The gears of new energy vehicles are required to withstand higher rotational speeds and greater loads,which puts forward higher precision essentials for gear manufacturing.However,machining process parameters can caus...The gears of new energy vehicles are required to withstand higher rotational speeds and greater loads,which puts forward higher precision essentials for gear manufacturing.However,machining process parameters can cause changes in cutting force/heat,resulting in affecting gear machining precision.Therefore,this paper studies the effect of different process parameters on gear machining precision.A multi-objective optimization model is established for the relationship between process parameters and tooth surface deviations,tooth profile deviations,and tooth lead deviations through the cutting speed,feed rate,and cutting depth of the worm wheel gear grinding machine.The response surface method(RSM)is used for experimental design,and the corresponding experimental results and optimal process parameters are obtained.Subsequently,gray relational analysis-principal component analysis(GRA-PCA),particle swarm optimization(PSO),and genetic algorithm-particle swarm optimization(GA-PSO)methods are used to analyze the experimental results and obtain different optimal process parameters.The results show that optimal process parameters obtained by the GRA-PCA,PSO,and GA-PSO methods improve the gear machining precision.Moreover,the gear machining precision obtained by GA-PSO is superior to other methods.展开更多
Unmanned aerial vehicles(UAVs)may be subjected to unintentional radio frequency interference(RFI)or hostile jamming attack which will lead to fail to track global navigation satellite system(GNSS)signals.Therefore,the...Unmanned aerial vehicles(UAVs)may be subjected to unintentional radio frequency interference(RFI)or hostile jamming attack which will lead to fail to track global navigation satellite system(GNSS)signals.Therefore,the simultaneous realization of anti-jamming and high-precision carrier phase difference positioning becomes a dilemmatic problem.In this paper,a distortionless phase digital beamforming(DBF)algorithm with self-calibration antenna arrays is proposed,which enables to obtain distortionless carrier phase while suppressing jamming.Additionally,architecture of high precision Beidou receiver based on anti-jamming antenna arrays is proposed.Finally,the performance of the algorithm is evaluated,including antenna calibration accuracy,carrier phase distortionless accuracy,and carrier phase measurement accuracy without jamming.Meanwhile,the maximal jamming to signal ratio(JSR)and real time kinematic(RTK)positioning accuracy under wideband jamming are also investigated.The experimental results based on the real-life Beidou signals show that the proposed method has an excellent performance for precise relative positioning under jamming when compared with other anti-jamming methods.展开更多
The design of mini-missiles(MMs)presents several novel challenges.The stringent mission requirement to reach a target with a certain precision imposes a high guidance precision.The miniaturization of the size of MMs m...The design of mini-missiles(MMs)presents several novel challenges.The stringent mission requirement to reach a target with a certain precision imposes a high guidance precision.The miniaturization of the size of MMs makes the design of the guidance,navigation,and control(GNC)have a larger-thanbefore impact on the main-body design(shape,motor,and layout design)and its design objective,i.e.,flight performance.Pursuing a trade-off between flight performance and guidance precision,all the relevant interactions have to be accounted for in the design of the main body and the GNC system.Herein,a multi-objective and multidisciplinary design optimization(MDO)is proposed.Disciplines pertinent to motor,aerodynamics,layout,trajectory,flight dynamics,control,and guidance are included in the proposed MDO framework.The optimization problem seeks to maximize the range and minimize the guidance error.The problem is solved by using the nondominated sorting genetic algorithm II.An optimum design that balances a longer range with a smaller guidance error is obtained.Finally,lessons learned about the design of the MM and insights into the trade-off between flight performance and guidance precision are given by comparing the optimum design to a design provided by the traditional approach.展开更多
