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Glycyrrhiza Flavonoids Promote Osteoblast Proliferation and Differentiation by Activating Runx2 via the PI3K/AKT Signaling Pathway
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作者 CHU Hongdan LIANG Zheng +4 位作者 XU Jingru WANG Zhenhua LI Gang GAN Jing XU Bo 《食品科学》 北大核心 2025年第20期188-198,共11页
In order to clarify the mechanism of action of licorice flavonoids in alleviating bone loss caused by osteoporosis,this study compared the effects of four glycyrrhiza flavonoids,naringenin,liquiritigenin,isoliquiritig... In order to clarify the mechanism of action of licorice flavonoids in alleviating bone loss caused by osteoporosis,this study compared the effects of four glycyrrhiza flavonoids,naringenin,liquiritigenin,isoliquiritigenin,and licochalcone A,on osteogenic differentiation and mineralization by molecular docking simulation,alkaline phosphatase(ALP)activity and osteocalcin(OCN)content assays,and Runt-related transcription factor 2(Runx2)expression,and explored their potential molecular mechanisms.The results of molecular docking showed that the docking score of liquiritigenin with the estrogen receptor(ER)was the highest.All four flavonoids up-regulated ALP activity and OCN concentration in MC3T3-E1 cells,thereby elevating the mineralization level,among which liquiritigenin was the most effective.Moreover,treatment with a phosphatidylinositol-3-kinase(PI3K)inhibitor(LY294002)inhibited liquiritigenin from inducing increased phosphorylation levels in the PI3K/protein kinase B(AKT)signaling pathway and up-regulation of Runx2 expression,suggesting that PI3K and AKT were involved in osteogenic action.Liquiritigenin reversed bone mineral density loss in a zebrafish osteoporosis model.These findings suggest that liquiritigenin has the most significant osteogenic effect among the four estrogen-like flavonoids,stimulating osteoblast differentiation and bone mineralization through the activation of Runx2 via the PI3K/AKT signaling pathways.In conclusion,this study highlights the great potential of liquiritigenin for preventing and treating osteoporosis. 展开更多
关键词 MC3T3-E1 cells LIQUIRITIGENIN OSTEOGENESIS phosphatidylinositol-3-kinase/protein kinase B signaling pathway zebrafish
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Low-frequency signal generation in space based on high-frequency electric-antenna array and Doppler effect
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作者 CUI Anjing LI Daojing +6 位作者 WU Jiang GAO Jinghan ZHOU Kai HU Chufeng WU Shumei SHI Danni LI Guang 《Journal of Systems Engineering and Electronics》 2025年第1期24-36,共13页
Low-frequency signals have been proven valuable in the fields of target detection and geological exploration.Nevertheless,the practical implementation of these signals is hindered by large antenna diameters,limiting t... Low-frequency signals have been proven valuable in the fields of target detection and geological exploration.Nevertheless,the practical implementation of these signals is hindered by large antenna diameters,limiting their potential applications.Therefore,it is imperative to study the creation of lowfrequency signals using antennas with suitable dimensions.In contrast to conventional mechanical antenna techniques,our study generates low-frequency signals in the spatial domain utilizing the principle of the Doppler effect.We also defines the antenna array architecture,the timing sequency,and the radiating element signal waveform,and provides experimental prototypes including 8/64 antennas based on earlier research.In the conducted experiments,121 MHz,40 MHz,and 10 kHz composite signals are generated by 156 MHz radiating element signals.The composite signal spectrum matches the simulations,proving our low-frequency signal generating method works.This holds significant implications for research on generating low-frequency signals with small-sized antennas. 展开更多
