During 1984 to 1990, a comparative etiologic studyand primary prevention for stomach cancer was carriedout in a high risk area in Zhuanghe County of LiaoningProvince. Because of the increase of consumption of fr-esh v...During 1984 to 1990, a comparative etiologic studyand primary prevention for stomach cancer was carriedout in a high risk area in Zhuanghe County of LiaoningProvince. Because of the increase of consumption of fr-esh vegetables and fruits (Protective factors), decreaseof eating salted pork and fishes which was verified tohave strong mutagenecity (risk factors), acute inflamma-tion and erosions accompanying with chronic gastritis havegot striking improvement. At the same time, serum betac-arotene also raised gradually. The authors stressed thatimprovement of economic situation and dietary habits mayplay an important role in primary prevention of precurso-res of stomach cancer but decrease of incidence of thiscancer is an event of 30 years or more later as the letentperiod of stomach cancer is rather long.展开更多
The objective of the study was to investigate the effects of dietary energy levels and sources on the blood metabolites,hormone secretion and the composition of follicular fluid in gilts.Fifty-four gilts with initial ...The objective of the study was to investigate the effects of dietary energy levels and sources on the blood metabolites,hormone secretion and the composition of follicular fluid in gilts.Fifty-four gilts with initial body weight of(59±4.2) kg were randomly allotted to six treatments.Treatments were low, normal,and high energy feeding levels,which were 87.5%,100%and 112.5%of recommendatory energy requirements by NRC(1998),respectively,and dietary energy sources(starch or fat).Blood samples and follicular fluids were collected on D18 and D19 of the second estrous cycle.The results showed that plasma concentrations of triglycerides and total cholesterol were higher in the fat group than that in the starch group(P【0.05),but those of glucose were similar between the two energy sources(P】0.05);dietary energy level exerted no effect on blood metabolites concentration(P】0.05).Gilts fed the high energy diet had a higher area under curve of plasma insulin(Insulin AUC),insulin-like growth factor-Ⅰ(IGF-Ⅰ) and leptin than did gilts fed the lower energy diet(P【0.05),but there was no significant difference between fat versus starch(P】0.05).Luteinizing hormone(LH) pulses were higher in gilts fed high energy rather than that in low energy diets(P】0.05),plasma concentration of estradiol(E<sub>2</sub>) was higher in the fat group than that in the starch group(P【0.05).The number of large follicles(diameter≥4 mm) and concentrations of IGF-Ⅰand E<sub>2</sub> in follicular fluid were increasing significant as the level of energy increased(P【0.05),but the numbers of large follicles and follicular fluid composition were not affected by the source of dietary energy(P】0.05).The results indicate that gilts fed high energy diets had elevated plasma concentrations of metabolic hormones,IGF-Ⅰand LH secretion,and increased follicular fluid concentrations of IGF-Ⅰ,E<sub>2</sub> and numbers of large follicles;gilts fed the dietary fat had a higher plasma concentration of cholesterol and E<sub>2</sub>.展开更多
The status of PCDDs and PCDFs content in retail foods from a certain area by Isotope Dilution HRGC-HRMS was surveyed and the local population PCDD/Fs exposure from diverse foods and health risk was evaluated.PCDD/Fs w...The status of PCDDs and PCDFs content in retail foods from a certain area by Isotope Dilution HRGC-HRMS was surveyed and the local population PCDD/Fs exposure from diverse foods and health risk was evaluated.PCDD/Fs was extracted from samples by Soxhlet extraction,concentrated and purified by FMS column chromatograph,carbon column enrichment.Confirmation and quantitative analysis at pg/g level of PCDD/Fs was performed by HRGC/HRMS using multiple ion detection mode(MID).TEQ concentration was calculated by WHO-TEF multiplying by concentration of seventeen PCDD/Fs congener.Median of PCDD/Fs concentration for fish,livestock,poultry,egg,vegetable oil,milk,vegetable totally 100 samples for ten diverse foods didn’t exceed the limit standards by EU.The level of PCDD/Fs for different food in the certain area was lower or comparable to the data reported by developed country in the world.The total weekly intake and monthly intake for local population or national population was 3.44,14.8 WHO-TEQ/kg BW and 1.5,6.42 pg WHO-TEQ/kg BW respectively,the value was lower than the Tolerable Weekly Intake of 14 pg WHO TEQ/kg BW for PCDDs,PCDFs and dioxin-like PCBs established by EU Scientific Committee for Food.The dietary PCDD/Fs intake for local people was higher than national population.And animal food was the dominant contributor to the total dietary intake,which accounted for more than 70 percent.These levels of consumption of diverse food containing typical levels of PCDD/Fs doesn’t present a risk to the health of the local population.But integrative dietary intake could be evaluated including of PCBs intake for population in the future.展开更多