Silicon(Si)diffraction microlens arrays are usually used to integrating with infrared focal plane arrays(IRFPAs)to improve their performance.The errors of lithography are unavoidable in the process of the Si diffrac-t...Silicon(Si)diffraction microlens arrays are usually used to integrating with infrared focal plane arrays(IRFPAs)to improve their performance.The errors of lithography are unavoidable in the process of the Si diffrac-tion microlens arrays preparation in the conventional engraving method.It has a serious impact on its performance and subsequent applications.In response to the problem of errors of Si diffraction microlens arrays in the conven-tional method,a novel self-alignment method for high precision Si diffraction microlens arrays preparation is pro-posed.The accuracy of the Si diffractive microlens arrays preparation is determined by the accuracy of the first li-thography mask in the novel self-alignment method.In the subsequent etching,the etched area will be protected by the mask layer and the sacrifice layer or the protective layer.The unprotection area is carved to effectively block the non-etching areas,accurately etch the etching area required,and solve the problem of errors.The high precision Si diffraction microlens arrays are obtained by the novel self-alignment method and the diffraction effi-ciency could reach 92.6%.After integrating with IRFPAs,the average blackbody responsity increased by 8.3%,and the average blackbody detectivity increased by 10.3%.It indicates that the Si diffraction microlens arrays can improve the filling factor and reduce crosstalk of IRFPAs through convergence,thereby improving the perfor-mance of the IRFPAs.The results are of great reference significance for improving their performance through opti-mizing the preparation level of micro nano devices.展开更多
The advent of gene editing represents one of the most transformative breakthroughs in life science,making genome manipulation more accessible than ever before.While traditional CRISPR/Cas-based gene editing,which invo...The advent of gene editing represents one of the most transformative breakthroughs in life science,making genome manipulation more accessible than ever before.While traditional CRISPR/Cas-based gene editing,which involves double-strand DNA breaks(DSBs),excels at gene disruption,it is less effective for accurate gene modification.The limitation arises because DSBs are primarily repaired via non-homologous end joining(NHEJ),which tends to introduce indels at the break site.While homology directed repair(HDR)can achieve precise editing when a donor DNA template is provided,the reliance on DSBs often results in unintended genome damage.HDR is restricted to specific cell cycle phases,limiting its application.Currently,gene editing has evolved to unprecedented levels of precision without relying on DSB and HDR.The development of innovative systems,such as base editing,prime editing,and CRISPR-associated transposases(CASTs),now allow for precise editing ranging from single nucleotides to large DNA fragments.Base editors(BEs)enable the direct conversion of one nucleotide to another,and prime editors(PEs)further expand gene editing capabilities by allowing for the insertion,deletion,or alteration of small DNA fragments.The CAST system,a recent innovation,allows for the precise insertion of large DNA fragments at specific genomic locations.In recent years,the optimization of these precise gene editing tools has led to significant improvements in editing efficiency,specificity,and versatility,with advancements such as the creation of base editors for nucleotide transversions,enhanced prime editing systems for more efficient and precise modifications,and refined CAST systems for targeted large DNA insertions,expanding the range of applications for these tools.Concurrently,these advances are complemented by significant improvements in in vivo delivery methods,which have paved the way for therapeutic application of precise gene editing tools.Effective delivery systems are critical for the success of gene therapies,and recent developments in both viral and non-viral vectors have improved the efficiency and safety of gene editing.For instance,adeno-associated viruses(AAVs)are widely used due to their high transfection efficiency and low immunogenicity,though challenges such as limited cargo capacity and potential for immune responses remain.Non-viral delivery systems,including lipid nanoparticles(LNPs),offer an alternative with lower immunogenicity and higher payload capacity,although their transfection efficiency can be lower.The therapeutic potential of these precise gene editing technologies is vast,particularly in treating genetic disorders.Preclinical studies have demonstrated the effectiveness of base editing in correcting genetic mutations responsible for diseases such as cardiomyopathy,liver disease,and hereditary hearing loss.These technologies promise to treat symptoms and potentially cure the underlying genetic causes of these conditions.Meanwhile,challenges remain,such as optimizing the safety and specificity of gene editing tools,improving delivery systems,and overcoming off-target effects,all of which are critical for their successful application in clinical settings.In summary,the continuous evolution of precise gene editing technologies,combined with advancements in delivery systems,is driving the field toward new therapeutic applications that can potentially transform the treatment of genetic disorders by targeting their root causes.展开更多
