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The"4+4"Medical Doctor(MD)Pilot Program at PUMC:Implementation,Performance,and Prospects 被引量:1
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作者 Jing-Jing Yi Wei-Wei Xu +6 位作者 Chao Ma He Di Jing Jin Le Zeng Wen-Ji Tu Wen-Wen Sun Qin Zhang 《Chinese Medical Sciences Journal》 CAS CSCD 2024年第2期144-148,共5页
Peking Union Medical College(PUMC)launched the"4+4"Medical Doctor(MD)pilot program in 2018,admitting students with non-medical backgrounds from top universities,aligning with national medical talent training... Peking Union Medical College(PUMC)launched the"4+4"Medical Doctor(MD)pilot program in 2018,admitting students with non-medical backgrounds from top universities,aligning with national medical talent training policies to foster diverse and eager learners in medicine.On the occasion of the graduation of the first class of the"4+4"MD pilot class at PUMC in 2023,we reviewed the teaching reform in the pilot program and carried out a systematic survey and interviews with students,faculties,and management staff of the pilot class.This article reports on the measures taken by the pilot class at PUMC in enrollment and curriculum setting,and demonstrates the achievements of the pilot class in terms of student academic background structure,knowledge acquisition and skill learning,scientific research ability,and course evaluation.The results indicated that the pilot class had met the national demand for the"Medicine+X"talent training model.More specifically,with a diverse academic backgrounds,the pilot class graduates had academic levels comparable to the eight-year medical education graduates,and their scientific research abilities were satisfactory.The pilot program at PUMC will optimize the curriculum setting,strengthen the construction of faculty,learning resources,and teaching facilities,and reform the academic evaluation methods,thus deepening the reform of medical education and improving the"4+4"MD program as a novel medical education model. 展开更多
关键词 "4+4"MD pilot program teaching reform medical education
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An Empirical Application of User-Guided Program Analysis
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作者 Wang Jigang Cheng Shengyu +1 位作者 Cao Jicheng He Meihua 《China Communications》 SCIE CSCD 2024年第7期325-333,共9页
Although static program analysis methods are frequently employed to enhance software quality,their efficiency in commercial settings is limited by their high false positive rate.The EUGENE tool can effectively lower t... Although static program analysis methods are frequently employed to enhance software quality,their efficiency in commercial settings is limited by their high false positive rate.The EUGENE tool can effectively lower the false positive rate.However,in continuous integration(CI)environments,the code is always changing,and user feedback from one version of the software cannot be applied to a subsequent version.Additionally,people find it difficult to distinguish between true positives and false positives in the analytical