There is an increasing attention on oxidative derivatives of triglycerides,a group of potential thermal processing induced food toxicants,which are formed during the thermal processing of food lipids.This review aims ...There is an increasing attention on oxidative derivatives of triglycerides,a group of potential thermal processing induced food toxicants,which are formed during the thermal processing of food lipids.This review aims to summarize current knowledge about their formation mechanisms,detection approaches,and toxicology impacts.Oxidative derivatives of triglycerides are generated through the oxidation,cyclization,polymerization,and hydrolysis of triglycerides under high-temperature and abundant oxygen.The analytical techniques,including GC,HPSEC,MS,^(1)H-NMR were discussed in analyzing these components.In addition,their toxic effects on human health,including effects on the liver,intestines,cardiovascular system,immune system,and metabolism were elucidated.Information in this review could be used to improve the understanding of oxidative derivatives of triglycerides and ultimately improve academic and industrial strategies for eliminating these compounds in thermal processing food systems.展开更多
CCCTC结合因子(CCCTC-binding factor,CTCF)是一种多功能且高度保守的转录调节因子,参与转录调控、染色质结构维护、细胞分化等多种生物学过程.本研究通过RT-qPCR检测CTCF基因在鸡不同组织中的表达量,发现CTCF在脑和心脏中高表达.构建的...CCCTC结合因子(CCCTC-binding factor,CTCF)是一种多功能且高度保守的转录调节因子,参与转录调控、染色质结构维护、细胞分化等多种生物学过程.本研究通过RT-qPCR检测CTCF基因在鸡不同组织中的表达量,发现CTCF在脑和心脏中高表达.构建的CTCF真核过表达载体转染鸡肝癌细胞系LMH(Leghorn Male Hepatoma,LMH)后,成功表达CTCF-Myc融合蛋白.油红O染色和比色法检测显示,过表达CTCF后,LMH细胞脂滴沉积和总甘油三酯(TG)显著增加(P<0.01),磷脂酸磷酸酶1(LIPIN1)基因表达下调(P<0.01),固醇调节元件结合蛋白1(SREBP1)、脂肪酸合酶(FASN)和乙酰辅酶A羧化酶α(ACACA)基因表达显著上调(P<0.05或P<0.01).结果表明,CTCF基因可能通过调控脂质代谢相关基因表达促进脂质沉积.展开更多
目的探讨超声造影联合血脂检测评价颈动脉易损斑块对缺血性脑卒中患者的预测价值。方法本研究为前瞻性研究,选择2023年1月至2024年5月佛山市南海区第四人民医院确诊的颈动脉易损斑块患者120例,其中缺血性脑卒中患者60例为研究组,无缺血...目的探讨超声造影联合血脂检测评价颈动脉易损斑块对缺血性脑卒中患者的预测价值。方法本研究为前瞻性研究,选择2023年1月至2024年5月佛山市南海区第四人民医院确诊的颈动脉易损斑块患者120例,其中缺血性脑卒中患者60例为研究组,无缺血性脑卒中患者60例为对照组。分别对2组进行常规超声、超声造影及血脂检查,分析研究组与对照组、研究组不同血流分级患者不稳定斑块积分比、斑块最大长度、斑块最大厚度、溃疡斑、面积狭窄、狭窄处峰值流速、阻力指数及血脂水平的差异。采用ROC曲线分析,并计算曲线下面积(the area under curve,AUC)。结果研究组与对照组不稳定斑块积分比、斑块最大长度、斑块最大厚度、溃疡斑、面积狭窄、狭窄处峰值流速、阻力指数、血流特征比较,差异有统计学意义(P<0.01)。研究组三酰甘油(triglyceride,TG)、总胆固醇(total cholesterol,TC)、低密度胆固醇(low density lipoprotein,LDL)、水平明显高于对照组,高密度胆固醇(high density lipoprotein,HDL)水平明显低于对照组(P<0.01)。研究组不同血流分级患者不稳定斑块积分比、斑块最大长度、斑块最大厚度、溃疡斑、面积狭窄、狭窄处峰值流速、阻力指数比较,差异有统计学意义(P<0.05,P<0.01)。研究组不同血流分级患者TC、TG、LDL、HDL水平比较,差异有统计学意义(P<0.01)。研究组血流分级Ⅲ级、Ⅱ级、Ⅰ级患者TC、TG、LDL依次降低,HDL依次升高(P<0.01)。Pearman相关性分析显示,血流分级与TC、TG、LDL水平呈正相关(r=0.456,r=0.652,r=0.362,P=0.000),与HDL水平呈负相关(r=-0.256,P=0.000)。ROC曲线分析显示,超声造影血流分级与血脂水平联合检测对颈动脉易损斑块缺血性脑卒中患者诊断的AUC明显高于单独检测,通过截断值分析,颈动脉易损斑块缺血性脑卒中患者超声造影血流分级为Ⅱ级以上,TC为5.22 mmol/L,TG为2.33 mmol/L,LDL为2.78 mmol/L,HDL为0.82 mmol/L。结论超声造影血流较高等级结合血脂水平异常表达可能可以作为缺血性脑卒中患者的预测指标。展开更多
