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Development and Therapeutic Applications of Precise Gene Editing Technology
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作者 ZHANG Yi-Meng YANG Xiao +1 位作者 WANG Jian LI Zhen-Hua 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2024年第10期2637-2647,共11页
The advent of gene editing represents one of the most transformative breakthroughs in life science,making genome manipulation more accessible than ever before.While traditional CRISPR/Cas-based gene editing,which invo... The advent of gene editing represents one of the most transformative breakthroughs in life science,making genome manipulation more accessible than ever before.While traditional CRISPR/Cas-based gene editing,which involves double-strand DNA breaks(DSBs),excels at gene disruption,it is less effective for accurate gene modification.The limitation arises because DSBs are primarily repaired via non-homologous end joining(NHEJ),which tends to introduce indels at the break site.While homology directed repair(HDR)can achieve precise editing when a donor DNA template is provided,the reliance on DSBs often results in unintended genome damage.HDR is restricted to specific cell cycle phases,limiting its application.Currently,gene editing has evolved to unprecedented levels of precision without relying on DSB and HDR.The development of innovative systems,such as base editing,prime editing,and CRISPR-associated transposases(CASTs),now allow for precise editing ranging from single nucleotides to large DNA fragments.Base editors(BEs)enable the direct conversion of one nucleotide to another,and prime editors(PEs)further expand gene editing capabilities by allowing for the insertion,deletion,or alteration of small DNA fragments.The CAST system,a recent innovation,allows for the precise insertion of large DNA fragments at specific genomic locations.In recent years,the optimization of these precise gene editing tools has led to significant improvements in editing efficiency,specificity,and versatility,with advancements such as the creation of base editors for nucleotide transversions,enhanced prime editing systems for more efficient and precise modifications,and refined CAST systems for targeted large DNA insertions,expanding the range of applications for these tools.Concurrently,these advances are complemented by significant improvements in in vivo delivery methods,which have paved the way for therapeutic application of precise gene editing tools.Effective delivery systems are critical for the success of gene therapies,and recent developments in both viral and non-viral vectors have improved the efficiency and safety of gene editing.For instance,adeno-associated viruses(AAVs)are widely used due to their high transfection efficiency and low immunogenicity,though challenges such as limited cargo capacity and potential for immune responses remain.Non-viral delivery systems,including lipid nanoparticles(LNPs),offer an alternative with lower immunogenicity and higher payload capacity,although their transfection efficiency can be lower.The therapeutic potential of these precise gene editing technologies is vast,particularly in treating genetic disorders.Preclinical studies have demonstrated the effectiveness of base editing in correcting genetic mutations responsible for diseases such as cardiomyopathy,liver disease,and hereditary hearing loss.These technologies promise to treat symptoms and potentially cure the underlying genetic causes of these conditions.Meanwhile,challenges remain,such as optimizing the safety and specificity of gene editing tools,improving delivery systems,and overcoming off-target effects,all of which are critical for their successful application in clinical settings.In summary,the continuous evolution of precise gene editing technologies,combined with advancements in delivery systems,is driving the field toward new therapeutic applications that can potentially transform the treatment of genetic disorders by targeting their root causes. 展开更多
