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Dynamic shared segment protection algorithm with differentiated reliability in GMPLS networks 被引量:1
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作者 Wang Yan Zheng Junhu Zeng Jiazhi 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2009年第1期178-184,共7页
To improve the resource utilization ratio and shorten the recovery time of the shared path protection with differentiated reliability (SPP-DiR) algorithm, an algorithm called dynamic shared segment protection with d... To improve the resource utilization ratio and shorten the recovery time of the shared path protection with differentiated reliability (SPP-DiR) algorithm, an algorithm called dynamic shared segment protection with differentiated reliability (DSSP-DiR) is proposed for survivable GMPLS networks. In the proposed algorithm, a primary path is dynamically divided into several segments according to the differentiated reliability requirements of the customers. In the SPP-DiR algorithm, the whole primary path should be protected, while in the DSSP- DiR algorithm, only partial segments on the primary path need to be protected, which can reduce more backup bandwidths than that in the SPP-DiR algorithm. Simulation results show that the DSSP-DiR algorithm achieves higher resource utilization ratio, lower protection failure probability, and shorter recovery time than the SPP-DiR algorithm. 展开更多
关键词 generalized multiprotocal label switching segment protection differentiated reliability resource uti-lization ratio.
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基于差分处理的EMD-LSTM短时空中交通流量预测
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作者 周睿 邱爽 +2 位作者 孟双杰 李明 张强 《科学技术与工程》 北大核心 2025年第2期842-849,共8页
随着中国民航的飞速发展,终端区空中交通流量与日俱增,短时空中交通流量预测对于精准实施空中交通流量管理具有重要意义。为提高短时空中交通流量预测的准确性,提出了基于数据差分处理(data differential processing)的经验模态分解(emp... 随着中国民航的飞速发展,终端区空中交通流量与日俱增,短时空中交通流量预测对于精准实施空中交通流量管理具有重要意义。为提高短时空中交通流量预测的准确性,提出了基于数据差分处理(data differential processing)的经验模态分解(empirical mode decomposition,EMD)和长短期记忆(long short-term memory,LSTM)相结合的短时空中交通流量预测模型。首先,该模型对短时空中交通流量序列进行经验模态分解;其次,为了提高预测精度,运用数据差分对时间序列进行平稳化处理;最后,将平稳处理后的序列分别输入LSTM网络模型进行预测,经过数据重构,得到最终的短时流量预测值。利用郑州新郑国际机场数据进行了实验验证,结果表明,该模型预测精度和拟合程度的典型指标RSME、MAE、R^(2)分别为0.29%,0.08%、96.40%,相较于其他方法,预测精度大幅度提高,可以为短时空中交通流量预测提供有益参考。 展开更多
关键词 空中交通流量管理 短时空中交通流量预测 经验模态分解(empirical mode decomposition EMD) 数据差分处理(data differential processing) 长短期记忆(long short-term memory LSTM)
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Two-to-one differential game via improved MOGWO 被引量:1
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作者 BAI Yu ZHOU Di +2 位作者 ZHANG Bolun HE Zhen HE Ping 《Journal of Systems Engineering and Electronics》 2025年第1期233-255,共23页
When the maneuverability of a pursuer is not significantly higher than that of an evader,it will be difficult to intercept the evader with only one pursuer.Therefore,this article adopts a two-to-one differential game ... When the maneuverability of a pursuer is not significantly higher than that of an evader,it will be difficult to intercept the evader with only one pursuer.Therefore,this article adopts a two-to-one differential game strategy,the game of kind is generally considered to be angle-optimized,which allows unlimited turns,but these practices do not take into account the effect of acceleration,which does not correspond to the actual situation,thus,based on the angle-optimized,the acceleration optimization and the acceleration upper bound constraint are added into the game for consideration.A two-to-one differential game problem is proposed in the three-dimensional space,and an improved multi-objective grey