Long-chain acyl coenzyme A synthetase(ACSL) is a member of the synthetase family encoded by a multigene family;it plays an important role in the absorption and transport of fatty acid.Here we review the roles of ACSL ...Long-chain acyl coenzyme A synthetase(ACSL) is a member of the synthetase family encoded by a multigene family;it plays an important role in the absorption and transport of fatty acid.Here we review the roles of ACSL in the regulating absorption and transport of fatty acid,as well as the connection between ACSL and some metabolic diseases.展开更多
The efficiencies of 6 kinds of macromolecules with dendritic structure in improving the flow properties of crude oil were investigated. The dendritic additives were synthesized using low-generation dendritic poly(amid...The efficiencies of 6 kinds of macromolecules with dendritic structure in improving the flow properties of crude oil were investigated. The dendritic additives were synthesized using low-generation dendritic poly(amidoamine) and alkyl longchain acrylic esters as starting materials, and their structures were characterized by the Fourier transform infrared spectroscopy, 1H-nuclear magnetic resonance and elemental analysis. The effects on the pour point and rheological properties of crude oil samples were studied. Efficiencies of dendritic long-chain esters were not only influenced by the alky chain length, but also by the generation of dendrimer. The longer the alkyl chain of dendritic long-chain ester was, the better the effect in the reduction of pour point and apparent viscosity was. Efficiencies of 1.5 generation dendritic long-chain ester with 8 branched chains for the reduction of pour point and apparent viscosity were superior to those of 0.5 generation dendritic long-chain ester with 4 branched chains. Under the same conditions, efficiencies of 1.5 generation dendritic eighteen ester were superior to those of other 1.5 generation dendritic long-chain esters for the reduction of pour point and viscosity of crude oil.展开更多
Carbon-based perovskite solar cells show great potential owing to their low-cost production and superior stability in ambient air.However,scaling up to high-efficiency carbon-based solar modules hinges on reliable dep...Carbon-based perovskite solar cells show great potential owing to their low-cost production and superior stability in ambient air.However,scaling up to high-efficiency carbon-based solar modules hinges on reliable deposition of uniform defect-free perovskite films over large areas,which is an unsettled but urgent issue.In this work,a long-chain gemini surfactant is introduced into perovskite precursor ink to enforce self-assembly into a network structure,considerably enhancing the coverage and smoothness of the perovskite films.The long gemini surfactant plays a distinctively synergistic role in perovskite film construction,crystallization kinetics modulation and defect passivation,leading to a certified record power conversion efficiency of 15.46%with Voc of 1.13 V and Jsc of 22.92 mA cm^(-2)for this type of modules.Importantly,all of the functional layers of the module are printed through a simple and high-speed(300 cm min^(-1))blade coating strategy in ambient atmosphere.These results mark a significant step toward the commercialization of all-printable carbon-based perovskite solar modules.展开更多