关键词 precise gene editing CRISPR/Cas system base editing prime editing gene therapy
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Beidou receiver based on anti-jamming antenna arrays with self-calibration for precise relative positioning 被引量:1
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作者 AN Yi KANG Ronglei +1 位作者 BAN Yalong YANG Shaoshuai 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第5期1132-1147,共16页
Unmanned aerial vehicles(UAVs)may be subjected to unintentional radio frequency interference(RFI)or hostile jamming attack which will lead to fail to track global navigation satellite system(GNSS)signals.Therefore,the... Unmanned aerial vehicles(UAVs)may be subjected to unintentional radio frequency interference(RFI)or hostile jamming attack which will lead to fail to track global navigation satellite system(GNSS)signals.Therefore,the simultaneous realization of anti-jamming and high-precision carrier phase difference positioning becomes a dilemmatic problem.In this paper,a distortionless phase digital beamforming(DBF)algorithm with self-calibration antenna arrays is proposed,which enables to obtain distortionless carrier phase while suppressing jamming.Additionally,architecture of high precision Beidou receiver based on anti-jamming antenna arrays is proposed.Finally,the performance of the algorithm is evaluated,including antenna calibration accuracy,carrier phase distortionless accuracy,and carrier phase measurement accuracy without jamming.Meanwhile,the maximal jamming to signal ratio(JSR)and real time kinematic(RTK)positioning accuracy under wideband jamming are also investigated.The experimental results based on the real-life Beidou signals show that the proposed method has an excellent performance for precise relative positioning under jamming when compared with other anti-jamming methods. 展开更多
关键词 Beidou receiver antenna array ANTI-JAMMING high precision distortionless carrier phase
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医科达Precise直线加速器无高压故障检修 被引量:5
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作者 王俐 《第三军医大学学报》 CAS CSCD 北大核心 2004年第14期1290-1290,1294,共2页
关键词 precise直线加速器 故障检修 高压电路
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Precise Integration Method of C-integral for Linear Viscoelastic Solids with Crack
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作者 Liu Jinghua Wu Changchun Huang Ruoyu 《上海交通大学学报》 EI CAS CSCD 北大核心 2004年第z2期25-31,共7页
Generally, viscoelastic solid constitutive equation can be written into differential form and integral form. From differential form of constitutive equation the mathematical representation of the state space equation ... Generally, viscoelastic solid constitutive equation can be written into differential form and integral form. From differential form of constitutive equation the mathematical representation of the state space equation can be derived. Due to the state space equation, general constitutive equation can be solved by precise integration method that can be used in many fields with the advantages of highly precision and convenience. For linear viscoelastic solids with crack, the finite elements program of the precise integration method for viscoelastic solid is developed, which appears to be efficient and precise. C-integral is used to be the characterising parameter. 展开更多
关键词 precise integration C-integral VISCOELASTIC finite element
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A PRECISE MEASUREMENT OF QHR IN NIM
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作者 L.Bliek G.Hein +2 位作者 W.Kowalski K.J.Ebeling H.Bruus 《计量学报》 CSCD 1991年第S1期6-11,共6页
