Brain injuries are frequently resulting in physical disabilities due to inadequate axonal regeneration.This review discusses the role of calcium binding proteins in axonal regeneration,and elucidates the potential usa...Brain injuries are frequently resulting in physical disabilities due to inadequate axonal regeneration.This review discusses the role of calcium binding proteins in axonal regeneration,and elucidates the potential usage of novel invertebrate calcium binding proteins in promoting axonal regeneration of mammalian central neurons.展开更多
Adult central neurons in some invertebrates can regenerate their axons and form synaptic connects follow- ing injury. Thus, identifying molecules that enable axonal regeneration may suggest new directions to stimulate...Adult central neurons in some invertebrates can regenerate their axons and form synaptic connects follow- ing injury. Thus, identifying molecules that enable axonal regeneration may suggest new directions to stimulate ax- onal re-growth in the CNS in vertebrates, which typically do not regenerate. In this talk, I will discuss the newly i-dentified pro-regenerative molecules from freshwater pond snail, Lymnaea stagnalis, and our first evidence that the snail molecule and its fragments promote the outgrowth capacity and prevent cell death of mammalian neurons. Our findings provide a potential alternative approach to identify new molecular mechanisms underlying neuroprotection following injury.展开更多
文摘Brain injuries are frequently resulting in physical disabilities due to inadequate axonal regeneration.This review discusses the role of calcium binding proteins in axonal regeneration,and elucidates the potential usage of novel invertebrate calcium binding proteins in promoting axonal regeneration of mammalian central neurons.
文摘Adult central neurons in some invertebrates can regenerate their axons and form synaptic connects follow- ing injury. Thus, identifying molecules that enable axonal regeneration may suggest new directions to stimulate ax- onal re-growth in the CNS in vertebrates, which typically do not regenerate. In this talk, I will discuss the newly i-dentified pro-regenerative molecules from freshwater pond snail, Lymnaea stagnalis, and our first evidence that the snail molecule and its fragments promote the outgrowth capacity and prevent cell death of mammalian neurons. Our findings provide a potential alternative approach to identify new molecular mechanisms underlying neuroprotection following injury.
