Background Adverse childhood experiences have a significant impact on different mental disorders.Objective To compare differences in adverse childhood experiences among those with different mental disorders and their ...Background Adverse childhood experiences have a significant impact on different mental disorders.Objective To compare differences in adverse childhood experiences among those with different mental disorders and their relationships in a cross-disorder manner.Methods The study included 1513 individuals aged≥18 years:339 patients with substance use disorders,125 patients with schizophrenia,342 patients with depression,136 patients with bipolar disorder,431 patients with obsessive-compulsive disorder(OCD),and 140 healthy controls.The Early Trauma Inventory Self Report-Short Form was used to investigate childhood traumatic experiences,and the Addiction Severity Index,Positive and Negative Syndrome Scale,Hamilton Depression Scale,Young Mania Rating Scale,and Yale-Brown Obsessive-Compulsive Scale were used to assess mental disorder severity.Correlation and multivariate logistic regression were analysed between adverse childhood experiences and clinical features.Results Levels of adverse childhood experiences were significantly different among different mental disorders.Moreover,25.8%of patients with substance use disorders reported childhood trauma,which was significantly higher than found in the other four psychiatric disorder groups.Emotional abuse scores were positively correlated with disease severity:the higher the total trauma score,the more severe the mental disorder.Conclusions Adverse childhood experiences are a common phenomenon in those with mental disorders,and the level of trauma affects mental disorder severity.Emotional abuse is closely related to many mental disorders.The incidence or severity of mental disorders can be reduced in the future by reducing the incidence of adverse childhood experiences or by timely intervention in childhood trauma.展开更多
INTRODUCTION Worldwide, cancer is an important cause of mortality in children aged over 1 year. Numerically, the major cancers include acute lymphoblastic leukemia, CNS tumors and lymphomas. Cancer incidence is increa...INTRODUCTION Worldwide, cancer is an important cause of mortality in children aged over 1 year. Numerically, the major cancers include acute lymphoblastic leukemia, CNS tumors and lymphomas. Cancer incidence is increasing in children globally as well as in Pakistan but the etiology is poorly understood. There are an estimated 160 000 new cases and 90 000 deaths per year worldwide in children aged under 15 years.The exact incidence in Pakistan is not known as there is no national tumor registry展开更多
Background:Childhood cardiovascular risk factors predict subclinical adult cardiovascular disease,but links to clinical events are unclear.Methods:In a prospective cohort study involving participants in the Internatio...Background:Childhood cardiovascular risk factors predict subclinical adult cardiovascular disease,but links to clinical events are unclear.Methods:In a prospective cohort study involving participants in the International Childhood Cardiovascular Cohorts(i3C)Consortium,we evaluated whether childhood risk factors(at the ages of 3 to 19 years)were associated with cardiovascular events in adulthood after a mean follow-up of 35 years.Body-mass index,systolic blood pressure.展开更多
Alternating hemiplegia of childhood is a rare neurodevelopmental disorder.Most cases are reported as sporadic disorder due to de novo variants,and few with family members involved.Two boys were hospitalized due to epi...Alternating hemiplegia of childhood is a rare neurodevelopmental disorder.Most cases are reported as sporadic disorder due to de novo variants,and few with family members involved.Two boys were hospitalized due to epileptic seizures occurred initially at age of six to seven months.During the course of the disease,there were repeated episodes of paroxysmal weakness or paralysis affecting one side of the body.Genetic testing showed that both patients carried heterozygous missense mutations in the ATP1A3 gene(OMIM:614820):c.3025(exon 22)A>G(p.K1009E)and c.2443(exon 18)G>A(p.E815K).Flunarizine can significantly improve the paroxysmal motor symptoms of pediatric patients with alternating hemiplegia.展开更多
Since childhood,William Wordsworth and John Ruskin have developed a very natural love for landscape and scenery.Although they have different ways to interpret what they see and how they feel,they both stick to their g...Since childhood,William Wordsworth and John Ruskin have developed a very natural love for landscape and scenery.Although they have different ways to interpret what they see and how they feel,they both stick to their genuine feelings without pre⁃tension in their poems.Those unpretentious feelings and behaviors,which are crucial to their later development to be remarkable artists,come from their original habit and attitude towards Nature as a child.All their life,they preserved this innocence in their work as a memory of childhood.展开更多
My childhood has gone and will never come back. Yet I still cannot forget those happy days of my childhood. I was brought up by my grandmother. She loved me very much. Every night, I sat by her after supper and listen...My childhood has gone and will never come back. Yet I still cannot forget those happy days of my childhood. I was brought up by my grandmother. She loved me very much. Every night, I sat by her after supper and listened to her fascinating stories. How I liked those tales! They always brought me to a different world.When I fell sick and had to be in bed, my grandmother took good care of me and made all kinds of delicious food for me.展开更多