目的:探究血清甘油三酯-葡萄糖(TyG)指数、摄食抑制因子-1(nesfatin-1)、视黄醇结合蛋白4(RBP4)联合预测糖尿病视网膜病变(DR)的价值,为DR早期预测提供支持。方法:回顾性分析。收集2022-02/2023-12我院接诊的2型糖尿病(T2DM)患者164例...目的:探究血清甘油三酯-葡萄糖(TyG)指数、摄食抑制因子-1(nesfatin-1)、视黄醇结合蛋白4(RBP4)联合预测糖尿病视网膜病变(DR)的价值,为DR早期预测提供支持。方法:回顾性分析。收集2022-02/2023-12我院接诊的2型糖尿病(T2DM)患者164例的临床资料,按照眼底检查结果分为DR组43例(其中增殖性DR 19例,非增殖性DR 24例),不合并DR的T2DM组121例。入院后记录患者基本资料,检查血清TyG指数、nesfatin-1、RBP4水平。结果:DR组病程长于T2DM组,空腹血糖、糖化血红蛋白、甘油三酯、总胆固醇、低密度脂蛋白及TyG指数、RBP4水平高于T2DM组,高密度脂蛋白、nesfatin-1水平低于T2DM组(均P<0.001)。多因素Logistic回归分析可知,T2DM病程(OR=1.338,95%CI:1.059-1.690)、糖化血红蛋白(OR=5.065,95%CI:1.659-15.470)、低密度脂蛋白(OR=12.715,95%CI:2.385-67.790)、TyG指数(OR=23.057,95%CI:2.936-181.073)、RBP4(OR=1.319,95%CI:1.028-1.692)是T2DM患者发生DR的危险因素,nesfatin-1(OR=0.007,95%CI:0.003-0.016)为保护因素。绘制ROC曲线显示,TyG指数、nesfatin-1、RBP4均对T2DM患者并发DR具有一定预测价值,曲线下面积(areas under curve,AUC)分别为0.804、0.878、0.738,各指标联合预测时AUC为0.946,预测敏感度为83.72%、特异度为92.56%。增殖性DR患者TyG指数、RBP4水平高于非增殖性DR患者,nesfatin-1水平低于非增殖性DR患者(均P<0.05)。Spearman相关性分析显示,TyG指数、RBP4水平与DR病情程度呈正相关,nesfatin-1水平与DR病情程度呈负相关(r_(s)=0.557、0.392、-0.359,均P<0.05)。Pearson相关分析显示,T2DM并发DR患者TyG指数与nesfatin-1水平呈负相关,与RBP4水平呈正相关,nesfatin-1与RBP4水平呈负相关(r=-0.486、0.538、-0.592,均P<0.05)。结论:血清TyG指数、nesfatin-1、RBP4水平与DR发病风险及病情程度有关,可作为DR早期预测的标志物,且联合预测效能更好。展开更多
基金funded by the National Natural Science Foundation of China (Grant No.32272426).
文摘There is an increasing attention on oxidative derivatives of triglycerides,a group of potential thermal processing induced food toxicants,which are formed during the thermal processing of food lipids.This review aims to summarize current knowledge about their formation mechanisms,detection approaches,and toxicology impacts.Oxidative derivatives of triglycerides are generated through the oxidation,cyclization,polymerization,and hydrolysis of triglycerides under high-temperature and abundant oxygen.The analytical techniques,including GC,HPSEC,MS,^(1)H-NMR were discussed in analyzing these components.In addition,their toxic effects on human health,including effects on the liver,intestines,cardiovascular system,immune system,and metabolism were elucidated.Information in this review could be used to improve the understanding of oxidative derivatives of triglycerides and ultimately improve academic and industrial strategies for eliminating these compounds in thermal processing food systems.
文摘CCCTC结合因子(CCCTC-binding factor,CTCF)是一种多功能且高度保守的转录调节因子,参与转录调控、染色质结构维护、细胞分化等多种生物学过程.本研究通过RT-qPCR检测CTCF基因在鸡不同组织中的表达量,发现CTCF在脑和心脏中高表达.构建的CTCF真核过表达载体转染鸡肝癌细胞系LMH(Leghorn Male Hepatoma,LMH)后,成功表达CTCF-Myc融合蛋白.油红O染色和比色法检测显示,过表达CTCF后,LMH细胞脂滴沉积和总甘油三酯(TG)显著增加(P<0.01),磷脂酸磷酸酶1(LIPIN1)基因表达下调(P<0.01),固醇调节元件结合蛋白1(SREBP1)、脂肪酸合酶(FASN)和乙酰辅酶A羧化酶α(ACACA)基因表达显著上调(P<0.05或P<0.01).结果表明,CTCF基因可能通过调控脂质代谢相关基因表达促进脂质沉积.
