Once there lived a very old peasant in a village. His name was Jack.He had a horse.It was almost as old as him. One day he set off with his young son to sell the horse before it died.They walked because the father did...Once there lived a very old peasant in a village. His name was Jack.He had a horse.It was almost as old as him. One day he set off with his young son to sell the horse before it died.They walked because the father did not want the horse to be too tired. They met two neighbours (邻居)on their way.The neighbours said, "Hello,why are展开更多
In this paper numerical analysis of underground structures, taking account the transverse isotropy system of rocks, was done using CAST 3M code by varying the shape of excavation and the coefficient of earth pressure ...In this paper numerical analysis of underground structures, taking account the transverse isotropy system of rocks, was done using CAST 3M code by varying the shape of excavation and the coefficient of earth pressure k. Numerical results reveal that the anisotropy behavior, the shape of hole and the coefficient of earth pressure k have significant influence to the mining induced stress field and rock deformations which directly control the stability of underground excavation design. The magnitude of horizontal stress obtained for the horse shoe shape excavation(25.2 MPa for k = 1; 52.7 MPa for k = 2)is lower than the magnitude obtained for circular hole(26.4 MPa for k = 1; 59.5 MPa for k = 2).Therefore, we have concluded that the horse shoe shape offers the best stability and the best design for engineer. The anisotropy system presented by rock mass can also influence the redistribution of stresses around hole opened. Numerical results have revealed that the magnitude of redistribution of horizontal stresses obtained for transverse isotropic rock(12.1 MPa for k = 0.5; 25.2 MPa for k = 1 and52.7 MPa for k = 2) is less than those obtained in the case of isotropic rock(27.6 MPa for k = 1;48.6 MPa for k = 2 and 90.81 MPa for k = 2). The more the rock has the anisotropic behavior, the more the mass of rock around the tunnel is stable.展开更多
Early-stage brain metastasis of breast cancer(BMBC), due to the existence of an intact blood–brain barrier(BBB), is one of the deadliest neurologic complications. To improve the efficacy of chemotherapy for BMBC, a T...Early-stage brain metastasis of breast cancer(BMBC), due to the existence of an intact blood–brain barrier(BBB), is one of the deadliest neurologic complications. To improve the efficacy of chemotherapy for BMBC, a Trojan horse strategy-based nanocarrier has been developed by integrating the cell membrane of a brain-homing cancer cell and a polymeric drug depot. With the camouflage of a MDA-MB-231/Br cell membrane, doxorubicin-loaded poly(D, L-lactic-co-glycolic acid) nanoparticle(DOX-PLGA@CM) shows enhanced cellular uptake and boosted killing potency for MDA-MB-231/Br cells. Furthermore, DOX-PLGA@CM is equipped with naturally selected molecules for BBB penetration, as evidenced by its boosted capacity in entering the brain of both healthy and early-stage BMBC mouse models. Consequently, DOX-PLGA@CM effectively reaches the metastatic tumor lesions in the brain, slows down cancer progression, reduces tumor burden, and extends the survival time for the BMBC animal.Furthermore, the simplicity and easy scale-up of the design opens a new window for the treatment of BMBC and other brain metastatic cancers.展开更多
India and China, even though close in distance, but distant in relationship. Recently, the world has witnessed the improvement of the bilateral relations between the two big nations. The White Horse Temple, as a site ...India and China, even though close in distance, but distant in relationship. Recently, the world has witnessed the improvement of the bilateral relations between the two big nations. The White Horse Temple, as a site constructed by discourses has transformed from‘the first government-funded temple in China'to one of the symbols of China-India friendship in the cultural exchange between the two nations. Critical discourse analysis(CDA) is an interdisciplinary approach to the study of discourse that views language as a form of social practice and focuses on the ways social and political domination are reproduced in text and talk. This paper, starts from the perspective of critical discourse analysis, is exploratory in that it aims to see how the discursive practice of the White Horse Temple constitutes the discourse of China-India relationship and is constituted by the power relationship between the two nations.展开更多
1. It was the day after the circus(马戏团) came to our village that Yakub and I first saw the little horse. He looked terrible. Every rib (肋骨)showed clearly. His hair-was coming out in patches. His head hang down.
