目的:探讨含米托蒽醌脂质体方案治疗高危儿童急性髓系白血病(AML)的安全性与有效性。方法:收集武汉儿童医院2022年1月至2023年2月应用含米托蒽醌脂质体方案治疗的AML高危患儿为观察组,对照组为应用去甲氧柔红霉素方案的AML高危患儿,分...目的:探讨含米托蒽醌脂质体方案治疗高危儿童急性髓系白血病(AML)的安全性与有效性。方法:收集武汉儿童医院2022年1月至2023年2月应用含米托蒽醌脂质体方案治疗的AML高危患儿为观察组,对照组为应用去甲氧柔红霉素方案的AML高危患儿,分析患儿的临床资料,比较两组患儿治疗后骨髓恢复时间、骨髓完全缓解(CR)率,微小残留病灶(MRD)清除率及治疗相关不良反应等临床特性。结果:患儿接受含米托蒽醌脂质体化疗方案在白细胞(17 vs 21 d)、粒细胞(18 vs 24d)、血小板(17 vs 24 d)及血红蛋白(20 vs 26 d)计数恢复时间上均明显优于去甲氧柔红霉素组(P<0.05)。观察组治疗有效率和MRD转阴率分别为90.9%和72.7%,对照组为94.1%和76.4%,均无显著性统计学差异(P>0.05),两组治疗总有效率类似。结论:含米托蒽醌脂质体化疗方案治疗高危儿童AML疗效不劣于去甲氧柔红霉素方案,但骨髓抑制时间明显缩短,安全性好。展开更多
In 0.12 mol/L hydrochloric acid and nitric acid media,mitoxantrone interacted with molybdate to form an ion-association complex,which can result in the significant enhancement of RRS intensity.The(maximum) scattering ...In 0.12 mol/L hydrochloric acid and nitric acid media,mitoxantrone interacted with molybdate to form an ion-association complex,which can result in the significant enhancement of RRS intensity.The(maximum) scattering wavelengths were 365 nm for RRS and scattering intensities are proportional to the concentration of mitoxantrone,which can be applied to the determination of mitoxantrone.The detection limits are(6 ng/mL) in nitric acid and 8 ng/mL in hydrochloric acid respectively.Because there are not such interactions between anthracycline anticancer drugs such as daunorubicin and epirubicin with molybdate,mitoxantrone can be determined selectively with other anthracycline anticancer drugs existing.The optimum experiment condition,affecting factor and the effect of coexisting substance were investigated in the paper.The application to the determination of mitoxantrone in serum and urine by RRS were not only sensitive but also simple and ra-pid.In addition,the interaction mechanism was discussed.展开更多
文摘目的:探讨含米托蒽醌脂质体方案治疗高危儿童急性髓系白血病(AML)的安全性与有效性。方法:收集武汉儿童医院2022年1月至2023年2月应用含米托蒽醌脂质体方案治疗的AML高危患儿为观察组,对照组为应用去甲氧柔红霉素方案的AML高危患儿,分析患儿的临床资料,比较两组患儿治疗后骨髓恢复时间、骨髓完全缓解(CR)率,微小残留病灶(MRD)清除率及治疗相关不良反应等临床特性。结果:患儿接受含米托蒽醌脂质体化疗方案在白细胞(17 vs 21 d)、粒细胞(18 vs 24d)、血小板(17 vs 24 d)及血红蛋白(20 vs 26 d)计数恢复时间上均明显优于去甲氧柔红霉素组(P<0.05)。观察组治疗有效率和MRD转阴率分别为90.9%和72.7%,对照组为94.1%和76.4%,均无显著性统计学差异(P>0.05),两组治疗总有效率类似。结论:含米托蒽醌脂质体化疗方案治疗高危儿童AML疗效不劣于去甲氧柔红霉素方案,但骨髓抑制时间明显缩短,安全性好。
文摘In 0.12 mol/L hydrochloric acid and nitric acid media,mitoxantrone interacted with molybdate to form an ion-association complex,which can result in the significant enhancement of RRS intensity.The(maximum) scattering wavelengths were 365 nm for RRS and scattering intensities are proportional to the concentration of mitoxantrone,which can be applied to the determination of mitoxantrone.The detection limits are(6 ng/mL) in nitric acid and 8 ng/mL in hydrochloric acid respectively.Because there are not such interactions between anthracycline anticancer drugs such as daunorubicin and epirubicin with molybdate,mitoxantrone can be determined selectively with other anthracycline anticancer drugs existing.The optimum experiment condition,affecting factor and the effect of coexisting substance were investigated in the paper.The application to the determination of mitoxantrone in serum and urine by RRS were not only sensitive but also simple and ra-pid.In addition,the interaction mechanism was discussed.