关键词 frequency conversion array signal processing experimental verification Doppler effect
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Modulated-unlimited sampling scheme and large dynamic range single carrier signals receiving in ultra-wideband frequency space
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作者 Zhaoyang Qiu Pei Wang Chenpu Li 《Defence Technology(防务技术)》 2025年第9期234-245,共12页
Large dynamic range and ultra-wideband receiving abilities are significant for many receivers. With these abilities, receivers can obtain signals with different power in ultra-wideband frequency space without informat... Large dynamic range and ultra-wideband receiving abilities are significant for many receivers. With these abilities, receivers can obtain signals with different power in ultra-wideband frequency space without information loss. However, conventional receiving scheme is hard to have large dynamic range and ultra-wideband receiving simultaneously because of the analog-to-digital converter(ADC) dynamic range and sample rate limitations. In this paper, based on the modulated sampling and unlimited sampling, a novel receiving scheme is proposed to achieve large dynamic range and ultra-wideband receiving. Focusing on the single carrier signals, the proposed scheme only uses a single self-rest ADC(SR-ADC) with low sample rate, and it achieves large dynamic range and ultra-wideband receiving simultaneously. Two receiving scenarios are considered, and they are cooperative strong signal receiving and non-cooperative strong/weak signals receiving. In the cooperative receiving scenario, an improved fast recovery method is proposed to obtain the modulated sampling output. In the non-cooperative receiving scenario, the strong and weak signals with different carrier frequencies are considered, and the signal processing method can recover and estimate each signal. Simulation results show that the proposed scheme can realize large dynamic range and ultra-wideband receiving simultaneously when the input signal-to-noise(SNR) ratio is high. 展开更多
关键词 Modulated-unlimited sampling Ultra-wideband receiving Large dynamic range signal recovery Parameter estimation
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Direction finding for wideband signal and multi-target with interferometer
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作者 PENG Bo SUN Jikang LI Chao 《Journal of Systems Engineering and Electronics》 2025年第5期1132-1139,共8页
According to the measurement principle of the traditional interferometer,a narrowband signal model is established and used,however,for wideband signals or multiple signals,this model is invalid.For the problems of dir... According to the measurement principle of the traditional interferometer,a narrowband signal model is established and used,however,for wideband signals or multiple signals,this model is invalid.For the problems of direction finding with interferometer for wideband signals and multiple signals scene,a frequency domain phase interferometer is proposed and the concrete implementation scheme is given.The proposed method computes the phase difference in frequency domain,and finds multi-target results with judging the spectrum amplitude changing,and uses the frequency phase difference to compute the arrival angle.Theoretical analysis and simulation results show that the proposed method effectively solves the problem of the angle estimation with phase interferometer for wideband signals,and has good performance in multiple signals scene with nonoverlapping spectrum or partially overlapping.In addition,the wider the signal bandwidth,the better direction finding performance of this algorithm. 展开更多