Herbert Sutcliffe and Harold Berman'A dark horse,' is one thatshows unexpected racing speed and 'comes in first, even though theexperts said he had little chance of winning. In politics, an unknown candida...Herbert Sutcliffe and Harold Berman'A dark horse,' is one thatshows unexpected racing speed and 'comes in first, even though theexperts said he had little chance of winning. In politics, an unknown candidate for office whowins a nomination or election is called 'a dark horse.' British Prime Minister Benjamin Disraeli is believedto have been the first to use the phrase. In his novel,'The Young Duke,' published in 1831, Disraeli de-展开更多
get it straight from the horse’s mouth的意思是指“消息等直接得来,而非间接获知”。it指thehorse’s age.即“马的年龄”。这一词组意为“从马嘴里直接得知马的年龄”。我们知道,要想知道马的年龄,只要看它的牙就行了。这就是这一...get it straight from the horse’s mouth的意思是指“消息等直接得来,而非间接获知”。it指thehorse’s age.即“马的年龄”。这一词组意为“从马嘴里直接得知马的年龄”。我们知道,要想知道马的年龄,只要看它的牙就行了。这就是这一习语的来源。展开更多
After years of hard working and coordinated with acrobatic and circus experts, Sichuan Circus created an excellent modern Magic Horse Show. Besides acrobatics, magic, comedy and singing and dancing, Magic
I rode a horse called Nansi through some of the 1500 square kilometres of the Brecon Beacons National Park in Wales.Nansi was a Welsh Cob and they are one of the world’s oldest types of horses and live wild in the na...I rode a horse called Nansi through some of the 1500 square kilometres of the Brecon Beacons National Park in Wales.Nansi was a Welsh Cob and they are one of the world’s oldest types of horses and live wild in the national park.It was nearly twenty years since I had ridden a horse.展开更多
Horses are strong and beautiful animals.There are more than 400 breeds of horses.Some are large,and others are small.Small ones are called ponies.Horses can travel long distances while carrying a rider.Some can also p...Horses are strong and beautiful animals.There are more than 400 breeds of horses.Some are large,and others are small.Small ones are called ponies.Horses can travel long distances while carrying a rider.Some can also pull heavy loads.Before people had cars,they used to use horses for travel and work.Today you don't see many horses.But some people still keep them and ride them for fun.展开更多
Around the world,people ride different kinds of animals.Horses are the most common.These animals are strong and fast.Riding a horse is a lot of fun,and it's good exercise.Camels are great for travel in the desert....Around the world,people ride different kinds of animals.Horses are the most common.These animals are strong and fast.Riding a horse is a lot of fun,and it's good exercise.Camels are great for travel in the desert.They can go long distances without needing much water.People ride elephants for adventure.They enjoy being near these large animals.It's fun to ride high up on an elephant.展开更多
文摘Once there lived a very old peasant in a village. His name was Jack.He had a horse.It was almost as old as him. One day he set off with his young son to sell the horse before it died.They walked because the father did not want the horse to be too tired. They met two neighbours (邻居)on their way.The neighbours said, "Hello,why are
文摘In this paper numerical analysis of underground structures, taking account the transverse isotropy system of rocks, was done using CAST 3M code by varying the shape of excavation and the coefficient of earth pressure k. Numerical results reveal that the anisotropy behavior, the shape of hole and the coefficient of earth pressure k have significant influence to the mining induced stress field and rock deformations which directly control the stability of underground excavation design. The magnitude of horizontal stress obtained for the horse shoe shape excavation(25.2 MPa for k = 1; 52.7 MPa for k = 2)is lower than the magnitude obtained for circular hole(26.4 MPa for k = 1; 59.5 MPa for k = 2).Therefore, we have concluded that the horse shoe shape offers the best stability and the best design for engineer. The anisotropy system presented by rock mass can also influence the redistribution of stresses around hole opened. Numerical results have revealed that the magnitude of redistribution of horizontal stresses obtained for transverse isotropic rock(12.1 MPa for k = 0.5; 25.2 MPa for k = 1 and52.7 MPa for k = 2) is less than those obtained in the case of isotropic rock(27.6 MPa for k = 1;48.6 MPa for k = 2 and 90.81 MPa for k = 2). The more the rock has the anisotropic behavior, the more the mass of rock around the tunnel is stable.