In this paper an equipment for precise measurement of QHR in NIM is described.The essential parts in this equipment are a resistance comparator of one-to-one ratio with a comparison uncertainty of 3×10-8 and two ... In this paper an equipment for precise measurement of QHR in NIM is described.The essential parts in this equipment are a resistance comparator of one-to-one ratio with a comparison uncertainty of 3×10-8 and two specially designed resistor networks for determination of ratio between 12906.4035Ω of QHR at i=2 and 10kΩ or 1kΩ The transfering procedure from QHR to 10kΩ or 1kΩ can be completed easily with this equipment by a few one to one comparisons with a total uncertainty of 展开更多
关键词 uncertainty specially completed precise links AUTOMATICALLY ADJUST SCANNER DIFFICULTY MAGNET
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Multi-objective optimization of grinding process parameters for improving gear machining precision 被引量:1
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作者 YOU Tong-fei HAN Jiang +4 位作者 TIAN Xiao-qing TANG Jian-ping LU Yi-guo LI Guang-hui XIA Lian 《Journal of Central South University》 2025年第2期538-551,共14页
The gears of new energy vehicles are required to withstand higher rotational speeds and greater loads,which puts forward higher precision essentials for gear manufacturing.However,machining process parameters can caus... The gears of new energy vehicles are required to withstand higher rotational speeds and greater loads,which puts forward higher precision essentials for gear manufacturing.However,machining process parameters can cause changes in cutting force/heat,resulting in affecting gear machining precision.Therefore,this paper studies the effect of different process parameters on gear machining precision.A multi-objective optimization model is established for the relationship between process parameters and tooth surface deviations,tooth profile deviations,and tooth lead deviations through the cutting speed,feed rate,and cutting depth of the worm wheel gear grinding machine.The response surface method(RSM)is used for experimental design,and the corresponding experimental results and optimal process parameters are obtained.Subsequently,gray relational analysis-principal component analysis(GRA-PCA),particle swarm optimization(PSO),and genetic algorithm-particle swarm optimization(GA-PSO)methods are used to analyze the experimental results and obtain different optimal process parameters.The results show that optimal process parameters obtained by the GRA-PCA,PSO,and GA-PSO methods improve the gear machining precision.Moreover,the gear machining precision obtained by GA-PSO is superior to other methods. 展开更多
关键词 worm wheel gear grinding machine gear machining precision machining process parameters multi objective optimization
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Study, development and related application of a miniature compact pulsed power supply with high repetition frequency
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作者 Zhangfei Wang Jian Liu +1 位作者 Chunxia Yang Baoming Li 《Defence Technology(防务技术)》 2025年第5期304-318,共15页
Capacitor-based pulsed power supply(PPS)is widely used in fields related to electromagnetic launch,plasma,and materials'synthesis,modification and processing.As industrial applications place higher requirements on... Capacitor-based pulsed power supply(PPS)is widely used in fields related to electromagnetic launch,plasma,and materials'synthesis,modification and processing.As industrial applications place higher requirements on compact and portable pulsed power supplies,the National Key Laboratory of Transient Physics(NKLTP)recently developed a pulsed power supply consisting of a set of compact pulse-forming units(PFU),each with a capacitor energy storage of 220 kJ.This integrated PPS comes with a complete system configuration,a miniature compact structure,a high rate of repetition,and high power,with energy storage density exceeding 1.2 MJ/m^(3).This paper describes the device-level design of the unit,the system layout,the control system,the thermal management system,and the experimental results of the pulsed power supply.The experimental results verified the good reliability of the PPS at high repetition rates with each unit module delivering an output current of more than 100 kA.Additionally,flexible current pulse shapes can be formed by setting the charging voltage and the trigger sequence of the PFUs.The pulse forming network(PFN)developed from these PFUs was successfully applied to electromagnetic launch. 展开更多