文摘目的探讨超声造影联合血脂检测评价颈动脉易损斑块对缺血性脑卒中患者的预测价值。方法本研究为前瞻性研究,选择2023年1月至2024年5月佛山市南海区第四人民医院确诊的颈动脉易损斑块患者120例,其中缺血性脑卒中患者60例为研究组,无缺血性脑卒中患者60例为对照组。分别对2组进行常规超声、超声造影及血脂检查,分析研究组与对照组、研究组不同血流分级患者不稳定斑块积分比、斑块最大长度、斑块最大厚度、溃疡斑、面积狭窄、狭窄处峰值流速、阻力指数及血脂水平的差异。采用ROC曲线分析,并计算曲线下面积(the area under curve,AUC)。结果研究组与对照组不稳定斑块积分比、斑块最大长度、斑块最大厚度、溃疡斑、面积狭窄、狭窄处峰值流速、阻力指数、血流特征比较,差异有统计学意义(P<0.01)。研究组三酰甘油(triglyceride,TG)、总胆固醇(total cholesterol,TC)、低密度胆固醇(low density lipoprotein,LDL)、水平明显高于对照组,高密度胆固醇(high density lipoprotein,HDL)水平明显低于对照组(P<0.01)。研究组不同血流分级患者不稳定斑块积分比、斑块最大长度、斑块最大厚度、溃疡斑、面积狭窄、狭窄处峰值流速、阻力指数比较,差异有统计学意义(P<0.05,P<0.01)。研究组不同血流分级患者TC、TG、LDL、HDL水平比较,差异有统计学意义(P<0.01)。研究组血流分级Ⅲ级、Ⅱ级、Ⅰ级患者TC、TG、LDL依次降低,HDL依次升高(P<0.01)。Pearman相关性分析显示,血流分级与TC、TG、LDL水平呈正相关(r=0.456,r=0.652,r=0.362,P=0.000),与HDL水平呈负相关(r=-0.256,P=0.000)。ROC曲线分析显示,超声造影血流分级与血脂水平联合检测对颈动脉易损斑块缺血性脑卒中患者诊断的AUC明显高于单独检测,通过截断值分析,颈动脉易损斑块缺血性脑卒中患者超声造影血流分级为Ⅱ级以上,TC为5.22 mmol/L,TG为2.33 mmol/L,LDL为2.78 mmol/L,HDL为0.82 mmol/L。结论超声造影血流较高等级结合血脂水平异常表达可能可以作为缺血性脑卒中患者的预测指标。
基金Supported by the National Natural Science Foundation of China(81373465)
文摘Long-chain acyl coenzyme A synthetase(ACSL) is a member of the synthetase family encoded by a multigene family;it plays an important role in the absorption and transport of fatty acid.Here we review the roles of ACSL in the regulating absorption and transport of fatty acid,as well as the connection between ACSL and some metabolic diseases.
基金supported financially by the Heilongjiang Postdoctorial Financial Foundation of China (Project NO. LBH-Zo8290)The Daqing Oil Field of China was thanked for providing the financial support and the crude oil
文摘The efficiencies of 6 kinds of macromolecules with dendritic structure in improving the flow properties of crude oil were investigated. The dendritic additives were synthesized using low-generation dendritic poly(amidoamine) and alkyl longchain acrylic esters as starting materials, and their structures were characterized by the Fourier transform infrared spectroscopy, 1H-nuclear magnetic resonance and elemental analysis. The effects on the pour point and rheological properties of crude oil samples were studied. Efficiencies of dendritic long-chain esters were not only influenced by the alky chain length, but also by the generation of dendrimer. The longer the alkyl chain of dendritic long-chain ester was, the better the effect in the reduction of pour point and apparent viscosity was. Efficiencies of 1.5 generation dendritic long-chain ester with 8 branched chains for the reduction of pour point and apparent viscosity were superior to those of 0.5 generation dendritic long-chain ester with 4 branched chains. Under the same conditions, efficiencies of 1.5 generation dendritic eighteen ester were superior to those of other 1.5 generation dendritic long-chain esters for the reduction of pour point and viscosity of crude oil.