Background:Childhood cardiovascular risk factors predict subclinical adult cardiovascular disease,but links to clinical events are unclear.Methods:In a prospective cohort study involving participants in the Internatio...Background:Childhood cardiovascular risk factors predict subclinical adult cardiovascular disease,but links to clinical events are unclear.Methods:In a prospective cohort study involving participants in the International Childhood Cardiovascular Cohorts(i3C)Consortium,we evaluated whether childhood risk factors(at the ages of 3 to 19 years)were associated with cardiovascular events in adulthood after a mean follow-up of 35 years.展开更多
文摘Background Adverse childhood experiences have a significant impact on different mental disorders.Objective To compare differences in adverse childhood experiences among those with different mental disorders and their relationships in a cross-disorder manner.Methods The study included 1513 individuals aged≥18 years:339 patients with substance use disorders,125 patients with schizophrenia,342 patients with depression,136 patients with bipolar disorder,431 patients with obsessive-compulsive disorder(OCD),and 140 healthy controls.The Early Trauma Inventory Self Report-Short Form was used to investigate childhood traumatic experiences,and the Addiction Severity Index,Positive and Negative Syndrome Scale,Hamilton Depression Scale,Young Mania Rating Scale,and Yale-Brown Obsessive-Compulsive Scale were used to assess mental disorder severity.Correlation and multivariate logistic regression were analysed between adverse childhood experiences and clinical features.Results Levels of adverse childhood experiences were significantly different among different mental disorders.Moreover,25.8%of patients with substance use disorders reported childhood trauma,which was significantly higher than found in the other four psychiatric disorder groups.Emotional abuse scores were positively correlated with disease severity:the higher the total trauma score,the more severe the mental disorder.Conclusions Adverse childhood experiences are a common phenomenon in those with mental disorders,and the level of trauma affects mental disorder severity.Emotional abuse is closely related to many mental disorders.The incidence or severity of mental disorders can be reduced in the future by reducing the incidence of adverse childhood experiences or by timely intervention in childhood trauma.
文摘INTRODUCTION Worldwide, cancer is an important cause of mortality in children aged over 1 year. Numerically, the major cancers include acute lymphoblastic leukemia, CNS tumors and lymphomas. Cancer incidence is increasing in children globally as well as in Pakistan but the etiology is poorly understood. There are an estimated 160 000 new cases and 90 000 deaths per year worldwide in children aged under 15 years.The exact incidence in Pakistan is not known as there is no national tumor registry
文摘Background:Childhood cardiovascular risk factors predict subclinical adult cardiovascular disease,but links to clinical events are unclear.Methods:In a prospective cohort study involving participants in the International Childhood Cardiovascular Cohorts(i3C)Consortium,we evaluated whether childhood risk factors(at the ages of 3 to 19 years)were associated with cardiovascular events in adulthood after a mean follow-up of 35 years.Body-mass index,systolic blood pressure.
基金Research Fund of Anhui Medical University(Grant Number:2019xkj176).
文摘Alternating hemiplegia of childhood is a rare neurodevelopmental disorder.Most cases are reported as sporadic disorder due to de novo variants,and few with family members involved.Two boys were hospitalized due to epileptic seizures occurred initially at age of six to seven months.During the course of the disease,there were repeated episodes of paroxysmal weakness or paralysis affecting one side of the body.Genetic testing showed that both patients carried heterozygous missense mutations in the ATP1A3 gene(OMIM:614820):c.3025(exon 22)A>G(p.K1009E)and c.2443(exon 18)G>A(p.E815K).Flunarizine can significantly improve the paroxysmal motor symptoms of pediatric patients with alternating hemiplegia.
文摘Since childhood,William Wordsworth and John Ruskin have developed a very natural love for landscape and scenery.Although they have different ways to interpret what they see and how they feel,they both stick to their genuine feelings without pre⁃tension in their poems.Those unpretentious feelings and behaviors,which are crucial to their later development to be remarkable artists,come from their original habit and attitude towards Nature as a child.All their life,they preserved this innocence in their work as a memory of childhood.
文摘My childhood has gone and will never come back. Yet I still cannot forget those happy days of my childhood. I was brought up by my grandmother. She loved me very much. Every night, I sat by her after supper and listened to her fascinating stories. How I liked those tales! They always brought me to a different world.When I fell sick and had to be in bed, my grandmother took good care of me and made all kinds of delicious food for me.
文摘Background:Childhood cardiovascular risk factors predict subclinical adult cardiovascular disease,but links to clinical events are unclear.Methods:In a prospective cohort study involving participants in the International Childhood Cardiovascular Cohorts(i3C)Consortium,we evaluated whether childhood risk factors(at the ages of 3 to 19 years)were associated with cardiovascular events in adulthood after a mean follow-up of 35 years.