关键词 phase interferometer wideband signal direction finding multi-signal direction finding frequency domain interferometer
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A method of line spectrum extraction based on target radiated spectrum feature and its post-processing 被引量:2
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作者 DAI Wenshu ZHENG Enming BAO Kaikai 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2021年第6期1381-1393,共13页
To improve the ability of detecting underwater targets under strong wideband interference environment,an efficient method of line spectrum extraction is proposed,which fully utilizes the feature of the target spectrum... To improve the ability of detecting underwater targets under strong wideband interference environment,an efficient method of line spectrum extraction is proposed,which fully utilizes the feature of the target spectrum that the high intense and stable line spectrum is superimposed on the wide continuous spectrum.This method modifies the traditional beam forming algorithm by calculating and fusing the beam forming results at multi-frequency band and multi-azimuth interval,showing an excellent way to extract the line spectrum when the interference and the target are not in the same azimuth interval simultaneously.Statistical efficiency of the estimated azimuth variance and corresponding power of the line spectrum band depends on the line spectra ratio(LSR)of the line spectrum.The change laws of the output signal to noise ratio(SNR)with the LSR,the input SNR,the integration time and the filtering bandwidth of different algorithms bring the selection principle of the critical LSR.As the basis,the detection gain of wideband energy integration and the narrowband line spectrum algorithm are theoretically analyzed.The simulation detection gain demonstrates a good match with the theoretical model.The application conditions of all methods are verified by the receiver operating characteristic(ROC)curve and experimental data from Qiandao Lake.In fact,combining the two methods for target detection reduces the missed detection rate.The proposed post-processing method in2-dimension with the Kalman filter in the time dimension and the background equalization algorithm in the azimuth dimension makes use of the strong correlation between adjacent frames,could further remove background fluctuation and improve the display effect. 展开更多
关键词 towed linear array sonar target radiated noise spectrum line spectra level ratio(LSR) receiver operating characteristic(ROC)curve post-processing
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Downregulation of MUC1 Inhibits Proliferation and Promotes Apoptosis by Inactivating NF-κB Signaling Pathway in Human Nasopharyngeal Carcinoma 被引量:1
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作者 WU Shou-Wu LIN Shao-Kun +11 位作者 NIAN Zhong-Zhu WANG Xin-Wen LIN Wei-Nian ZHUANG Li-Ming WU Zhi-Sheng HUANG Zhi-Wei WANG A-Min GAO Ni-Li CHEN Jia-Wen YUAN Wen-Ting LU Kai-Xian LIAO Jun 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2024年第9期2182-2193,共12页
Objective To investigate the effect of mucin 1(MUC1)on the proliferation and apoptosis of nasopharyngeal carcinoma(NPC)and its regulatory mechanism.Methods The 60 NPC and paired para-cancer normal tissues were collect... Objective To investigate the effect of mucin 1(MUC1)on the proliferation and apoptosis of nasopharyngeal carcinoma(NPC)and its regulatory mechanism.Methods The 60 NPC and paired para-cancer normal tissues were collected from October 2020 to July 2021 in Quanzhou First Hospital.The expression of MUC1 was measured by real-time quantitative PCR(qPCR)in the patients with PNC.The 5-8F and HNE1 cells were transfected with siRNA control(si-control)or siRNA targeting MUC1(si-MUC1).Cell proliferation was analyzed by cell counting kit-8 and colony