The progress of science is in part attributed to the development of new methodologies. The application of mass spectrometry (MS) and nuclear magnetic resonance (NMR) in the study of biological macromolecules is such a...The progress of science is in part attributed to the development of new methodologies. The application of mass spectrometry (MS) and nuclear magnetic resonance (NMR) in the study of biological macromolecules is such a representative example, which is the subject of this year’s Nobel prize award in chemistry shared by three scientists. The works include the development of soft desorption ionization methods for mass spectrometric analysis of biological macromolecules and the development of NMR for determining the three-dimensional structure of biological macromolecules in solution. These developments revolutionized the analytical methods for biomolecules such as proteins and facilitate the study of biological macromolecules so much enough to have deep effects on the whole life sciences.展开更多
敞开式电离质谱(Ambient ionization mass spectrometry,AIMS)是指在大气压环境下,无需或只需简单的样品前处理即可对样品中目标物进行分析的质谱技术。AIMS具有简单、快速、无损和适用范围广等优势,被广泛应用于法医毒物分析领域。该...敞开式电离质谱(Ambient ionization mass spectrometry,AIMS)是指在大气压环境下,无需或只需简单的样品前处理即可对样品中目标物进行分析的质谱技术。AIMS具有简单、快速、无损和适用范围广等优势,被广泛应用于法医毒物分析领域。该文对敞开式电离(Ambient ionization,AI)技术进行了简单概述,将检材分为体内检材和体外检材两大类,综述了AIMS技术在不同类型检材毒物分析中的应用,并对其在法医毒物分析中的发展前景进行了展望。展开更多
文摘The progress of science is in part attributed to the development of new methodologies. The application of mass spectrometry (MS) and nuclear magnetic resonance (NMR) in the study of biological macromolecules is such a representative example, which is the subject of this year’s Nobel prize award in chemistry shared by three scientists. The works include the development of soft desorption ionization methods for mass spectrometric analysis of biological macromolecules and the development of NMR for determining the three-dimensional structure of biological macromolecules in solution. These developments revolutionized the analytical methods for biomolecules such as proteins and facilitate the study of biological macromolecules so much enough to have deep effects on the whole life sciences.
文摘敞开式电离质谱(Ambient ionization mass spectrometry,AIMS)是指在大气压环境下,无需或只需简单的样品前处理即可对样品中目标物进行分析的质谱技术。AIMS具有简单、快速、无损和适用范围广等优势,被广泛应用于法医毒物分析领域。该文对敞开式电离(Ambient ionization,AI)技术进行了简单概述,将检材分为体内检材和体外检材两大类,综述了AIMS技术在不同类型检材毒物分析中的应用,并对其在法医毒物分析中的发展前景进行了展望。