output.In this study,we developed the EUGENE-CI technique to address the CI problem and the EUGENE-rank lightweight heuristic algorithm to rate the reports of the analysis output in accordance with the likelihood that they are true positives.On the three projects ethereum,go-cloud,and kubernetes,we assessed our methodologies.According to the trial findings,EUGENE-CI may drastically reduce false positives while EUGENE-rank can make it much easier for users to identify the real positives among a vast number of reports.We paired our techniques with GoInsight~1 and discovered a vulnerability.We also offered a patch to the community. 展开更多
关键词 continuous integration report ranking static program analysis
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Branch and Bound Algorithm for Globally Solving Minimax Linear Fractional Programming
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作者 WANG Hui-man SHEN Pei-ping LIANG Yu-xin 《Chinese Quarterly Journal of Mathematics》 2024年第4期388-398,共11页
In this paper,we study the minimax linear fractional programming problem on a non-empty bounded set,called problem(MLFP),and we design a branch and bound algorithm to find a globally optimal solution of(MLFP).Firstly,... In this paper,we study the minimax linear fractional programming problem on a non-empty bounded set,called problem(MLFP),and we design a branch and bound algorithm to find a globally optimal solution of(MLFP).Firstly,we convert the problem(MLFP)to a problem(EP2)that is equivalent to it.Secondly,by applying the convex relaxation technique to problem(EP2),a convex quadratic relaxation problem(CQRP)is obtained.Then,the overall framework of the algorithm is given and its convergence is proved,the worst-case iteration number is also estimated.Finally,experimental data are listed to illustrate the effectiveness of the algorithm. 展开更多
关键词 Minimax linear fractional programming Global optimal solution Branch and bound
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Impacts of forest plantation programs on sectoral CO_(2) emissions regionally in New Zealand
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作者 Saeed Solaymani Andrew Dunningham 《Journal of Forestry Research》 SCIE EI CAS CSCD 2024年第6期13-28,共16页
Investing in projects that support environmental benefits,such as tree harvesting,has the potential to reduce air pollution levels in the atmosphere in the future.However,this kind of investment may increase the curre... Investing in projects that support environmental benefits,such as tree harvesting,has the potential to reduce air pollution levels in the atmosphere in the future.However,this kind of investment may increase the current level of emissions.Therefore,it is necessary to estimate how much the policy affects the current level of CO_(2) emissions.This makes sure the policy doesn’t increase the level of CO_(2) emis-sions.This study aims to analyze the effect of the One Bil-lion Trees program on CO_(2) emissions in New Zealand by employing the 2020 input–output table analysis.This inves-tigation examines the direct and indirect effects of policy