Calcitonin receptor-like receptor(CRLR)is a human protein,that produces a calcitonin gene-related peptide receptor(CGRP)when associates with human receptor activity-modifying protein-1(HRAMP1).CGRP is believed to be i...Calcitonin receptor-like receptor(CRLR)is a human protein,that produces a calcitonin gene-related peptide receptor(CGRP)when associates with human receptor activity-modifying protein-1(HRAMP1).CGRP is believed to be involved in triggering of migraine.Many strategies were employed to design antimigraine drug using various CGRP antagonist/ligands but most of them have failed due to their inability to reach the target“CGRP receptor”as they get metabolized before conferring their pharmacological action and exhibit toxic effect to the liver.The present study,evaluated the binding of 13 phyto-chemical compounds of“Abrus precatorius”identified through GCMS analysis against the protein CGRP using“Discovery Studio software”.The molecular docking study and ADME/T properties prediction were performed with the compounds using C-DOCKER module.The results showed that five lead compounds of A.precatorius may act as good inhibitors for migraine headache and the compounds can be re-designed and synthesized for better antimigraine activity.展开更多
The study describes the scope of clonal propagation of guava (Psidium guajava Linn.) by stem cutting collected from mature stockplants. Cuttings were treated with 0, 0.2%, 0.4% and 0.8% IBA solution and rooted in the ...The study describes the scope of clonal propagation of guava (Psidium guajava Linn.) by stem cutting collected from mature stockplants. Cuttings were treated with 0, 0.2%, 0.4% and 0.8% IBA solution and rooted in the non-mist propagator. Rooted cuttings were allowed to grow in the polybags filled with soil and cow-dung mixed in the ratio of 3: 1 (by volume) for three months to assess the steckling capacity and initial growth performance. The study reveals that the species is amenable for clonal propagation by mature stem cutting. The highest rooting percentage (60%) was observed in the cuttings treated with 0.4% IBA solution followed by 0.2% IBA and the lowest was in controlled cuttings. The maximum number of primary root (32.7) was developed in the cuttings treated with 0.8% IBA solution followed by 0.4% IBA and the lowest was in the cuttings without IBA treatment. The highest survival percentage (70.9) was observed in the cuttings rooted with 0.4% IBA treatment and the lowest (58.3) was in the cuttings without any treatment. However, there was no significant variation in height growth of cutlings due to IBA treatments in rooting.展开更多
文摘Calcitonin receptor-like receptor(CRLR)is a human protein,that produces a calcitonin gene-related peptide receptor(CGRP)when associates with human receptor activity-modifying protein-1(HRAMP1).CGRP is believed to be involved in triggering of migraine.Many strategies were employed to design antimigraine drug using various CGRP antagonist/ligands but most of them have failed due to their inability to reach the target“CGRP receptor”as they get metabolized before conferring their pharmacological action and exhibit toxic effect to the liver.The present study,evaluated the binding of 13 phyto-chemical compounds of“Abrus precatorius”identified through GCMS analysis against the protein CGRP using“Discovery Studio software”.The molecular docking study and ADME/T properties prediction were performed with the compounds using C-DOCKER module.The results showed that five lead compounds of A.precatorius may act as good inhibitors for migraine headache and the compounds can be re-designed and synthesized for better antimigraine activity.
文摘The study describes the scope of clonal propagation of guava (Psidium guajava Linn.) by stem cutting collected from mature stockplants. Cuttings were treated with 0, 0.2%, 0.4% and 0.8% IBA solution and rooted in the non-mist propagator. Rooted cuttings were allowed to grow in the polybags filled with soil and cow-dung mixed in the ratio of 3: 1 (by volume) for three months to assess the steckling capacity and initial growth performance. The study reveals that the species is amenable for clonal propagation by mature stem cutting. The highest rooting percentage (60%) was observed in the cuttings treated with 0.4% IBA solution followed by 0.2% IBA and the lowest was in controlled cuttings. The maximum number of primary root (32.7) was developed in the cuttings treated with 0.8% IBA solution followed by 0.4% IBA and the lowest was in the cuttings without IBA treatment. The highest survival percentage (70.9) was observed in the cuttings rooted with 0.4% IBA treatment and the lowest (58.3) was in the cuttings without any treatment. However, there was no significant variation in height growth of cutlings due to IBA treatments in rooting.
