Myocardium hypertrophy is a compensated response to cardiac disease in which intracellular Ca2+ concentration is elevated,the essential signal that results in hypertrophy.The cardiac sodium-calcium exchanger(NCX) is a...Myocardium hypertrophy is a compensated response to cardiac disease in which intracellular Ca2+ concentration is elevated,the essential signal that results in hypertrophy.The cardiac sodium-calcium exchanger(NCX) is a bidirectional ion transporter in sarcolemma.The decrease in NCX activity as well as its inverse mode is one of the main mechanisms that contribute to cytosolic Ca2+ loading in hypertrophy.The extracellular signal molecules,the change of Na+ /Ca2+ concentrations and intracellular modulating proteins during cardiac hypertrophy can affect the activity or NCX function,and increase intracellular Ca2+.We summarized the regulatory mechanism of NCX in myocardium hypertrophy.展开更多
文摘Myocardium hypertrophy is a compensated response to cardiac disease in which intracellular Ca2+ concentration is elevated,the essential signal that results in hypertrophy.The cardiac sodium-calcium exchanger(NCX) is a bidirectional ion transporter in sarcolemma.The decrease in NCX activity as well as its inverse mode is one of the main mechanisms that contribute to cytosolic Ca2+ loading in hypertrophy.The extracellular signal molecules,the change of Na+ /Ca2+ concentrations and intracellular modulating proteins during cardiac hypertrophy can affect the activity or NCX function,and increase intracellular Ca2+.We summarized the regulatory mechanism of NCX in myocardium hypertrophy.