关键词 Electromagnetic railgun Pulsed power supply Energy storage density Thermal management system Precision control system
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基于改进Faster R-CNN的热轧带钢表面缺陷检测 被引量:4
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作者 邓慧 曾磊 《控制工程》 CSCD 北大核心 2024年第4期752-759,共8页
热轧带钢是钢铁行业的重要产品,其表面缺陷是影响产品质量的重要因素。针对传统缺陷检测算法存在的过程繁琐、精度不足和效率低下等问题,提出一种基于改进更快速区域卷积神经网络(faster region-based convolutional neural network,Fas... 热轧带钢是钢铁行业的重要产品,其表面缺陷是影响产品质量的重要因素。针对传统缺陷检测算法存在的过程繁琐、精度不足和效率低下等问题,提出一种基于改进更快速区域卷积神经网络(faster region-based convolutional neural network,Faster R-CNN)的检测算法,实现对热轧带钢表面缺陷的高效、高精度检测。首先,采用特征相加的方法对底层细节特征和高层语义特征进行融合;然后,采用精准的感兴趣区域池化(precise region of interest pooling,Precise ROI Pooling)获取固定大小的特征向量,避免特征出现位置偏差;最后,利用均值偏移聚类算法对带钢数据集进行聚类,获得适用于热轧带钢表面缺陷检测的先验框尺寸。实验结果表明,所提算法在热轧带钢表面缺陷检测数据集上的平均精度均值达到了85.34%,检测速度为23.5帧/s,且鲁棒性良好,满足实际的工业检测需求。 展开更多
关键词 表面缺陷检测 Faster R-CNN 特征融合 precise ROI Pooling 均值偏移
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基于构型优选的5G集群无人机协同导航方法 被引量:1
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作者 高超 黄郑 +2 位作者 赵轩 王红星 龙涛 《系统仿真学报》 CAS CSCD 北大核心 2024年第4期981-990,共10页
针对现有基于测距的集群UAV协同导航方法普遍忽略了空间构型对定位定能的影响,难以获得精确的导航定位结果,提出一种基于空间构型优选的5G集群UAV协同导航方法。构建了复杂环境下基于5G信号的UAV相对测距误差模型,基于最小几何精度因子(... 针对现有基于测距的集群UAV协同导航方法普遍忽略了空间构型对定位定能的影响,难以获得精确的导航定位结果,提出一种基于空间构型优选的5G集群UAV协同导航方法。构建了复杂环境下基于5G信号的UAV相对测距误差模型,基于最小几何精度因子(geometric dilution of precision,GDOP)准则建立了协同导航节点寻优策略,实现了协同导航空间构型的实时优选;设计了基于5G测距网络的协同导航滤波器,对UAV导航信息进行在线估计和实时补偿,提高集群UAV的协同定位精度。仿真结果表明:该方法从机定位精度平均提升了约42.05%,为集群UAV实现在卫星不可用条件下的自主导航提供了一种有效的新方法。 展开更多
关键词 5G测距 协同导航 多无人机 GDOP(geometric dilution of precision) 最优构型
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Re-identifying beef cattle using improved AlignedReID++ 被引量:1
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作者 YING Xiaoyi ZHAO Jizheng +7 位作者 YANG Lingling ZHOU Xinyi WANG Lei GAO Yannian ZAN Linsen YANG Wucai LIU Han SONG Huaibo 《农业工程学报》 EI CAS CSCD 北大核心 2024年第18期132-146,共15页
Accurate and continuous identification of individual cattle is crucial to precision farming in recent years.It is also the prerequisite to monitor the individual feed intake and feeding time of beef cattle at medium t... Accurate and continuous identification of individual cattle is crucial to precision farming in recent years.It is also the prerequisite to monitor the individual feed intake and feeding time of beef cattle at medium to long distances over different cameras.However,beef cattle can tend to frequently move and change their feeding position during feeding.Furthermore,the great variations in their head direction and complex environments(light,occlusion,and background)can also lead to some difficulties in the recognition,particularly for the bio-similarities among individual cattle.Among them,AlignedReID++model is characterized by both global and local information for image matching.In particular,the dynamically matching local information(DMLI)algorithm has been introduced into the local branch to automatically align the horizontal local information.In this research,the AlignedReID++model was utilized and improved to achieve the better performance in cattle re-identification(ReID).Initially,triplet attention(TA)modules were integrated into the BottleNecks of ResNet50 Backbone.The feature extraction was then enhanced through cross-dimensional interactions with the minimal computational overhead.Since the TA modules in AlignedReID++baseline model increased the model size and floating point operations(FLOPs)by 0.005 M and 0.05 G,the rank-1 accuracy and mean average precision(mAP)were improved by 1.0 percentage points and 2.94 percentage