How to effectively evaluate the firing precision of weapon equipment at low cost is one of the core contents of improving the test level of weapon system.A new method to evaluate the firing precision of the MLRS consi...How to effectively evaluate the firing precision of weapon equipment at low cost is one of the core contents of improving the test level of weapon system.A new method to evaluate the firing precision of the MLRS considering the credibility of simulation system based on Bayesian theory is proposed in this paper.First of all,a comprehensive index system for the credibility of the simulation system of the firing precision of the MLRS is constructed combined with the group analytic hierarchy process.A modified method for determining the comprehensive weight of the index is established to improve the rationality of the index weight coefficients.The Bayesian posterior estimation formula of firing precision considering prior information is derived in the form of mixed prior distribution,and the rationality of prior information used in estimation model is discussed quantitatively.With the simulation tests,the different evaluation methods are compared to validate the effectiveness of the proposed method.Finally,the experimental results show that the effectiveness of estimation method for firing precision is improved by more than 25%.展开更多
Global navigation satellite system-reflection(GNSS-R)sea surface altimetry based on satellite constellation platforms has become a new research direction and inevitable trend,which can meet the altimetric precision at...Global navigation satellite system-reflection(GNSS-R)sea surface altimetry based on satellite constellation platforms has become a new research direction and inevitable trend,which can meet the altimetric precision at the global scale required for underwater navigation.At present,there are still research gaps for GNSS-R altimetry under this mode,and its altimetric capability cannot be specifically assessed.Therefore,GNSS-R satellite constellations that meet the global altimetry needs to be designed.Meanwhile,the matching precision prediction model needs to be established to quantitatively predict the GNSS-R constellation altimetric capability.Firstly,the GNSS-R constellations altimetric precision under different configuration parameters is calculated,and the mechanism of the influence of orbital altitude,orbital inclination,number of satellites and simulation period on the precision is analyzed,and a new multilayer feedforward neural network weighted joint prediction model is established.Secondly,the fit of the prediction model is verified and the performance capability of the model is tested by calculating the R2 value of the model as 0.9972 and the root mean square error(RMSE)as 0.0022,which indicates that the prediction capability of the model is excellent.Finally,using the novel multilayer feedforward neural network weighted joint prediction model,and considering the research results and realistic costs,it is proposed that when the constellation is set to an orbital altitude of 500 km,orbital inclination of 75and the number of satellites is 6,the altimetry precision can reach 0.0732 m within one year simulation period,which can meet the requirements of underwater navigation precision,and thus can provide a reference basis for subsequent research on spaceborne GNSS-R sea surface altimetry.展开更多
In this paper, the factors of affecting surface roughness and profiles accuracy of the machined larege depth diamter ratio aspheric surfaces in ultra-precision grinding process are analyzed theoretically. An ultra-pre...In this paper, the factors of affecting surface roughness and profiles accuracy of the machined larege depth diamter ratio aspheric surfaces in ultra-precision grinding process are analyzed theoretically. An ultra-precision aspheric grinding system is then designed and manufactured. Aerostatic form is adopted to build the spindle of the workpiece, transverse guideway, longitudinal guideway and the spindle of the grinder in this system. The following specification is achieved, such as the turning accuracy of the spindle of the workpiece is 0.05 μm, radial rigidity of the spindle is GE 220N/μm, axial rigidity is GE 160 N/μm, radial rigidity of the guideway is GE 200N/μm, the highest rotational speed of the grinder is 80 000 rev/min and its turning accuracy is 0.1 μm, the resolution of linear displacement of the transverse and longitudinal guideway is 4.9 nm. Adjusting range of this adjusting mechanism is 2 mm in the Y direction, the adjusting accuracy of the precise adjusting mechanism is 0.1 μm. Micro displacement measuring system of this ultra-precision aspheric grinding adopts two-backfeed strategy, and angle displacement back-feed is realized by photoelectric encoder, it’s resolution is 655 360 pulse/rev. after 4 frequency multiplication, it’s angle displacement resolution is achieved 2 621 440 pulse/rev. Straight-line displacement is monitored by single frequency laser interferometer (DLSTAX LTM-20B, made in Japan). This CNC system adopts inimitable bi-arc step length flex CN interpolation algorithm, it’s CN system resolution is 5 nm.So this aspheric grinding system ensures profile accuracy of the machined part. The resolution of this interferometer is 5 nm. Finally, lots of ultra-precision grinding experiments are carried out on this grinding system. Some optical aspheric parts, with profiles accuracy of 0.3 μm, surface roughness less than 0.01 μm, are obtained.展开更多