wolf optimization(IMOGWO)algorithm is proposed to solve the optimal game point of this problem.With the equations that describe the relative motions between the pursuers and the evader in the three-dimensional space,a multi-objective function with constraints is given as the performance index to design an optimal strategy for the differential game.Then the optimal game point is solved by using the IMOGWO algorithm.It is proved based on Markov chains that with the IMOGWO,the Pareto solution set is the solution of the differential game.Finally,it is verified through simulations that the pursuers can capture the escapee,and via comparative experiments,it is shown that the IMOGWO algorithm performs well in terms of running time and memory usage. 展开更多
关键词 differential game improved multi-objective grey wolf optimization(IMOGWO) cooperative pursuit optimal game point
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Catalpol Promotes Differentiation of Neural Stem Cells into Oligodendrocyte via Caveolin-1-dependent Pathway in The 3D Microfluidic Chip
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作者 WANG Ya-Chen WANG Liang +1 位作者 SHEN Li-Ming LIU Jing 《生物化学与生物物理进展》 北大核心 2025年第11期2842-2853,共12页
Objective Cerebral palsy(CP)is a prevalent neurodevelopmental disorder acquired during the perinatal period,with periventricular white matter injury(PWMI)serving as its primary pathological hallmark.PWMI is characteri... Objective Cerebral palsy(CP)is a prevalent neurodevelopmental disorder acquired during the perinatal period,with periventricular white matter injury(PWMI)serving as its primary pathological hallmark.PWMI is characterized by the loss of oligodendrocytes(OLs)and the disintegration of myelin sheaths,leading to impaired neural connectivity and motor dysfunction.Neural stem cells(NSCs)represent a promising regenerative source for replenishing lost OLs;however,conventional twodimensional(2D)in vitro culture systems lack the three-dimensional(3D)physiological microenvironment.Microfluidic chip technology has emerged as a powerful tool to overcome this limitation by enabling precise spatial and temporal control over 3D microenvironmental conditions,including the establishment of stable concentration gradients of bioactive molecules.Catalpol,an iridoid glycoside derived from traditional medicinal plants,exhibits dual antioxidant and anti-apoptotic properties.Despite its therapeutic potential,the capacity of catalpol to drive NSC differentiation toward OLs under biomimetic 3D conditions,as well as the underlying molecular mechanisms,remains poorly understood.This study aims to develop a microfluidic-based 3D biomimetic platform to systematically investigate the concentration-dependent effects of catalpol on promoting NSCs-to-OLs differentiation and to elucidate the role of the caveolin-1(Cav-1)signaling pathway in this process.Methods We developed a novel multiplexed microfluidic device featuring parallel microchannels with integrated gradient generators capable of establishing and maintaining precise linear concentration gradients(0-3 g/L catalpol)across 3D NSCs cultures.This platform facilitated the continuous perfusion culture of NSC-derived 3D spheroids,mimicking the dynamic in vivo microenvironment.Real-time cell viability was assessed using Calcein-AM/propidium iodide(PI)dual staining,with fluorescence imaging quantifying live/dead cell ratios.Oligodendrocyte differentiation was evaluated through quantitative reverse transcription polymerase chain reaction(qRT-PCR)for MBP and SOX10 gene expression,complemented by immunofluorescence staining to visualize corresponding protein changes.To