This paper reports that in the presence of cetyltrimethyl ammonium bromide as phase transfer catalyst,D-glucosamine hydrochloride reacts with 2,4-dinitrophenol to synthesize 1-O-(2’,4’-dinitrophenyl)-2-acetamido-β-...This paper reports that in the presence of cetyltrimethyl ammonium bromide as phase transfer catalyst,D-glucosamine hydrochloride reacts with 2,4-dinitrophenol to synthesize 1-O-(2’,4’-dinitrophenyl)-2-acetamido-β-D-glucoside.Chemical structure of the new compound was confirmed by elemental analysis,IR and UV.展开更多
Nucleoside reverse transcriptase inhibitors are the only drugs so far approved for the treatment of AIDS. Several nucleoside analogs are potent inhibitors of human immunodeficiency virus(HIV) in cell culture. However,...Nucleoside reverse transcriptase inhibitors are the only drugs so far approved for the treatment of AIDS. Several nucleoside analogs are potent inhibitors of human immunodeficiency virus(HIV) in cell culture. However, in many cases the nucleoside derivatives have a poor affinity for nucleoside kinases. Nucleoside 5′-phosphorothioates is relatively resistant to enzymatic transformations. In this paper, 2′,3′-O-alkoxymethylidene adenosine 5′-thiophosphoramidates were synthesized through a highly efficient approach. The new compounds were characterized by NMR, IR and ESI-MS.展开更多
1-氯-3-丁烯-2-酮(1-chloro-3-buten-2-one,CBO)是致癌性环境污染物1,3-丁二烯的一种体外代谢产物,具有细胞毒性和遗传毒性,易形成DNA加成产物以及谷胱甘肽偶联产物.预计CBO-谷胱甘肽偶联产物在肾脏被代谢为CBO-N-乙酰半胱氨酸(N-acetyl...1-氯-3-丁烯-2-酮(1-chloro-3-buten-2-one,CBO)是致癌性环境污染物1,3-丁二烯的一种体外代谢产物,具有细胞毒性和遗传毒性,易形成DNA加成产物以及谷胱甘肽偶联产物.预计CBO-谷胱甘肽偶联产物在肾脏被代谢为CBO-N-乙酰半胱氨酸(N-acetylcysteine,NAC)偶联产物,最终随尿排出体外.因此,CBO-NAC偶联产物能够作为CBO生物标志物.然而,CBO与NAC的反应尚未见报道.研究了CBO与NAC在体外生理条件下(pH=7.4,37℃)的反应,观察到两种产物.通过一维和二维核磁共振光谱(nuclear magnetic resonance spectroscopy,NMR)确定两种产物的结构分别是1-氯-4-(N-乙酰-S-半胱氨酸基)-2-丁酮和1,4-双(N-乙酰-S-半胱氨酸基)-2-丁酮,后者是一种新化合物.这些产物的识别为后续研究打好了基础.展开更多
文摘This paper reports that in the presence of cetyltrimethyl ammonium bromide as phase transfer catalyst,D-glucosamine hydrochloride reacts with 2,4-dinitrophenol to synthesize 1-O-(2’,4’-dinitrophenyl)-2-acetamido-β-D-glucoside.Chemical structure of the new compound was confirmed by elemental analysis,IR and UV.
文摘Nucleoside reverse transcriptase inhibitors are the only drugs so far approved for the treatment of AIDS. Several nucleoside analogs are potent inhibitors of human immunodeficiency virus(HIV) in cell culture. However, in many cases the nucleoside derivatives have a poor affinity for nucleoside kinases. Nucleoside 5′-phosphorothioates is relatively resistant to enzymatic transformations. In this paper, 2′,3′-O-alkoxymethylidene adenosine 5′-thiophosphoramidates were synthesized through a highly efficient approach. The new compounds were characterized by NMR, IR and ESI-MS.
文摘1-氯-3-丁烯-2-酮(1-chloro-3-buten-2-one,CBO)是致癌性环境污染物1,3-丁二烯的一种体外代谢产物,具有细胞毒性和遗传毒性,易形成DNA加成产物以及谷胱甘肽偶联产物.预计CBO-谷胱甘肽偶联产物在肾脏被代谢为CBO-N-乙酰半胱氨酸(N-acetylcysteine,NAC)偶联产物,最终随尿排出体外.因此,CBO-NAC偶联产物能够作为CBO生物标志物.然而,CBO与NAC的反应尚未见报道.研究了CBO与NAC在体外生理条件下(pH=7.4,37℃)的反应,观察到两种产物.通过一维和二维核磁共振光谱(nuclear magnetic resonance spectroscopy,NMR)确定两种产物的结构分别是1-氯-4-(N-乙酰-S-半胱氨酸基)-2-丁酮和1,4-双(N-乙酰-S-半胱氨酸基)-2-丁酮,后者是一种新化合物.这些产物的识别为后续研究打好了基础.