on both the demand and supply sides across six regions of New Zealand.The results of this study for the first year of plantation suggest that the policy increases the level of CO_(2) emissions in all regions,especially in the Waikato region.The direct and indirect impact of the policy leads to 64 kt of CO_(2) emissions on the demand side and 270 kt of CO_(2) emis-sions on the supply side.These lead to 0.19 and 0.74%of total CO_(2) emissions being attributed to investment shocks.Continuing the policy is recommended,as it has a low effect on CO_(2) emissions.However,it is crucial to prioritize the use of low-carbon machinery that uses fossil fuels during the plantation process. 展开更多
关键词 Regional input–output analysis Forest investment program Sectoral CO_(2) emissions Environmental policies Supply-side policy Demand-side policy
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Progress of International Meridian Circle Program
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作者 WANG Chi BLANC Michel +13 位作者 ZHANG Shunrong DENARDINI Clezio Marcos LIU William SHEN Xuhui WU Jian XU Jiyao LI Hui ZHANG Qinghe REN Liwen ZHU Yajun LI Guozhu DING Zonghua LIU Zhengkuan YANG Fang 《空间科学学报》 CAS CSCD 北大核心 2024年第4期741-745,共5页
In 2024,the Chinese Meridian Project(CMP)completed its construction,deploying 282 instruments across 31 stations.This achievement not only provides a robust foundation but also serves as a reference template for the I... In 2024,the Chinese Meridian Project(CMP)completed its construction,deploying 282 instruments across 31 stations.This achievement not only provides a robust foundation but also serves as a reference template for the International Meridian Circle Program(IMCP).The IMCP aims to integrate and establish a comprehensive network of ground-based monitoring stations designed to track the propagation of space weather events from the Sun to Earth.Additionally,it monitors various disturbances generated within the Earth system that impact geospace.Over the past two years,significant progress has been made on the IMCP.In particular,the second phase of construction for the China-Brazil Joint Laboratory for Space Weather has been completed,and the North Pole and Southeast Asia networks are under active construction.The 2024 IMCP joint observation campaign was successfully conducted.To facilitate these developments,the scientific program committee of IMCP was established,following the success of 2023 IMCP workshop and the space weather school,which was co-hosted with the Asia-Pacific Space Cooperation Organization(APSCO)and sponsored by Chinese Academy of Sciences(CAS)and Scientific Committee on Solar-Terrestrial Physics(SCOSTEP).Preparations are now underway for the 2024 workshop in collaboration with the National Institute for Space Research(INPE)in Brazil. 展开更多
关键词 Chinese Meridian Project(CMP) International Meridian Circle program(IMCP) China-Brazil Joint Laboratory for Space Weather North Pole and Southeast Asia networks
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未知环境中基于控制障碍函数的机器人安全控制研究综述