formation assay,and apoptosis was analyzed by flow cytometry analysis in the 5-8F and HNE1 cells.The qPCR and ELISA were executed to analyze the levels of TNF-αand IL-6.Western blot was performed to measure the expression of MUC1,NFкB and apoptosis-related proteins(Bax and Bcl-2).Results The expression of MUC1 was up-regulated in the NPC tissues,and NPC patients with the high MUC1 expression were inclined to EBV infection,growth and metastasis of NPC.Loss of MUC1 restrained malignant features,including the proliferation and apoptosis,downregulated the expression of p-IкB、p-P65 and Bcl-2 and upregulated the expression of Bax in the NPC cells.Conclusion Downregulation of MUC1 restrained biological characteristics of malignancy,including cell proliferation and apoptosis,by inactivating NF-κB signaling pathway in NPC. 展开更多
关键词 mucin 1 nasopharyngeal carcinoma NF-κB signaling pathway PROLIFERATION APOPTOSIS
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Detection method of forward-scatter signal based on Rényi entropy 被引量:2
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作者 ZHENG Yuqing AI Xiaofeng +2 位作者 YANG Yong ZHAO Feng XIAO Shunping 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第4期865-873,共9页
The application scope of the forward scatter radar(FSR)based on the Global Navigation Satellite System(GNSS)can be expanded by improving the detection capability.Firstly,the forward-scatter signal model when the targe... The application scope of the forward scatter radar(FSR)based on the Global Navigation Satellite System(GNSS)can be expanded by improving the detection capability.Firstly,the forward-scatter signal model when the target crosses the baseline is constructed.Then,the detection method of the for-ward-scatter signal based on the Rényi entropy of time-fre-quency distribution is proposed and the detection performance with different time-frequency distributions is compared.Simula-tion results show that the method based on the smooth pseudo Wigner-Ville distribution(SPWVD)can achieve the best perfor-mance.Next,combined with the geometry of FSR,the influence on detection performance of the relative distance between the target and the baseline is analyzed.Finally,the proposed method is validated by the anechoic chamber measurements and the results show that the detection ability has a 10 dB improvement compared with the common constant false alarm rate(CFAR)detection. 展开更多
关键词 forward scatter radar(FSR) Global Navigation Satellite System(GNSS) time-frequency distribution Rényi entropy signal detection
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Special Section on High-Dimensional Signal Processing
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《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第3期F0002-F0002,共1页
Massive amounts of data are acquired in modern and future information technology industries such as communication,radar,and remote sensing.The presence of large dimensionality and size in these data offers new opportu... Massive amounts of data are acquired in modern and future information technology industries such as communication,radar,and remote sensing.The presence of large dimensionality and size in these data offers new opportunities to enhance the performance of signal processing in such applications and even motivate new ones.However,the curse of dimensionality is always a challenge when processing such high-dimensional signals.In practical tasks,high-dimensional signals need to be acquired,processed,and analyzed with high accuracy,robustness,and computational efficiency.This special section aims to address these challenges,where articles attempt to develop new theories and methods that are best suited to the high dimensional nature of the signals involved,and explore modern and emerging applications in this area. 展开更多
