China(Projects No.52202012)the National Natural Science Foundation of China(Projects No.51834007)。
文摘With the development of ordnance technology,the survival and safety of individual combatants in hightech warfare are under serious threat,and the Personal Protective Equipment(PPE),as an important guarantee to reduce casualties and maintain military combat effectiveness,is widely developed.This paper systematically reviewed various PPE based on individual combat through literature research and comprehensive discussion,and introduced in detail the latest application progress of PPE in terms of material and technology from three aspects:individual integrated protection system,traditional protection equipment,and intelligent protection equipment,respectively,and discussed in depth the functional improvement and optimization status brought by advanced technology for PPE,focusing on the achievements of individual equipment technology application.Finally,the problems and technical bottlenecks in the development of PPE were analyzed and summarized,and the development trend of PPE were pointed out.The results of the review will provide a forward-looking reference for the current development of individual PPE,and are important guidance for the design and technological innovation of advanced equipment based on the future technological battlefield.
基金National Natural Science Foundation of China(31530053)
文摘Gossypium, as the one of the biggest genera, the most diversity, and the highest economic value in field crops, is assuming an increasingly important role in studies on plant taxonomy, polyploidization, phylogeny, cytogenetics, and genomics. Here we update and provide a brief summary of the emerging picture of species relationships and diversification, and a set of the designations for individual genomes and chromosomes in Gossypium. This cytogenetic and genomic nomenclature will facilitate comparative studies worldwide, which range from basic taxonomic exploration to breeding and germplasm introgression.
基金Supported by the National Key Research and Development Program of China(2019YFE0125600)China Agriculture Research System(CARS-36)。
文摘Individual identification of dairy cows is the prerequisite for automatic analysis and intelligent perception of dairy cows'behavior.At present,individual identification of dairy cows based on deep convolutional neural network had the disadvantages in prolonged training at the additions of new cows samples.Therefore,a cow individual identification framework was proposed based on deep feature extraction and matching,and the individual identification of dairy cows based on this framework could avoid repeated training.Firstly,the trained convolutional neural network model was used as the feature extractor;secondly,the feature extraction was used to extract features and stored the features into the template feature library to complete the enrollment;finally,the identifies of dairy cows were identified.Based on this framework,when new cows joined the herd,enrollment could be completed quickly.In order to evaluate the application performance of this method in closed-set and open-set individual identification of dairy cows,back images of 524 cows were collected,among which the back images of 150 cows were selected as the training data to train feature extractor.The data of the remaining 374 cows were used to generate the template data set and the data to be identified.The experiment results showed that in the closed-set individual identification of dairy cows,the highest identification accuracy of top-1 was 99.73%,the highest identification accuracy from top-2 to top-5 was 100%,and the identification time of a single cow was 0.601 s,this method was verified to be effective.In the open-set individual identification of dairy cows,the recall was 90.38%,and the accuracy was 89.46%.When false accept rate(FAR)=0.05,true accept rate(TAR)=84.07%,this method was verified that the application had certain research value in open-set individual identification of dairy cows,which provided a certain idea for the application of individual identification in the field of intelligent animal husbandry.
文摘Multiple BAC-FISH is a powerful tool for modern cytogenetic researching in both animals and plants.But in cotton,this technique is unavailable due to the high percentage of repetitive sequences.
基金Projects(51175265,51305207)supported by the National Natural Science Foundation of China
文摘Magnetorheological(MR) cell with multi-coil was designed to enlarge the range of controllable transmission torque by increasing the effective length. Individual input current was proposed to maximize its potential for reducing power consumption and generating large yield stress. Finite element analysis was performed to analyze magnetic field distribution, based on which a prototype MR cell was fabricated and tested to investigate the performance of various combinations of individual input currents. A good correlation was identified between experimental results and FEA predications. The results show that the power consumption can be reduced to 42.4%, maintaining large transmission torque, by distributing the total current(2 A) to three individual magnetic coils. In addition, optimal results of four input currents considering a multi-objective function are obtained by changing the weighting factor λ. The advantage of this design, such as lower power consumption and more control flexibility, makes it more competitive in engineering applications that require large energy consumption.
基金2015SJB065,general project of university philosophy&social science,2015
文摘On the basis of scientific practice,Marx scientifically illustrated the three phases of human development,and put forward that"individual character"is the highest stage of development.He correctly revealed the man's all-round development thought and implementation approach.As a theoretical source and logical starting point,Lenin combined it with real life.On the one hand,Lenin developed Marx's people theory into a more specific"overall development of individuals"generally,and improved the practical level;on the other hand,he self-consciously implemented the thought in practice so that Marxist theory was pushed to a higher new state.
