Hefei Light Source(HLS)is a synchrotron radiation light source that primarily produces vacuum ultraviolet and soft X-rays.It currently consists of ten experimental stations,including a soft X-ray microscopy station.As...Hefei Light Source(HLS)is a synchrotron radiation light source that primarily produces vacuum ultraviolet and soft X-rays.It currently consists of ten experimental stations,including a soft X-ray microscopy station.As part of its on-going efforts to establish a centralized scientific data management platform,HLS is in the process of developing a test sys-tem that covers the entire lifecycle of scientific data,including data generation,acquisition,processing,analysis,and de-struction.However,the instruments used in the soft X-ray microscopy experimental station rely on commercial propriet-ary software for data acquisition and processing.We developed a semi-automatic data acquisition program to facilitate the integration of soft X-ray microscopy stations into a centralized scientific data management platform.Additionally,we cre-ated an online data processing platform to assist users in analyzing their scientific data.The system we developed and de-ployed meets the design requirements,successfully integrating the soft X-ray microscopy station into the full lifecycle management of scientific data.展开更多
A light source of multi-star simulator capable of background adjustment and magnitude control has been designed.Two integrating spheres are employed as the star-point light source and the background light source respe...A light source of multi-star simulator capable of background adjustment and magnitude control has been designed.Two integrating spheres are employed as the star-point light source and the background light source respectively.A beam splitter prism has been designed to serve as the beam combiner for the star-point and the background light sources,and a mathematical model has been constructed respectively to compute the light flux of the two integrating spheres.A magnitude testing system and a background testing system have been created using low-light illuminometer,luminance meter,and testing instruments to measure the star-point magnitude and the background luminance of the multi-star simulator.The test results suggest that the star-point magnitude is adjustable from0 to+5 m_v,with a simulation precision superior to ±0.026 m_v.The maximum background luminance is 3.8×10~5 cd·m^(-2),and the minimum background luminance is6.4×10^(-2)cd·m^(-2).The designed light source system can meet the requirements for simulating the stellar map with a sky background.展开更多
随着中国人口结构老龄化,公共卫生领域迫切需要应对阿尔茨海默病(Alzheimer’s disease,AD)带来的重大社会发展问题。AD临床治疗能够使用的药物十分有限且使用一段时间后治疗效果不佳。尽管全球投入大量物力和财力进行药物研发,但药物...随着中国人口结构老龄化,公共卫生领域迫切需要应对阿尔茨海默病(Alzheimer’s disease,AD)带来的重大社会发展问题。AD临床治疗能够使用的药物十分有限且使用一段时间后治疗效果不佳。尽管全球投入大量物力和财力进行药物研发,但药物治疗临床试验进展十分缓慢。近30年来,仅有7款AD药物获得美国食品药品监督管理局(Food and Drug Administration,FDA)批准。传统药物治疗价格昂贵且只能起到延缓AD病情作用,而无法阻止神经元进行性退化过程。因此,探究发展AD新兴治疗手段刻不容缓。光生物调节(photobiomodulation,PBM)是一种非侵入性的治疗方法,利用红光或近红外光刺激细胞代谢和细胞学反应。PBM可以改善脑部代谢和血液循环,修复脑部受损神经元,激发树突和神经元生长,有望发展成为与药物治疗互补的无创伤神经治疗手段。本文阐述了AD病理学特征、致病机理与现有治疗策略面临的难题,综述了PBM治疗AD的细胞与动物模型和临床研究,总结了光疗历史与先进PBM光疗设备研发现状,最后对发展用于AD PBM治疗的先进光子技术与光疗器械装备进行了展望。展开更多
To investigate the applicability of four commonly used color difference formulas(CIELAB,CIE94,CMC(1:1),and CIEDE2000)in the printing field on 3D objects,as well as the impact of four standard light sources(D65,D50,A,a...To investigate the applicability of four commonly used color difference formulas(CIELAB,CIE94,CMC(1:1),and CIEDE2000)in the printing field on 3D objects,as well as the impact of four standard light sources(D65,D50,A,and TL84)on 3D color difference evaluations,50 glossy spheres with a diameter of 2cm based on the Sailner J4003D color printing device were created.These spheres were centered around the five recommended colors(gray,red,yellow,green,and blue)by CIE.Color difference was calculated according to the four formulas,and 111 pairs of experimental samples meeting the CIELAB gray scale color difference requirements(1.0-14.0)were selected.Ten observers,aged between 22 and 27 with normal color vision,were participated in this study,using the gray scale method from psychophysical experiments to conduct color difference evaluations under the four light sources,with repeated experiments for each observer.The results indicated that the overall effect of the D65 light source on 3D objects color difference was minimal.In contrast,D50 and A light sources had a significant impact within the small color difference range,while the TL84 light source influenced both large and small color difference considerably.Among the four color difference formulas,CIEDE2000 demonstrated the best predictive performance for color difference in 3D objects,followed by CMC(1:1),CIE94,and CIELAB.展开更多
基金supported by the Fundamental Research Funds for the Central Universities(WK2310000102)。
文摘Hefei Light Source(HLS)is a synchrotron radiation light source that primarily produces vacuum ultraviolet and soft X-rays.It currently consists of ten experimental stations,including a soft X-ray microscopy station.As part of its on-going efforts to establish a centralized scientific data management platform,HLS is in the process of developing a test sys-tem that covers the entire lifecycle of scientific data,including data generation,acquisition,processing,analysis,and de-struction.However,the instruments used in the soft X-ray microscopy experimental station rely on commercial propriet-ary software for data acquisition and processing.We developed a semi-automatic data acquisition program to facilitate the integration of soft X-ray microscopy stations into a centralized scientific data management platform.Additionally,we cre-ated an online data processing platform to assist users in analyzing their scientific data.The system we developed and de-ployed meets the design requirements,successfully integrating the soft X-ray microscopy station into the full lifecycle management of scientific data.