关键词 signal MASSIVE dimensionality
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The in-depth transmission and reception process of the factors influencing review helpfulness from the signaling timeline perspective
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作者 Mohan Wang Fei Wan +1 位作者 Jiaying Zhang Songyun Xia 《中国科学技术大学学报》 CSCD 北大核心 2024年第10期35-50,I0006,I0007,共18页
Many existing studies have considered the factors influencing review helpfulness,mainly focusing on reviewer impact,review informativeness,and managerial response,based on signaling theory.However,previous studies hav... Many existing studies have considered the factors influencing review helpfulness,mainly focusing on reviewer impact,review informativeness,and managerial response,based on signaling theory.However,previous studies have simply regarded these factors as independent signals,thus ignoring their in-depth transmission and reception processes.The conclusions about the impact of reviewers on review helpfulness are also inconsistent due to the inaccurate measure-ment of variables.To fill the above gaps,we followed the signaling timeline theoretical framework used in signaling the-ory and employed a bootstrapping analysis to examine how reviewer impact,review informativeness,and hotel manageri-al responses interact to influence review helpfulness.In this study,we used a unique dataset that included official labels from one leading online travel agency.The results show that reviewer impact may affect review helpfulness sequentially through review informativeness and hotel managerial response.Furthermore,by using official labels,both reviewer expert-ise and reviewer experience significantly affect review helpfulness.Finally,we discussed the theoretical and practical im-plications of these findings. 展开更多
关键词 signaling timeline review helpfulness reviewer impact review informativeness managerial response
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Automatic modulation recognition of radiation source signals based on two-dimensional data matrix and improved residual neural network
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作者 Guanghua Yi Xinhong Hao +3 位作者 Xiaopeng Yan Jian Dai Yangtian Liu Yanwen Han 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第3期364-373,共10页
Automatic modulation recognition(AMR)of radiation source signals is a research focus in the field of cognitive radio.However,the AMR of radiation source signals at low SNRs still faces a great challenge.Therefore,the ... Automatic modulation recognition(AMR)of radiation source signals is a research focus in the field of cognitive radio.However,the AMR of radiation source signals at low SNRs still faces a great challenge.Therefore,the AMR method of radiation source signals based on two-dimensional data matrix and improved residual neural network is proposed in this paper.First,the time series of the radiation source signals are reconstructed into two-dimensional data matrix,which greatly simplifies the signal preprocessing process.Second,the depthwise convolution and large-size convolutional kernels based residual neural network(DLRNet)is proposed to improve the feature extraction capability of the AMR model.Finally,the model performs feature extraction and classification on the two-dimensional data matrix to obtain the recognition vector that represents the signal modulation type.Theoretical analysis and simulation results show that the AMR method based on two-dimensional data matrix and improved residual network can significantly improve the accuracy of the AMR method.The recognition accuracy of the proposed method maintains a high level greater than 90% even at -14 dB SNR. 展开更多
关键词 Automatic modulation recognition Radiation source signals Two-dimensional data matrix Residual neural network Depthwise convolution