利用英国Hadley中心QUMP模式（Quantifying Uncertainties in Model Projections）集合的5组敏感性试验产生的全球气候背景场驱动区域气候模拟系统PRECIS（Providing Regional Climates for Impacts Studies）产生的降尺度数据,分析PRE...利用英国Hadley中心QUMP模式（Quantifying Uncertainties in Model Projections）集合的5组敏感性试验产生的全球气候背景场驱动区域气候模拟系统PRECIS（Providing Regional Climates for Impacts Studies）产生的降尺度数据,分析PRECIS对中国地面气温变化的模拟能力,同时对SRES A1B温室气体排放情景下21世纪中期（2021-2050年）中国区域的温度做出预估。模拟能力分析结果显示：PRECIS在5组背景场驱动下都可以较好地模拟出气候基准时段（1961-1900年）中国区域气温的年变化和时空分布特征,但存在暖偏差,高敏感度模拟实验的暖偏差幅度要大于中低敏感度。预估结果显示：5组敏感性试验降尺度模拟的温度均呈增加趋势,其中最低温度的变暖幅度高于平均温度和最高温度。高敏感度试验Q10模拟的升温幅度介于低敏感度模拟和中敏感度模拟之间,其他敏感性试验表现出高敏感度模拟的升温幅度高于中敏感度模拟,而中敏感度模拟高于低敏感度模拟。从模拟的升温空间分布上看,西北地区升温幅度最显著,可达2.08-2.61°C,华南地区升温幅度相对较小,为1.33-1.84°C,但不同敏感度模拟的升温幅度具有一定的区域差异。展开更多
To improve the positioning accuracy in GPS point positioning, the geometric dilution of precision （GDOP） including HDOP, VDOP, TDOP, PDOP is commonly considered. The properties of the DOP for the GPS satellite navig...To improve the positioning accuracy in GPS point positioning, the geometric dilution of precision （GDOP） including HDOP, VDOP, TDOP, PDOP is commonly considered. The properties of the DOP for the GPS satellite navigation system are studied and the coordinate system is improved in order to decrease the amount of variables. In the end, by simulation and discussing the results, the corresponding conclusions are presented.展开更多
To investigate the effects of billet geometry on the cold precision forging process of a helical gear, six different billet geometries were designed utilizing the relief-hole principle. And the influences of the bille...To investigate the effects of billet geometry on the cold precision forging process of a helical gear, six different billet geometries were designed utilizing the relief-hole principle. And the influences of the billet geometry on the forming load and the deformation uniformity were analyzed by three-dimensional （3D） finite element method （FEM） under the commercial software DEFORM 3D. The billet geometry was optimized to meet lower forming load and better deformation uniformity requirement. Deformation mechanism was studied through the distribution of flow velocity field and effective strain field. The forging experiments of the helical gear were successfully performed using lead material as a model material under the same process conditions used in the FE simulations. The results show that the forming load decreases as the diameter of relief-hole do increases, but the effect of do on the deformation uniformity is very complicated. The forming load is lower and the deformation is more uniform when do is 10 mm.展开更多
The finite element analysis （FEA） software Ansys was employed to study the stress state of the dies of both plane and non-plane parting face structures with uniform interference and the die of plane parting face str...The finite element analysis （FEA） software Ansys was employed to study the stress state of the dies of both plane and non-plane parting face structures with uniform interference and the die of plane parting face structure with non-uniform interference. Considering the symmetry of the die, a half gear tooth model of the two-ring assembled die with 2.5 GPa inner pressure was constructed. Four paths were defined to investigate the stress state at the bottom comer of the die where stress concentration was serious. FEA results show that the change of parting face from non-plane to plane can greatly reduce the stress at the teeth tips of the die so that the tip fracture is avoided. The interference structure of the die is the most important influencing factor for the stress concentration at the bottom comer. When non-uniform interference is adopted the first principal stress at the comer on the defined paths of the die is much lower than that with uniform interference. The bottom hole radius is another important influencing factor for the comer stress concentration. The first principal stress at the comer of the plane parting face die with non-uniform interference is reduced from 2.3 to 1.9 GPa when the hole radius increases from 12.5 to 16.0 mm. The optimization of the die structure increases the life of the die from 100 to 6 000 hits.展开更多
The casting-forging combined technique and the closed die forging without flash-less are both new developed material working methods. The former can not only decrease forming operations of forgings, but also increase ...The casting-forging combined technique and the closed die forging without flash-less are both new developed material working methods. The former can not only decrease forming operations of forgings, but also increase the material utilization ratio. Therefore, it is applied to produce more complex forgings. The latter is required for forging precise parts without burrs. The alternator pole is a complex forging, which was usually produced by hot forging, upsetting-extrusion or upsetting-extrusion and bending processes. During these processes, not only the forming force is higher, but the material of burrs accounts for 30 percent or so of total required material. And burrs are difficult to remove in the sequential machining process. In accordance with defects exiting in current manufacturing of alternator poles by upsetting-extruding process, such as more material demand, higher forming force and