dissect the molecular mechanism,the Cav-1-specific pharmacological inhibitor methyl‑β‑cyclodextrin(MCD)was employed to perturb the pathway,and its effects on differentiation markers were analyzed.Results Catalpol demonstrated excellent biocompatibility,with cell viability exceeding 96%across the entire tested concentration range(0-3 g/L),confirming its non-cytotoxic nature.At the optimal concentration of 0-3 g/L,catalpol significantly upregulated both MBP and SOX10 expression(P<0.05,P<0.01),indicating robust promotion of oligodendroglial differentiation.Intriguingly,Cav-1 mRNA expression was progressively downregulated during NSC differentiation into OLs.Further inhibition of Cav-1 with MCD further enhanced this effect,leading to a statistically significant increase in OL-specific gene expression(P<0.05,P<0.01),suggesting Cav-1 acts as a negative regulator of OLs differentiation.Conclusion This study established an integrated microfluidic gradient chip-3D NSC spheroid culture system,which combines the advantages of precise chemical gradient control with physiologically relevant 3D cell culture.The findings demonstrate that 3 g/L catalpol effectively suppresses Cav-1 signaling to drive NSC differentiation into functional OLs.This work not only provides novel insights into the Cav-1-dependent mechanisms of myelination but also delivers a scalable technological platform for future research on remyelination therapies,with potential applications in cerebral palsy and other white matter disorders.The platform’s modular design permits adaptation for screening other neurogenic compounds or investigating additional signaling pathways involved in OLs maturation. 展开更多
关键词 CATALPOL neural stem cells OLIGODENDROCYTES DIFFERENTIATION CAVEOLIN-1 microfluidic chip
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Products of multiplication,composition and differentiation on weighted Bergman spaces in the unit ball
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作者 ZHANG Chao QIN Yuehai 《中山大学学报(自然科学版)(中英文)》 北大核心 2025年第2期160-169,共10页
The boundness and compactness of products of multiplication,composition and differentiation on weighted Bergman spaces in the unit ball are studied.We define the differentiation operator on the space of holomorphic fu... The boundness and compactness of products of multiplication,composition and differentiation on weighted Bergman spaces in the unit ball are studied.We define the differentiation operator on the space of holomorphic functions in the unit ball by radial derivative.Then we extend the Sharma's results. 展开更多
关键词 composition operator multiplication operator differentiation operator weighted Bergman space
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Smoluchowski-Kramers Approximation for Stochastic Differential Equations under Discretization
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作者 Li Ge 《应用概率统计》 北大核心 2025年第4期622-635,共14页
This paper studies the Smoluchowski–Kramers approximation for a discrete-time dynamical system modeled as the motion of a particle in a force field.We show that the approximation holds for the drift-implicit Euler–M... This paper studies the Smoluchowski–Kramers approximation for a discrete-time dynamical system modeled as the motion of a particle in a force field.We show that the approximation holds for the drift-implicit Euler–Maruyama discretization and derive its convergence rate.In particular,the solution of the discretized system converges to the solution of the first-order limit equation in the mean-square sense,and this convergence is independent of the order in which the mass parameterμand the step size h tend to zero. 展开更多