Soil cadmium(Cd)contamination resulted from mining and smelting is a major environmental concern,and health risk associated with Cd exposure to multi-media through muti-pathway is increasing.Cd concentrations in soils...Soil cadmium(Cd)contamination resulted from mining and smelting is a major environmental concern,and health risk associated with Cd exposure to multi-media through muti-pathway is increasing.Cd concentrations in soils,vegetables and paddy rice were investigated,and potential non-carcinogenic and carcinogenic health risks exposure to Cd were estimated at six villages around the Dabaoshan Mine,South China.A total of 87 soil samples were found to exceed the China's maximum permission level(MPL)for Cd,while the highest value of 4.42 mg/kg was found near irrigation ditch associated with Hengshi River in Xinyi(XY)Village.Cd contents in vegetables and rice exceeded the maximum permissible concentration by more than five times in every village.Cadmium accumulation in plants is in the order of celery>lactuca sativa L>Chinese cabbage>Romaine lettuce>asparagus lettuce>mustard>cabbage mustard>cabbage.The mean hazard quotient(HQ)of all villages is in the range of [5.29,25.75],and the mean values of cancer risk for investigated areas are more than 10 times greater than the USEPA(2009)threshold limit value of 10-4.Moreover,human non-carcinogenic and carcinogenic risks are mainly attributable to paddy rice intake,followed by vegetables intake,soil ingestion,inhalation,and dermal contact.The results indicate that Cd has a huge potential risk on human health for the local residents.展开更多
Growing evidence indicates that cancer incidence across the world is not similar,and it is more prevalent in certain populations than others,suggesting the critical role for dietary and lifestyle factors.For instance ...Growing evidence indicates that cancer incidence across the world is not similar,and it is more prevalent in certain populations than others,suggesting the critical role for dietary and lifestyle factors.For instance cancer incidence among people from the Indian subcontinent,where most spices are consumed,is much lower than that in the Western World.Spices have been consumed for centuries for a variety of purposes e.g.as flavoring agents,colorants,and preservatives.However,there is increasing evidence for the importance of plant-based foods in regular diet to lowering the risk of most chronic diseases,so spices are now emerging as more than just flavor aids,but as agents that can not only prevent but may even treat disease.Besides suppressing inflammatory pathways,spice-derived nutraceuticals can suppress survival,proliferation,invasion,and angiogenesis of tumor cells.Increasing evidence indicates that genetic alterations are relatively rare,and epigenetic changes(DNA methylation,histone modifications and expression of noncoding RNAs)plays a bigger role in human cancer,and can be easily influenced by environmental,lifestyle and dietary factors,and some estimates suggest that over two-thirds of the cancer incidence can be accounted for by the environmental and dietary factors alone.Among all these factors,diet is probably the single most important factor which may influence carcinogenesis more comprehensively,because diet is readily modifiable and have the potential to modulate multiple epigenetic processes.Polyphenols in dietary botanicals represent a versatile group of phytochemicals with many potentially beneficial activities in terms of disease prevention.Dietary polyphenols(bioflavanoids)have antioxidant and anti-inflammatory properties that might explain their chemopreventive effects.However,the actual therapeutic potential of these compounds may not have been completely realized due to lack of understanding on the effects of these agents on epigenetic modifications.Recent,but limited evidence indicates that some of the polyphenols,including curcumin(from turmeric),genestein(from soy),EGCG(from green tea),diallyl disulfide(from garlic),sulforaphane(from broccoli)and resveratrol(from grapes)may induce epigenetic changes in various cancer cell lines.This presentation will describe some of the current scientific evidence for the role of epigenetic alterations induced by curcumin and boswellia,in support of their anti-cancer activities,which provides a strong scientific foundation for preclinical and human clinical intervention studies in future.展开更多
Lycium barbarum is a traditional Chinese medicinal plant that has been widely used as a functional food and dietary supplement.Lycium barbarum polysaccharide(LBP)is an important active substance found in Lycium barbar...Lycium barbarum is a traditional Chinese medicinal plant that has been widely used as a functional food and dietary supplement.Lycium barbarum polysaccharide(LBP)is an important active substance found in Lycium barbarum[1].It has been recorded in the“Ben Cao Gang Mu(Compendium of Materia Medica)”to have anti-aging and skin whitening effects.Previous studies have focused on its antioxidant properties to explain its efficacy[2].展开更多
基金This research was supported in part by a Grant-Aid for Oversea Cancer Research from the Ministry of Education,Science and Cultrue of Japan and reported at the 9th Asia Pacific Cancer Conference(Lahore, Pakistan, 1989) and the 15th International Cancer Co
文摘During 1984 to 1990, a comparative etiologic studyand primary prevention for stomach cancer was carriedout in a high risk area in Zhuanghe County of LiaoningProvince. Because of the increase of consumption of fr-esh vegetables and fruits (Protective factors), decreaseof eating salted pork and fishes which was verified tohave strong mutagenecity (risk factors), acute inflamma-tion and erosions accompanying with chronic gastritis havegot striking improvement. At the same time, serum betac-arotene also raised gradually. The authors stressed thatimprovement of economic situation and dietary habits mayplay an important role in primary prevention of precurso-res of stomach cancer but decrease of incidence of thiscancer is an event of 30 years or more later as the letentperiod of stomach cancer is rather long.