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Impact of correlated private signals on continuous-time insider trading
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作者 ZHOU Yonghui XIAO Kai 《运筹学学报(中英文)》 CSCD 北大核心 2024年第3期97-107,共11页
A model of continuous-time insider trading in which a risk-neutral in-sider possesses two imperfect correlated signals of a risky asset is studied.By conditional expectation theory and filtering theory,we first establ... A model of continuous-time insider trading in which a risk-neutral in-sider possesses two imperfect correlated signals of a risky asset is studied.By conditional expectation theory and filtering theory,we first establish three lemmas:normal corre-lation,equivalent pricing and equivalent profit,which can guarantee to turn our model into a model with insider knowing full information.Then we investigate the impact of the two correlated signals on the market equilibrium consisting of optimal insider trading strategy and semi-strong pricing rule.It shows that in the equilibrium,(1)the market depth is constant over time;(2)if the two noisy signals are not linerly correlated,then all private information of the insider is incorporated into prices in the end while the whole information on the asset value can not incorporated into prices in the end;(3)if the two noisy signals are linear correlated such that the insider can infer the whole information of the asset value,then our model turns into a model with insider knowing full information;(4)if the two noisy signals are the same then the total ex ant profit of the insider is increasing with the noise decreasing,while down to O as the noise going up to infinity;(5)if the two noisy signals are not linear correlated then with one noisy signal fixed,the total ex ante profit of the insider is single-peaked with a unique minimum with respect to the other noisy signal value,and furthermore as the noisy value going to O it gets its maximum,the profit in the case that the real value is observed. 展开更多
关键词 continuous-time insider trading risk neutral private correlated signals linear bayesian equilibrium market depth residual information
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Low-complexity signal detection for massive MIMO systems via trace iterative method
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作者 IMRAN A.Khoso ZHANG Xiaofei +2 位作者 ABDUL Hayee Shaikh IHSAN A.Khoso ZAHEER Ahmed Dayo 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第3期549-557,共9页
Linear minimum mean square error(MMSE)detection has been shown to achieve near-optimal performance for massive multiple-input multiple-output(MIMO)systems but inevitably involves complicated matrix inversion,which ent... Linear minimum mean square error(MMSE)detection has been shown to achieve near-optimal performance for massive multiple-input multiple-output(MIMO)systems but inevitably involves complicated matrix inversion,which entails high complexity.To avoid the exact matrix inversion,a considerable number of implicit and explicit approximate matrix inversion based detection methods is proposed.By combining the advantages of both the explicit and the implicit matrix inversion,this paper introduces a new low-complexity signal detection algorithm.Firstly,the relationship between implicit and explicit techniques is analyzed.Then,an enhanced Newton iteration method is introduced to realize an approximate MMSE detection for massive MIMO uplink systems.The proposed improved Newton iteration significantly reduces the complexity of conventional Newton iteration.However,its complexity is still high for higher iterations.Thus,it is applied only for first two iterations.For subsequent iterations,we propose a novel trace iterative method(TIM)based low-complexity algorithm,which has significantly lower complexity than higher Newton iterations.Convergence guarantees of the proposed detector are also provided.Numerical simulations verify that the proposed detector exhibits significant performance enhancement over recently reported iterative detectors and achieves close-to-MMSE performance while retaining the low-complexity advantage for systems with hundreds of antennas. 展开更多