关键词 stochastic differential equations Smoluchowski-Kramers approximation driftimplicit Euler-Maruyama scheme convergence rate
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TSH抑制疗法对分化型甲状腺癌患者术后血清Tg、VEGF、TSGF、CD44V6、sIL-2R及T淋巴细胞亚群水平的影响 被引量:28
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作者 张力丹 席永昌 +2 位作者 尤立强 张建阳 张建媛 《海南医学院学报》 CAS 2018年第2期242-245,共4页
目的:探讨促甲状腺激素(thyroid stimulating hormone,TSH)抑制疗法对分化型甲状腺癌(differentiated thyroid carcinoma,DTC)患者术后血清甲状腺球蛋白(thyroglobulin,Tg)、血管内皮生长因子(vascular endothelial growth factor,VEGF... 目的:探讨促甲状腺激素(thyroid stimulating hormone,TSH)抑制疗法对分化型甲状腺癌(differentiated thyroid carcinoma,DTC)患者术后血清甲状腺球蛋白(thyroglobulin,Tg)、血管内皮生长因子(vascular endothelial growth factor,VEGF)、肿瘤特异性生长因子(tumors pecific growth factor,TSGF)、白细胞分化抗原44变异型6(CD44V6)、可溶性白细胞介素-2受体(soluble interleukin-2receptor,sIL-2R)及T淋巴细胞亚群水平的影响。方法:选择2014年1月~2017年1月我院收治的接受甲状腺全切手术治疗的100例DTC患者,随机分为对照组和实验组,各50例。对照组患者常规给予甲状腺素替代治疗,实验组患者给予TSH抑制疗法(口服左甲状腺素钠片,控制血清TSH水平低于0.1mU/L),两组患者均给予治疗1个月。比较两组患者治疗前后血清Tg、VEGF、TSGF、CD44V6、sIL-2R水平及外周血CD3^+、CD4^+、CD8^+水平。结果:两组治疗前的血清Tg、VEGF、TSGF、CD44V6、sIL-2R水平比较,均无显著性差异(P>0.05);两组治疗后的血清Tg、VEGF、TSGF、CD44V6、sIL-2R水平相比治疗前均较低,且实验组治疗后血清Tg、VEGF、TSGF、CD44V6、sIL-2R水平变化均显著优于对照组(P<0.05)。两组治疗前的外周血CD3^+、CD4^+、CD8^+水平比较,均无显著性差异(P>0.05);两组治疗后的外周血CD3^+、CD4^+水平相比治疗前均较高、CD8^+水平相比治疗前均较低,且实验组治疗后血外周血CD3^+、CD4^+、CD8^+水平变化均优于对照组,具有显著性差异(P<0.05)。结论:DTC行甲状腺全切手术治疗后接受TSH抑制疗法能够有效降低血清Tg、VEGF、TSGF、CD44V6、sIL-2R水平,改善细胞免疫功能,值得在临床上推广应用。 展开更多
关键词 促甲状腺激素抑制疗法 分化型甲状腺癌(differentiated thyroid carcinoma DTC) 甲状腺球蛋白(thyroglobulin Tg) 血管内皮生长因子(vascular endothelial growth factor VEGF) 肿瘤特异性生长因子(tumors pecific growth factor TSGF) 白细胞分化抗原44变异型6(CD44V6) 可溶性白细胞介素-2受体(soluble interleukin-2receptor sIL-2R) T淋巴细胞亚群
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The predictive value of NLR and SII in anti⁃MDA5 antibody⁃positive dermatomyositis with rapidly progressive interstitial lung disease
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作者 CAI Qingqing YOU Hanxiao +7 位作者 WANG Lei LÜChengyin SHI Yumeng QIU Yulu WU Lingyun WANG Fang ZHANG Miaojia TAN Wenfeng 《南京医科大学学报(自然科学版)》 北大核心 2025年第2期196-207,共12页
Objective:To evaluate the predictive value of the neutrophil⁃to⁃lymphocyte ratio(NLR)and the systemic immune⁃inflammation index(SII)in predicting patients with anti⁃melanoma differentiation⁃associated gene 5⁃positive(... Objective:To evaluate the predictive value of the neutrophil⁃to⁃lymphocyte ratio(NLR)and the systemic immune⁃inflammation index(SII)in predicting patients with anti⁃melanoma differentiation⁃associated gene 5⁃positive(anti⁃MDA5+)dermatomyositis(DM)develop into the rapidly progressive interstitial lung disease(RPILD).Methods:We retrospectively analyzed the clinical and laboratory data of 124 anti⁃MDA5+DM patients from the First Affiliated Hospital of Nanjing Medical University between March 2019 and September 2023.We identified independent risk factors associated with the development and mortality of RPILD with the Cox regression analysis,and determined the optimal cut⁃off values for predicting adverse outcomes with the receiver operating characteristic(ROC)curve analysis.Results:Among the 124 patients,36 patients(29.03%)developed RPILD,and 39 patients(31.45%)died during the follow⁃up period.The results of multivariate Cox regression analysis showed that the elevated NLR was an independent risk factor for RPILD development,while the elevated SII expression was independently associated with the increased mortality of RPILD.Based on the ROC curve analysis,NLR>6.12 was a predictor for RPILD,and SII>875.79 was associated with increased mortality risk of RPILD.Conclusion:Both NLR and SII are accessible,cost⁃effective,and reliable prognostic indicators for the prognosis of patients with anti⁃MDA5^(+)DM,providing a valuable guidance for clinical management and risk stratification of the disease. 展开更多
