摘要
目的探讨乙型肝炎肝硬化(HBC)患者肠道菌群水平与总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)的关系。方法选取2021年7月至2022年6月在联勤保障部队第九二三医院感染科治疗的HBC患者(肝硬化组)、乙型肝炎患者(乙肝组),以及在体检中心体检的健康受试者(对照组),每组各80例。检测并比较各组肠道菌群水平、糖脂代谢指标,分析两者的关系。结果肝硬化组肠杆菌和肠球菌水平最高,且乙肝组肠杆菌和肠球菌水平高于对照组,差异有统计学意义(P<0.05);肝硬化组双歧杆菌和乳杆菌水平最低,且乙肝组双歧杆菌和乳杆菌水平低于对照组,差异有统计学意义(P<0.05)。肝硬化组空腹血糖(FBG)、TC、TG及LDL-C水平最高,且乙肝组FBG、TC、TG及LDL-C水平高于对照组,差异有统计学意义(P<0.05);肝硬化组HDL-C水平最低,且乙肝组HDL-C水平低于对照组,差异有统计学意义(P<0.05)。肠杆菌、肠球菌均与FBG、TC、TG及LDL-C呈正相关,与HDL-C呈负相关。双歧杆菌、乳杆菌均与FBG、TC、TG及LDL-C呈负相关,与HDL-C呈正相关。结论HBC患者肠道菌群水平与TC、TG、HDL-C及LDL-C水平密切相关,这为今后利用肠道菌群治疗相关疾病提供了可能性。
Objective To explore the relationship between intestinal flora and the levels of total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)in patients with hepatitis B cirrhosis(HBC).Methods HBC patients(cirrhosis group)and hepatitis B patients(hepatitis B group)treated in the Department of Infectious Disease of the No.923 Hospital of the Joint Logistic Support Force from July 2021 to June 2022,and healthy subjects who had a physical examination at the Physical Examination Center(control group)were selected,with 80 cases in each group.The levels of intestinal flora and indicators of glycolipid metabolism were detected and compared between the groups,and the relationship between the two was analyzed.Results The levels of Enterobacteriaceae and Enterococcus were the highest in the cirrhosis group,and the levels of Enterobacteriaceae and Enterococcus were higher in the hepatitis B group than in the control group,with statistically significant differences(P<0.05).The levels of Bifidobacterium and Lactobacillus were the lowest in the cirrhosis group,and the levels of Bifidobacterium and Lactobacillus were lower in the hepatitis B group than in the control group,with statistically significant differences(P<0.05).Fasting blood glucose(FBG),TC,TG and LDL-C levels were the highest in the cirrhosis group,and FBG,TC,TG and LDL-C levels were higher in the hepatitis B group than in the control group,with statistically significant differences(P<0.05).HDL-C levels were the lowest in the cirrhosis group,and HDL-C levels were lower in the hepatitis B group than in the control group,with statistically significant differences(P<0.05).Enterobacteriaceae and Enterococcus were all positively correlated with FBG,TC,TG and LDL-C,and negatively correlated with HDL-C.Bifidobacterium and Lactobacillus were all negatively correlated with FBG,TC,TG and LDL-C and positively correlated with HDL-C.Conclusion There is a strong relationship between the level of intestinal flora and the level of TC,TG,HDL-C,LDL-C in patients with HBC,which provides the possibility of using intestinal flora to treat related diseases in the future.
作者
陆晖
谭可平
陈婵
覃国琦
陆鹏
LU Hui;TAN Keping;CHEN Chan;QIN Guoqi;LU Peng(Department of Infectious Disease,the No.923 Hospital of the Joint Logistic Support Force,Guangxi,Nanning 530021,China)
出处
《中国医药科学》
2025年第1期19-22,共4页
China Medicine And Pharmacy
基金
广西壮族自治区卫生健康委员会科研课题(Z20210601)。
关键词
乙型肝炎
肝硬化
肠道菌群
总胆固醇
甘油三酯
高密度脂蛋白胆固醇
低密度脂蛋白胆固醇
相关性
Hepatitis B
Cirrhosis
Intestinal flora
Total cholesterol
Triglycerides
High-density lipoprotein cholesterol
Low-density lipoprotein cholesterol
Correlation
作者简介
通讯作者:谭可平。