difficulty of next machining, a casting-forging precision process of alternator poles was developed and investigated in this paper. In the process, the pole was formed by two operations. One is the pre-forming operation by casting. The other is the final forming operation by the closed precision forging process. This can not only shorten processes, decrease material and power demand, but also increase precision of forgings. First, the casting blocker was designed considering the casting process and the forging ratio and the mode of deformation. Then the die structure for closed precision forging was designed, and the closing device for forging dies with spring assemblies in order to provide the necessary closing force was also designed. Finally the forming processes was investigated by test and numerical simulation method to optimum process parameters and die structure design parameters. The result can provide basis for applying the process to manufacture poles in practice.展开更多
基金Projects(U22B2084,52275483,52075142)supported by the National Natural Science Foundation of ChinaProject(2023ZY01050)supported by the Ministry of Industry and Information Technology High Quality Development,China。
文摘The gears of new energy vehicles are required to withstand higher rotational speeds and greater loads,which puts forward higher precision essentials for gear manufacturing.However,machining process parameters can cause changes in cutting force/heat,resulting in affecting gear machining precision.Therefore,this paper studies the effect of different process parameters on gear machining precision.A multi-objective optimization model is established for the relationship between process parameters and tooth surface deviations,tooth profile deviations,and tooth lead deviations through the cutting speed,feed rate,and cutting depth of the worm wheel gear grinding machine.The response surface method(RSM)is used for experimental design,and the corresponding experimental results and optimal process parameters are obtained.Subsequently,gray relational analysis-principal component analysis(GRA-PCA),particle swarm optimization(PSO),and genetic algorithm-particle swarm optimization(GA-PSO)methods are used to analyze the experimental results and obtain different optimal process parameters.The results show that optimal process parameters obtained by the GRA-PCA,PSO,and GA-PSO methods improve the gear machining precision.Moreover,the gear machining precision obtained by GA-PSO is superior to other methods.
基金supported by the Key Research and Development Program of Science&Technology Department of Sichuan Province(2021YFG0155)the Technical Innovation Fund of Southwest China Institute of Electronic Technology(H21004.2).
文摘Unmanned aerial vehicles(UAVs)may be subjected to unintentional radio frequency interference(RFI)or hostile jamming attack which will lead to fail to track global navigation satellite system(GNSS)signals.Therefore,the simultaneous realization of anti-jamming and high-precision carrier phase difference positioning becomes a dilemmatic problem.In this paper,a distortionless phase digital beamforming(DBF)algorithm with self-calibration antenna arrays is proposed,which enables to obtain distortionless carrier phase while suppressing jamming.Additionally,architecture of high precision Beidou receiver based on anti-jamming antenna arrays is proposed.Finally,the performance of the algorithm is evaluated,including antenna calibration accuracy,carrier phase distortionless accuracy,and carrier phase measurement accuracy without jamming.Meanwhile,the maximal jamming to signal ratio(JSR)and real time kinematic(RTK)positioning accuracy under wideband jamming are also investigated.The experimental results based on the real-life Beidou signals show that the proposed method has an excellent performance for precise relative positioning under jamming when compared with other anti-jamming methods.
文摘The design of mini-missiles(MMs)presents several novel challenges.The stringent mission requirement to reach a target with a certain precision imposes a high guidance precision.The miniaturization of the size of MMs makes the design of the guidance,navigation,and control(GNC)have a larger-thanbefore impact on the main-body design(shape,motor,and layout design)and its design objective,i.e.,flight performance.Pursuing a trade-off between flight performance and guidance precision,all the relevant interactions have to be accounted for in the design of the main body and the GNC system.Herein,a multi-objective and multidisciplinary design optimization(MDO)is proposed.Disciplines pertinent to motor,aerodynamics,layout,trajectory,flight dynamics,control,and guidance are included in the proposed MDO framework.The optimization problem seeks to maximize the range and minimize the guidance error.The problem is solved by using the nondominated sorting genetic algorithm II.An optimum design that balances a longer range with a smaller guidance error is obtained.Finally,lessons learned about the design of the MM and insights into the trade-off between flight performance and guidance precision are given by comparing the optimum design to a design provided by the traditional approach.
