Tubulointerstitial lesions, occurring in many kinds of renal diseases, have been found to be the predominant factor in the impairment of renal function. The severe and extensive lesions often predict a poor outcome in...Tubulointerstitial lesions, occurring in many kinds of renal diseases, have been found to be the predominant factor in the impairment of renal function. The severe and extensive lesions often predict a poor outcome in future. It has been tested recent years that the infiltrating inflammatory cells might play important roles in the onset and deterioration of tubulointerstitial injuries. On the other hand, the resident cells, including the tubular epithelial cells and the fibroblasts, also directly take part in tubulointerstitial inflammation and fibrosis. Researches also display implicated interactions between the infiltrating cells and the resident cells, which contribute to the amplification of inflammation and the progress of fibrosis.展开更多
近年来,肿瘤浸润性B淋巴细胞(tumor-infiltrating B lymphocytes,TIL-B)在肿瘤的发生和发展中扮演着复杂且重要的角色。这些细胞通过多种机制参与抗肿瘤免疫反应,但同时也可能在特定刺激下获得抑制功能,转化为调节性B细胞(regulatory B ...近年来,肿瘤浸润性B淋巴细胞(tumor-infiltrating B lymphocytes,TIL-B)在肿瘤的发生和发展中扮演着复杂且重要的角色。这些细胞通过多种机制参与抗肿瘤免疫反应,但同时也可能在特定刺激下获得抑制功能,转化为调节性B细胞(regulatory B cells,Bregs),进而抑制肿瘤免疫应答,促进肿瘤的进展。越来越多的证据表明,TIL-B不仅是抗肿瘤免疫治疗中有效的靶标,而且在疾病预后方面也具有重要作用。本文综述了TIL-B研究现状,总结了其在肿瘤免疫中的作用机制,分析了当前的治疗策略和预后评估方法,并对未来的研究方向进行了展望。通过深入理解TIL-B的复杂性,可以为开发新的肿瘤治疗策略提供理论基础和潜在靶点。展开更多
文摘Tubulointerstitial lesions, occurring in many kinds of renal diseases, have been found to be the predominant factor in the impairment of renal function. The severe and extensive lesions often predict a poor outcome in future. It has been tested recent years that the infiltrating inflammatory cells might play important roles in the onset and deterioration of tubulointerstitial injuries. On the other hand, the resident cells, including the tubular epithelial cells and the fibroblasts, also directly take part in tubulointerstitial inflammation and fibrosis. Researches also display implicated interactions between the infiltrating cells and the resident cells, which contribute to the amplification of inflammation and the progress of fibrosis.
文摘近年来,肿瘤浸润性B淋巴细胞(tumor-infiltrating B lymphocytes,TIL-B)在肿瘤的发生和发展中扮演着复杂且重要的角色。这些细胞通过多种机制参与抗肿瘤免疫反应,但同时也可能在特定刺激下获得抑制功能,转化为调节性B细胞(regulatory B cells,Bregs),进而抑制肿瘤免疫应答,促进肿瘤的进展。越来越多的证据表明,TIL-B不仅是抗肿瘤免疫治疗中有效的靶标,而且在疾病预后方面也具有重要作用。本文综述了TIL-B研究现状,总结了其在肿瘤免疫中的作用机制,分析了当前的治疗策略和预后评估方法,并对未来的研究方向进行了展望。通过深入理解TIL-B的复杂性,可以为开发新的肿瘤治疗策略提供理论基础和潜在靶点。