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作者 周毅 张浩 +2 位作者 施孟佶 林伯先 石磊 《电子科技大学学报》 北大核心 2025年第1期29-38,共10页
随着机器人系统工作环境的复杂程度日益增加,以及对实时性需求的逐步提升,机器人的安全避障能力将面临新的挑战,控制障碍函数作为一种基于控制器的安全方法在机器人安全控制系统中迎来新的发展契机。调研分析了控制障碍函数及基于二次... 随着机器人系统工作环境的复杂程度日益增加,以及对实时性需求的逐步提升,机器人的安全避障能力将面临新的挑战,控制障碍函数作为一种基于控制器的安全方法在机器人安全控制系统中迎来新的发展契机。调研分析了控制障碍函数及基于二次规划的优化控制器,总结了机器人在已知和未知环境中的避障问题,综述了高斯过程和强化学习两种理论合成控制障碍函数的策略。最后,讨论了未来基于控制障碍函数的空地协同机器人安全控制需要重点关注的问题,为未来控制障碍函数的理论研究和技术应用提供了参考。 展开更多
关键词 控制障碍函数 非线性系统 安全关键控制 二次规划
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成人正畸患者牙周组织健康干预方案的构建
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作者 张玉革 刘均娥 +1 位作者 王磊 谭小彤 《中国护理管理》 北大核心 2025年第2期203-207,共5页
目的:构建成人正畸患者牙周组织健康干预方案,为临床实践提供参考。方法:2024年2月—3月,采用文献回顾、小组讨论、专家咨询等方法,以健康行为过程取向理论为指导,构建成人正畸患者牙周组织健康干预方案,通过德尔菲法对15名专家进行函询... 目的:构建成人正畸患者牙周组织健康干预方案,为临床实践提供参考。方法:2024年2月—3月,采用文献回顾、小组讨论、专家咨询等方法,以健康行为过程取向理论为指导,构建成人正畸患者牙周组织健康干预方案,通过德尔菲法对15名专家进行函询,根据专家修改意见对所涉及的条目进行修订,形成方案终稿。结果:2轮函询专家权威系数为0.829,积极系数为100%,变异系数为0.091~0.532和0.044~0.196,肯德尔和谐系数为0.246和0.293(P<0.01)。最终形成的干预方案包括前意向阶段、意向阶段、行动阶段3个阶段,共计17条具体干预措施。结论:成人正畸患者牙周组织健康干预方案具有科学性、可靠性和实用性,具有口腔专科护理特色,易于临床推广,能够为临床医护人员开展口腔健康教育提供参考。 展开更多
关键词 正畸 牙周健康 方案构建 可视化菌斑检测 健康行为过程取向理论 德尔菲技术
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考虑综合效益的周期型停车预约分配模型
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作者 宋现敏 刘博 +3 位作者 李海涛 湛天舒 李世豪 张云翔 《交通运输系统工程与信息》 北大核心 2025年第1期24-35,共12页
为解决停车预约服务平台与用户之间存在的泊位运营问题,本文基于停车分配过程中服务平台的直接收益与服务水平间的关系,考虑用户出行特征的多样性,提出一种停车预约分配优化模型。为实现平台运营服务收益最大化,以运营商收益最大和用户... 为解决停车预约服务平台与用户之间存在的泊位运营问题,本文基于停车分配过程中服务平台的直接收益与服务水平间的关系,考虑用户出行特征的多样性,提出一种停车预约分配优化模型。为实现平台运营服务收益最大化,以运营商收益最大和用户出行成本的综合效益最小为目标建立联合优化函数,构建考虑停车分配时效性的周期型最优停车预约分配模型(POPA),并设计自适应升温的模拟退火-粒子群优化算法求解大规模停车分配问题。实验结果表明:综合考虑分配时效性和平台收益等多个因素,预约平台的最佳分配时段长度应为1 h,改进算法使求解效果提高了6.14%,灵敏度分析证明了惩罚因子的引入可在不影响用户时间成本与车位利用率的情况下,使平台的用户请求接受率提升2.25%~18.17%;通过对比分析,所提模型较用户最优模型提升了38.11%的实际收益,较平台最优模型降低了15.31%的平均用户时间成本。此外,通过拓展性数值测试证明了所提模型在大规模复杂场景中的适用性和有效性。 展开更多
关键词 交通工程 泊位运营 整数规划模型 停车分配 模拟退火-粒子群优化算法
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高速公路市政化改造互通立交设计研究思路
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作者 王兵 张婷 付元坤 《路基工程》 2025年第1期161-167,共7页
高速公路互通立交布设线形指标高,占地规模大,而城市互通在满足功能的前提下,往往要尽可能节省占地,改造类项目还需充分考虑利用既有工程。以石家庄市复兴大街(原新元高速公路)市政化改造项目中南三环互通立交为例,分析总结公路市政化... 高速公路互通立交布设线形指标高,占地规模大,而城市互通在满足功能的前提下,往往要尽可能节省占地,改造类项目还需充分考虑利用既有工程。以石家庄市复兴大街(原新元高速公路)市政化改造项目中南三环互通立交为例,分析总结公路市政化改造中互通立交的设计思路及要点,设计研究中除考虑本身节点交通需求外,还需与周边节点及出入口布局结合起来,做到点面间的相互协调。 展开更多
关键词 市政化改造 互通立交 改造思路及原则 方案研究 收费设施
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家庭赋权方案对语前聋人工耳蜗植入患儿照顾者的影响
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作者 李莉 刘永玲 +1 位作者 田梓蓉 贺怡然 《中国听力语言康复科学杂志》 2025年第1期92-96,共5页
目的探讨家庭赋权方案对人工耳蜗植入(CI)患儿照顾者的心理弹性及家庭坚韧力量的影响。方法选取2023年2月~2024年1月在北京市某三甲医院接受CI手术的患儿照顾者为研究对象,随机分为试验组33例和对照组30例。试验组在常规康复训练方式的... 目的探讨家庭赋权方案对人工耳蜗植入(CI)患儿照顾者的心理弹性及家庭坚韧力量的影响。方法选取2023年2月~2024年1月在北京市某三甲医院接受CI手术的患儿照顾者为研究对象,随机分为试验组33例和对照组30例。试验组在常规康复训练方式的基础上接受家庭赋权方案干预,对照组接受常规康复训练方式。采用标准化心理弹性量表(connordavidson resilience scale,CD-RISC)和家庭坚韧力量(family hardiness index,FHI)评估工具,比较两组照顾者干预前后的心理弹性、家庭坚韧力量。结果经过家庭赋权方案干预后,试验组CI患儿照顾者的心理弹性总分(73.24±9.51)显著提升,家庭坚韧力量总分(71.97±9.81)也明显增强,与对照组相比具有统计学差异(P<0.05)。结论家庭赋权方案不仅提升了CI儿童照顾者的心理弹性,还显著增强了家庭的整体坚韧力量,为患儿创造了更加有利的康复环境。 展开更多