基金Supported by the National Natural Science Foundation of China(NSFC 62105100)the National Key research and development program in the 14th five year plan(2021YFA1200700)。
文摘Silicon(Si)diffraction microlens arrays are usually used to integrating with infrared focal plane arrays(IRFPAs)to improve their performance.The errors of lithography are unavoidable in the process of the Si diffrac-tion microlens arrays preparation in the conventional engraving method.It has a serious impact on its performance and subsequent applications.In response to the problem of errors of Si diffraction microlens arrays in the conven-tional method,a novel self-alignment method for high precision Si diffraction microlens arrays preparation is pro-posed.The accuracy of the Si diffractive microlens arrays preparation is determined by the accuracy of the first li-thography mask in the novel self-alignment method.In the subsequent etching,the etched area will be protected by the mask layer and the sacrifice layer or the protective layer.The unprotection area is carved to effectively block the non-etching areas,accurately etch the etching area required,and solve the problem of errors.The high precision Si diffraction microlens arrays are obtained by the novel self-alignment method and the diffraction effi-ciency could reach 92.6%.After integrating with IRFPAs,the average blackbody responsity increased by 8.3%,and the average blackbody detectivity increased by 10.3%.It indicates that the Si diffraction microlens arrays can improve the filling factor and reduce crosstalk of IRFPAs through convergence,thereby improving the perfor-mance of the IRFPAs.The results are of great reference significance for improving their performance through opti-mizing the preparation level of micro nano devices.
文摘The advent of gene editing represents one of the most transformative breakthroughs in life science,making genome manipulation more accessible than ever before.While traditional CRISPR/Cas-based gene editing,which involves double-strand DNA breaks(DSBs),excels at gene disruption,it is less effective for accurate gene modification.The limitation arises because DSBs are primarily repaired via non-homologous end joining(NHEJ),which tends to introduce indels at the break site.While homology directed repair(HDR)can achieve precise editing when a donor DNA template is provided,the reliance on DSBs often results in unintended genome damage.HDR is restricted to specific cell cycle phases,limiting its application.Currently,gene editing has evolved to unprecedented levels of precision without relying on DSB and HDR.The development of innovative systems,such as base editing,prime editing,and CRISPR-associated transposases(CASTs),now allow for precise editing ranging from single nucleotides to large DNA fragments.Base editors(BEs)enable the direct conversion of one nucleotide to another,and prime editors(PEs)further expand gene editing capabilities by allowing for the insertion,deletion,or alteration of small DNA fragments.The CAST system,a recent innovation,allows for the precise insertion of large DNA fragments at specific genomic locations.In recent years,the optimization of these precise gene editing tools has led to significant improvements in editing efficiency,specificity,and versatility,with advancements such as the creation of base editors for nucleotide transversions,enhanced prime editing systems for more efficient and precise modifications,and refined CAST systems for targeted large DNA insertions,expanding the range of applications for these tools.Concurrently,these advances are complemented by significant improvements in in vivo delivery methods,which have paved the way for therapeutic application of precise gene editing tools.Effective delivery systems are critical for the success of gene therapies,and recent developments in both viral and non-viral vectors have improved the efficiency and safety of gene editing.For instance,adeno-associated viruses(AAVs)are widely used due to their high transfection efficiency and low immunogenicity,though challenges such as limited cargo capacity and potential for immune responses remain.Non-viral delivery systems,including lipid nanoparticles(LNPs),offer an alternative with lower immunogenicity and higher payload capacity,although their transfection efficiency can be lower.The therapeutic potential of these precise gene editing technologies is vast,particularly in treating genetic disorders.Preclinical studies have demonstrated the effectiveness of base editing in correcting genetic mutations responsible for diseases such as cardiomyopathy,liver disease,and hereditary hearing loss.These technologies promise to treat symptoms and potentially cure the underlying genetic causes of these conditions.Meanwhile,challenges remain,such as optimizing the safety and specificity of gene editing tools,improving delivery systems,and overcoming off-target effects,all of which are critical for their successful application in clinical settings.In summary,the continuous evolution of precise gene editing technologies,combined with advancements in delivery systems,is driving the field toward new therapeutic applications that can potentially transform the treatment of genetic disorders by targeting their root causes.
基金National Natural Science Foundation of China(Grant Nos.11972193 and 92266201)。
文摘How to effectively evaluate the firing precision of weapon equipment at low cost is one of the core contents of improving the test level of weapon system.A new method to evaluate the firing precision of the MLRS considering the credibility of simulation system based on Bayesian theory is proposed in this paper.First of all,a comprehensive index system for the credibility of the simulation system of the firing precision of the MLRS is constructed combined with the group analytic hierarchy process.A modified method for determining the comprehensive weight of the index is established to improve the rationality of the index weight coefficients.The Bayesian posterior estimation formula of firing precision considering prior information is derived in the form of mixed prior distribution,and the rationality of prior information used in estimation model is discussed quantitatively.With the simulation tests,the different evaluation methods are compared to validate the effectiveness of the proposed method.Finally,the experimental results show that the effectiveness of estimation method for firing precision is improved by more than 25%.