基金supported by Program for Changjiang Scholars and Innovative Research Team in University (IRT0555)National Natural Science Foundation (30471257) of China
文摘The objective of the study was to investigate the effects of dietary energy levels and sources on the blood metabolites,hormone secretion and the composition of follicular fluid in gilts.Fifty-four gilts with initial body weight of(59±4.2) kg were randomly allotted to six treatments.Treatments were low, normal,and high energy feeding levels,which were 87.5%,100%and 112.5%of recommendatory energy requirements by NRC(1998),respectively,and dietary energy sources(starch or fat).Blood samples and follicular fluids were collected on D18 and D19 of the second estrous cycle.The results showed that plasma concentrations of triglycerides and total cholesterol were higher in the fat group than that in the starch group(P【0.05),but those of glucose were similar between the two energy sources(P】0.05);dietary energy level exerted no effect on blood metabolites concentration(P】0.05).Gilts fed the high energy diet had a higher area under curve of plasma insulin(Insulin AUC),insulin-like growth factor-Ⅰ(IGF-Ⅰ) and leptin than did gilts fed the lower energy diet(P【0.05),but there was no significant difference between fat versus starch(P】0.05).Luteinizing hormone(LH) pulses were higher in gilts fed high energy rather than that in low energy diets(P】0.05),plasma concentration of estradiol(E<sub>2</sub>) was higher in the fat group than that in the starch group(P【0.05).The number of large follicles(diameter≥4 mm) and concentrations of IGF-Ⅰand E<sub>2</sub> in follicular fluid were increasing significant as the level of energy increased(P【0.05),but the numbers of large follicles and follicular fluid composition were not affected by the source of dietary energy(P】0.05).The results indicate that gilts fed high energy diets had elevated plasma concentrations of metabolic hormones,IGF-Ⅰand LH secretion,and increased follicular fluid concentrations of IGF-Ⅰ,E<sub>2</sub> and numbers of large follicles;gilts fed the dietary fat had a higher plasma concentration of cholesterol and E<sub>2</sub>.
文摘The status of PCDDs and PCDFs content in retail foods from a certain area by Isotope Dilution HRGC-HRMS was surveyed and the local population PCDD/Fs exposure from diverse foods and health risk was evaluated.PCDD/Fs was extracted from samples by Soxhlet extraction,concentrated and purified by FMS column chromatograph,carbon column enrichment.Confirmation and quantitative analysis at pg/g level of PCDD/Fs was performed by HRGC/HRMS using multiple ion detection mode(MID).TEQ concentration was calculated by WHO-TEF multiplying by concentration of seventeen PCDD/Fs congener.Median of PCDD/Fs concentration for fish,livestock,poultry,egg,vegetable oil,milk,vegetable totally 100 samples for ten diverse foods didn’t exceed the limit standards by EU.The level of PCDD/Fs for different food in the certain area was lower or comparable to the data reported by developed country in the world.The total weekly intake and monthly intake for local population or national population was 3.44,14.8 WHO-TEQ/kg BW and 1.5,6.42 pg WHO-TEQ/kg BW respectively,the value was lower than the Tolerable Weekly Intake of 14 pg WHO TEQ/kg BW for PCDDs,PCDFs and dioxin-like PCBs established by EU Scientific Committee for Food.The dietary PCDD/Fs intake for local people was higher than national population.And animal food was the dominant contributor to the total dietary intake,which accounted for more than 70 percent.These levels of consumption of diverse food containing typical levels of PCDD/Fs doesn’t present a risk to the health of the local population.But integrative dietary intake could be evaluated including of PCBs intake for population in the future.