关键词 signal detection LOW-COMPLEXITY linear minimum mean square error(MMSE) massive multiple-input multiple-output(MIMO) trace iterative method(TIM)
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Blind radar signal separation algorithm based on third-order degree of cyclostationarity criteria
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作者 FAN Xiangyu LIU Bin +2 位作者 DONG Danna CHEN You WANG Yuancheng 《Journal of Systems Engineering and Electronics》 CSCD 2024年第6期1441-1453,共13页
Separation and recognition of radar signals is the key function of modern radar reconnaissance,which is of great sig-nificance for electronic countermeasures and anti-countermea-sures.In order to improve the ability o... Separation and recognition of radar signals is the key function of modern radar reconnaissance,which is of great sig-nificance for electronic countermeasures and anti-countermea-sures.In order to improve the ability of separating mixed signals in complex electromagnetic environment,a blind source separa-tion algorithm based on degree of cyclostationarity(DCS)crite-rion is constructed in this paper.Firstly,the DCS criterion is con-structed by using the cyclic spectrum theory.Then the algo-rithm flow of blind source separation is designed based on DCS criterion.At the same time,Givens matrix is constructed to make the blind source separation algorithm suitable for multiple sig-nals with different cyclostationary frequencies.The feasibility of this method is further proved.The theoretical and simulation results show that the algorithm can effectively separate and re-cognize common multi-radar signals. 展开更多
关键词 blind signal separation cyclostationary frequency Givens matrix degree of cyclostationarity(DCS)blind source separation algorithm
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基于国产DSP和FPGA的高速信号处理板硬件电路设计 被引量:2
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作者 孙艳萍 边晨通 +1 位作者 屈文涛 宋淑军 《仪表技术与传感器》 北大核心 2025年第5期33-38,共6页
针对目前高速信号处理板多选用国外芯片,国产化程度较低的问题,文中基于DSP和FPGA芯片完成了高速信号处理板国产化设计。首先考虑高速信号处理板应用于人工智能、图像处理等领域,是一种高精度和复杂运算的场景,因此选择DSP芯片FTDOC35BB... 针对目前高速信号处理板多选用国外芯片,国产化程度较低的问题,文中基于DSP和FPGA芯片完成了高速信号处理板国产化设计。首先考虑高速信号处理板应用于人工智能、图像处理等领域,是一种高精度和复杂运算的场景,因此选择DSP芯片FTDOC35BB_FT_M6678为主设计信号处理模块,选择FPGA芯片FMQL45T900为主设计控制单元模块;然后在CANDENCE软件中进一步采用分布式设计硬件电路,完成了高速信号接口模块、DDR3存储模块、EMIF模块的电路设计;最后使用CCS5.5集成开发环境对高速信号处理板各个接口及外设进行了测试。测试指标均达到要求,证明该高速信号处理板国产化设计切实可行,加速了高速信号处理板的国产化进程。 展开更多
关键词 国产化 FPGA DSP 高速信号
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基于Nrf2/HO-1和NF-κB信号通路探讨清化止泻方对腹泻型肠易激综合征大鼠巨噬细胞极化的影响 被引量:2
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作者 黄华 王永通 +2 位作者 丁旭枫 蒋捷 季利江 《中成药》 北大核心 2025年第2期438-445,共8页
目的探讨清化止泻方对腹泻型肠易激综合征(IBS-D)大鼠的改善作用及其对M1/M2型巨噬细胞极化的影响。方法SD大鼠随机分为空白组、模型组、匹维溴铵组(20 mg/kg)和清化止泻方低、高剂量组(13.64、27.29 g/kg),每组10只,采用慢性束缚应激... 目的探讨清化止泻方对腹泻型肠易激综合征(IBS-D)大鼠的改善作用及其对M1/M2型巨噬细胞极化的影响。方法SD大鼠随机分为空白组、模型组、匹维溴铵组(20 mg/kg)和清化止泻方低、高剂量组(13.64、27.29 g/kg),每组10只,采用慢性束缚应激加番泻叶水煎剂灌胃法构建IBS-D大鼠模型,各组给予相应剂量药物14 d。观察各组大鼠进食状况、粪便性状和体质量变化;腹部撤离反射(AWR)测定大鼠肠疼痛敏感性;HE染色观察结肠黏膜组织病理学;TUNEL染色观察结肠组织细胞凋亡情况;免疫荧光染色检测大鼠结肠组织ZO-1、Occludin、Nrf2蛋白表达;流式细胞术检测肠系膜淋巴结中M1型和M2巨噬细胞比值;Western blot法检测结肠组织Nrf2、HO-1、p-IκBα、p-P65蛋白表达。结果与模型组比较,清化止泻方各剂量组大鼠体质量、AWR痛觉阈值升高(P<0.05,P<0.01);结肠组织结构基本完整,上皮细胞排列整齐,未见大量细胞变性脱落;结肠组织ZO-1、Occludin蛋白荧光强度增强(P<0.05,P<0.01);结肠组织细胞凋亡率降低(P<0.05,P<0.01);肠系膜淋巴结巨噬细胞向M2极化(P<0.05,P<0.01);结肠组织Nrf2、HO-1蛋白表达升高(P<0.05,P<0.01),p-IκBα/IκBα和p-P65/P65蛋白表达降低(P<0.05,P<0.01)。结论清化止泻方可改善IBS-D大鼠肠上皮黏膜屏障功能,其作用可能与激活Nrf2/HO-1信号通路,抑制NF-κB信号通路活化,调控巨噬细胞向M2极化有关。 展开更多