基金the National Natural Science Foundation of China under Grant(42274119)the Liaoning Revitalization Talents Program under Grant(XLYC2002082)+1 种基金National Key Research and Development Plan Key Special Projects of Science and Technology Military Civil Integration(2022YFF1400500)the Key Project of Science and Technology Commission of the Central Military Commission.
文摘Global navigation satellite system-reflection(GNSS-R)sea surface altimetry based on satellite constellation platforms has become a new research direction and inevitable trend,which can meet the altimetric precision at the global scale required for underwater navigation.At present,there are still research gaps for GNSS-R altimetry under this mode,and its altimetric capability cannot be specifically assessed.Therefore,GNSS-R satellite constellations that meet the global altimetry needs to be designed.Meanwhile,the matching precision prediction model needs to be established to quantitatively predict the GNSS-R constellation altimetric capability.Firstly,the GNSS-R constellations altimetric precision under different configuration parameters is calculated,and the mechanism of the influence of orbital altitude,orbital inclination,number of satellites and simulation period on the precision is analyzed,and a new multilayer feedforward neural network weighted joint prediction model is established.Secondly,the fit of the prediction model is verified and the performance capability of the model is tested by calculating the R2 value of the model as 0.9972 and the root mean square error(RMSE)as 0.0022,which indicates that the prediction capability of the model is excellent.Finally,using the novel multilayer feedforward neural network weighted joint prediction model,and considering the research results and realistic costs,it is proposed that when the constellation is set to an orbital altitude of 500 km,orbital inclination of 75and the number of satellites is 6,the altimetry precision can reach 0.0732 m within one year simulation period,which can meet the requirements of underwater navigation precision,and thus can provide a reference basis for subsequent research on spaceborne GNSS-R sea surface altimetry.
文摘In this paper, the factors of affecting surface roughness and profiles accuracy of the machined larege depth diamter ratio aspheric surfaces in ultra-precision grinding process are analyzed theoretically. An ultra-precision aspheric grinding system is then designed and manufactured. Aerostatic form is adopted to build the spindle of the workpiece, transverse guideway, longitudinal guideway and the spindle of the grinder in this system. The following specification is achieved, such as the turning accuracy of the spindle of the workpiece is 0.05 μm, radial rigidity of the spindle is GE 220N/μm, axial rigidity is GE 160 N/μm, radial rigidity of the guideway is GE 200N/μm, the highest rotational speed of the grinder is 80 000 rev/min and its turning accuracy is 0.1 μm, the resolution of linear displacement of the transverse and longitudinal guideway is 4.9 nm. Adjusting range of this adjusting mechanism is 2 mm in the Y direction, the adjusting accuracy of the precise adjusting mechanism is 0.1 μm. Micro displacement measuring system of this ultra-precision aspheric grinding adopts two-backfeed strategy, and angle displacement back-feed is realized by photoelectric encoder, it’s resolution is 655 360 pulse/rev. after 4 frequency multiplication, it’s angle displacement resolution is achieved 2 621 440 pulse/rev. Straight-line displacement is monitored by single frequency laser interferometer (DLSTAX LTM-20B, made in Japan). This CNC system adopts inimitable bi-arc step length flex CN interpolation algorithm, it’s CN system resolution is 5 nm.So this aspheric grinding system ensures profile accuracy of the machined part. The resolution of this interferometer is 5 nm. Finally, lots of ultra-precision grinding experiments are carried out on this grinding system. Some optical aspheric parts, with profiles accuracy of 0.3 μm, surface roughness less than 0.01 μm, are obtained.