基金Supported by Jilin Province Key Scientific and Technological Projects(20160204008GX)National Key Laboratory Fund Project(61420020210162002)Changchun University of Science and Technology Innovation Fund(XJJLG-2016-15)
文摘A light source of multi-star simulator capable of background adjustment and magnitude control has been designed.Two integrating spheres are employed as the star-point light source and the background light source respectively.A beam splitter prism has been designed to serve as the beam combiner for the star-point and the background light sources,and a mathematical model has been constructed respectively to compute the light flux of the two integrating spheres.A magnitude testing system and a background testing system have been created using low-light illuminometer,luminance meter,and testing instruments to measure the star-point magnitude and the background luminance of the multi-star simulator.The test results suggest that the star-point magnitude is adjustable from0 to+5 m_v,with a simulation precision superior to ±0.026 m_v.The maximum background luminance is 3.8×10~5 cd·m^(-2),and the minimum background luminance is6.4×10^(-2)cd·m^(-2).The designed light source system can meet the requirements for simulating the stellar map with a sky background.
文摘随着中国人口结构老龄化,公共卫生领域迫切需要应对阿尔茨海默病(Alzheimer’s disease,AD)带来的重大社会发展问题。AD临床治疗能够使用的药物十分有限且使用一段时间后治疗效果不佳。尽管全球投入大量物力和财力进行药物研发,但药物治疗临床试验进展十分缓慢。近30年来,仅有7款AD药物获得美国食品药品监督管理局(Food and Drug Administration,FDA)批准。传统药物治疗价格昂贵且只能起到延缓AD病情作用,而无法阻止神经元进行性退化过程。因此,探究发展AD新兴治疗手段刻不容缓。光生物调节(photobiomodulation,PBM)是一种非侵入性的治疗方法,利用红光或近红外光刺激细胞代谢和细胞学反应。PBM可以改善脑部代谢和血液循环,修复脑部受损神经元,激发树突和神经元生长,有望发展成为与药物治疗互补的无创伤神经治疗手段。本文阐述了AD病理学特征、致病机理与现有治疗策略面临的难题,综述了PBM治疗AD的细胞与动物模型和临床研究,总结了光疗历史与先进PBM光疗设备研发现状,最后对发展用于AD PBM治疗的先进光子技术与光疗器械装备进行了展望。
文摘To investigate the applicability of four commonly used color difference formulas(CIELAB,CIE94,CMC(1:1),and CIEDE2000)in the printing field on 3D objects,as well as the impact of four standard light sources(D65,D50,A,and TL84)on 3D color difference evaluations,50 glossy spheres with a diameter of 2cm based on the Sailner J4003D color printing device were created.These spheres were centered around the five recommended colors(gray,red,yellow,green,and blue)by CIE.Color difference was calculated according to the four formulas,and 111 pairs of experimental samples meeting the CIELAB gray scale color difference requirements(1.0-14.0)were selected.Ten observers,aged between 22 and 27 with normal color vision,were participated in this study,using the gray scale method from psychophysical experiments to conduct color difference evaluations under the four light sources,with repeated experiments for each observer.The results indicated that the overall effect of the D65 light source on 3D objects color difference was minimal.In contrast,D50 and A light sources had a significant impact within the small color difference range,while the TL84 light source influenced both large and small color difference considerably.Among the four color difference formulas,CIEDE2000 demonstrated the best predictive performance for color difference in 3D objects,followed by CMC(1:1),CIE94,and CIELAB.