关键词 清化止泻方 腹泻型肠易激综合征 巨噬细胞 巨噬细胞极化 Nrf2/HO-1信号通路 NF-ΚB信号通路
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径向电流作用下的高压电缆缓冲层烧蚀多物理量信号演变规律 被引量:3
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作者 吴明 洪涵韬 +3 位作者 任志刚 张云飞 李建英 高景晖 《高电压技术》 北大核心 2025年第2期936-945,共10页
近年来高压电缆中缓冲层烧蚀导致的电缆本体击穿事故频发,严重影响了电网的安全稳定运行。缓冲层的含水率及外界压力是影响高压电缆缓冲层烧蚀故障发展的重要因素。基于此,搭建了缓冲层在不同含水率及不同受力下的烧蚀模拟试验平台,研... 近年来高压电缆中缓冲层烧蚀导致的电缆本体击穿事故频发,严重影响了电网的安全稳定运行。缓冲层的含水率及外界压力是影响高压电缆缓冲层烧蚀故障发展的重要因素。基于此,搭建了缓冲层在不同含水率及不同受力下的烧蚀模拟试验平台,研究不同条件下缓冲层烧蚀产生的温度、超声以及电信号,获得了烧蚀缺陷的多物理量演变规律。同时结合对烧蚀缓冲层的微观形貌特征以及烧蚀产物成分的表征,分析了不同条件下的缓冲层烧蚀信号产生的机理,发现电流径向集中引起的热效应和缓冲层内气隙放电是导致缓冲层温度升高的原因,而气隙放电是导致超声信号和电信号产生的原因。研究发现,相较干燥缓冲层烧蚀,含水情况下的缓冲层会和铝护套发生电化学腐蚀,会使得超声信号和电信号变大,且中间会有小的信号产生。该研究为高压电缆缓冲层烧蚀检测装置的开发提供了理论和实验基础。 展开更多
关键词 电力电缆 缓冲层 烧蚀故障 超声信号 径向电流
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信息不对称视角下企业投资时机信号传递模型 被引量:2
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作者 张勇 张晶 罗鹏飞 《系统工程学报》 北大核心 2025年第3期360-373,共14页
从信息不对称视角,研究企业类型数量对企业投融资决策的影响.采用信号传递理论,建立多企业动态博弈模型,给出企业应用投资时机传递类型信号的单交差条件和最小潜力差分离均衡条件,考察企业资产证券化融资的产品价值.研究表明,多企业分... 从信息不对称视角,研究企业类型数量对企业投融资决策的影响.采用信号传递理论,建立多企业动态博弈模型,给出企业应用投资时机传递类型信号的单交差条件和最小潜力差分离均衡条件,考察企业资产证券化融资的产品价值.研究表明,多企业分离均衡是一个多阶段的分离过程,企业越先分离表明企业增长潜力越高;多企业既要满足单交差条件,还要企业间的增长潜力差均满足对应的最小潜力差分离均衡条件,这样投资时机才是传递企业真实类型的可靠信号,该信号有利于提高多资产支持的证券化产品总价值;企业类型数量的增加会提高分离均衡的难度,增加高潜力企业的逆向选择成本. 展开更多
关键词 信息不对称 投资时机 信号传递 资产支持证券
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基于参数优化变分模态分解的信号降噪方法 被引量:1
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作者 何玉洁 李新娥 贺俊 《现代电子技术》 北大核心 2025年第2期70-76,共7页
针对心电信号中肌电干扰噪声难以去除的问题,提出一种基于参数优化变分模态分解(VMD)的信号降噪方法。通过设计动态边界策略和反向种群生成方式,对白鲸优化(BWO)算法进行改进;采用改进白鲸优化算法对VMD参数自适应寻优,确定分解层数K与... 针对心电信号中肌电干扰噪声难以去除的问题,提出一种基于参数优化变分模态分解(VMD)的信号降噪方法。通过设计动态边界策略和反向种群生成方式,对白鲸优化(BWO)算法进行改进;采用改进白鲸优化算法对VMD参数自适应寻优,确定分解层数K与惩罚因子α;对含噪心电信号进行分解,得到k个本征模态函数(IMF)分量,同时采用相关系数法进行有效模态和含噪模态识别;对噪声主导的模态分量采用小波阈值降噪,并重构信号主导模态与降噪后模态。对仿真信号与含真实肌电干扰的心电信号进行降噪处理,实验结果表明,所提方法去噪效果优于小波阈值去噪法、EMD法、EMD-小波阈值去噪法,真实含噪的心电信号经该方法去噪后自相关系数可达0.91以上。 展开更多
关键词 变分模态分解 信号降噪 参数优化 改进白鲸优化算法 心电信号 IMF分量 小波阈值降噪 肌电干扰
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应用咽鼓管功能声测法和阶跃式纯音线谱信号对健康成人咽鼓管开放功能的研究 被引量:1
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作者 金蕾 郑阳阳 +1 位作者 倪坤 李晓艳 《听力学及言语疾病杂志》 北大核心 2025年第2期145-149,共5页
目的探究咽鼓管功能声测法合理的纯音声源信号频率区间,并初步建立正常值范围。方法选取31例健康成人受试者,分段采用3~6 kHz频带上间隔100 Hz的阶跃式纯音线谱信号作为声源进行咽鼓管功能声测法测试,分析结果。结果本研究发现3.5、4.3... 目的探究咽鼓管功能声测法合理的纯音声源信号频率区间,并初步建立正常值范围。方法选取31例健康成人受试者,分段采用3~6 kHz频带上间隔100 Hz的阶跃式纯音线谱信号作为声源进行咽鼓管功能声测法测试,分析结果。结果本研究发现3.5、4.3、4.35、4.5、4.65、4.8、5.0、5.15 kHz 8个频点通过率均较高,是较为合适的纯音信号频点;将这8个频率点上的线谱数据汇总后统计分析,计算出LVc值的95%可信区间,即95%的LVc值>5.5 dB,取整数后将6 dB设为LVc门限阈值。结论本研究发现咽鼓管功能声测法较合适的纯音线谱声源频率为3.5、4.3、4.35、4.5、4.65、4.8、5.0、5.15 kHz 8个频点,声源信号在吞咽动作发生前后约0.5~1秒范围内相对声压级超过6 dB幅值变化可作为咽鼓管有效开放指标。 展开更多
关键词 咽鼓管功能 纯音信号 声测法
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巨噬细胞极化对血管平滑肌细胞PI3K/Akt/mTOR信号通路的影响 被引量:1
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作者 冯莹 张妍 +3 位作者 雷杰 刘娟 方勇 贺立群 《中国免疫学杂志》 北大核心 2025年第2期315-319,共5页
目的:探讨巨噬细胞极化对血管平滑肌细胞PI3K/Akt/mTOR信号通路和炎症反应的影响。方法:佛波酯诱导THP-1细胞成为巨噬细胞,分别用LPS和IFN-γ、IL-4和IL-13处理48 h,更换不含血清的新鲜培养基培养24 h,取上清作为条件培养基。将血管平... 目的:探讨巨噬细胞极化对血管平滑肌细胞PI3K/Akt/mTOR信号通路和炎症反应的影响。方法:佛波酯诱导THP-1细胞成为巨噬细胞,分别用LPS和IFN-γ、IL-4和IL-13处理48 h,更换不含血清的新鲜培养基培养24 h,取上清作为条件培养基。将血管平滑肌细胞分成对照组、M0培养基组、M1培养基组和M2培养基组。CCK-8检测细胞增殖能力,流式细胞术检测细胞凋亡,ELISA检测细胞上清中炎症因子IL-1α、IL-6和TGF-β表达,RT-qPCR和Western blot检测血管平滑肌细胞中PI3K、Akt、mTOR mRNA和磷酸化蛋白表达。结果:与对照组相比,M0培养基组细胞增殖能力、细胞上清中TGF-β水平显著降低(P<0.01),细胞凋亡率、细胞上清中IL-1α和IL-6水平、细胞中PI3K、Akt、mTOR mRNA和蛋白磷酸化水平显著升高(P<0.01);与M0培养基组相比,M1培养基组细胞增殖能力、细胞上清中TGF-β水平显著降低(P<0.05),细胞凋亡率、细胞上清中IL-1α和IL-6水平、细胞中PI3K、Akt、mTOR mRNA和蛋白磷酸化水平显著升高(P<0.01),M2培养基组趋势相反(P<0.05)。结论:巨噬细胞极化能够通过调控PI3K/Akt/mTOR信号通路调节炎症细胞因子表达,参与动脉粥样硬化炎症反应。 展开更多
关键词 巨噬细胞极化 动脉粥样硬化 PI3K/Akt/mTOR信号通路
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