points,respectively.Specifically,the rank-1 accuracies were outperformed by 0.86 percentage points and 0.12 percentage points,respectively,compared with the convolution block attention module(CBAM)and efficient channel attention(ECA)modules,although 0.94 percentage points were lower than that of squeeze-and-excitation(SE)modules.The mAP metric values were exceeded by 0.22,0.86 and 0.12 percentage points,respectively,compared with the SE,CBAM,and ECA modules.Additionally,the Cross-Entropy Loss function was replaced with the CosFace Loss function in the global branch of baseline model.CosFace Loss and Hard Triplet Loss were jointly employed to train the baseline model for the better identification on the similar individuals.AlignedReID++with CosFace Loss was outperformed the baseline model by 0.24 and 0.92 percentage points in the rank-1 accuracy and mAP,respectively,whereas,AlignedReID++with ArcFace Loss was exceeded by 0.36 and 0.56 percentage points,respectively.The improved model with the TA modules and CosFace Loss was achieved in a rank-1 accuracy of 94.42%,rank-5 accuracy of 98.78%,rank-10 accuracy of 99.34%,mAP of 63.90%,FLOPs of 5.45 G,frames per second(FPS)of 5.64,and model size of 23.78 M.The rank-1 accuracies were exceeded by 1.84,4.72,0.76 and 5.36 percentage points,respectively,compared with the baseline model,part-based convolutional baseline(PCB),multiple granularity network(MGN),and relation-aware global attention(RGA),while the mAP metrics were surpassed 6.42,5.86,4.30 and 7.38 percentage points,respectively.Meanwhile,the rank-1 accuracy was 0.98 percentage points lower than TransReID,but the mAP metric was exceeded by 3.90 percentage points.Moreover,the FLOPs of improved model were only 0.05 G larger than that of baseline model,while smaller than those of PCB,MGN,RGA,and TransReID by 0.68,6.51,25.4,and 16.55 G,respectively.The model size of improved model was 23.78 M,which was smaller than those of the baseline model,PCB,MGN,RGA,and TransReID by 0.03,2.33,45.06,14.53 and 62.85 M,respectively.The inference speed of improved model on a CPU was lower than those of PCB,MGN,and baseline model,but higher than TransReID and RGA.The t-SNE feature embedding visualization demonstrated that the global and local features were achieve in the better intra-class compactness and inter-class variability.Therefore,the improved model can be expected to effectively re-identify the beef cattle in natural environments of breeding farm,in order to monitor the individual feed intake and feeding time. 展开更多
关键词 method IDENTIFY beef cattle precision livestock re-identification AlignedReID++ deep learning
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Design methodology of a mini-missile considering flight performance and guidance precision 被引量:1
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作者 ZHANG Licong GONG Chunlin +1 位作者 SU Hua ANDREA Da Ronch 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2024年第1期195-210,共16页
The design of mini-missiles(MMs)presents several novel challenges.The stringent mission requirement to reach a target with a certain precision imposes a high guidance precision.The miniaturization of the size of MMs m... The design of mini-missiles(MMs)presents several novel challenges.The stringent mission requirement to reach a target with a certain precision imposes a high guidance precision.The miniaturization of the size of MMs makes the design of the guidance,navigation,and control(GNC)have a larger-thanbefore impact on the main-body design(shape,motor,and layout design)and its design objective,i.e.,flight performance.Pursuing a trade-off between flight performance and guidance precision,all the relevant interactions have to be accounted for in the design of the main body and the GNC system.Herein,a multi-objective and multidisciplinary design optimization(MDO)is proposed.Disciplines pertinent to motor,aerodynamics,layout,trajectory,flight dynamics,control,and guidance are included in the proposed MDO framework.The optimization problem seeks to maximize the range and minimize the guidance error.The problem is solved by using the nondominated sorting genetic algorithm II.An optimum design that balances a longer range with a smaller guidance error is obtained.Finally,lessons learned about the design of the MM and insights into the trade-off between flight performance and guidance precision are given by comparing the optimum design to a design provided by the traditional approach. 展开更多