关键词 家庭赋权方案 人工耳蜗植入 语前聋 照顾者 家庭坚韧力量 心理弹性
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城市道路智能网联汽车专用车道设置研究
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作者 王连震 马志飞 +1 位作者 程国柱 郑夫水 《交通运输系统工程与信息》 北大核心 2025年第1期56-66,共11页
为科学有效地设置城市道路智能网联汽车专用车道,减少智能网联汽车与人工驾驶汽车的路权冲突,提高安全和效率,本文建立城市道路智能网联汽车专用车道双层规划模型。上层模型以总出行时间最少和交通事故率最低为优化目标,将是否设置智能... 为科学有效地设置城市道路智能网联汽车专用车道,减少智能网联汽车与人工驾驶汽车的路权冲突,提高安全和效率,本文建立城市道路智能网联汽车专用车道双层规划模型。上层模型以总出行时间最少和交通事故率最低为优化目标,将是否设置智能网联汽车专用车道作为决策变量,采用具有增强精英保留算子的遗传算法(Strengthen Elitist Genetic Algorithm,SEGA)进行求解。下层模型基于用户均衡原则进行交通流分配,采用嵌入黄金分割法的Frank-Wolfe算法求解。使用Nguyen-Dupuis网络作为案例研究,验证模型及SEGA算法的有效性,并分析不同渗透率、通行能力和OD总量对总出行时间和交通事故率的影响。算例表明:渗透率为10%和80%时,设置城市道路智能网联汽车(Connected and Automated Vehicles,CAV)专用车道均会导致总出行时间升高;渗透率为40%时,可以实现总出行时间降低2.68%。渗透率低于20%时,事故率会不同程度增加;渗透率为40%时,事故率降低14.30%;渗透率为80%时,事故率降低5.77%。随着OD总量的增加,总出行时间降低幅度在0~6%之间,变化趋势不明显。低交通需求(14400 veh·h^(-1))时,事故率降低13.45%;中交通需求(21600 veh·h^(-1))时,事故率降低3.16%;高交通需求(31200 veh·h^(-1))时,事故率升高10.35%。设置城市道路CAV专用车道的最优条件为中低交通需求水平下,渗透率为40%时。研究成果可为制定城市道路CAV专用车道设置方案提供理论依据。 展开更多
关键词 城市交通 专用车道 双层规划 设置优化 智能网联汽车
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卓越工程师计划2.0视角下智能建造人才培养机制构建
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作者 周振国 徐其博 +1 位作者 刘欣 张兵 《工程管理学报》 2025年第1期154-158,共5页
卓越工程师工程计划2.0强调新工科建设,与智能建造人才培养目标一致。同时智能建造在企业的发展已经走在了高校人才培养的前面,因此高校应厘清智能建造人才需求,以培养学生核心能力为中心,整合教学资源;以产教融合为抓手,组建师资队伍;... 卓越工程师工程计划2.0强调新工科建设,与智能建造人才培养目标一致。同时智能建造在企业的发展已经走在了高校人才培养的前面,因此高校应厘清智能建造人才需求,以培养学生核心能力为中心,整合教学资源;以产教融合为抓手,组建师资队伍;以全面实践为基础,重构实践教学体系,构建高校、企业、政府多位一体的智能建造人才培养机制。 展开更多
关键词 卓越工程师计划2.0 智能建造 人才培养机制 产教融合
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PD-L1单抗加强紫杉醇联合香菇多糖体外抗人乳腺癌MDA-MB-231作用
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作者 李汾 平娜娜 +2 位作者 曾菊绒 胥晓丽 刘鹏 《西安交通大学学报(医学版)》 北大核心 2025年第1期94-100,共7页
目的 探讨程序性细胞死亡-配体1(PD-L1)单抗、紫杉醇(PTX)联合香菇多糖(LNT)体外对人乳腺癌细胞(MDA-MB-231)的作用。方法 将MDA-MB-231、人外周血单个核细胞(PBMC)和MDA-MB-231+PBMC共培养,随机分为对照组、PTX组、LNT组、MPDL3280A(PD... 目的 探讨程序性细胞死亡-配体1(PD-L1)单抗、紫杉醇(PTX)联合香菇多糖(LNT)体外对人乳腺癌细胞(MDA-MB-231)的作用。方法 将MDA-MB-231、人外周血单个核细胞(PBMC)和MDA-MB-231+PBMC共培养,随机分为对照组、PTX组、LNT组、MPDL3280A(PD-L1单抗)组、PTX+LNT组和PTX+LNT+MPDL3280A组。采用CCK8检测细胞的活性;流式细胞术检测MHC-I和PD-L1的表达;ELISA试剂盒检测IFN-γ和TNF-α的含量。结果 与对照组相比,PTX组、MPDL3280A组、PTX+LNT组及PTX+LNT+MPDL3280A组显著抑制MDA-MB-231的活性(P<0.01);LNT组和PTX+LNT+MPDL3280A组显著促进PBMC的免疫作用(P<0.05,P<0.01);PTX+LNT+MPDL3280A组显著抑制MDA-MB-231+PBMC共培养MDA-MB-231的活性(0.56±0.16 vs. 0.39±0.13,P<0.05);LNT显著促进MDA-MB-231上PD-L1的表达和PBMC分泌IFN-γ(P<0.05)。结论 PD-L1单抗通过阻断PD-L1与PD-1之间的作用,提高免疫,促进PTX联合LNT的体外抗三阴性乳腺癌作用。 展开更多
关键词 程序性细胞死亡-配体1(PD-L1)单抗 紫杉醇(PTX) 香菇多糖(LNT) 抗人乳腺癌MDA-MB-231
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MACHINING-FEATURE BASED 3-AXIS AUTOMATIC NC PROGRAMMING FOR HIGH-SPEED MILLING 被引量:1
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作者 孙全平 汪通悦 +1 位作者 廖文和 何宁 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2007年第2期150-156,共7页