关键词 anti⁃melanoma differentiation⁃associated gene 5⁃positive dermatomyositis neutrophil⁃to⁃lymphocyte ratio rapidly pro⁃gressive interstitial lung disease systemic immune⁃inflammation index
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A novel trajectories optimizing method for dynamic soaring based on deep reinforcement learning
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作者 Wanyong Zou Ni Li +2 位作者 Fengcheng An Kaibo Wang Changyin Dong 《Defence Technology(防务技术)》 2025年第4期99-108,共10页
Dynamic soaring,inspired by the wind-riding flight of birds such as albatrosses,is a biomimetic technique which leverages wind fields to enhance the endurance of unmanned aerial vehicles(UAVs).Achieving a precise soar... Dynamic soaring,inspired by the wind-riding flight of birds such as albatrosses,is a biomimetic technique which leverages wind fields to enhance the endurance of unmanned aerial vehicles(UAVs).Achieving a precise soaring trajectory is crucial for maximizing energy efficiency during flight.Existing nonlinear programming methods are heavily dependent on the choice of initial values which is hard to determine.Therefore,this paper introduces a deep reinforcement learning method based on a differentially flat model for dynamic soaring trajectory planning and optimization.Initially,the gliding trajectory is parameterized using Fourier basis functions,achieving a flexible trajectory representation with a minimal number of hyperparameters.Subsequently,the trajectory optimization problem is formulated as a dynamic interactive process of Markov decision-making.The hyperparameters of the trajectory are optimized using the Proximal Policy Optimization(PPO2)algorithm from deep reinforcement learning(DRL),reducing the strong reliance on initial value settings in the optimization process.Finally,a comparison between the proposed method and the nonlinear programming method reveals that the trajectory generated by the proposed approach is smoother while meeting the same performance requirements.Specifically,the proposed method achieves a 34%reduction in maximum thrust,a 39.4%decrease in maximum thrust difference,and a 33%reduction in maximum airspeed difference. 展开更多
关键词 Dynamic soaring Differential flatness Trajectory optimization Proximal policy optimization
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Mode-switching cooperative defense strategy for the orbit pursuit-evasion-defense game
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作者 Yongshang Wei Tianxi Liu Cheng Wei 《Defence Technology(防务技术)》 2025年第2期272-286,共15页
This paper presents a mode-switching collaborative defense strategy for spacecraft pursuit-evasiondefense scenarios.In these scenarios,the pursuer tries to avoid the defender while capturing the evader,while the evade... This paper presents a mode-switching collaborative defense strategy for spacecraft pursuit-evasiondefense scenarios.In these scenarios,the pursuer tries to avoid the defender while capturing the evader,while the evader and defender form an alliance to prevent the pursuer from achieving its goal.First,the behavioral modes of the pursuer,including attack and avoidance modes,were established using differential game theory.These modes are then recognized by an interactive multiple model-matching algorithm(IMM),that uses several smooth variable structure filters to match the modes of the pursuer and update their probabilities in real time.Based on the