关键词 mini-missiles(MMs) GUIDANCE NAVIGATION and control(GNC)system multi-objective optimization multidisciplinary design optimization(MDO) flight performance guidance precision
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A novel self-alignment method for high precision silicon diffraction microlens arrays preparation and its integration with infrared focal plane arrays
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作者 HOU Zhi-Jin CHEN Yan +2 位作者 WANG Xu-Dong WANG Jian-Lu CHU Jun-Hao 《红外与毫米波学报》 SCIE EI CAS CSCD 北大核心 2024年第5期589-594,共6页
Silicon(Si)diffraction microlens arrays are usually used to integrating with infrared focal plane arrays(IRFPAs)to improve their performance.The errors of lithography are unavoidable in the process of the Si diffrac-t... Silicon(Si)diffraction microlens arrays are usually used to integrating with infrared focal plane arrays(IRFPAs)to improve their performance.The errors of lithography are unavoidable in the process of the Si diffrac-tion microlens arrays preparation in the conventional engraving method.It has a serious impact on its performance and subsequent applications.In response to the problem of errors of Si diffraction microlens arrays in the conven-tional method,a novel self-alignment method for high precision Si diffraction microlens arrays preparation is pro-posed.The accuracy of the Si diffractive microlens arrays preparation is determined by the accuracy of the first li-thography mask in the novel self-alignment method.In the subsequent etching,the etched area will be protected by the mask layer and the sacrifice layer or the protective layer.The unprotection area is carved to effectively block the non-etching areas,accurately etch the etching area required,and solve the problem of errors.The high precision Si diffraction microlens arrays are obtained by the novel self-alignment method and the diffraction effi-ciency could reach 92.6%.After integrating with IRFPAs,the average blackbody responsity increased by 8.3%,and the average blackbody detectivity increased by 10.3%.It indicates that the Si diffraction microlens arrays can improve the filling factor and reduce crosstalk of IRFPAs through convergence,thereby improving the perfor-mance of the IRFPAs.The results are of great reference significance for improving their performance through opti-mizing the preparation level of micro nano devices. 展开更多
关键词 SELF-ALIGNMENT diffraction microlens arrays high precision INTEGRATION SI IRFPAs
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GPS PPP技术用于滑坡监测的试验与结果分析 被引量:34
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作者 王利 张勤 +2 位作者 黄观文 涂锐 张双成 《岩土力学》 EI CAS CSCD 北大核心 2014年第7期2118-2124,共7页
为了研究全球定位系统(GPS)精密单点定位(PPP)技术用于滑坡等地质灾害监测时可能达到的精度和可靠性等问题,结合某类滑坡的大型物理模型试验,在滑坡体上布设了若干GPS监测点进行连续实时动态监测,利用PPP技术对该滑坡从稳定、开始滑动... 为了研究全球定位系统(GPS)精密单点定位(PPP)技术用于滑坡等地质灾害监测时可能达到的精度和可靠性等问题,结合某类滑坡的大型物理模型试验,在滑坡体上布设了若干GPS监测点进行连续实时动态监测,利用PPP技术对该滑坡从稳定、开始滑动直至产生破坏的全过程监测数据进行了处理与分析,并与GPS单历元差分定位、载波相位实时差分定位技术监测结果进行了对比。结果表明:GPS PPP技术监测结果的内符合精度约为10 mm,外符合精度约为40 mm,且GPS PPP技术具有一些差分GPS无法比拟的优势,如无需基准站支持、作业成本低、效率高、可直接获取监测点在国际地球参考框架下的绝对坐标等。该技术完全可用于滑坡等地质灾害的实时动态监测和预警。 展开更多
关键词 全球定位系统(GPS) 精密单点定位(PPP) 滑坡 变形监测 global POSITIONING system (GPS) precise point POSITIONING (PPP)
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A new method for evaluating the firing precision of multiple launch rocket system based on Bayesian theory