Machining-features of the workplace are described by using of the object-oriented (O-O) technology. Geometrical machining-features are recognized in the given cut region by using the maximum membership priciple abou... Machining-features of the workplace are described by using of the object-oriented (O-O) technology. Geometrical machining-features are recognized in the given cut region by using the maximum membership priciple about the fuzzy set. Depending on the IF-THEN rule and the fuzzy matching method, the rough information of the machining-process for high-speed milling (HSM) is extracted based on the database of machining-process for HSM. The optimization model of machining-process scheme is established to obtain shorter cut time, lower cost or higher surface quality. It is helpful to form successful cases for HSM. NC programming for HSM is realized according to optimized machining-process data from HSM cases selected by the optimization model and the extracted information of machining-process. 展开更多
关键词 high-speed milling machining-feature) process-knowledge NC programming
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AN APPLICATION OF EVOLUTIONARY PROGRAMMING IN FIR FILTER DESIGN WITH FREQUENCY SAMPLING METHOD 被引量:2
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作者 刘文波 于盛林 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2000年第2期218-223,共6页
Frequency sampling is one of the popular methods in FIR digital filter design. In the frequency sampling method the value of transition band samples, which are usually obtained by consulting a table, must be determi... Frequency sampling is one of the popular methods in FIR digital filter design. In the frequency sampling method the value of transition band samples, which are usually obtained by consulting a table, must be determined in order to make the attenuation within the stopband maximal. However, the value obtained by searching for table can not be ensured to be optimal. Evolutionary programming (EP), a multi agent stochastic optimization technique, can lead to global optimal solutions for complex problems. In this paper a new application of EP to frequency sampling method is introduced. Two examples of lowpass and bandpass FIR filters are presented, and the steps of EP realization and experimental results are given. Experimental results show that the value of transition band samples obtained by EP can be ensured to be optimal and the performance of the filter is improved. 展开更多
关键词 evolutionary programming FIR filter frequency sampling
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层状弹性体系力学的最新研究进展——论BISAR源程序中一处明显的错误
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作者 王凯 《力学与实践》 2025年第1期189-194,共6页
层状弹性体系力学是多层柔性路面设计与计算的理论基础。BISAR程序是世界著名的多层弹性体系力学计算程序。本文在国内首次通过力学计算公式的推导和数值计算论证了BISAR源程序中一处明显的错误。由于该错误的存在,导致当采用BISAR程序... 层状弹性体系力学是多层柔性路面设计与计算的理论基础。BISAR程序是世界著名的多层弹性体系力学计算程序。本文在国内首次通过力学计算公式的推导和数值计算论证了BISAR源程序中一处明显的错误。由于该错误的存在,导致当采用BISAR程序计算在圆形均布单向水平载荷作用下的层状弹性体系时,层状弹性体系表面位于载荷圆范围内的计算点的τ_(θz1)或τ_(zr1)的计算结果均是错误的,在BISAR程序50年的历史中,从未见此发现。上述研究工作为BISAR源程序的进一步修改与完善提供了宝贵的资料。 展开更多
关键词 层状弹性体系力学 最新研究进展 BISAR程序 数值计算
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Necessary and Sufficient Conditions in Smooth Programming with Generalized Convexity 被引量:1