linear-quadratic optimization theory,combined with the results of strategy identification,a two-way cooperative optimal strategy for the defender and evader is proposed,where the evader aids the defender to intercept the pursuer by performing luring maneuvers.Simulation results show that the interactive multi-model algorithm based on several smooth variable structure filters perform well in the strategy identification of the pursuer,and the cooperative defense strategy based on strategy identification has good interception performance when facing pursuers,who are able to flexibly adjust their game objectives. 展开更多
关键词 Cooperative policy Differential games Orbit pursuit-evasion-defense game Mod recognition
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Distributed event-triggered control for UAV swarm target fencing with network connectivity preservation and collision avoidance
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作者 Xiuxia Yang Hao Yu +1 位作者 Yi Zhang Wenqiang Yao 《Defence Technology(防务技术)》 2025年第8期412-427,共16页
This paper proposes a distributed event-triggered control(ETC)framework to address cooperative target fencing challenges in UAV swarm.The proposed architecture eliminates the reliance on preset formation parameters wh... This paper proposes a distributed event-triggered control(ETC)framework to address cooperative target fencing challenges in UAV swarm.The proposed architecture eliminates the reliance on preset formation parameters while achieving multi-objective cooperative control for target fencing,network connectivity preservation,collision avoidance,and communication efficiency optimization.Firstly,a differential state observer is constructed to obtain the target's unmeasurable states.Secondly,leveraging swarm selforganization principles,a geometric-constraint-free distributed fencing controller is designed by integrating potential field methods with consensus theory.The controller dynamically adjusts inter-UAV distances via single potential function,enabling coordinated optimization of persistent network connectivity and collision-free motion during target fencing.Thirdly,a dual-threshold ETC mechanism based on velocity consensus deviation and fencing error is proposed,which can be triggered based on task features to dynamically adjust the communication frequency,significantly reduce the communication burden and exclude Zeno behavior.Theoretical analysis demonstrates the stability of closed-loop systems.Multi-scenario simulations show that the proposed method can achieve robust fencing under target maneuverability,partial UAV failures,and communication disturbances. 展开更多
关键词 Dual-threshold ETC mechanism UAV swarm Cooperative control Distributed control Target fencing Differential state observer
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Design of a novel discrete dual-switching tracking differentiator
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作者 HAN Kun ZHANG Hao-bo 《Journal of Central South University》 2025年第6期2208-2223,共16页
Signal filtering and differential acquisition are classic yet challenging issues in control engineering.The discrete-time optimal control(DTOC)based on classic tracking differentiator(TD)can effectively extract differ... Signal filtering and differential acquisition are classic yet challenging issues in control engineering.The discrete-time optimal control(DTOC)based on classic tracking differentiator(TD)can effectively extract differentiation signals and filter signals,while eliminating the chattering problem that arises during the discretization of the continuous solution.However,under external disturbance,the convergence