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作者 Yunfei Miao Guoping Wang Wei Tian 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第2期232-241,共10页
How to effectively evaluate the firing precision of weapon equipment at low cost is one of the core contents of improving the test level of weapon system.A new method to evaluate the firing precision of the MLRS consi... How to effectively evaluate the firing precision of weapon equipment at low cost is one of the core contents of improving the test level of weapon system.A new method to evaluate the firing precision of the MLRS considering the credibility of simulation system based on Bayesian theory is proposed in this paper.First of all,a comprehensive index system for the credibility of the simulation system of the firing precision of the MLRS is constructed combined with the group analytic hierarchy process.A modified method for determining the comprehensive weight of the index is established to improve the rationality of the index weight coefficients.The Bayesian posterior estimation formula of firing precision considering prior information is derived in the form of mixed prior distribution,and the rationality of prior information used in estimation model is discussed quantitatively.With the simulation tests,the different evaluation methods are compared to validate the effectiveness of the proposed method.Finally,the experimental results show that the effectiveness of estimation method for firing precision is improved by more than 25%. 展开更多
关键词 Multiple launch rocket system Bayesian theory Simulation credibility Mixed prior distribution Firing precision
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Improving the spaceborne GNSS-R altimetric precision based on the novel multilayer feedforward neural network weighted joint prediction model
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作者 Yiwen Zhang Wei Zheng Zongqiang Liu 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第2期271-284,共14页
Global navigation satellite system-reflection(GNSS-R)sea surface altimetry based on satellite constellation platforms has become a new research direction and inevitable trend,which can meet the altimetric precision at... Global navigation satellite system-reflection(GNSS-R)sea surface altimetry based on satellite constellation platforms has become a new research direction and inevitable trend,which can meet the altimetric precision at the global scale required for underwater navigation.At present,there are still research gaps for GNSS-R altimetry under this mode,and its altimetric capability cannot be specifically assessed.Therefore,GNSS-R satellite constellations that meet the global altimetry needs to be designed.Meanwhile,the matching precision prediction model needs to be established to quantitatively predict the GNSS-R constellation altimetric capability.Firstly,the GNSS-R constellations altimetric precision under different configuration parameters is calculated,and the mechanism of the influence of orbital altitude,orbital inclination,number of satellites and simulation period on the precision is analyzed,and a new multilayer feedforward neural network weighted joint prediction model is established.Secondly,the fit of the prediction model is verified and the performance capability of the model is tested by calculating the R2 value of the model as 0.9972 and the root mean square error(RMSE)as 0.0022,which indicates that the prediction capability of the model is excellent.Finally,using the novel multilayer feedforward neural network weighted joint prediction model,and considering the research results and realistic costs,it is proposed that when the constellation is set to an orbital altitude of 500 km,orbital inclination of 75and the number of satellites is 6,the altimetry precision can reach 0.0732 m within one year simulation period,which can meet the requirements of underwater navigation precision,and thus can provide a reference basis for subsequent research on spaceborne GNSS-R sea surface altimetry. 展开更多