基金Project(51204074)supported by the National Natural Science Foundation of ChinaProjects(2010009017,201209048,ZX021-201106-031)supported by the National Environmental Protection Public Welfare Industry Targeted Research Fund,China
文摘Soil cadmium(Cd)contamination resulted from mining and smelting is a major environmental concern,and health risk associated with Cd exposure to multi-media through muti-pathway is increasing.Cd concentrations in soils,vegetables and paddy rice were investigated,and potential non-carcinogenic and carcinogenic health risks exposure to Cd were estimated at six villages around the Dabaoshan Mine,South China.A total of 87 soil samples were found to exceed the China's maximum permission level(MPL)for Cd,while the highest value of 4.42 mg/kg was found near irrigation ditch associated with Hengshi River in Xinyi(XY)Village.Cd contents in vegetables and rice exceeded the maximum permissible concentration by more than five times in every village.Cadmium accumulation in plants is in the order of celery>lactuca sativa L>Chinese cabbage>Romaine lettuce>asparagus lettuce>mustard>cabbage mustard>cabbage.The mean hazard quotient(HQ)of all villages is in the range of [5.29,25.75],and the mean values of cancer risk for investigated areas are more than 10 times greater than the USEPA(2009)threshold limit value of 10-4.Moreover,human non-carcinogenic and carcinogenic risks are mainly attributable to paddy rice intake,followed by vegetables intake,soil ingestion,inhalation,and dermal contact.The results indicate that Cd has a huge potential risk on human health for the local residents.
文摘Growing evidence indicates that cancer incidence across the world is not similar,and it is more prevalent in certain populations than others,suggesting the critical role for dietary and lifestyle factors.For instance cancer incidence among people from the Indian subcontinent,where most spices are consumed,is much lower than that in the Western World.Spices have been consumed for centuries for a variety of purposes e.g.as flavoring agents,colorants,and preservatives.However,there is increasing evidence for the importance of plant-based foods in regular diet to lowering the risk of most chronic diseases,so spices are now emerging as more than just flavor aids,but as agents that can not only prevent but may even treat disease.Besides suppressing inflammatory pathways,spice-derived nutraceuticals can suppress survival,proliferation,invasion,and angiogenesis of tumor cells.Increasing evidence indicates that genetic alterations are relatively rare,and epigenetic changes(DNA methylation,histone modifications and expression of noncoding RNAs)plays a bigger role in human cancer,and can be easily influenced by environmental,lifestyle and dietary factors,and some estimates suggest that over two-thirds of the cancer incidence can be accounted for by the environmental and dietary factors alone.Among all these factors,diet is probably the single most important factor which may influence carcinogenesis more comprehensively,because diet is readily modifiable and have the potential to modulate multiple epigenetic processes.Polyphenols in dietary botanicals represent a versatile group of phytochemicals with many potentially beneficial activities in terms of disease prevention.Dietary polyphenols(bioflavanoids)have antioxidant and anti-inflammatory properties that might explain their chemopreventive effects.However,the actual therapeutic potential of these compounds may not have been completely realized due to lack of understanding on the effects of these agents on epigenetic modifications.Recent,but limited evidence indicates that some of the polyphenols,including curcumin(from turmeric),genestein(from soy),EGCG(from green tea),diallyl disulfide(from garlic),sulforaphane(from broccoli)and resveratrol(from grapes)may induce epigenetic changes in various cancer cell lines.This presentation will describe some of the current scientific evidence for the role of epigenetic alterations induced by curcumin and boswellia,in support of their anti-cancer activities,which provides a strong scientific foundation for preclinical and human clinical intervention studies in future.
文摘Lycium barbarum is a traditional Chinese medicinal plant that has been widely used as a functional food and dietary supplement.Lycium barbarum polysaccharide(LBP)is an important active substance found in Lycium barbarum[1].It has been recorded in the“Ben Cao Gang Mu(Compendium of Materia Medica)”to have anti-aging and skin whitening effects.Previous studies have focused on its antioxidant properties to explain its efficacy[2].