mode may change,leading to overshoot and noise amplification.In this paper,a dual-switching strategy is proposed,which can alternate between the base double-integral system and its dual system according to the quadrant of the system’s state.And a novel linearized control law is also introduced,deriving a novel dual-switch tracking differentiator.Further analysis of system convergence and time optimality is provided.Simulation results show that the application of this dual-switching strategy notably reduces overshoot in both tracking and differential signals while enhancing noise filtering performance.Moreover,experiments conducted on a permanent magnet synchronous motor(PMSM)platform,where the proposed TD acts as a filter in the speed feedback loop,demonstrate that the standard deviation between the reference speed and the target speed(at a constant speed of 378 r/min)decreased from 5.63 r/min to 4.93 r/min,compared to the moving average algorithm. 展开更多
关键词 tracking differentiator discrete time optimal control dual-switching strategy speed filtering
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2型糖尿病肾病患者生长分化因子-15的表达及临床意义 被引量:27
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作者 李慧 高方 +1 位作者 薛耀明 钱毅 《南方医科大学学报》 CAS CSCD 北大核心 2014年第3期387-390,395,共5页
目的:探讨生长分化因子-15(GDF-15)在2型糖尿病肾病中的表达水平及其临床意义。方法纳入80例2型糖尿病(T2DM)患者,根据Mogensen分期标准,分为正常白蛋白尿组(30例)、微量白蛋白尿组(20例)和大量白蛋白尿组(30例),采用ELIS... 目的:探讨生长分化因子-15(GDF-15)在2型糖尿病肾病中的表达水平及其临床意义。方法纳入80例2型糖尿病(T2DM)患者,根据Mogensen分期标准,分为正常白蛋白尿组(30例)、微量白蛋白尿组(20例)和大量白蛋白尿组(30例),采用ELISA法测定血浆GDF-15水平。结果大量白蛋白尿组GDF-15水平高于微量白蛋白尿组和正常白蛋白尿组(P均&lt;0.01),分别为1773.9(1099.1-2357.4)pg/ml、864.0(636.1-994.3)pg/ml和704.5(548.8-975.8)pg/ml;微量白蛋白尿组GDF-15水平高于正常白蛋白尿组(P&gt;0.05),且在肾功能轻度受损(60≤肾小球滤过率&lt;90 ml/min/1.73 m2)时GDF-15浓度即有增加,为999.5(769.2-1372.1)pg/ml。偏相关分析显示,血浆GDF-15与糖尿病病程、尿微量白蛋白(mAlb)、尿素氮(BUN)及肌酐(sCr)呈正相关(r=0.246,0.493,0.390,0.471,P均&lt;0.05),与估计的肾小球滤过率(eGFR)及血浆白蛋白(Alb)呈负相关(r=-0.438,-0.397,P均&lt;0.01)。多元线性回归分析提示较高水平的GDF-15为mAlb增加的独立危险因素。在对肾功能受损(eGFR&lt;90 ml/min/1.73 m2)的诊断中,GDF-15和mAlb的曲线下面积分别为0.801和0.717,GDF-15曲线下面积大于mAlb(P&lt;0.05)。当733.78 pg/ml作为GDF-15诊断肾功能受损的临界值时,敏感性和特异性达到最佳,分别为88.1%和58.1%。结论GDF-15在2型糖尿病肾病不同临床阶段有不同程度的增高,不但与mAlb、eGFR有良好的相关性,而且是mAlb增加的独立危险因素,故在2型糖尿病肾病的早期诊断、病情评估及预测其疾病转归方面具有一定的应用价值。 展开更多
关键词 2型糖尿病 肾病 生长分化因子-15 growth DIFFERENTIATION factor-15
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基于DE-DMPC的UAV编队重构防碰撞控制 被引量:12
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作者 魏瑞轩 吕明海 +1 位作者 茹常剑 许卓凡 《系统工程与电子技术》 EI CSCD 北大核心 2014年第12期2473-2478,共6页
当战场环境发生变化时,无人驾驶飞机(unmanned aerial vehicle,UAV)编队只有进行编队重构,才能保证编队的生存能力。在重构过程中碰撞问题严重威胁UAV安全应着重考虑。通过对UAV编队重构防碰撞问题进行分析,提出采用分布式模型预测控制(... 当战场环境发生变化时,无人驾驶飞机(unmanned aerial vehicle,UAV)编队只有进行编队重构,才能保证编队的生存能力。在重构过程中碰撞问题严重威胁UAV安全应着重考虑。通过对UAV编队重构防碰撞问题进行分析,提出采用分布式模型预测控制(distributed model predictive control,DMPC)的方法,将编队重构问题转化为滚动在线优化问题。结合碰撞约束建立重构代价函数,针对代价函数求解复杂的问题,提出采用改进微分进化(differential evolution,DE)算法求解代价函数,并对算法的收敛性进行了分析。仿真实验表明,所提出的算法能够有效实现编队重构防碰撞控制,同时其代价更小、寻优能力更强。 展开更多
关键词 无人机 编队重构 防碰撞 微分进化 unmanned AERIAL vehicle (UAV ) differential evolution (DE)
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8b/10b编码实现LVDS交流耦合传输中的直流平衡 被引量:11
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作者 刘泳锐 张彦军 +1 位作者 刘龙飞 雷建胜 《科学技术与工程》 北大核心 2012年第35期9693-9696,9701,共5页
LVDS在高速数据传输中得到了广泛应用,但在传输过程中存在交流耦合,使得连续出现的0或1信号传输会出现丢数、误码等问题。通过介绍直流平衡在交流耦合中的作用,采用8b/10b编码的方法,实现了直流平衡。同时说明了8b/10b编码的具体实现过... LVDS在高速数据传输中得到了广泛应用,但在传输过程中存在交流耦合,使得连续出现的0或1信号传输会出现丢数、误码等问题。通过介绍直流平衡在交流耦合中的作用,采用8b/10b编码的方法,实现了直流平衡。同时说明了8b/10b编码的具体实现过程中的重点和细节。通过仿真和实际数据收发,证实了该方案的可行性、准确性,提高了LVDS数据传输能力。 展开更多
关键词 低压差分信号(Low VOLTAGE DIFFERENTIAL SIGNALING LVDS)8b 10b 交流耦合 直流平衡