文摘利用英国Hadley中心QUMP模式（Quantifying Uncertainties in Model Projections）集合的5组敏感性试验产生的全球气候背景场驱动区域气候模拟系统PRECIS（Providing Regional Climates for Impacts Studies）产生的降尺度数据,分析PRECIS对中国地面气温变化的模拟能力,同时对SRES A1B温室气体排放情景下21世纪中期（2021-2050年）中国区域的温度做出预估。模拟能力分析结果显示：PRECIS在5组背景场驱动下都可以较好地模拟出气候基准时段（1961-1900年）中国区域气温的年变化和时空分布特征,但存在暖偏差,高敏感度模拟实验的暖偏差幅度要大于中低敏感度。预估结果显示：5组敏感性试验降尺度模拟的温度均呈增加趋势,其中最低温度的变暖幅度高于平均温度和最高温度。高敏感度试验Q10模拟的升温幅度介于低敏感度模拟和中敏感度模拟之间,其他敏感性试验表现出高敏感度模拟的升温幅度高于中敏感度模拟,而中敏感度模拟高于低敏感度模拟。从模拟的升温空间分布上看,西北地区升温幅度最显著,可达2.08-2.61°C,华南地区升温幅度相对较小,为1.33-1.84°C,但不同敏感度模拟的升温幅度具有一定的区域差异。
基金a grant from Science and Technology Commission of Shanghai Municipality (05dz15006)
文摘To improve the positioning accuracy in GPS point positioning, the geometric dilution of precision （GDOP） including HDOP, VDOP, TDOP, PDOP is commonly considered. The properties of the DOP for the GPS satellite navigation system are studied and the coordinate system is improved in order to decrease the amount of variables. In the end, by simulation and discussing the results, the corresponding conclusions are presented.
基金Project(51105287)supported by the National Natural Science Foundation of China
文摘To investigate the effects of billet geometry on the cold precision forging process of a helical gear, six different billet geometries were designed utilizing the relief-hole principle. And the influences of the billet geometry on the forming load and the deformation uniformity were analyzed by three-dimensional （3D） finite element method （FEM） under the commercial software DEFORM 3D. The billet geometry was optimized to meet lower forming load and better deformation uniformity requirement. Deformation mechanism was studied through the distribution of flow velocity field and effective strain field. The forging experiments of the helical gear were successfully performed using lead material as a model material under the same process conditions used in the FE simulations. The results show that the forming load decreases as the diameter of relief-hole do increases, but the effect of do on the deformation uniformity is very complicated. The forming load is lower and the deformation is more uniform when do is 10 mm.
基金Project(2006BAF04B06) supported by the National Key Technology R & D Program of ChinaProject(2005AA101B19) supported by the Key Technology R & D Program of Hubei Province, China
文摘The finite element analysis （FEA） software Ansys was employed to study the stress state of the dies of both plane and non-plane parting face structures with uniform interference and the die of plane parting face structure with non-uniform interference. Considering the symmetry of the die, a half gear tooth model of the two-ring assembled die with 2.5 GPa inner pressure was constructed. Four paths were defined to investigate the stress state at the bottom comer of the die where stress concentration was serious. FEA results show that the change of parting face from non-plane to plane can greatly reduce the stress at the teeth tips of the die so that the tip fracture is avoided. The interference structure of the die is the most important influencing factor for the stress concentration at the bottom comer. When non-uniform interference is adopted the first principal stress at the comer on the defined paths of the die is much lower than that with uniform interference. The bottom hole radius is another important influencing factor for the comer stress concentration. The first principal stress at the comer of the plane parting face die with non-uniform interference is reduced from 2.3 to 1.9 GPa when the hole radius increases from 12.5 to 16.0 mm. The optimization of the die structure increases the life of the die from 100 to 6 000 hits.
文摘The casting-forging combined technique and the closed die forging without flash-less are both new developed material working methods. The former can not only decrease forming operations of forgings, but also increase the material utilization ratio. Therefore, it is applied to produce more complex forgings. The latter is required for forging precise parts without burrs. The alternator pole is a complex forging, which was usually produced by hot forging, upsetting-extrusion or upsetting-extrusion and bending processes. During these processes, not only the forming force is higher, but the material of burrs accounts for 30 percent or so of total required material. And burrs are difficult to remove in the sequential machining process. In accordance with defects exiting in current manufacturing of alternator poles by upsetting-extruding process, such as more material demand, higher forming force and difficulty of next machining, a casting-forging precision process of alternator poles was developed and investigated in this paper. In the process, the pole was formed by two operations. One is the pre-forming operation by casting. The other is the final forming operation by the closed precision forging process. This can not only shorten processes, decrease material and power demand, but also increase precision of forgings. First, the casting blocker was designed considering the casting process and the forging ratio and the mode of deformation. Then the die structure for closed precision forging was designed, and the closing device for forging dies with spring assemblies in order to provide the necessary closing force was also designed. Finally the forming processes was investigated by test and numerical simulation method to optimum process parameters and die structure design parameters. The result can provide basis for applying the process to manufacture poles in practice.