基金the National Institutes of Health(1R01AG054839-01A1,1R41CA254500-01A1,and 1R21CA252360-01)for financial support of the research。
文摘Early-stage brain metastasis of breast cancer(BMBC), due to the existence of an intact blood–brain barrier(BBB), is one of the deadliest neurologic complications. To improve the efficacy of chemotherapy for BMBC, a Trojan horse strategy-based nanocarrier has been developed by integrating the cell membrane of a brain-homing cancer cell and a polymeric drug depot. With the camouflage of a MDA-MB-231/Br cell membrane, doxorubicin-loaded poly(D, L-lactic-co-glycolic acid) nanoparticle(DOX-PLGA@CM) shows enhanced cellular uptake and boosted killing potency for MDA-MB-231/Br cells. Furthermore, DOX-PLGA@CM is equipped with naturally selected molecules for BBB penetration, as evidenced by its boosted capacity in entering the brain of both healthy and early-stage BMBC mouse models. Consequently, DOX-PLGA@CM effectively reaches the metastatic tumor lesions in the brain, slows down cancer progression, reduces tumor burden, and extends the survival time for the BMBC animal.Furthermore, the simplicity and easy scale-up of the design opens a new window for the treatment of BMBC and other brain metastatic cancers.
文摘India and China, even though close in distance, but distant in relationship. Recently, the world has witnessed the improvement of the bilateral relations between the two big nations. The White Horse Temple, as a site constructed by discourses has transformed from‘the first government-funded temple in China'to one of the symbols of China-India friendship in the cultural exchange between the two nations. Critical discourse analysis(CDA) is an interdisciplinary approach to the study of discourse that views language as a form of social practice and focuses on the ways social and political domination are reproduced in text and talk. This paper, starts from the perspective of critical discourse analysis, is exploratory in that it aims to see how the discursive practice of the White Horse Temple constitutes the discourse of China-India relationship and is constituted by the power relationship between the two nations.
文摘1. It was the day after the circus(马戏团) came to our village that Yakub and I first saw the little horse. He looked terrible. Every rib (肋骨)showed clearly. His hair-was coming out in patches. His head hang down.
文摘Herbert Sutcliffe and Harold Berman'A dark horse,' is one thatshows unexpected racing speed and 'comes in first, even though theexperts said he had little chance of winning. In politics, an unknown candidate for office whowins a nomination or election is called 'a dark horse.' British Prime Minister Benjamin Disraeli is believedto have been the first to use the phrase. In his novel,'The Young Duke,' published in 1831, Disraeli de-
文摘After years of hard working and coordinated with acrobatic and circus experts, Sichuan Circus created an excellent modern Magic Horse Show. Besides acrobatics, magic, comedy and singing and dancing, Magic
文摘I rode a horse called Nansi through some of the 1500 square kilometres of the Brecon Beacons National Park in Wales.Nansi was a Welsh Cob and they are one of the world’s oldest types of horses and live wild in the national park.It was nearly twenty years since I had ridden a horse.
文摘Horses are strong and beautiful animals.There are more than 400 breeds of horses.Some are large,and others are small.Small ones are called ponies.Horses can travel long distances while carrying a rider.Some can also pull heavy loads.Before people had cars,they used to use horses for travel and work.Today you don't see many horses.But some people still keep them and ride them for fun.
文摘Around the world,people ride different kinds of animals.Horses are the most common.These animals are strong and fast.Riding a horse is a lot of fun,and it's good exercise.Camels are great for travel in the desert.They can go long distances without needing much water.People ride elephants for adventure.They enjoy being near these large animals.It's fun to ride high up on an elephant.
