2025年3月24日,《分子细胞》(Molecular Cell)在线发表了浙江大学医学院吕志民教授团队的研究成果“PI3Kβfunctions as a protein kinase to promote cellular protein O-GlcNAcylation and acetyl-CoA production for tumor growth”(...2025年3月24日,《分子细胞》(Molecular Cell)在线发表了浙江大学医学院吕志民教授团队的研究成果“PI3Kβfunctions as a protein kinase to promote cellular protein O-GlcNAcylation and acetyl-CoA production for tumor growth”(DOI:10.1016/j.molcel.2025.02.024)。展开更多
Embryonic stem cells undergo extensive self-renewal and have the capacity to differentiate along multiple cell lineages.Research on totipotency and directional differentiation of embryonic stem cells in order to treat...Embryonic stem cells undergo extensive self-renewal and have the capacity to differentiate along multiple cell lineages.Research on totipotency and directional differentiation of embryonic stem cells in order to treat intractable disease,such as cancer,heart failure,atherosclerosis by tissue regeneration and cell transplantation are investigated.Epigenetic modification,including DNA methylation,chromatin restructure,and non-coding RNA-mediated regulatory events,regulate the differentiation of embryonic stem cells without detectable genetic changes.These mechanisms are often associated with starting-up and maintenance of epigenetic silence.The achievement and focuses on the molecular mechanism of embryonic stem cells during directional differentiation regulated by epigenetic modification are reviewed.展开更多
文摘2025年3月24日,《分子细胞》(Molecular Cell)在线发表了浙江大学医学院吕志民教授团队的研究成果“PI3Kβfunctions as a protein kinase to promote cellular protein O-GlcNAcylation and acetyl-CoA production for tumor growth”(DOI:10.1016/j.molcel.2025.02.024)。
文摘Embryonic stem cells undergo extensive self-renewal and have the capacity to differentiate along multiple cell lineages.Research on totipotency and directional differentiation of embryonic stem cells in order to treat intractable disease,such as cancer,heart failure,atherosclerosis by tissue regeneration and cell transplantation are investigated.Epigenetic modification,including DNA methylation,chromatin restructure,and non-coding RNA-mediated regulatory events,regulate the differentiation of embryonic stem cells without detectable genetic changes.These mechanisms are often associated with starting-up and maintenance of epigenetic silence.The achievement and focuses on the molecular mechanism of embryonic stem cells during directional differentiation regulated by epigenetic modification are reviewed.