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作者 孙清滢 叶留青 《Chinese Quarterly Journal of Mathematics》 CSCD 2000年第4期33-37,共5页
Hanson and Mond have grven sets of necessary and sufficient conditions for optimality in constrained optimization by introducing classes of generalized functions, called type Ⅰ functions. Recently, Bector definded un... Hanson and Mond have grven sets of necessary and sufficient conditions for optimality in constrained optimization by introducing classes of generalized functions, called type Ⅰ functions. Recently, Bector definded univex functions, a new class of functions that unifies several concepts of generalized convexity. In this paper, additional conditions are attached to the Kuhn Tucker conditions giving a set of conditions which are both necessary and sufficient for optimality in constrained optimization, under appropriate constraint qualifications. 展开更多
关键词 necessary and sufficient conditions generalized convexity nonlinear programming multiobjective programming type functions
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中原地区高速公路共线方案多角度统筹研究
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作者 张婷 《路基工程》 2025年第1期173-177,共5页
随着高速路网的不断加密,常常会遇到高速与高速小角度交叉并行的问题,一般常采用十字交叉的不共线方案,但也有设置两个T型枢纽,其间设共线段的共线方案。从高速公路网规划、高速公路功能定位、项目区重要控制因素、地方建议意见、项目... 随着高速路网的不断加密,常常会遇到高速与高速小角度交叉并行的问题,一般常采用十字交叉的不共线方案,但也有设置两个T型枢纽,其间设共线段的共线方案。从高速公路网规划、高速公路功能定位、项目区重要控制因素、地方建议意见、项目工程投资等多种角度,对高速公路共线与否进行深入剖析,通过工程实例探讨解决该问题的方法和思路,为今后类似工程方案的科学决策提供参考。 展开更多
关键词 高速路网 选线 共线研究 小角度交叉 方案比选 科学统筹
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A Modified Algorithm for Nonliear Integer Programming 被引量:2
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作者 孙会霞 《Chinese Quarterly Journal of Mathematics》 CSCD 2002年第3期24-29,共6页
Based on the analysis to the random sear ch algorithm of LUUS, a modified random directed integer search algorithm (MRDI SA) is given for first time. And a practical example is given to show that the adva ntage of th... Based on the analysis to the random sear ch algorithm of LUUS, a modified random directed integer search algorithm (MRDI SA) is given for first time. And a practical example is given to show that the adva ntage of this kind of algorithm is the reliability can’t be infuenced by the ini tial value X (0) and the start search domain R (0) . Besides, i t can be applied to solve the higher dimensional constrained nonlinear integer p rogramming problem. 展开更多
关键词 random search integer programming optimal soluti on RELIABILITY
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纳米材料诱导肿瘤细胞铜死亡的研究进展 被引量:1
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作者 何扩 丁彬彬 +1 位作者 马平安 林君 《高等学校化学学报》 北大核心 2025年第1期33-49,共17页
纳米材料选择性诱导肿瘤细胞发生程序性细胞死亡(PCD)被视为一种很有前途的癌症治疗方法.铜死亡是一种最近被发现的由细胞内铜离子过载引起、以脂酰化线粒体酶的聚集和Fe-S蛋白质丢失为特征的全新的PCD模式.目前,多种纳米材料已被开发... 纳米材料选择性诱导肿瘤细胞发生程序性细胞死亡(PCD)被视为一种很有前途的癌症治疗方法.铜死亡是一种最近被发现的由细胞内铜离子过载引起、以脂酰化线粒体酶的聚集和Fe-S蛋白质丢失为特征的全新的PCD模式.目前,多种纳米材料已被开发并用于诱导肿瘤细胞铜死亡,实现癌症治疗.大量的研究表明,将铜死亡与其它肿瘤治疗方式联合使用可取得更好的治疗效果,展现出巨大的潜力.本文综合评述了细胞铜死亡的相关机制及特征,总结和概括了纳米材料诱导的肿瘤细胞铜死亡策略及相关机制,重点分类概述了纳米材料诱导的铜死亡联合治疗的最新研究进展,并对这一新兴的肿瘤治疗方式的未来前景进行了总结和展望. 展开更多
关键词 铜死亡 程序性细胞死亡 纳米材料 肿瘤治疗
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