基金supported by the National Natural Science Foundation of China(U2001217,22261160370 and 21972006)Guangdong-Hong Kong-Macao Joint Innovation Foundation(2021A0505110003)+1 种基金Shenzhen Basic Research(JCYJ20220818101018038 and JCYJ20200109110628172)Guangdong Province Regional Joint Innovation Foundation(2020B1515120039)。
文摘Carbon-based perovskite solar cells show great potential owing to their low-cost production and superior stability in ambient air.However,scaling up to high-efficiency carbon-based solar modules hinges on reliable deposition of uniform defect-free perovskite films over large areas,which is an unsettled but urgent issue.In this work,a long-chain gemini surfactant is introduced into perovskite precursor ink to enforce self-assembly into a network structure,considerably enhancing the coverage and smoothness of the perovskite films.The long gemini surfactant plays a distinctively synergistic role in perovskite film construction,crystallization kinetics modulation and defect passivation,leading to a certified record power conversion efficiency of 15.46%with Voc of 1.13 V and Jsc of 22.92 mA cm^(-2)for this type of modules.Importantly,all of the functional layers of the module are printed through a simple and high-speed(300 cm min^(-1))blade coating strategy in ambient atmosphere.These results mark a significant step toward the commercialization of all-printable carbon-based perovskite solar modules.
文摘目的:探究血清甘油三酯-葡萄糖(TyG)指数、摄食抑制因子-1(nesfatin-1)、视黄醇结合蛋白4(RBP4)联合预测糖尿病视网膜病变(DR)的价值,为DR早期预测提供支持。方法:回顾性分析。收集2022-02/2023-12我院接诊的2型糖尿病(T2DM)患者164例的临床资料,按照眼底检查结果分为DR组43例(其中增殖性DR 19例,非增殖性DR 24例),不合并DR的T2DM组121例。入院后记录患者基本资料,检查血清TyG指数、nesfatin-1、RBP4水平。结果:DR组病程长于T2DM组,空腹血糖、糖化血红蛋白、甘油三酯、总胆固醇、低密度脂蛋白及TyG指数、RBP4水平高于T2DM组,高密度脂蛋白、nesfatin-1水平低于T2DM组(均P<0.001)。多因素Logistic回归分析可知,T2DM病程(OR=1.338,95%CI:1.059-1.690)、糖化血红蛋白(OR=5.065,95%CI:1.659-15.470)、低密度脂蛋白(OR=12.715,95%CI:2.385-67.790)、TyG指数(OR=23.057,95%CI:2.936-181.073)、RBP4(OR=1.319,95%CI:1.028-1.692)是T2DM患者发生DR的危险因素,nesfatin-1(OR=0.007,95%CI:0.003-0.016)为保护因素。绘制ROC曲线显示,TyG指数、nesfatin-1、RBP4均对T2DM患者并发DR具有一定预测价值,曲线下面积(areas under curve,AUC)分别为0.804、0.878、0.738,各指标联合预测时AUC为0.946,预测敏感度为83.72%、特异度为92.56%。增殖性DR患者TyG指数、RBP4水平高于非增殖性DR患者,nesfatin-1水平低于非增殖性DR患者(均P<0.05)。Spearman相关性分析显示,TyG指数、RBP4水平与DR病情程度呈正相关,nesfatin-1水平与DR病情程度呈负相关(r_(s)=0.557、0.392、-0.359,均P<0.05)。Pearson相关分析显示,T2DM并发DR患者TyG指数与nesfatin-1水平呈负相关,与RBP4水平呈正相关,nesfatin-1与RBP4水平呈负相关(r=-0.486、0.538、-0.592,均P<0.05)。结论:血清TyG指数、nesfatin-1、RBP4水平与DR发病风险及病情程度有关,可作为DR早期预测的标志物,且联合预测效能更好。