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基于相对增益和改进粒子群算法的PSS与直流调制协调策略 被引量:17
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作者 王曦 李兴源 赵睿 《中国电机工程学报》 EI CSCD 北大核心 2014年第34期6177-6184,共8页
现有电力系统稳定器(power system stabilizer,PSS)和直流调制多使用本地信号作为控制器反馈输入信号,控制器间的交互作用可能降低甚至破坏系统稳定性。提出了一种基于广域测量信号的PSS与直流调制协调策略,首先通过留数法选择对于振荡... 现有电力系统稳定器(power system stabilizer,PSS)和直流调制多使用本地信号作为控制器反馈输入信号,控制器间的交互作用可能降低甚至破坏系统稳定性。提出了一种基于广域测量信号的PSS与直流调制协调策略,首先通过留数法选择对于振荡模态可观性较强的广域信号作为阻尼控制器备选反馈信号;其次通过相对增益方法选择使PSS和直流调制交互影响最小的备选信号作为最佳反馈信号;而后设计分散控制器,并运用基于混沌和差分进化的混合粒子群优化算法对PSS和直流调制控制器参数进行协调优化。最后,通过EPRI 36节点系统仿真验证了协调策略的正确性和有效性。 展开更多
关键词 协调控制 广域测量系统 相对增益 混沌和差分进化的混合粒子群 反馈信号 wide-area measurement system (WAMS) chaos and differential evolution particle SWARM optimization algorithm (CDEHPSO)
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一种时差/频率差快速联合估计方法 被引量:13
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作者 孙正波 叶尚福 《电波科学学报》 EI CSCD 北大核心 2006年第5期641-646,共6页
利用主星和邻近星转发信号的互模糊函数(CrossAmbiguityFunction-CAF)进行定位参数的估计是通信卫星干扰源定位的一种重要方法。由于这种参数估计是二维平面上的迭代搜索运算,达到估计精度需要处理很长的数据,计算量巨大,处理速度一直... 利用主星和邻近星转发信号的互模糊函数(CrossAmbiguityFunction-CAF)进行定位参数的估计是通信卫星干扰源定位的一种重要方法。由于这种参数估计是二维平面上的迭代搜索运算,达到估计精度需要处理很长的数据,计算量巨大,处理速度一直是该方法应用的瓶颈。分析了参数估计精度对时间/带宽的要求,设计了具有不同分辨率的时域双模式搜索流程直接减少信号处理的数据点数,并提出了用卫星星历辅助产生搜索初值的方法,降低了CAF参数估计的运算量。新方法与传统试探方法的运算量比较和对实际信号的处理实验验证了处理方法的有效性。 展开更多
关键词 卫星干扰源定位 时间差(DTO—differential time offset) 频率差(DFO—differential frequency offset) CAF DFT 粗估计 精估计
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冻结过程中肾细胞体积变化的实验研究与数值计算 被引量:2
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作者 王雅博 诸凯 +2 位作者 张于峰 安娜 王艳娇 《天津大学学报(自然科学与工程技术版)》 EI CAS CSCD 北大核心 2014年第2期149-154,共6页
以肾细胞为研究对象,采用低温显微系统研究了不同降温速率时细胞的脱水传质过程,观察了冻结过程中细胞体积的变化;同时,采用差示扫描量热仪(DSC)测定了肾细胞冻结过程中的放热量,通过理论模型计算出细胞冻结过程中的体积变化.由低温显... 以肾细胞为研究对象,采用低温显微系统研究了不同降温速率时细胞的脱水传质过程,观察了冻结过程中细胞体积的变化;同时,采用差示扫描量热仪(DSC)测定了肾细胞冻结过程中的放热量,通过理论模型计算出细胞冻结过程中的体积变化.由低温显微镜直接观察和DSC方法获得了相似的细胞体积和体积变化趋势.最后,针对不同的降温速率,根据细胞水分渗透模型计算出细胞膜水分的渗透系数和表观渗透活化能.这些参数的获得为优化细胞的保存条件提供了理论依据. 展开更多
关键词 肾细胞 低温保存 细胞水分渗透 差示扫描量热仪 differential SCANNING CALORIMETRY (DSC)
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大鼠脊髓损伤后三七总皂苷治疗增强脊髓损伤区突触分化诱导基因1(SynDIG1)的表达 被引量:4
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作者 徐纪伟 孙丹华 陈旭东 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2016年第3期356-359,共4页
目前对脊髓损伤的临床治疗仍是研究难题之一,主要是因为脊髓内的神经细胞再生修复能力较弱以及脊髓损伤后的微环境内出现大量神经生长抑制因子,特别是在脊髓损伤后由于炎症刺激神经突触囊泡导致谷氨酸大量释放,短时间内突触间隙的谷氨... 目前对脊髓损伤的临床治疗仍是研究难题之一,主要是因为脊髓内的神经细胞再生修复能力较弱以及脊髓损伤后的微环境内出现大量神经生长抑制因子,特别是在脊髓损伤后由于炎症刺激神经突触囊泡导致谷氨酸大量释放,短时间内突触间隙的谷氨酸浓度急剧升高,致使神经细胞受到兴奋性毒性损伤,所以治疗脊髓损伤是采取药物治疗,减少神经生长抑制因子分泌,调整脊髓内神经细胞再生修复的微环境,有利于神经细胞的再生修复。 展开更多
关键词 三七总皂苷 脊髓损伤 突触分化诱导基因1(synapse DIFFERENTIATION induced gene 1) 表达 大鼠
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齐口裂腹鱼MyD88基因的cDNA序列及特征分析 被引量:3
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作者 叶华 朱成科 +2 位作者 郑宗林 吴青 郑曙明 《淡水渔业》 CSCD 北大核心 2014年第1期14-19,共6页
利用RT-PCR和RACE-PCR技术获得了齐口裂腹鱼( Schizothorax prenanti) TLR信号转导途径中的关键接头分子MyD88基因cDNA全长序列,该序列共1479 bp,包括编码284个氨基酸残基的855 bp的开放阅读框,177 bp 5′非翻译区和447 bp 3′非... 利用RT-PCR和RACE-PCR技术获得了齐口裂腹鱼( Schizothorax prenanti) TLR信号转导途径中的关键接头分子MyD88基因cDNA全长序列,该序列共1479 bp,包括编码284个氨基酸残基的855 bp的开放阅读框,177 bp 5′非翻译区和447 bp 3′非翻译区,编码284个氨基酸。利用SMART软件分析,结果显示,该蛋白在N端和C端分别存在死亡结构域(Death domain, DD)和TIR结构域(Toll/IL-1 receptor homology domain, TIR)。齐口裂腹鱼MyD88氨基酸序列与鲤( Cyprinus carpio)、斑马鱼( Danio rerio)、大黄鱼( Larimichthys crocea)、花鲈( Lateolabrax japonicas)、虹鳟( Oncorhynchus mykiss)的相似性为69.37%~91.90%,其中与斑马鱼的相似性最高。用 NJ 法构建的系统进化树中,齐口裂腹鱼MyD88和其它鱼类MyD88聚为一枝。 展开更多
关键词 齐口裂腹鱼(Schizothorax prenanti) TOLL 样受体 髓样分化因子88(MyD88) MYELOID differentiation factor 88 (MyD88)
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