关键词 GNSS-R satellite constellations Sea surface altimetric precision Underwater navigation Multilayer feedforward neural network
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SRES B2情景下中国区域最高、最低气温及日较差变化分布特征初步分析 被引量:44
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作者 张勇 许吟隆 +1 位作者 董文杰 曹丽娟 《地球物理学报》 SCIE EI CAS CSCD 北大核心 2007年第3期714-723,共10页
本文利用Hadley气候预测与研究中心的区域气候模式系统PRECIS进行中国区域气候基准时段(1961-1990年)和SRESB2情景下2071—2100年(2080s)最高、最低气温及日较差变化响应的分析.气候基准时段的模拟结果与观测资料的对比分析表明:P... 本文利用Hadley气候预测与研究中心的区域气候模式系统PRECIS进行中国区域气候基准时段(1961-1990年)和SRESB2情景下2071—2100年(2080s)最高、最低气温及日较差变化响应的分析.气候基准时段的模拟结果与观测资料的对比分析表明:PRECIS具有对中国区域最高、最低气温及日较差的模拟能力,能够模拟出中国区域最高、最低气温及日较差的局地分布特征.对SRESB2情景下相对于气候基准时段的最高、最低气温及日较差变化响应分析表明:中国区域2080s时段年、冬季和夏季平均最高、最低气温变化均呈一致增加的趋势,北方地区增温幅度普遍大于南方地区.夏季东北地区极端高温事件发生的频率将会增加,而冬季华北地区极端冷害事件发生频率将会减少.未来中国区域年平均日较差将出现北方地区减小而南方地区增加的趋势.冬季长江中下游以南地区日较差呈增加趋势,而夏季华东地区、西北地区及内蒙古中部日较差将呈减小趋势,其中在青藏高原北部地区存在一个较强的低值中心. 展开更多
关键词 PRECIS 最高气温 最低气温 日较差 SRES 132情景
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PRECIS对华南地区气候模拟能力的验证 被引量:11
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作者 许吟隆 黄晓莹 +2 位作者 张勇 温之平 黎伟标 《中山大学学报(自然科学版)》 CAS CSCD 北大核心 2007年第5期93-97,共5页
分别采用ECMWF 1979-1993再分析数据作为准观测边界条件和由HadAM3P模拟的大尺度场驱动英国Hadley气候预测和研究中心的区域气候模式系统PRECIS,将华南地区的模拟结果与实测资料进行比较,验证PRECIS对华南地区区域气候的模拟能力,并检验... 分别采用ECMWF 1979-1993再分析数据作为准观测边界条件和由HadAM3P模拟的大尺度场驱动英国Hadley气候预测和研究中心的区域气候模式系统PRECIS,将华南地区的模拟结果与实测资料进行比较,验证PRECIS对华南地区区域气候的模拟能力,并检验GCM模拟的大尺度边界场的误差对PRECIS模拟能力的影响。结果显示PRECIS模拟的年平均气温、降水的区域分布和频率分布与实测数据均有较好的一致性,气温的相关系数为0.95,降水超过0.6。通过统计学方法的分析,表明PRECIS能较好的模拟出华南地区气候的周期变化和时空特征分布。通过比较分析GCM模拟的大尺度场作为边界条件驱动PRECIS的模拟结果,显示GCM产生的边界值的偏差对PRECIS的模拟效果没有明显的影响。 展开更多
关键词 PRECIS 华南地区 模式验证 气温 降水
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中国未来极端降水事件的变化——基于气候变化预估结果的分析 被引量:33
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作者 张勇 许吟隆 +1 位作者 董文杰 曹丽娟 《自然灾害学报》 CSCD 北大核心 2006年第S1期228-234,共7页
利用区域气候模式PRECIS单向嵌套Hadley气候中心海-气耦合模式HadCM3高分辨率的大气部分HadAM3P,分别进行了气候基准时段(1961—1990年)和2080 s时段(2071—2100年)中国区域各30年时间长度的模拟试验,以分析PRECIS对当代中国区域极端降... 利用区域气候模式PRECIS单向嵌套Hadley气候中心海-气耦合模式HadCM3高分辨率的大气部分HadAM3P,分别进行了气候基准时段(1961—1990年)和2080 s时段(2071—2100年)中国区域各30年时间长度的模拟试验,以分析PRECIS对当代中国区域极端降水事件的模拟能力和SRES B2情景下2080s时段相对于气候基准时段中国区域极端降水事件的可能变化趋势。气候基准时段模拟结果与观测值的对比分析表明:PRECIS能够较好地模拟出中国区域年平均极端降水事件的空间分布特征,但模式模拟的大雨事件和湿日数高值区范围较观测值偏大,对华南地区暴雨事件和日最大降水事件的模拟结果较观测值偏低。SRES B2情景下,2080s时段年平均大雨事件除东北和华南地区外,全国均呈增多趋势。暴雨事件在西部地区以减少为主,而东部地区主要呈增加趋势。年平均日最大降水事件的分布型与大雨事件基本一致。湿日数除华北、西北和青藏高原部分地区外均呈减少趋势。未来长江流域洪涝灾害事件发生的频率将可能增大。 展开更多
关键词 区域气候模式 PRECIS 模式验证 SRES B2情景 极端降水事件
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华南地区未来地面温度和降水变化的情景分析 被引量:34
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作者 黄晓莹 温之平 +1 位作者 杜尧东 许吟隆 《热带气象学报》 CSCD 北大核心 2008年第3期254-258,共5页
利用英国Hadley气候预测和研究中心的区域气候模式系统PRECIS,模拟分析基于政府间气候变化专门委员会(IPCC)2000年发布的《排放情景特别报告》(SRES)中设计的B2情景下华南区域2071~2100年的温度和降水量的可能变化,结果显示:2071~210... 利用英国Hadley气候预测和研究中心的区域气候模式系统PRECIS,模拟分析基于政府间气候变化专门委员会(IPCC)2000年发布的《排放情景特别报告》(SRES)中设计的B2情景下华南区域2071~2100年的温度和降水量的可能变化,结果显示:2071~2100年均地面温度相对于气候基准时段(1961~1990年)上升约2~4℃;华南区域未来夏季降水量在22°N以北区域较气候基准时段增加,而以南区域减少;冬季降水则表现为华南区域较气候基准时段减少。2071~2100年华南区域的温度气候趋势系数为正值,年均降水气候趋势系数为负值。2071~2100年的高温事件和强降水事件的发生频率均比气候基准时段明显增加。 展开更多
关键词 PRECIS SRES B2情景 华南地区 地面温度 降水 气候变化
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SRES A2情景下中国区域21世纪末平均和极端气候变化的模拟 被引量:14
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作者 杨红龙 许吟隆 +2 位作者 张镭 潘婕 陶生才 《气候变化研究进展》 CSCD 2010年第3期157-163,共7页
利用Hadley气候预测与研究中心的区域气候模式系统PRECIS单向嵌套该中心全球海-气耦合气候模式HadCM3高分辨率的大气部分HadAM3H,分析了SRES A2情景下2071—2100年相对于气候基准时段(1961—1990年)中国区域的气候变化,包括气温和降水... 利用Hadley气候预测与研究中心的区域气候模式系统PRECIS单向嵌套该中心全球海-气耦合气候模式HadCM3高分辨率的大气部分HadAM3H,分析了SRES A2情景下2071—2100年相对于气候基准时段(1961—1990年)中国区域的气候变化,包括气温和降水的年际、季节和日时间尺度的变化以及极端气候事件的变化趋势。模拟结果表明:气温呈明显增加趋势,其中新疆和东北地区增温明显。而降水表现了更大的年际变化和季节变化,冬季南方降水减少,但沿黄河流域的降水明显增加,夏季与冬季相比呈现出相反的趋势。此外,连续高温日数呈现增加趋势,而连续霜冻日数呈现减少趋势。连续湿日数也表现出一定的增加趋势。 展开更多
关键词 PRECIS SRES A2情景 极端事件
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