目的:应用Meta分析方法研究claudin-10表达与原发性消化系统恶性肿瘤患者临床病理和预后的相关性。方法:检索PubMed、Web of Science、Ovid MEDLINE、CNKI、维普、万方数据库,提取claudin-10表达与患者临床病理特征关系以及预后的数据,...目的:应用Meta分析方法研究claudin-10表达与原发性消化系统恶性肿瘤患者临床病理和预后的相关性。方法:检索PubMed、Web of Science、Ovid MEDLINE、CNKI、维普、万方数据库,提取claudin-10表达与患者临床病理特征关系以及预后的数据,应用RevMan 5.3和Stata15.1软件进行Meta分析。结果:纳入6篇文献,512例原发性消化系统恶性肿瘤患者。原发性消化系统恶性肿瘤组织中claudin-10的高表达率显著高于正常对照组,差异具有统计学意义[OR=3.22,95%CI(2.26,4.60),P<0.01]。claudin-10高表达与肿瘤大小[OR=6.21,95%CI(2.44,15.83),P<0.01]、分化程度[OR=0.56,95%CI(0.32,0.99),P=0.05]、淋巴结转移[OR=3.41,95%CI(1.09,10.65),P=0.03]呈正相关;与患者性别[OR=1.62,95%CI(0.91,2.90),P=0.10]、年龄[OR=1.72,95%CI(0.97,3.07),P=0.06]、远处转移[OR=4.51,95%CI(0.55,36.70),P=0.16]、患者预后[HR=1.99,95%CI(0.93,4.23),P=0.08]无关。结论:claudin-10表达与原发性消化系统恶性肿瘤的临床病理特征相关,是潜在的肿瘤标志物。展开更多
Various hypotheses have been put forward to explain the pathogenesis of hemorrhoidal diseases. However,the etiology and mechanisms of hemorrhoids are far from clear,and as a consequence the present therapeutic objecti...Various hypotheses have been put forward to explain the pathogenesis of hemorrhoidal diseases. However,the etiology and mechanisms of hemorrhoids are far from clear,and as a consequence the present therapeutic objective is just to relieve or abolish the symptoms of hemorrhoids. In this review,the recent research advances on the pathophysiological characteristics that are closely associated with hemorrhoids are analyzed and discussed,which include constipation,high anal resting pressure,anal mucosa damage,aging of the anal cushion supporting tissue,blood and vessel alterations,obstruction of microcirculation and biochemical changes.展开更多
文摘目的:应用Meta分析方法研究claudin-10表达与原发性消化系统恶性肿瘤患者临床病理和预后的相关性。方法:检索PubMed、Web of Science、Ovid MEDLINE、CNKI、维普、万方数据库,提取claudin-10表达与患者临床病理特征关系以及预后的数据,应用RevMan 5.3和Stata15.1软件进行Meta分析。结果:纳入6篇文献,512例原发性消化系统恶性肿瘤患者。原发性消化系统恶性肿瘤组织中claudin-10的高表达率显著高于正常对照组,差异具有统计学意义[OR=3.22,95%CI(2.26,4.60),P<0.01]。claudin-10高表达与肿瘤大小[OR=6.21,95%CI(2.44,15.83),P<0.01]、分化程度[OR=0.56,95%CI(0.32,0.99),P=0.05]、淋巴结转移[OR=3.41,95%CI(1.09,10.65),P=0.03]呈正相关;与患者性别[OR=1.62,95%CI(0.91,2.90),P=0.10]、年龄[OR=1.72,95%CI(0.97,3.07),P=0.06]、远处转移[OR=4.51,95%CI(0.55,36.70),P=0.16]、患者预后[HR=1.99,95%CI(0.93,4.23),P=0.08]无关。结论:claudin-10表达与原发性消化系统恶性肿瘤的临床病理特征相关,是潜在的肿瘤标志物。
文摘Various hypotheses have been put forward to explain the pathogenesis of hemorrhoidal diseases. However,the etiology and mechanisms of hemorrhoids are far from clear,and as a consequence the present therapeutic objective is just to relieve or abolish the symptoms of hemorrhoids. In this review,the recent research advances on the pathophysiological characteristics that are closely associated with hemorrhoids are analyzed and discussed,which include constipation,high anal resting pressure,anal mucosa damage,aging of the anal cushion supporting tissue,blood and vessel alterations,obstruction of microcirculation and biochemical changes.
