How the initial fluctuation affects on the elliptic flow is investigated by investigating the rapidity, transverse 4-velocity, centrality dependencies of elliptic flow for Au+Au at 1 GeV/A with the help of an Isospin ...How the initial fluctuation affects on the elliptic flow is investigated by investigating the rapidity, transverse 4-velocity, centrality dependencies of elliptic flow for Au+Au at 1 GeV/A with the help of an Isospin Quantum Molecular Dynamics (IQMD). In addition, we compare the flow calculated with respect to participant plane created by the initial geometry in coordinate space with the flow reconstructed by the experimental event-plane method, and compare the flow with the experimental data of the FOPI collaboration. It shows that there exists some discrepancy between the flows reconstructed by the above two methods.展开更多
This study aimed to explore the effect of Bifidobacterium animalis F1-7 on the improvement of atherosclerotic inflammation.Arteriosclerosis model ApoE^(-/-)mice were orally administered with B.animalis F1-7 for 12 wee...This study aimed to explore the effect of Bifidobacterium animalis F1-7 on the improvement of atherosclerotic inflammation.Arteriosclerosis model ApoE^(-/-)mice were orally administered with B.animalis F1-7 for 12 weeks.The probiotic intervention reduced the plaque areas in aorta and the accumulation of macrophages,and downregulated the expression of toll-like receptor 4(TLR4)/nuclear factorκB(NF-κB)pathway to reduce the levels of inflammatory factors.The widely-targeted metabolomics analysis showed that acetyl-L-carnitine(ALC)in the intestine of atherosclerotic mice was significantly increased after B.animalis F1-7 intervention.Correlation analysis proved that ALC was associated with atherosclerotic inflammatory response.By using oxidized low density lipoprotein induced macrophage foam cells,we further verified that ALC could reduce lipid accumulation and inflammatory response in foam cells by downregulating the TLR4/NF-κB pathway.Finally,our results revealed that B.animalis F1-7 upregulated the metabolite ALC to downregulate the inflammatory responses,leading to the reduction of plaque accumulation of atherosclerosis.展开更多
基金Supported by National Natural Science Foundation of China(Nos.11220101005,11035009,10979074 and 11205230)Major State Basic Research Development Program in China(No.2013CB834405)
文摘How the initial fluctuation affects on the elliptic flow is investigated by investigating the rapidity, transverse 4-velocity, centrality dependencies of elliptic flow for Au+Au at 1 GeV/A with the help of an Isospin Quantum Molecular Dynamics (IQMD). In addition, we compare the flow calculated with respect to participant plane created by the initial geometry in coordinate space with the flow reconstructed by the experimental event-plane method, and compare the flow with the experimental data of the FOPI collaboration. It shows that there exists some discrepancy between the flows reconstructed by the above two methods.
基金supported by Shandong Taishan industry leading talent project(LJNY202101)the National Key R&D of China(2018YFC0311201)。
文摘This study aimed to explore the effect of Bifidobacterium animalis F1-7 on the improvement of atherosclerotic inflammation.Arteriosclerosis model ApoE^(-/-)mice were orally administered with B.animalis F1-7 for 12 weeks.The probiotic intervention reduced the plaque areas in aorta and the accumulation of macrophages,and downregulated the expression of toll-like receptor 4(TLR4)/nuclear factorκB(NF-κB)pathway to reduce the levels of inflammatory factors.The widely-targeted metabolomics analysis showed that acetyl-L-carnitine(ALC)in the intestine of atherosclerotic mice was significantly increased after B.animalis F1-7 intervention.Correlation analysis proved that ALC was associated with atherosclerotic inflammatory response.By using oxidized low density lipoprotein induced macrophage foam cells,we further verified that ALC could reduce lipid accumulation and inflammatory response in foam cells by downregulating the TLR4/NF-κB pathway.Finally,our results revealed that B.animalis F1-7 upregulated the metabolite ALC to downregulate the inflammatory responses,leading to the reduction of plaque accumulation of atherosclerosis.
